Venom’s antinociceptive property in the primitive ant Dinoponera quadriceps

Detalhes bibliográficos
Autor(a) principal: Sousa, Paloma L.
Data de Publicação: 2012
Outros Autores: Quinet, Yves Patric, Ponte, Edson L., Vale, Jaqueline F.do, Torres, Alba Fabíola C., Pereira, Maria G., Assreuy, Ana Maria S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/5772
Resumo: Ethnopharmacologicalrelevance: In northeasternBrazil, Dinoponera (Ponerinae)antsmacerateareused to treatearacheanditssting,rheumatism,andbackpain.Suchapopularuseisarelevantfactthat called forexperimentalevaluationoftheantinociceptiveactivityof Dinoponera venom. Materialsandmethods:Dinoponeraquadriceps venom(DqV;5–500 mg/kg;i.v.)ormorphine(3.4mg/kg;s.c.) wereevaluatedinmicemodelsofnociception(n¼8 animals/group).Negativecontrolsreceivedsterilesaline (0.9%NaCl;i.v.). Results: DqVshowed64%proteincontentandexhibitedantinociceptiveactivity,withoutaffectingmotor function,inthetests:formalin(72%),writhing(52%),vonFrey(71%)andhotplate(45%).Theantinociceptive activitywasabolishedunderproteindenaturantconditions. Conclusions: Thisstudyprovidedthefirstdemonstrationoftheantinociceptivepropertyof Dinoponera quadriceps venominmicemodelsofchemical,mechanical and thermalnociception,corroboratingthe popularuseandsuggestingitspotentialtherapeuticutilizationinpainfulconditions.
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spelling Venom’s antinociceptive property in the primitive ant Dinoponera quadricepsVenenos de FormigaDoenças ReumáticasEthnopharmacologicalrelevance: In northeasternBrazil, Dinoponera (Ponerinae)antsmacerateareused to treatearacheanditssting,rheumatism,andbackpain.Suchapopularuseisarelevantfactthat called forexperimentalevaluationoftheantinociceptiveactivityof Dinoponera venom. Materialsandmethods:Dinoponeraquadriceps venom(DqV;5–500 mg/kg;i.v.)ormorphine(3.4mg/kg;s.c.) wereevaluatedinmicemodelsofnociception(n¼8 animals/group).Negativecontrolsreceivedsterilesaline (0.9%NaCl;i.v.). Results: DqVshowed64%proteincontentandexhibitedantinociceptiveactivity,withoutaffectingmotor function,inthetests:formalin(72%),writhing(52%),vonFrey(71%)andhotplate(45%).Theantinociceptive activitywasabolishedunderproteindenaturantconditions. Conclusions: Thisstudyprovidedthefirstdemonstrationoftheantinociceptivepropertyof Dinoponera quadriceps venominmicemodelsofchemical,mechanical and thermalnociception,corroboratingthe popularuseandsuggestingitspotentialtherapeuticutilizationinpainfulconditions.Journal of Ethnopharmacology2013-09-10T10:50:33Z2013-09-10T10:50:33Z2012-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSOUSA, P. L. et al. Venom's antinociceptive property in the primitive ant Dinoponera quadriceps. Journal of Ethnopharmacology, Lausanne, Suiça, v. 144, n. 1, p. 213-216, out. 2012.0378-8741http://www.repositorio.ufc.br/handle/riufc/5772Sousa, Paloma L.Quinet, Yves PatricPonte, Edson L.Vale, Jaqueline F.doTorres, Alba Fabíola C.Pereira, Maria G.Assreuy, Ana Maria S.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-05-19T14:24:41Zoai:repositorio.ufc.br:riufc/5772Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:42:55.152340Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Venom’s antinociceptive property in the primitive ant Dinoponera quadriceps
title Venom’s antinociceptive property in the primitive ant Dinoponera quadriceps
spellingShingle Venom’s antinociceptive property in the primitive ant Dinoponera quadriceps
Sousa, Paloma L.
Venenos de Formiga
Doenças Reumáticas
title_short Venom’s antinociceptive property in the primitive ant Dinoponera quadriceps
title_full Venom’s antinociceptive property in the primitive ant Dinoponera quadriceps
title_fullStr Venom’s antinociceptive property in the primitive ant Dinoponera quadriceps
title_full_unstemmed Venom’s antinociceptive property in the primitive ant Dinoponera quadriceps
title_sort Venom’s antinociceptive property in the primitive ant Dinoponera quadriceps
author Sousa, Paloma L.
author_facet Sousa, Paloma L.
Quinet, Yves Patric
Ponte, Edson L.
Vale, Jaqueline F.do
Torres, Alba Fabíola C.
Pereira, Maria G.
Assreuy, Ana Maria S.
author_role author
author2 Quinet, Yves Patric
Ponte, Edson L.
Vale, Jaqueline F.do
Torres, Alba Fabíola C.
Pereira, Maria G.
Assreuy, Ana Maria S.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sousa, Paloma L.
Quinet, Yves Patric
Ponte, Edson L.
Vale, Jaqueline F.do
Torres, Alba Fabíola C.
Pereira, Maria G.
Assreuy, Ana Maria S.
dc.subject.por.fl_str_mv Venenos de Formiga
Doenças Reumáticas
topic Venenos de Formiga
Doenças Reumáticas
description Ethnopharmacologicalrelevance: In northeasternBrazil, Dinoponera (Ponerinae)antsmacerateareused to treatearacheanditssting,rheumatism,andbackpain.Suchapopularuseisarelevantfactthat called forexperimentalevaluationoftheantinociceptiveactivityof Dinoponera venom. Materialsandmethods:Dinoponeraquadriceps venom(DqV;5–500 mg/kg;i.v.)ormorphine(3.4mg/kg;s.c.) wereevaluatedinmicemodelsofnociception(n¼8 animals/group).Negativecontrolsreceivedsterilesaline (0.9%NaCl;i.v.). Results: DqVshowed64%proteincontentandexhibitedantinociceptiveactivity,withoutaffectingmotor function,inthetests:formalin(72%),writhing(52%),vonFrey(71%)andhotplate(45%).Theantinociceptive activitywasabolishedunderproteindenaturantconditions. Conclusions: Thisstudyprovidedthefirstdemonstrationoftheantinociceptivepropertyof Dinoponera quadriceps venominmicemodelsofchemical,mechanical and thermalnociception,corroboratingthe popularuseandsuggestingitspotentialtherapeuticutilizationinpainfulconditions.
publishDate 2012
dc.date.none.fl_str_mv 2012-10
2013-09-10T10:50:33Z
2013-09-10T10:50:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SOUSA, P. L. et al. Venom's antinociceptive property in the primitive ant Dinoponera quadriceps. Journal of Ethnopharmacology, Lausanne, Suiça, v. 144, n. 1, p. 213-216, out. 2012.
0378-8741
http://www.repositorio.ufc.br/handle/riufc/5772
identifier_str_mv SOUSA, P. L. et al. Venom's antinociceptive property in the primitive ant Dinoponera quadriceps. Journal of Ethnopharmacology, Lausanne, Suiça, v. 144, n. 1, p. 213-216, out. 2012.
0378-8741
url http://www.repositorio.ufc.br/handle/riufc/5772
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of Ethnopharmacology
publisher.none.fl_str_mv Journal of Ethnopharmacology
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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