The kinetics of ampicillin release from hydroxyapatite for bones regeneration

• Autor(a) principal: Silva, Giovanilton Ferreira da
• Data de Publicação: 2009
• Outros Autores: Albuquerque, José Silvio Veras, Oliveira, Caroliny Gomes de, Nogueira, Ricardo Emílio Ferreira Quevedo, Ferreira, Andrea Lopes de Oliveira
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
• Texto Completo: http://www.repositorio.ufc.br/handle/riufc/67219
• topic: Ampicillin release; Bones regeneration; Adsorption experiment; Drug delivery

Semisynthetic beta-lactam antibiotics are among the most used pharmaceuticals. Their use in veterinary and human medicine is in continuous expansion. There is a growing need for developing bioactive implants. Advantages of implantable drug delivery tools can include high release efficiency, precise dose control, low toxicity, and allow to overcome disadvantages connected with conventional methods. In this respect, hydroxyapatite (HA) is an elective material. It enables to produce architectures similar to those of real bones. Here we studied a kinetic model to describe ampicillin release from HA. In the course of adsorption experiment, ampicillin was dissolved, maintained at 30°C and shaken at 60 strokes/minute. Samples were withdrawn periodically for analysis and then returned to the mixture. Adsorbed amounts were measured by the difference of the concentration of the antibiotics before and after adsorption using UV adsorption at 225 nm. The aim of this work was to evaluate its application as ampicillin delivery carrier.