Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/40943 |
Resumo: | Background Diarrheal diseases are an important cause of morbidity and mortality among children in developing countries. We aimed to study the etiology and severity of diarrhea in children living in the low-income semiarid region of Brazil. Methodology This is a cross-sectional, age-matched case-control study of diarrhea in children aged 2–36 months from six cities in Brazil’s semiarid region. Clinical, epidemiological, and anthropometric data were matched with fecal samples collected for the identification of enteropathogens. Results We enrolled 1,200 children, 596 cases and 604 controls. By univariate analysis, eight enteropathogens were associated with diarrhea: Norovirus GII (OR 5.08, 95% CI 2.10, 12.30), Adenovirus (OR 3.79, 95% CI 1.41, 10.23), typical enteropathogenic Escherichia coli (tEPEC), (OR 3.28, 95% CI 1.39, 7.73), enterotoxigenic E. coli (ETEC LT and ST producing toxins), (OR 2.58, 95% CI 0.99, 6.69), rotavirus (OR 1.91, 95% CI 1.20, 3.02), shiga toxinproducing E. coli (STEC; OR 1.77, 95% CI 1.16, 2.69), enteroaggregative E. coli (EAEC), (OR 1.45, 95% CI 1.16, 1.83) and Giardia spp. (OR 1.39, 95% CI 1.05, 1.84). By logistic regression of all enteropathogens, the best predictors of diarrhea were norovirus, adenovirus, rotavirus, STEC, Giardia spp. and EAEC. A high diarrhea severity score was associated with EAEC. Conclusions Six enteropathogens: Norovirus, Adenovirus, Rotavirus, STEC, Giardia spp., and EAEC were associated with diarrhea in children from Brazil’s semiarid region. EAEC was associated with increased diarrhea severity. |
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Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control studyDiarreiaDiarrheaMorbidityMorbidadeMortalidade-CriançaBackground Diarrheal diseases are an important cause of morbidity and mortality among children in developing countries. We aimed to study the etiology and severity of diarrhea in children living in the low-income semiarid region of Brazil. Methodology This is a cross-sectional, age-matched case-control study of diarrhea in children aged 2–36 months from six cities in Brazil’s semiarid region. Clinical, epidemiological, and anthropometric data were matched with fecal samples collected for the identification of enteropathogens. Results We enrolled 1,200 children, 596 cases and 604 controls. By univariate analysis, eight enteropathogens were associated with diarrhea: Norovirus GII (OR 5.08, 95% CI 2.10, 12.30), Adenovirus (OR 3.79, 95% CI 1.41, 10.23), typical enteropathogenic Escherichia coli (tEPEC), (OR 3.28, 95% CI 1.39, 7.73), enterotoxigenic E. coli (ETEC LT and ST producing toxins), (OR 2.58, 95% CI 0.99, 6.69), rotavirus (OR 1.91, 95% CI 1.20, 3.02), shiga toxinproducing E. coli (STEC; OR 1.77, 95% CI 1.16, 2.69), enteroaggregative E. coli (EAEC), (OR 1.45, 95% CI 1.16, 1.83) and Giardia spp. (OR 1.39, 95% CI 1.05, 1.84). By logistic regression of all enteropathogens, the best predictors of diarrhea were norovirus, adenovirus, rotavirus, STEC, Giardia spp. and EAEC. A high diarrhea severity score was associated with EAEC. Conclusions Six enteropathogens: Norovirus, Adenovirus, Rotavirus, STEC, Giardia spp., and EAEC were associated with diarrhea in children from Brazil’s semiarid region. EAEC was associated with increased diarrhea severity.PLoS Neglected Tropical Diseases2019-04-17T14:11:14Z2019-04-17T14:11:14Z2019-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfLIMA, Aldo A. M. et al. Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study. PLoS Negl Trop Dis, v. 13, n. 2, e0007154, feb. 2019.1935-27271935-2735 (On line)http://www.repositorio.ufc.br/handle/riufc/40943Lima, Aldo A. M.Oliveira, Domingos B.Quetz, Josiane S.Havt, AlexandrePrata, Mara M. G.Lima, Ila F. N.Soares, Alberto M.Q. Filho, JoséLima, Noélia L.Medeiros, Pedro H. Q. S.Santos, Ana K. S.Veras, Herlice N.Gondim, Rafhaella N. D. G.Pankov, Rafaela C.Bona, Mariana D.Rodrigues, Francisco A. P.Moreira, Renato A.Moreira, Ana C. O. M.Bertolini, MarceloBertolini, Luciana R.Freitas, Vicente J. F.Houpt, Eric R.Guerran, Richard L.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-03-14T19:41:29Zoai:repositorio.ufc.br:riufc/40943Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:34:10.822899Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study |
title |
Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study |
spellingShingle |
Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study Lima, Aldo A. M. Diarreia Diarrhea Morbidity Morbidade Mortalidade-Criança |
title_short |
Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study |
title_full |
Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study |
title_fullStr |
Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study |
title_full_unstemmed |
Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study |
title_sort |
Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study |
author |
Lima, Aldo A. M. |
author_facet |
Lima, Aldo A. M. Oliveira, Domingos B. Quetz, Josiane S. Havt, Alexandre Prata, Mara M. G. Lima, Ila F. N. Soares, Alberto M. Q. Filho, José Lima, Noélia L. Medeiros, Pedro H. Q. S. Santos, Ana K. S. Veras, Herlice N. Gondim, Rafhaella N. D. G. Pankov, Rafaela C. Bona, Mariana D. Rodrigues, Francisco A. P. Moreira, Renato A. Moreira, Ana C. O. M. Bertolini, Marcelo Bertolini, Luciana R. Freitas, Vicente J. F. Houpt, Eric R. Guerran, Richard L. |
author_role |
author |
author2 |
Oliveira, Domingos B. Quetz, Josiane S. Havt, Alexandre Prata, Mara M. G. Lima, Ila F. N. Soares, Alberto M. Q. Filho, José Lima, Noélia L. Medeiros, Pedro H. Q. S. Santos, Ana K. S. Veras, Herlice N. Gondim, Rafhaella N. D. G. Pankov, Rafaela C. Bona, Mariana D. Rodrigues, Francisco A. P. Moreira, Renato A. Moreira, Ana C. O. M. Bertolini, Marcelo Bertolini, Luciana R. Freitas, Vicente J. F. Houpt, Eric R. Guerran, Richard L. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Aldo A. M. Oliveira, Domingos B. Quetz, Josiane S. Havt, Alexandre Prata, Mara M. G. Lima, Ila F. N. Soares, Alberto M. Q. Filho, José Lima, Noélia L. Medeiros, Pedro H. Q. S. Santos, Ana K. S. Veras, Herlice N. Gondim, Rafhaella N. D. G. Pankov, Rafaela C. Bona, Mariana D. Rodrigues, Francisco A. P. Moreira, Renato A. Moreira, Ana C. O. M. Bertolini, Marcelo Bertolini, Luciana R. Freitas, Vicente J. F. Houpt, Eric R. Guerran, Richard L. |
dc.subject.por.fl_str_mv |
Diarreia Diarrhea Morbidity Morbidade Mortalidade-Criança |
topic |
Diarreia Diarrhea Morbidity Morbidade Mortalidade-Criança |
description |
Background Diarrheal diseases are an important cause of morbidity and mortality among children in developing countries. We aimed to study the etiology and severity of diarrhea in children living in the low-income semiarid region of Brazil. Methodology This is a cross-sectional, age-matched case-control study of diarrhea in children aged 2–36 months from six cities in Brazil’s semiarid region. Clinical, epidemiological, and anthropometric data were matched with fecal samples collected for the identification of enteropathogens. Results We enrolled 1,200 children, 596 cases and 604 controls. By univariate analysis, eight enteropathogens were associated with diarrhea: Norovirus GII (OR 5.08, 95% CI 2.10, 12.30), Adenovirus (OR 3.79, 95% CI 1.41, 10.23), typical enteropathogenic Escherichia coli (tEPEC), (OR 3.28, 95% CI 1.39, 7.73), enterotoxigenic E. coli (ETEC LT and ST producing toxins), (OR 2.58, 95% CI 0.99, 6.69), rotavirus (OR 1.91, 95% CI 1.20, 3.02), shiga toxinproducing E. coli (STEC; OR 1.77, 95% CI 1.16, 2.69), enteroaggregative E. coli (EAEC), (OR 1.45, 95% CI 1.16, 1.83) and Giardia spp. (OR 1.39, 95% CI 1.05, 1.84). By logistic regression of all enteropathogens, the best predictors of diarrhea were norovirus, adenovirus, rotavirus, STEC, Giardia spp. and EAEC. A high diarrhea severity score was associated with EAEC. Conclusions Six enteropathogens: Norovirus, Adenovirus, Rotavirus, STEC, Giardia spp., and EAEC were associated with diarrhea in children from Brazil’s semiarid region. EAEC was associated with increased diarrhea severity. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-04-17T14:11:14Z 2019-04-17T14:11:14Z 2019-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
LIMA, Aldo A. M. et al. Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study. PLoS Negl Trop Dis, v. 13, n. 2, e0007154, feb. 2019. 1935-2727 1935-2735 (On line) http://www.repositorio.ufc.br/handle/riufc/40943 |
identifier_str_mv |
LIMA, Aldo A. M. et al. Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study. PLoS Negl Trop Dis, v. 13, n. 2, e0007154, feb. 2019. 1935-2727 1935-2735 (On line) |
url |
http://www.repositorio.ufc.br/handle/riufc/40943 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
PLoS Neglected Tropical Diseases |
publisher.none.fl_str_mv |
PLoS Neglected Tropical Diseases |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813028858576764928 |