Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study

Detalhes bibliográficos
Autor(a) principal: Lima, Aldo A. M.
Data de Publicação: 2019
Outros Autores: Oliveira, Domingos B., Quetz, Josiane S., Havt, Alexandre, Prata, Mara M. G., Lima, Ila F. N., Soares, Alberto M., Q. Filho, José, Lima, Noélia L., Medeiros, Pedro H. Q. S., Santos, Ana K. S., Veras, Herlice N., Gondim, Rafhaella N. D. G., Pankov, Rafaela C., Bona, Mariana D., Rodrigues, Francisco A. P., Moreira, Renato A., Moreira, Ana C. O. M., Bertolini, Marcelo, Bertolini, Luciana R., Freitas, Vicente J. F., Houpt, Eric R., Guerran, Richard L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/40943
Resumo: Background Diarrheal diseases are an important cause of morbidity and mortality among children in developing countries. We aimed to study the etiology and severity of diarrhea in children living in the low-income semiarid region of Brazil. Methodology This is a cross-sectional, age-matched case-control study of diarrhea in children aged 2–36 months from six cities in Brazil’s semiarid region. Clinical, epidemiological, and anthropometric data were matched with fecal samples collected for the identification of enteropathogens. Results We enrolled 1,200 children, 596 cases and 604 controls. By univariate analysis, eight enteropathogens were associated with diarrhea: Norovirus GII (OR 5.08, 95% CI 2.10, 12.30), Adenovirus (OR 3.79, 95% CI 1.41, 10.23), typical enteropathogenic Escherichia coli (tEPEC), (OR 3.28, 95% CI 1.39, 7.73), enterotoxigenic E. coli (ETEC LT and ST producing toxins), (OR 2.58, 95% CI 0.99, 6.69), rotavirus (OR 1.91, 95% CI 1.20, 3.02), shiga toxinproducing E. coli (STEC; OR 1.77, 95% CI 1.16, 2.69), enteroaggregative E. coli (EAEC), (OR 1.45, 95% CI 1.16, 1.83) and Giardia spp. (OR 1.39, 95% CI 1.05, 1.84). By logistic regression of all enteropathogens, the best predictors of diarrhea were norovirus, adenovirus, rotavirus, STEC, Giardia spp. and EAEC. A high diarrhea severity score was associated with EAEC. Conclusions Six enteropathogens: Norovirus, Adenovirus, Rotavirus, STEC, Giardia spp., and EAEC were associated with diarrhea in children from Brazil’s semiarid region. EAEC was associated with increased diarrhea severity.
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spelling Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control studyDiarreiaDiarrheaMorbidityMorbidadeMortalidade-CriançaBackground Diarrheal diseases are an important cause of morbidity and mortality among children in developing countries. We aimed to study the etiology and severity of diarrhea in children living in the low-income semiarid region of Brazil. Methodology This is a cross-sectional, age-matched case-control study of diarrhea in children aged 2–36 months from six cities in Brazil’s semiarid region. Clinical, epidemiological, and anthropometric data were matched with fecal samples collected for the identification of enteropathogens. Results We enrolled 1,200 children, 596 cases and 604 controls. By univariate analysis, eight enteropathogens were associated with diarrhea: Norovirus GII (OR 5.08, 95% CI 2.10, 12.30), Adenovirus (OR 3.79, 95% CI 1.41, 10.23), typical enteropathogenic Escherichia coli (tEPEC), (OR 3.28, 95% CI 1.39, 7.73), enterotoxigenic E. coli (ETEC LT and ST producing toxins), (OR 2.58, 95% CI 0.99, 6.69), rotavirus (OR 1.91, 95% CI 1.20, 3.02), shiga toxinproducing E. coli (STEC; OR 1.77, 95% CI 1.16, 2.69), enteroaggregative E. coli (EAEC), (OR 1.45, 95% CI 1.16, 1.83) and Giardia spp. (OR 1.39, 95% CI 1.05, 1.84). By logistic regression of all enteropathogens, the best predictors of diarrhea were norovirus, adenovirus, rotavirus, STEC, Giardia spp. and EAEC. A high diarrhea severity score was associated with EAEC. Conclusions Six enteropathogens: Norovirus, Adenovirus, Rotavirus, STEC, Giardia spp., and EAEC were associated with diarrhea in children from Brazil’s semiarid region. EAEC was associated with increased diarrhea severity.PLoS Neglected Tropical Diseases2019-04-17T14:11:14Z2019-04-17T14:11:14Z2019-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfLIMA, Aldo A. M. et al. Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study. PLoS Negl Trop Dis, v. 13, n. 2, e0007154, feb. 2019.1935-27271935-2735 (On line)http://www.repositorio.ufc.br/handle/riufc/40943Lima, Aldo A. M.Oliveira, Domingos B.Quetz, Josiane S.Havt, AlexandrePrata, Mara M. G.Lima, Ila F. N.Soares, Alberto M.Q. Filho, JoséLima, Noélia L.Medeiros, Pedro H. Q. S.Santos, Ana K. S.Veras, Herlice N.Gondim, Rafhaella N. D. G.Pankov, Rafaela C.Bona, Mariana D.Rodrigues, Francisco A. P.Moreira, Renato A.Moreira, Ana C. O. M.Bertolini, MarceloBertolini, Luciana R.Freitas, Vicente J. F.Houpt, Eric R.Guerran, Richard L.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-03-14T19:41:29Zoai:repositorio.ufc.br:riufc/40943Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:34:10.822899Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study
title Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study
spellingShingle Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study
Lima, Aldo A. M.
Diarreia
Diarrhea
Morbidity
Morbidade
Mortalidade-Criança
title_short Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study
title_full Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study
title_fullStr Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study
title_full_unstemmed Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study
title_sort Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study
author Lima, Aldo A. M.
author_facet Lima, Aldo A. M.
Oliveira, Domingos B.
Quetz, Josiane S.
Havt, Alexandre
Prata, Mara M. G.
Lima, Ila F. N.
Soares, Alberto M.
Q. Filho, José
Lima, Noélia L.
Medeiros, Pedro H. Q. S.
Santos, Ana K. S.
Veras, Herlice N.
Gondim, Rafhaella N. D. G.
Pankov, Rafaela C.
Bona, Mariana D.
Rodrigues, Francisco A. P.
Moreira, Renato A.
Moreira, Ana C. O. M.
Bertolini, Marcelo
Bertolini, Luciana R.
Freitas, Vicente J. F.
Houpt, Eric R.
Guerran, Richard L.
author_role author
author2 Oliveira, Domingos B.
Quetz, Josiane S.
Havt, Alexandre
Prata, Mara M. G.
Lima, Ila F. N.
Soares, Alberto M.
Q. Filho, José
Lima, Noélia L.
Medeiros, Pedro H. Q. S.
Santos, Ana K. S.
Veras, Herlice N.
Gondim, Rafhaella N. D. G.
Pankov, Rafaela C.
Bona, Mariana D.
Rodrigues, Francisco A. P.
Moreira, Renato A.
Moreira, Ana C. O. M.
Bertolini, Marcelo
Bertolini, Luciana R.
Freitas, Vicente J. F.
Houpt, Eric R.
Guerran, Richard L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Aldo A. M.
Oliveira, Domingos B.
Quetz, Josiane S.
Havt, Alexandre
Prata, Mara M. G.
Lima, Ila F. N.
Soares, Alberto M.
Q. Filho, José
Lima, Noélia L.
Medeiros, Pedro H. Q. S.
Santos, Ana K. S.
Veras, Herlice N.
Gondim, Rafhaella N. D. G.
Pankov, Rafaela C.
Bona, Mariana D.
Rodrigues, Francisco A. P.
Moreira, Renato A.
Moreira, Ana C. O. M.
Bertolini, Marcelo
Bertolini, Luciana R.
Freitas, Vicente J. F.
Houpt, Eric R.
Guerran, Richard L.
dc.subject.por.fl_str_mv Diarreia
Diarrhea
Morbidity
Morbidade
Mortalidade-Criança
topic Diarreia
Diarrhea
Morbidity
Morbidade
Mortalidade-Criança
description Background Diarrheal diseases are an important cause of morbidity and mortality among children in developing countries. We aimed to study the etiology and severity of diarrhea in children living in the low-income semiarid region of Brazil. Methodology This is a cross-sectional, age-matched case-control study of diarrhea in children aged 2–36 months from six cities in Brazil’s semiarid region. Clinical, epidemiological, and anthropometric data were matched with fecal samples collected for the identification of enteropathogens. Results We enrolled 1,200 children, 596 cases and 604 controls. By univariate analysis, eight enteropathogens were associated with diarrhea: Norovirus GII (OR 5.08, 95% CI 2.10, 12.30), Adenovirus (OR 3.79, 95% CI 1.41, 10.23), typical enteropathogenic Escherichia coli (tEPEC), (OR 3.28, 95% CI 1.39, 7.73), enterotoxigenic E. coli (ETEC LT and ST producing toxins), (OR 2.58, 95% CI 0.99, 6.69), rotavirus (OR 1.91, 95% CI 1.20, 3.02), shiga toxinproducing E. coli (STEC; OR 1.77, 95% CI 1.16, 2.69), enteroaggregative E. coli (EAEC), (OR 1.45, 95% CI 1.16, 1.83) and Giardia spp. (OR 1.39, 95% CI 1.05, 1.84). By logistic regression of all enteropathogens, the best predictors of diarrhea were norovirus, adenovirus, rotavirus, STEC, Giardia spp. and EAEC. A high diarrhea severity score was associated with EAEC. Conclusions Six enteropathogens: Norovirus, Adenovirus, Rotavirus, STEC, Giardia spp., and EAEC were associated with diarrhea in children from Brazil’s semiarid region. EAEC was associated with increased diarrhea severity.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-17T14:11:14Z
2019-04-17T14:11:14Z
2019-02
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv LIMA, Aldo A. M. et al. Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study. PLoS Negl Trop Dis, v. 13, n. 2, e0007154, feb. 2019.
1935-2727
1935-2735 (On line)
http://www.repositorio.ufc.br/handle/riufc/40943
identifier_str_mv LIMA, Aldo A. M. et al. Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study. PLoS Negl Trop Dis, v. 13, n. 2, e0007154, feb. 2019.
1935-2727
1935-2735 (On line)
url http://www.repositorio.ufc.br/handle/riufc/40943
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PLoS Neglected Tropical Diseases
publisher.none.fl_str_mv PLoS Neglected Tropical Diseases
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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