Topical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice

• Autor(a) principal: Pinto, Natália Bitú
• Data de Publicação: 2010
• Outros Autores: Morais, Talita Cavalcante, Carvalho, Karine Maria Martins Bezerra, Silva, Cecília Rocha, Andrade, Geanne Matos de, Brito, Gerly Anne de Castro, Veras, Maria Leopoldina, Pessoa, Otília Deusdênia Loiola, Rao, Vietla Satyanarayana, Santos, Flávia Almeida
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
• Texto Completo: http://www.repositorio.ufc.br/handle/riufc/5548
• topic: Antígeno Polipeptídico Tecidual; Dermatite; Ratos

The anti-inflammatory effect of physalin E, a seco-steroid isolated from Physalis angulata L. was evaluated on acute and chronic models of dermatitis induced by 12-O-tetradecanoyl-phorbol-13- acetate (TPA) and oxazolone, respectively, in mouse ear. The changes in ear edema/thickness, production of pro-inflammatory cytokines (TNF- a and IFN- g ), myeloperoxidase (MPO) activity, and histological and immunohistochemical findings were analysed, as indicators of dermal inflammation. Similar to dexamethasone, topically applied Physalin E (0.125; 0.25 and 0.5 mg/ear) potently inhibited the TPA and oxazolone-induced dermatitis, leading to substantial reductions in ear edema/thickness, pro-inflammatory cytokines, and MPO activity. These effects were reversed by mifepristone, a steroid antagonist and confirmed by immunohistochemical and histopathological analysis. The data suggest that physalin E may be a potent and topically effective anti-inflammatory agent useful to treat the acute and chronic skin inflammatory conditions.