Risk factors for acute kidney injury and 30-day mortality after liver transplantation

Detalhes bibliográficos
Autor(a) principal: Barreto, Adller G. C.
Data de Publicação: 2015
Outros Autores: Daher, Elizabeth de Francesco, Silva Junior, Geraldo B., Garcia, José Huygens P., Magalhães, Clarissa B. A., Lima, José Milton C., Viana, Cyntia F. G., Pereira, Eanes Delgado Barros
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/15216
Resumo: Introduction. The aim of this study is to evaluate the risk factors for acute kidney injury (AKI) and 30-day mortality after liver transplantation. Material and methods. This is a retrospective cohort of consecutive adults undergoing orthotopic liver transplantation (OLT) at a referral hospital in Brazil, from January 2013 to January 2014. Risk factors for AKI and death were investigated. Results. A total 134 patients were included, with median age of 56 years. AKI was found in 46.7% of patients in the first 72 h after OLT. Risk factors for AKI were: viral hepatitis (OR 2.9, 95% CI = 1.2-7), warm ischemia time (OR 1.1, 95% CI = 1.01-1.2) and serum lactate (OR 1.3, 95%CI = 1.02-1.89). The length of intensive care unit (ICU) stay was longer in AKI group: 4 (3-7) days vs. 3 (2-4) days (p = 0.001), as well as overall hospitalization stay: 16 (9-26) days vs. 10 (8- 14) days (p = 0.001). The 30-day mortality was 15%. AKI was an independent risk factor for mortality (OR 4.3, 95% CI = 1.3-14.6). MELD-Na ≥ 22 was a predictor for hemodialysis need (OR 8.4, 95%CI = 1.5-46.5). Chronic kidney disease (CKD) was found in 36 patients (56.2% of AKI patients). Conclusions. Viral hepatitis, longer warm ischemia time and high levels of serum lactate are risk factors for AKI after OLT. AKI is a risk factor for death and can lead to CKD in a high percentage of patients after OLT. A high MELD-Na score is a predictor for hemodialysis need.
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spelling Risk factors for acute kidney injury and 30-day mortality after liver transplantationInsuficiência RenalInsuficiência HepáticaObtenção de Tecidos e ÓrgãosIntroduction. The aim of this study is to evaluate the risk factors for acute kidney injury (AKI) and 30-day mortality after liver transplantation. Material and methods. This is a retrospective cohort of consecutive adults undergoing orthotopic liver transplantation (OLT) at a referral hospital in Brazil, from January 2013 to January 2014. Risk factors for AKI and death were investigated. Results. A total 134 patients were included, with median age of 56 years. AKI was found in 46.7% of patients in the first 72 h after OLT. Risk factors for AKI were: viral hepatitis (OR 2.9, 95% CI = 1.2-7), warm ischemia time (OR 1.1, 95% CI = 1.01-1.2) and serum lactate (OR 1.3, 95%CI = 1.02-1.89). The length of intensive care unit (ICU) stay was longer in AKI group: 4 (3-7) days vs. 3 (2-4) days (p = 0.001), as well as overall hospitalization stay: 16 (9-26) days vs. 10 (8- 14) days (p = 0.001). The 30-day mortality was 15%. AKI was an independent risk factor for mortality (OR 4.3, 95% CI = 1.3-14.6). MELD-Na ≥ 22 was a predictor for hemodialysis need (OR 8.4, 95%CI = 1.5-46.5). Chronic kidney disease (CKD) was found in 36 patients (56.2% of AKI patients). Conclusions. Viral hepatitis, longer warm ischemia time and high levels of serum lactate are risk factors for AKI after OLT. AKI is a risk factor for death and can lead to CKD in a high percentage of patients after OLT. A high MELD-Na score is a predictor for hemodialysis need.Annals of Hepatology2016-02-18T15:14:56Z2016-02-18T15:14:56Z2015-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBARRETO, A. G. et al. Risk factors for acute kidney injury and 30-day mortality after liver transplantation. Annals of hepatology, México, v. 14, n. 5, p. 688-694, set./out. 2015.1665-2681http://www.repositorio.ufc.br/handle/riufc/15216Barreto, Adller G. C.Daher, Elizabeth de FrancescoSilva Junior, Geraldo B.Garcia, José Huygens P.Magalhães, Clarissa B. A.Lima, José Milton C.Viana, Cyntia F. G.Pereira, Eanes Delgado Barrosengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-05-13T18:28:08Zoai:repositorio.ufc.br:riufc/15216Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:30:49.968505Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Risk factors for acute kidney injury and 30-day mortality after liver transplantation
title Risk factors for acute kidney injury and 30-day mortality after liver transplantation
spellingShingle Risk factors for acute kidney injury and 30-day mortality after liver transplantation
Barreto, Adller G. C.
Insuficiência Renal
Insuficiência Hepática
Obtenção de Tecidos e Órgãos
title_short Risk factors for acute kidney injury and 30-day mortality after liver transplantation
title_full Risk factors for acute kidney injury and 30-day mortality after liver transplantation
title_fullStr Risk factors for acute kidney injury and 30-day mortality after liver transplantation
title_full_unstemmed Risk factors for acute kidney injury and 30-day mortality after liver transplantation
title_sort Risk factors for acute kidney injury and 30-day mortality after liver transplantation
author Barreto, Adller G. C.
author_facet Barreto, Adller G. C.
Daher, Elizabeth de Francesco
Silva Junior, Geraldo B.
Garcia, José Huygens P.
Magalhães, Clarissa B. A.
Lima, José Milton C.
Viana, Cyntia F. G.
Pereira, Eanes Delgado Barros
author_role author
author2 Daher, Elizabeth de Francesco
Silva Junior, Geraldo B.
Garcia, José Huygens P.
Magalhães, Clarissa B. A.
Lima, José Milton C.
Viana, Cyntia F. G.
Pereira, Eanes Delgado Barros
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barreto, Adller G. C.
Daher, Elizabeth de Francesco
Silva Junior, Geraldo B.
Garcia, José Huygens P.
Magalhães, Clarissa B. A.
Lima, José Milton C.
Viana, Cyntia F. G.
Pereira, Eanes Delgado Barros
dc.subject.por.fl_str_mv Insuficiência Renal
Insuficiência Hepática
Obtenção de Tecidos e Órgãos
topic Insuficiência Renal
Insuficiência Hepática
Obtenção de Tecidos e Órgãos
description Introduction. The aim of this study is to evaluate the risk factors for acute kidney injury (AKI) and 30-day mortality after liver transplantation. Material and methods. This is a retrospective cohort of consecutive adults undergoing orthotopic liver transplantation (OLT) at a referral hospital in Brazil, from January 2013 to January 2014. Risk factors for AKI and death were investigated. Results. A total 134 patients were included, with median age of 56 years. AKI was found in 46.7% of patients in the first 72 h after OLT. Risk factors for AKI were: viral hepatitis (OR 2.9, 95% CI = 1.2-7), warm ischemia time (OR 1.1, 95% CI = 1.01-1.2) and serum lactate (OR 1.3, 95%CI = 1.02-1.89). The length of intensive care unit (ICU) stay was longer in AKI group: 4 (3-7) days vs. 3 (2-4) days (p = 0.001), as well as overall hospitalization stay: 16 (9-26) days vs. 10 (8- 14) days (p = 0.001). The 30-day mortality was 15%. AKI was an independent risk factor for mortality (OR 4.3, 95% CI = 1.3-14.6). MELD-Na ≥ 22 was a predictor for hemodialysis need (OR 8.4, 95%CI = 1.5-46.5). Chronic kidney disease (CKD) was found in 36 patients (56.2% of AKI patients). Conclusions. Viral hepatitis, longer warm ischemia time and high levels of serum lactate are risk factors for AKI after OLT. AKI is a risk factor for death and can lead to CKD in a high percentage of patients after OLT. A high MELD-Na score is a predictor for hemodialysis need.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
2016-02-18T15:14:56Z
2016-02-18T15:14:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv BARRETO, A. G. et al. Risk factors for acute kidney injury and 30-day mortality after liver transplantation. Annals of hepatology, México, v. 14, n. 5, p. 688-694, set./out. 2015.
1665-2681
http://www.repositorio.ufc.br/handle/riufc/15216
identifier_str_mv BARRETO, A. G. et al. Risk factors for acute kidney injury and 30-day mortality after liver transplantation. Annals of hepatology, México, v. 14, n. 5, p. 688-694, set./out. 2015.
1665-2681
url http://www.repositorio.ufc.br/handle/riufc/15216
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Annals of Hepatology
publisher.none.fl_str_mv Annals of Hepatology
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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