Risk factors for acute kidney injury and 30-day mortality after liver transplantation
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/15216 |
Resumo: | Introduction. The aim of this study is to evaluate the risk factors for acute kidney injury (AKI) and 30-day mortality after liver transplantation. Material and methods. This is a retrospective cohort of consecutive adults undergoing orthotopic liver transplantation (OLT) at a referral hospital in Brazil, from January 2013 to January 2014. Risk factors for AKI and death were investigated. Results. A total 134 patients were included, with median age of 56 years. AKI was found in 46.7% of patients in the first 72 h after OLT. Risk factors for AKI were: viral hepatitis (OR 2.9, 95% CI = 1.2-7), warm ischemia time (OR 1.1, 95% CI = 1.01-1.2) and serum lactate (OR 1.3, 95%CI = 1.02-1.89). The length of intensive care unit (ICU) stay was longer in AKI group: 4 (3-7) days vs. 3 (2-4) days (p = 0.001), as well as overall hospitalization stay: 16 (9-26) days vs. 10 (8- 14) days (p = 0.001). The 30-day mortality was 15%. AKI was an independent risk factor for mortality (OR 4.3, 95% CI = 1.3-14.6). MELD-Na ≥ 22 was a predictor for hemodialysis need (OR 8.4, 95%CI = 1.5-46.5). Chronic kidney disease (CKD) was found in 36 patients (56.2% of AKI patients). Conclusions. Viral hepatitis, longer warm ischemia time and high levels of serum lactate are risk factors for AKI after OLT. AKI is a risk factor for death and can lead to CKD in a high percentage of patients after OLT. A high MELD-Na score is a predictor for hemodialysis need. |
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Risk factors for acute kidney injury and 30-day mortality after liver transplantationInsuficiência RenalInsuficiência HepáticaObtenção de Tecidos e ÓrgãosIntroduction. The aim of this study is to evaluate the risk factors for acute kidney injury (AKI) and 30-day mortality after liver transplantation. Material and methods. This is a retrospective cohort of consecutive adults undergoing orthotopic liver transplantation (OLT) at a referral hospital in Brazil, from January 2013 to January 2014. Risk factors for AKI and death were investigated. Results. A total 134 patients were included, with median age of 56 years. AKI was found in 46.7% of patients in the first 72 h after OLT. Risk factors for AKI were: viral hepatitis (OR 2.9, 95% CI = 1.2-7), warm ischemia time (OR 1.1, 95% CI = 1.01-1.2) and serum lactate (OR 1.3, 95%CI = 1.02-1.89). The length of intensive care unit (ICU) stay was longer in AKI group: 4 (3-7) days vs. 3 (2-4) days (p = 0.001), as well as overall hospitalization stay: 16 (9-26) days vs. 10 (8- 14) days (p = 0.001). The 30-day mortality was 15%. AKI was an independent risk factor for mortality (OR 4.3, 95% CI = 1.3-14.6). MELD-Na ≥ 22 was a predictor for hemodialysis need (OR 8.4, 95%CI = 1.5-46.5). Chronic kidney disease (CKD) was found in 36 patients (56.2% of AKI patients). Conclusions. Viral hepatitis, longer warm ischemia time and high levels of serum lactate are risk factors for AKI after OLT. AKI is a risk factor for death and can lead to CKD in a high percentage of patients after OLT. A high MELD-Na score is a predictor for hemodialysis need.Annals of Hepatology2016-02-18T15:14:56Z2016-02-18T15:14:56Z2015-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBARRETO, A. G. et al. Risk factors for acute kidney injury and 30-day mortality after liver transplantation. Annals of hepatology, México, v. 14, n. 5, p. 688-694, set./out. 2015.1665-2681http://www.repositorio.ufc.br/handle/riufc/15216Barreto, Adller G. C.Daher, Elizabeth de FrancescoSilva Junior, Geraldo B.Garcia, José Huygens P.Magalhães, Clarissa B. A.Lima, José Milton C.Viana, Cyntia F. G.Pereira, Eanes Delgado Barrosengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-05-13T18:28:08Zoai:repositorio.ufc.br:riufc/15216Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:30:49.968505Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Risk factors for acute kidney injury and 30-day mortality after liver transplantation |
title |
Risk factors for acute kidney injury and 30-day mortality after liver transplantation |
spellingShingle |
Risk factors for acute kidney injury and 30-day mortality after liver transplantation Barreto, Adller G. C. Insuficiência Renal Insuficiência Hepática Obtenção de Tecidos e Órgãos |
title_short |
Risk factors for acute kidney injury and 30-day mortality after liver transplantation |
title_full |
Risk factors for acute kidney injury and 30-day mortality after liver transplantation |
title_fullStr |
Risk factors for acute kidney injury and 30-day mortality after liver transplantation |
title_full_unstemmed |
Risk factors for acute kidney injury and 30-day mortality after liver transplantation |
title_sort |
Risk factors for acute kidney injury and 30-day mortality after liver transplantation |
author |
Barreto, Adller G. C. |
author_facet |
Barreto, Adller G. C. Daher, Elizabeth de Francesco Silva Junior, Geraldo B. Garcia, José Huygens P. Magalhães, Clarissa B. A. Lima, José Milton C. Viana, Cyntia F. G. Pereira, Eanes Delgado Barros |
author_role |
author |
author2 |
Daher, Elizabeth de Francesco Silva Junior, Geraldo B. Garcia, José Huygens P. Magalhães, Clarissa B. A. Lima, José Milton C. Viana, Cyntia F. G. Pereira, Eanes Delgado Barros |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Barreto, Adller G. C. Daher, Elizabeth de Francesco Silva Junior, Geraldo B. Garcia, José Huygens P. Magalhães, Clarissa B. A. Lima, José Milton C. Viana, Cyntia F. G. Pereira, Eanes Delgado Barros |
dc.subject.por.fl_str_mv |
Insuficiência Renal Insuficiência Hepática Obtenção de Tecidos e Órgãos |
topic |
Insuficiência Renal Insuficiência Hepática Obtenção de Tecidos e Órgãos |
description |
Introduction. The aim of this study is to evaluate the risk factors for acute kidney injury (AKI) and 30-day mortality after liver transplantation. Material and methods. This is a retrospective cohort of consecutive adults undergoing orthotopic liver transplantation (OLT) at a referral hospital in Brazil, from January 2013 to January 2014. Risk factors for AKI and death were investigated. Results. A total 134 patients were included, with median age of 56 years. AKI was found in 46.7% of patients in the first 72 h after OLT. Risk factors for AKI were: viral hepatitis (OR 2.9, 95% CI = 1.2-7), warm ischemia time (OR 1.1, 95% CI = 1.01-1.2) and serum lactate (OR 1.3, 95%CI = 1.02-1.89). The length of intensive care unit (ICU) stay was longer in AKI group: 4 (3-7) days vs. 3 (2-4) days (p = 0.001), as well as overall hospitalization stay: 16 (9-26) days vs. 10 (8- 14) days (p = 0.001). The 30-day mortality was 15%. AKI was an independent risk factor for mortality (OR 4.3, 95% CI = 1.3-14.6). MELD-Na ≥ 22 was a predictor for hemodialysis need (OR 8.4, 95%CI = 1.5-46.5). Chronic kidney disease (CKD) was found in 36 patients (56.2% of AKI patients). Conclusions. Viral hepatitis, longer warm ischemia time and high levels of serum lactate are risk factors for AKI after OLT. AKI is a risk factor for death and can lead to CKD in a high percentage of patients after OLT. A high MELD-Na score is a predictor for hemodialysis need. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09 2016-02-18T15:14:56Z 2016-02-18T15:14:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
BARRETO, A. G. et al. Risk factors for acute kidney injury and 30-day mortality after liver transplantation. Annals of hepatology, México, v. 14, n. 5, p. 688-694, set./out. 2015. 1665-2681 http://www.repositorio.ufc.br/handle/riufc/15216 |
identifier_str_mv |
BARRETO, A. G. et al. Risk factors for acute kidney injury and 30-day mortality after liver transplantation. Annals of hepatology, México, v. 14, n. 5, p. 688-694, set./out. 2015. 1665-2681 |
url |
http://www.repositorio.ufc.br/handle/riufc/15216 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Annals of Hepatology |
publisher.none.fl_str_mv |
Annals of Hepatology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
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1813028835185131520 |