Uso da pele de tilápia (Oreochromis niloticus), como curativo biológico oclusivo, no tratamento de queimaduras

• Autor(a) principal: Lima-Junior, Edmar Maciel
• Data de Publicação: 2017
• Outros Autores: Picollo, Nelson Sarto, Miranda, Marcelo José Borges de, Ribeiro, Wesley Lyeverton Correia, Alves, Ana Paula Negreiros Nunes, Ferreira, Guilherme Emilio, Parente, Ezequiel Aguiar, Moraes Filho, Manoel Odorico de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
• Texto Completo: http://www.repositorio.ufc.br/handle/riufc/28917
• topic: Queimaduras; Cicatrização; Tilápia; Ferimentos e Lesões

OBJECTIVE: To evaluate the use of tilapia skin as a temporary occlusive dressing in superficial and deep second degree burns in rats. METHODS: A prospective, qualitative and quantitative study, in which 40 Wistar rats randomly divided into four groups and underwent surgery for burn production: C1, the wounds were washed with saline solution; C2, open dressing treated with silver sulfadiazine 1%; T1, superficial 2nd degree burn treated with an occlusive dressing of tilapia skin; and T2, deep 2nd degree burn also treated with tilapia skin. The animals were treated for 22 consecutive days. Blood was collected for hematological and biochemical tests on the last day and the animals were euthanized for histological analysis of the wound. RESULTS: On day 21, groups T1 and T2 showed improved delineation of the wound edges. Microscopic examination revealed that samples of groups T1 and T2 were represented by fibrous connective tissue devoid of epithelial lining, displaying lymphoplasmacytic inflammatory infiltrate, with varying degrees of intensity, and permeated by occasional polymorphonuclear granulocytes neutrophils restricted to the surface area. In groups C2, T1 and T2 the deep connective tissue had no inflammation. Blood tests presented no significant changes (p<0.05). CONCLUSION: The tilapia skin showed good grip on the wounds caused by burns in the tested rats, interfering positively on the healing process and not causing significant changes in hematological and biochemical parameters. These results allow the continuation of the investigations to clinical trials to confirm the safety and efficacy of its use as a biological dressing.