Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activities
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
| Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/27266 |
Resumo: | A series of 2-hydroxy-3-arylnaphthalene-1,4-diones (3-aryllawsones) were synthesized by Suzuki-Miyaura cross coupling reaction of 3-iodolawsone with arylboronic acids/esters. The hydroxylated resulting products were transformed into their corresponding N , N -diethyl carbamates. The antineoplastic and antileishmanial activities of the compounds were evaluated and compared with lapachol and its carbamate, providing promising results. |
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Repositório Institucional da Universidade Federal do Ceará (UFC) |
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Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activitiesQuinonesQuinonasLevopropoxifenoA series of 2-hydroxy-3-arylnaphthalene-1,4-diones (3-aryllawsones) were synthesized by Suzuki-Miyaura cross coupling reaction of 3-iodolawsone with arylboronic acids/esters. The hydroxylated resulting products were transformed into their corresponding N , N -diethyl carbamates. The antineoplastic and antileishmanial activities of the compounds were evaluated and compared with lapachol and its carbamate, providing promising results.Journal of the Brazilian Chemical Society2017-11-08T14:22:35Z2017-11-08T14:22:35Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGOMES, S. L. S. et al. Suzuki-Miyaura coupling between 3-Iodolawsone and Arylboronic acids. Synthesis of Lapachol analogues with antineoplastic and antileishmanial activities. Journal of the Brazilian Chemical Society, São Paulo, v. 28, n. 8, p. 1573-1584, 2017.0103-5053http://www.repositorio.ufc.br/handle/riufc/27266Gomes, Sara L. S.Militão, Gardenia C. G.Costa, Arinice M.Pessoa, Cláudia Ó.Costa-Lotufo, Letícia V.Torres-Santos, Eduardo C.Costa, Paulo R. R.Silva, Alcides J. M. daCunha-Junior, Edézio F.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-10-17T17:17:32Zoai:repositorio.ufc.br:riufc/27266Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:42:55.338589Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
| dc.title.none.fl_str_mv |
Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activities |
| title |
Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activities |
| spellingShingle |
Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activities Gomes, Sara L. S. Quinones Quinonas Levopropoxifeno |
| title_short |
Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activities |
| title_full |
Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activities |
| title_fullStr |
Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activities |
| title_full_unstemmed |
Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activities |
| title_sort |
Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activities |
| author |
Gomes, Sara L. S. |
| author_facet |
Gomes, Sara L. S. Militão, Gardenia C. G. Costa, Arinice M. Pessoa, Cláudia Ó. Costa-Lotufo, Letícia V. Torres-Santos, Eduardo C. Costa, Paulo R. R. Silva, Alcides J. M. da Cunha-Junior, Edézio F. |
| author_role |
author |
| author2 |
Militão, Gardenia C. G. Costa, Arinice M. Pessoa, Cláudia Ó. Costa-Lotufo, Letícia V. Torres-Santos, Eduardo C. Costa, Paulo R. R. Silva, Alcides J. M. da Cunha-Junior, Edézio F. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gomes, Sara L. S. Militão, Gardenia C. G. Costa, Arinice M. Pessoa, Cláudia Ó. Costa-Lotufo, Letícia V. Torres-Santos, Eduardo C. Costa, Paulo R. R. Silva, Alcides J. M. da Cunha-Junior, Edézio F. |
| dc.subject.por.fl_str_mv |
Quinones Quinonas Levopropoxifeno |
| topic |
Quinones Quinonas Levopropoxifeno |
| description |
A series of 2-hydroxy-3-arylnaphthalene-1,4-diones (3-aryllawsones) were synthesized by Suzuki-Miyaura cross coupling reaction of 3-iodolawsone with arylboronic acids/esters. The hydroxylated resulting products were transformed into their corresponding N , N -diethyl carbamates. The antineoplastic and antileishmanial activities of the compounds were evaluated and compared with lapachol and its carbamate, providing promising results. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-11-08T14:22:35Z 2017-11-08T14:22:35Z 2017 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
GOMES, S. L. S. et al. Suzuki-Miyaura coupling between 3-Iodolawsone and Arylboronic acids. Synthesis of Lapachol analogues with antineoplastic and antileishmanial activities. Journal of the Brazilian Chemical Society, São Paulo, v. 28, n. 8, p. 1573-1584, 2017. 0103-5053 http://www.repositorio.ufc.br/handle/riufc/27266 |
| identifier_str_mv |
GOMES, S. L. S. et al. Suzuki-Miyaura coupling between 3-Iodolawsone and Arylboronic acids. Synthesis of Lapachol analogues with antineoplastic and antileishmanial activities. Journal of the Brazilian Chemical Society, São Paulo, v. 28, n. 8, p. 1573-1584, 2017. 0103-5053 |
| url |
http://www.repositorio.ufc.br/handle/riufc/27266 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Journal of the Brazilian Chemical Society |
| publisher.none.fl_str_mv |
Journal of the Brazilian Chemical Society |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
| instname_str |
Universidade Federal do Ceará (UFC) |
| instacron_str |
UFC |
| institution |
UFC |
| reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
| collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
| repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
| repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
| _version_ |
1813028917365178368 |