Reversão pelo ácido alfa-lipóico dos efeitos eletroencefalográficos, comportamentais e ponderais induzidos pela mirtazapina em ratos

• Autor(a) principal: Cysne Filho, Francisco Mauricio Sales
• Data de Publicação: 2020
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
• Texto Completo: http://www.repositorio.ufc.br/handle/riufc/50201
• topic: Mirtazapina; Peso Corporal; Eletroencefalografia; Comportamento

Mirtazapine (MIRT) is a safe antidepressant drug, effective in the treatment of patients with treatment-resistant depression. However, the frequently reported side effects of MIRT use, sedation and weight gain, impair pharmacotherapeutic adherence. A recent study revealed the ability of the antioxidant alpha-lipoic acid (ALA) to, when associated, reverse sedation induced by MIRT. This evidence, considered together with the anti-obesity property of ALA demonstrated by previous research, motivated the present study to evaluate the reversal of behavioral (hole-board, rotarod, chimney and horizontal wire tests), electroencephalographic and weight effects induced by MIRT in adult male Wistar rats by ALA. The animals were randomly divided and stereotaxic surgery was performed to implant the electrode in the right hippocampus. After 72 hours, the experimental protocol started with the first registration of body weight and administration of drugs for 8 days according to the following experimental groups: control, MIRT (3 mg/kg), ALA (200 mg/kg) and MIRT+ALA (MIRT 3 mg/kg and ALA 200 mg/kg). On the 7th day, body weight was once again recorded and the rats submitted to behavioral tests. On the 8th day, the electroencephalographic record was performed. Regarding the hole-board test MIRT decreased the number of crossings, head-dip and rearing, compared to the control group, and ALA was unable to reverse these effects. In the rotarod test MIRT decreased the first fall time and the time on the rod and increased the number of falls, being these effects reversed by ALA. In the chimney test MIRT increased the climbing time, compared to the control group, and ALA reversed this change. In the horizontal wire test MIRT reduced the average fall time and this effect was also reversed by ALA. In the electroencephalogram study, ALA decreased the average spectral power of the theta band, reversed the decrease caused by MIRT in the beta low band, but was not able to reverse the decrease caused by MIRT in the gamma low band. In the other bands, delta, alpha, beta high and gamma high, there were no changes in the average spectral power when compared to the control group. MIRT also caused an increase in body weight and ALA reversed this change. Thus, ALA is promising as an option of association with MIRT in order to reverse the sedation induced by it, as observed in behavioral tests, being this effect probably related to its ability to decrease theta activity and reverse the decrease in average spectral power of beta low band caused by MIRT, as well as the increase in body weight. These findings raise evidence that ALA, as an adjunct, can contribute to increase patients' adherence to MIRT therapy.