Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex

Detalhes bibliográficos
Autor(a) principal: Graça, Jose Ronaldo Vasconcelos
Data de Publicação: 2019
Outros Autores: Neves, José Ricardo Cunha, Silva, Sidney Wendell Goiana da, Okoba, Willy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/46339
Resumo: Introduction: The esophagus is subject to frequent reflux of gastric contents as a normal phenomenon during episodes of transient lower esophageal sphincter relaxation (tLESR), responsible too, for pathologic reflux. However, pathologic reflux is mostly associated with reflux of acid contents. Distending the stomach provokes an increase in frequency of tLESR. Objective: To investigate the effect of distending the rectum on the tLESR and possible involved pathways. Methods: Forty four (Protocol: 096/07) street dogs were selected and divided into respective protocols: Rectal distention (RD), Gastric distention (GD), RD+GD, Atropine+RD, Hexamethonium+RD, Baclofen+RD, Bilateral Pudendal nerve section+RD and Spinal cord transection+RD. We determined and compared the tLESR of each group and subjected data to statistical analysis. Values of p <0.05 were regarded as statistically significant. Results: RD provoked a significant increase in the tLESR just as GD, with RD+GD provoking the highest value of tLESR. This increase in tLESR due to RD was prevented in A+RD, B+RD, Bilateral Pudendal nerve section+RD and Spinal cord transection+RD but not Hexamethonium+RD protocols. Conclusion: RD is a significant inducer of an increase in tLESR with participation of muscharinic and GABAβ, sensitive and spinal cord neurons, but not nicotinic receptors
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spelling Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflexDistensão retal aumenta a duração do relaxamento transitório do esfíncter esofagiano inferior em animais anestesiados : reflexo reto-esofagianoRetoCãesJunção EsofagogástricaIntroduction: The esophagus is subject to frequent reflux of gastric contents as a normal phenomenon during episodes of transient lower esophageal sphincter relaxation (tLESR), responsible too, for pathologic reflux. However, pathologic reflux is mostly associated with reflux of acid contents. Distending the stomach provokes an increase in frequency of tLESR. Objective: To investigate the effect of distending the rectum on the tLESR and possible involved pathways. Methods: Forty four (Protocol: 096/07) street dogs were selected and divided into respective protocols: Rectal distention (RD), Gastric distention (GD), RD+GD, Atropine+RD, Hexamethonium+RD, Baclofen+RD, Bilateral Pudendal nerve section+RD and Spinal cord transection+RD. We determined and compared the tLESR of each group and subjected data to statistical analysis. Values of p <0.05 were regarded as statistically significant. Results: RD provoked a significant increase in the tLESR just as GD, with RD+GD provoking the highest value of tLESR. This increase in tLESR due to RD was prevented in A+RD, B+RD, Bilateral Pudendal nerve section+RD and Spinal cord transection+RD but not Hexamethonium+RD protocols. Conclusion: RD is a significant inducer of an increase in tLESR with participation of muscharinic and GABAβ, sensitive and spinal cord neurons, but not nicotinic receptorsO esofago é sujeito a episódios frequentes e fisiológicos de refluxo durante o intervalo do relaxamento transitório do esfíncter esofágico inferior (tLSER). Ao mesmo tempo, o tLSER é responsável pelo refluxo patológico, envolvendo conteúdo ácido. A distensão gástrica (GD) provoca aumento de episódios de tLSER. Objetivo: Investigar o efeito da distensão retal (RD) sobre tLSER e os mecanismos envolvidos. Métodos: 44 cães de rua foram aleatoriamente distribuídos conforme os protocolos respectivos: RD, GD, RD+GD, Atropina (A)+RD, Hexametônio+RD, Baclofeno (B)+RD, secção bilateral do nervo pudendo+RD e secção total da corda espinhal +RD. Comparamos os dados de tLSER de cada grupo e submetemos à analise estatística. Valor p <0,05 foi determinado como significante. Resultados: RD provocou aumento significado do tLESR, semelhante à GD, enquanto RD+GD resultou em valores ainda maiores de aumento do tLESR. O aumento do tLESR foi abolido nos seguintes protocolos: A+RD, B+RD, secção bilateral do nervo pudendo+RD e secção total da corda espinhal +RD, mas não no protocolo Hexametônio+RD. Conclusão: RD provoca aumento significado do tLESR em animais sedados e envolve a participação muscarinica, GABAβ, vias sensoriais ascendentes e eferentes. Não há participação dos receptores nicotínicos.Revista de Medicina da UFC2019-10-01T15:07:00Z2019-10-01T15:07:00Z2019-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGRAÇA, Jose Ronaldo Vasconcelos et al. Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex. Rev Med UFC, Fortaleza, v. 59, n. 3, p. 24-31, jul./set. 2019.2447-6595 (Online)http://www.repositorio.ufc.br/handle/riufc/46339Graça, Jose Ronaldo VasconcelosNeves, José Ricardo CunhaSilva, Sidney Wendell Goiana daOkoba, Willyengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-04-20T13:52:03Zoai:repositorio.ufc.br:riufc/46339Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:24:19.771312Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex
Distensão retal aumenta a duração do relaxamento transitório do esfíncter esofagiano inferior em animais anestesiados : reflexo reto-esofagiano
title Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex
spellingShingle Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex
Graça, Jose Ronaldo Vasconcelos
Reto
Cães
Junção Esofagogástrica
title_short Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex
title_full Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex
title_fullStr Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex
title_full_unstemmed Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex
title_sort Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex
author Graça, Jose Ronaldo Vasconcelos
author_facet Graça, Jose Ronaldo Vasconcelos
Neves, José Ricardo Cunha
Silva, Sidney Wendell Goiana da
Okoba, Willy
author_role author
author2 Neves, José Ricardo Cunha
Silva, Sidney Wendell Goiana da
Okoba, Willy
author2_role author
author
author
dc.contributor.author.fl_str_mv Graça, Jose Ronaldo Vasconcelos
Neves, José Ricardo Cunha
Silva, Sidney Wendell Goiana da
Okoba, Willy
dc.subject.por.fl_str_mv Reto
Cães
Junção Esofagogástrica
topic Reto
Cães
Junção Esofagogástrica
description Introduction: The esophagus is subject to frequent reflux of gastric contents as a normal phenomenon during episodes of transient lower esophageal sphincter relaxation (tLESR), responsible too, for pathologic reflux. However, pathologic reflux is mostly associated with reflux of acid contents. Distending the stomach provokes an increase in frequency of tLESR. Objective: To investigate the effect of distending the rectum on the tLESR and possible involved pathways. Methods: Forty four (Protocol: 096/07) street dogs were selected and divided into respective protocols: Rectal distention (RD), Gastric distention (GD), RD+GD, Atropine+RD, Hexamethonium+RD, Baclofen+RD, Bilateral Pudendal nerve section+RD and Spinal cord transection+RD. We determined and compared the tLESR of each group and subjected data to statistical analysis. Values of p <0.05 were regarded as statistically significant. Results: RD provoked a significant increase in the tLESR just as GD, with RD+GD provoking the highest value of tLESR. This increase in tLESR due to RD was prevented in A+RD, B+RD, Bilateral Pudendal nerve section+RD and Spinal cord transection+RD but not Hexamethonium+RD protocols. Conclusion: RD is a significant inducer of an increase in tLESR with participation of muscharinic and GABAβ, sensitive and spinal cord neurons, but not nicotinic receptors
publishDate 2019
dc.date.none.fl_str_mv 2019-10-01T15:07:00Z
2019-10-01T15:07:00Z
2019-07
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv GRAÇA, Jose Ronaldo Vasconcelos et al. Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex. Rev Med UFC, Fortaleza, v. 59, n. 3, p. 24-31, jul./set. 2019.
2447-6595 (Online)
http://www.repositorio.ufc.br/handle/riufc/46339
identifier_str_mv GRAÇA, Jose Ronaldo Vasconcelos et al. Rectal distention increases the frequency and duration of transient lower esophageal sphincter relaxations in anesthetized dogs: a putative rectoesophageal reflex. Rev Med UFC, Fortaleza, v. 59, n. 3, p. 24-31, jul./set. 2019.
2447-6595 (Online)
url http://www.repositorio.ufc.br/handle/riufc/46339
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Revista de Medicina da UFC
publisher.none.fl_str_mv Revista de Medicina da UFC
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1813028789725167616

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