Cytotoxic evaluation of substituted benzaldehydes

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Felipe A. R.
Data de Publicação: 2014
Outros Autores: Oliveira, Augusto C. A., Cavalcanti, Bruno C., Costa, Marcília P., Pessoa, Claudia, Souza, Marcus V. N. de, Pinheiro, Alessandra C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/8682
Resumo: A series of fifty-four commercial aldehydes have been synthesized and evaluated for their activity against peripheral blood mononuclear cells (PBMC) and four human cancer cell lines, exhibiting potent citotoxicity (IC50 ranging from 0.36 to 4.75 μg mL-1). The structureactivity relationship (SAR) analysis indicated that the number, the positions and the type of substituents attached into the aromatic and heteroaromatic ring are critical for the biological activity. The aldehydes 24, 26, 48 and 49 displayed a potent citotoxicity activity compared to the reference drug doxorubicin being, therefore, this discovery important for the rational design of new compounds against cancer.
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spelling Cytotoxic evaluation of substituted benzaldehydesAldeídosCitotoxinasGlioblastomaA series of fifty-four commercial aldehydes have been synthesized and evaluated for their activity against peripheral blood mononuclear cells (PBMC) and four human cancer cell lines, exhibiting potent citotoxicity (IC50 ranging from 0.36 to 4.75 μg mL-1). The structureactivity relationship (SAR) analysis indicated that the number, the positions and the type of substituents attached into the aromatic and heteroaromatic ring are critical for the biological activity. The aldehydes 24, 26, 48 and 49 displayed a potent citotoxicity activity compared to the reference drug doxorubicin being, therefore, this discovery important for the rational design of new compounds against cancer.EUROPEAN CHEMICAL BULLETIN2014-08-12T11:02:02Z2014-08-12T11:02:02Z2014-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfRODRIGUES, F. A. R. et al. Cytotoxic evaluation of substituted benzaldehydes. European Chemical Bulletin, v. 3, p. 555-557, mar. 2014.2063-5346http://www.repositorio.ufc.br/handle/riufc/8682Rodrigues, Felipe A. R.Oliveira, Augusto C. A.Cavalcanti, Bruno C.Costa, Marcília P.Pessoa, ClaudiaSouza, Marcus V. N. dePinheiro, Alessandra C.engreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-21T14:48:39Zoai:repositorio.ufc.br:riufc/8682Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:22:43.223387Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Cytotoxic evaluation of substituted benzaldehydes
title Cytotoxic evaluation of substituted benzaldehydes
spellingShingle Cytotoxic evaluation of substituted benzaldehydes
Rodrigues, Felipe A. R.
Aldeídos
Citotoxinas
Glioblastoma
title_short Cytotoxic evaluation of substituted benzaldehydes
title_full Cytotoxic evaluation of substituted benzaldehydes
title_fullStr Cytotoxic evaluation of substituted benzaldehydes
title_full_unstemmed Cytotoxic evaluation of substituted benzaldehydes
title_sort Cytotoxic evaluation of substituted benzaldehydes
author Rodrigues, Felipe A. R.
author_facet Rodrigues, Felipe A. R.
Oliveira, Augusto C. A.
Cavalcanti, Bruno C.
Costa, Marcília P.
Pessoa, Claudia
Souza, Marcus V. N. de
Pinheiro, Alessandra C.
author_role author
author2 Oliveira, Augusto C. A.
Cavalcanti, Bruno C.
Costa, Marcília P.
Pessoa, Claudia
Souza, Marcus V. N. de
Pinheiro, Alessandra C.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Felipe A. R.
Oliveira, Augusto C. A.
Cavalcanti, Bruno C.
Costa, Marcília P.
Pessoa, Claudia
Souza, Marcus V. N. de
Pinheiro, Alessandra C.
dc.subject.por.fl_str_mv Aldeídos
Citotoxinas
Glioblastoma
topic Aldeídos
Citotoxinas
Glioblastoma
description A series of fifty-four commercial aldehydes have been synthesized and evaluated for their activity against peripheral blood mononuclear cells (PBMC) and four human cancer cell lines, exhibiting potent citotoxicity (IC50 ranging from 0.36 to 4.75 μg mL-1). The structureactivity relationship (SAR) analysis indicated that the number, the positions and the type of substituents attached into the aromatic and heteroaromatic ring are critical for the biological activity. The aldehydes 24, 26, 48 and 49 displayed a potent citotoxicity activity compared to the reference drug doxorubicin being, therefore, this discovery important for the rational design of new compounds against cancer.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-12T11:02:02Z
2014-08-12T11:02:02Z
2014-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv RODRIGUES, F. A. R. et al. Cytotoxic evaluation of substituted benzaldehydes. European Chemical Bulletin, v. 3, p. 555-557, mar. 2014.
2063-5346
http://www.repositorio.ufc.br/handle/riufc/8682
identifier_str_mv RODRIGUES, F. A. R. et al. Cytotoxic evaluation of substituted benzaldehydes. European Chemical Bulletin, v. 3, p. 555-557, mar. 2014.
2063-5346
url http://www.repositorio.ufc.br/handle/riufc/8682
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv EUROPEAN CHEMICAL BULLETIN
publisher.none.fl_str_mv EUROPEAN CHEMICAL BULLETIN
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1813028778648010752

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