Monocrotaline : histological damage and oxidant activity in brain areas of mice
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
dARK ID: | ark:/83112/001300001w9br |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/5724 |
Resumo: | This work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25–30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were sacrificed by decapitation and the brain areas (HC, PHC, PFC, or ST) were removed for histopathological analysis or dissected and homogenized for measurement of OS parameters (lipid peroxidation, nitrite, and catalase) by spectrophotometry. Histological evaluation of brain structures of rats treated with MCT (50 and 100 mg/kg) revealed lesions in the hippocampus and parahippocampal cortex compared to control. Lipid peroxidation was evident in all brain areas after administration of MCT. Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. In conclusion, monocrotaline caused cell lesions in the hippocampus and parahippocampal cortex regions and produced oxidative stress in the HC, PFC, and ST in mice. These findings may contribute to the neurological effects associated with this compound. |
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Monocrotaline : histological damage and oxidant activity in brain areas of miceMonocrotalinaRatosThis work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25–30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were sacrificed by decapitation and the brain areas (HC, PHC, PFC, or ST) were removed for histopathological analysis or dissected and homogenized for measurement of OS parameters (lipid peroxidation, nitrite, and catalase) by spectrophotometry. Histological evaluation of brain structures of rats treated with MCT (50 and 100 mg/kg) revealed lesions in the hippocampus and parahippocampal cortex compared to control. Lipid peroxidation was evident in all brain areas after administration of MCT. Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. In conclusion, monocrotaline caused cell lesions in the hippocampus and parahippocampal cortex regions and produced oxidative stress in the HC, PFC, and ST in mice. These findings may contribute to the neurological effects associated with this compound.Oxidative medicine and cellular longevity2013-09-03T10:48:39Z2013-09-03T10:48:39Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHONÓRIO JUNIOR, J. E. R et al. Monocrotaline : histological damage and oxidant activity in brain areas of mice. Oxidative Medicine and Cellular Longevity, v. 2012, p. 1-10, 2012.1942-0900http://www.repositorio.ufc.br/handle/riufc/5724ark:/83112/001300001w9brHonório Junior, José Eduardo RibeiroVasconcelos, Germana SilvaRodrigues, Francisca Taciana SousaSena Filho, José GuedesBarbosa-Filho, José MariaAguiar, Carlos Clayton TorresLeal, Luzia Kalyne Almeida MoreiraSoares, Pedro Marcos GomesWoods, David JohnFonteles, Marta Maria de FrançaVasconcelos, Silvânia Maria Mendesengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-15T17:23:53Zoai:repositorio.ufc.br:riufc/5724Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:54:45.452502Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Monocrotaline : histological damage and oxidant activity in brain areas of mice |
title |
Monocrotaline : histological damage and oxidant activity in brain areas of mice |
spellingShingle |
Monocrotaline : histological damage and oxidant activity in brain areas of mice Honório Junior, José Eduardo Ribeiro Monocrotalina Ratos |
title_short |
Monocrotaline : histological damage and oxidant activity in brain areas of mice |
title_full |
Monocrotaline : histological damage and oxidant activity in brain areas of mice |
title_fullStr |
Monocrotaline : histological damage and oxidant activity in brain areas of mice |
title_full_unstemmed |
Monocrotaline : histological damage and oxidant activity in brain areas of mice |
title_sort |
Monocrotaline : histological damage and oxidant activity in brain areas of mice |
author |
Honório Junior, José Eduardo Ribeiro |
author_facet |
Honório Junior, José Eduardo Ribeiro Vasconcelos, Germana Silva Rodrigues, Francisca Taciana Sousa Sena Filho, José Guedes Barbosa-Filho, José Maria Aguiar, Carlos Clayton Torres Leal, Luzia Kalyne Almeida Moreira Soares, Pedro Marcos Gomes Woods, David John Fonteles, Marta Maria de França Vasconcelos, Silvânia Maria Mendes |
author_role |
author |
author2 |
Vasconcelos, Germana Silva Rodrigues, Francisca Taciana Sousa Sena Filho, José Guedes Barbosa-Filho, José Maria Aguiar, Carlos Clayton Torres Leal, Luzia Kalyne Almeida Moreira Soares, Pedro Marcos Gomes Woods, David John Fonteles, Marta Maria de França Vasconcelos, Silvânia Maria Mendes |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Honório Junior, José Eduardo Ribeiro Vasconcelos, Germana Silva Rodrigues, Francisca Taciana Sousa Sena Filho, José Guedes Barbosa-Filho, José Maria Aguiar, Carlos Clayton Torres Leal, Luzia Kalyne Almeida Moreira Soares, Pedro Marcos Gomes Woods, David John Fonteles, Marta Maria de França Vasconcelos, Silvânia Maria Mendes |
dc.subject.por.fl_str_mv |
Monocrotalina Ratos |
topic |
Monocrotalina Ratos |
description |
This work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25–30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were sacrificed by decapitation and the brain areas (HC, PHC, PFC, or ST) were removed for histopathological analysis or dissected and homogenized for measurement of OS parameters (lipid peroxidation, nitrite, and catalase) by spectrophotometry. Histological evaluation of brain structures of rats treated with MCT (50 and 100 mg/kg) revealed lesions in the hippocampus and parahippocampal cortex compared to control. Lipid peroxidation was evident in all brain areas after administration of MCT. Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. In conclusion, monocrotaline caused cell lesions in the hippocampus and parahippocampal cortex regions and produced oxidative stress in the HC, PFC, and ST in mice. These findings may contribute to the neurological effects associated with this compound. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 2013-09-03T10:48:39Z 2013-09-03T10:48:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
HONÓRIO JUNIOR, J. E. R et al. Monocrotaline : histological damage and oxidant activity in brain areas of mice. Oxidative Medicine and Cellular Longevity, v. 2012, p. 1-10, 2012. 1942-0900 http://www.repositorio.ufc.br/handle/riufc/5724 |
dc.identifier.dark.fl_str_mv |
ark:/83112/001300001w9br |
identifier_str_mv |
HONÓRIO JUNIOR, J. E. R et al. Monocrotaline : histological damage and oxidant activity in brain areas of mice. Oxidative Medicine and Cellular Longevity, v. 2012, p. 1-10, 2012. 1942-0900 ark:/83112/001300001w9br |
url |
http://www.repositorio.ufc.br/handle/riufc/5724 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxidative medicine and cellular longevity |
publisher.none.fl_str_mv |
Oxidative medicine and cellular longevity |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1818374030324924416 |