Monocrotaline : histological damage and oxidant activity in brain areas of mice

Detalhes bibliográficos
Autor(a) principal: Honório Junior, José Eduardo Ribeiro
Data de Publicação: 2012
Outros Autores: Vasconcelos, Germana Silva, Rodrigues, Francisca Taciana Sousa, Sena Filho, José Guedes, Barbosa-Filho, José Maria, Aguiar, Carlos Clayton Torres, Leal, Luzia Kalyne Almeida Moreira, Soares, Pedro Marcos Gomes, Woods, David John, Fonteles, Marta Maria de França, Vasconcelos, Silvânia Maria Mendes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
dARK ID: ark:/83112/001300001w9br
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/5724
Resumo: This work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25–30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were sacrificed by decapitation and the brain areas (HC, PHC, PFC, or ST) were removed for histopathological analysis or dissected and homogenized for measurement of OS parameters (lipid peroxidation, nitrite, and catalase) by spectrophotometry. Histological evaluation of brain structures of rats treated with MCT (50 and 100 mg/kg) revealed lesions in the hippocampus and parahippocampal cortex compared to control. Lipid peroxidation was evident in all brain areas after administration of MCT. Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. In conclusion, monocrotaline caused cell lesions in the hippocampus and parahippocampal cortex regions and produced oxidative stress in the HC, PFC, and ST in mice. These findings may contribute to the neurological effects associated with this compound.
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spelling Monocrotaline : histological damage and oxidant activity in brain areas of miceMonocrotalinaRatosThis work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25–30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were sacrificed by decapitation and the brain areas (HC, PHC, PFC, or ST) were removed for histopathological analysis or dissected and homogenized for measurement of OS parameters (lipid peroxidation, nitrite, and catalase) by spectrophotometry. Histological evaluation of brain structures of rats treated with MCT (50 and 100 mg/kg) revealed lesions in the hippocampus and parahippocampal cortex compared to control. Lipid peroxidation was evident in all brain areas after administration of MCT. Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. In conclusion, monocrotaline caused cell lesions in the hippocampus and parahippocampal cortex regions and produced oxidative stress in the HC, PFC, and ST in mice. These findings may contribute to the neurological effects associated with this compound.Oxidative medicine and cellular longevity2013-09-03T10:48:39Z2013-09-03T10:48:39Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfHONÓRIO JUNIOR, J. E. R et al. Monocrotaline : histological damage and oxidant activity in brain areas of mice. Oxidative Medicine and Cellular Longevity, v. 2012, p. 1-10, 2012.1942-0900http://www.repositorio.ufc.br/handle/riufc/5724ark:/83112/001300001w9brHonório Junior, José Eduardo RibeiroVasconcelos, Germana SilvaRodrigues, Francisca Taciana SousaSena Filho, José GuedesBarbosa-Filho, José MariaAguiar, Carlos Clayton TorresLeal, Luzia Kalyne Almeida MoreiraSoares, Pedro Marcos GomesWoods, David JohnFonteles, Marta Maria de FrançaVasconcelos, Silvânia Maria Mendesengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-15T17:23:53Zoai:repositorio.ufc.br:riufc/5724Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:54:45.452502Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Monocrotaline : histological damage and oxidant activity in brain areas of mice
title Monocrotaline : histological damage and oxidant activity in brain areas of mice
spellingShingle Monocrotaline : histological damage and oxidant activity in brain areas of mice
Honório Junior, José Eduardo Ribeiro
Monocrotalina
Ratos
title_short Monocrotaline : histological damage and oxidant activity in brain areas of mice
title_full Monocrotaline : histological damage and oxidant activity in brain areas of mice
title_fullStr Monocrotaline : histological damage and oxidant activity in brain areas of mice
title_full_unstemmed Monocrotaline : histological damage and oxidant activity in brain areas of mice
title_sort Monocrotaline : histological damage and oxidant activity in brain areas of mice
author Honório Junior, José Eduardo Ribeiro
author_facet Honório Junior, José Eduardo Ribeiro
Vasconcelos, Germana Silva
Rodrigues, Francisca Taciana Sousa
Sena Filho, José Guedes
Barbosa-Filho, José Maria
Aguiar, Carlos Clayton Torres
Leal, Luzia Kalyne Almeida Moreira
Soares, Pedro Marcos Gomes
Woods, David John
Fonteles, Marta Maria de França
Vasconcelos, Silvânia Maria Mendes
author_role author
author2 Vasconcelos, Germana Silva
Rodrigues, Francisca Taciana Sousa
Sena Filho, José Guedes
Barbosa-Filho, José Maria
Aguiar, Carlos Clayton Torres
Leal, Luzia Kalyne Almeida Moreira
Soares, Pedro Marcos Gomes
Woods, David John
Fonteles, Marta Maria de França
Vasconcelos, Silvânia Maria Mendes
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Honório Junior, José Eduardo Ribeiro
Vasconcelos, Germana Silva
Rodrigues, Francisca Taciana Sousa
Sena Filho, José Guedes
Barbosa-Filho, José Maria
Aguiar, Carlos Clayton Torres
Leal, Luzia Kalyne Almeida Moreira
Soares, Pedro Marcos Gomes
Woods, David John
Fonteles, Marta Maria de França
Vasconcelos, Silvânia Maria Mendes
dc.subject.por.fl_str_mv Monocrotalina
Ratos
topic Monocrotalina
Ratos
description This work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25–30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were sacrificed by decapitation and the brain areas (HC, PHC, PFC, or ST) were removed for histopathological analysis or dissected and homogenized for measurement of OS parameters (lipid peroxidation, nitrite, and catalase) by spectrophotometry. Histological evaluation of brain structures of rats treated with MCT (50 and 100 mg/kg) revealed lesions in the hippocampus and parahippocampal cortex compared to control. Lipid peroxidation was evident in all brain areas after administration of MCT. Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. In conclusion, monocrotaline caused cell lesions in the hippocampus and parahippocampal cortex regions and produced oxidative stress in the HC, PFC, and ST in mice. These findings may contribute to the neurological effects associated with this compound.
publishDate 2012
dc.date.none.fl_str_mv 2012
2013-09-03T10:48:39Z
2013-09-03T10:48:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv HONÓRIO JUNIOR, J. E. R et al. Monocrotaline : histological damage and oxidant activity in brain areas of mice. Oxidative Medicine and Cellular Longevity, v. 2012, p. 1-10, 2012.
1942-0900
http://www.repositorio.ufc.br/handle/riufc/5724
dc.identifier.dark.fl_str_mv ark:/83112/001300001w9br
identifier_str_mv HONÓRIO JUNIOR, J. E. R et al. Monocrotaline : histological damage and oxidant activity in brain areas of mice. Oxidative Medicine and Cellular Longevity, v. 2012, p. 1-10, 2012.
1942-0900
ark:/83112/001300001w9br
url http://www.repositorio.ufc.br/handle/riufc/5724
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxidative medicine and cellular longevity
publisher.none.fl_str_mv Oxidative medicine and cellular longevity
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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