Violacein antimicrobial activity on Staphylococcus epidermidis and synergistic effect on commercially available antibiotics

• Autor(a) principal: Dodou, H.V.
• Data de Publicação: 2017
• Outros Autores: Batista, A. H. de Morais, Sales, G.W.P., Medeiros, S. C. de, Rodrigues, M. L., Nogueira, P.C.N., Silveira, E.R., Nogueira, N. A. P.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
• Texto Completo: http://www.repositorio.ufc.br/handle/riufc/26557
• topic: Staphylococcus epidermidis; Antibacterianos; Anti-Bacterial Agents

Aims: The study aimed to assess whether violacein has antimicrobial activity on Staphylococcus epidermidis and synergistically modulates the action of commercially available antimicrobial drugs. Methods and Results: Violacein showed excellent antimicrobial activity on biofilm-forming and nonbiofilm-forming S. epidermidis strains (ATCC 35984) (ATCC 12228), with bacteriostatic (MIC = 20 lg ml 1 and 10 lg ml 1 respectively) and bactericidal effects (MBC = 20 lg ml 1 for both strains), observed in short periods of exposure. The violacein bactericidal concentration led to S. epidermidis death after 2–3 h of exposure. Additionally, violacein synergistically modulated the activity of different antimicrobial classes on S. epidermidis ATCC 12228 (81 8%; n = 9) and on S. epidermidis ATCC 35984 (54 5%; n = 6), reducing the MIC of these antibiotics by up to 16-fold. Conclusion: Violacein shows excellent antimicrobial activity on S. epidermidis strains. Significance and Impact of the Study: Violacein shows the potential for the development of a new drug for the treatment of infections caused by S. epidermidis.