Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/10809 |
Resumo: | Background: Green tea has been used as a daily beverage for several years. Anti-inflammatory effect of tea has also been depicted in different papers. Therefore we had set forward this study to examine the potential antiinflammatory activity of green tea in small intestine mucositis experimental models. Aims: Evaluation of antiinflammatory effects of green tea on mice. Materials and Methods: Green tea decoction (20%) was prepared by soaking 20 g of green tea in 100 ml boiled water separately, soaked for 2 minutes and thereafter filtered. Inflammatory activity was induced using methotrexate (2.75 g/kg/24 h sc), and a protecting effect of mucositis condition was investigated by vitamin E and Camellia sinensis decoction. Study Design: An experimental study was approved by an Animal Ethical Commitee. Results: Green tea decoction (20%) has shown significant anti-inflammatory effects (65% and 70%) on methotrexate-induced acute mucositis model. In villous atrophy Green tea decoction (10% and 20%) has shown no protecting action at different intestinal segments. But at intestinal crypt hyperplasia, green tea decoction has shown 65.74%, as compared to mucositis group. An increase of apoptotic bodies were acchieved at MTX group, CS reduced this occurrence. Conclusion: Taken together, our data indicate that green tea (20%) has a potential anti-inflammatory compared vitamin E antioxidant action and corroborates with the current trend of tea being promoted as “health drink”. However more pharmacological and biochemical assays is necessary to elucidate mechanisms. |
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Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in miceMucositeVitamina ECamellia sinensisBackground: Green tea has been used as a daily beverage for several years. Anti-inflammatory effect of tea has also been depicted in different papers. Therefore we had set forward this study to examine the potential antiinflammatory activity of green tea in small intestine mucositis experimental models. Aims: Evaluation of antiinflammatory effects of green tea on mice. Materials and Methods: Green tea decoction (20%) was prepared by soaking 20 g of green tea in 100 ml boiled water separately, soaked for 2 minutes and thereafter filtered. Inflammatory activity was induced using methotrexate (2.75 g/kg/24 h sc), and a protecting effect of mucositis condition was investigated by vitamin E and Camellia sinensis decoction. Study Design: An experimental study was approved by an Animal Ethical Commitee. Results: Green tea decoction (20%) has shown significant anti-inflammatory effects (65% and 70%) on methotrexate-induced acute mucositis model. In villous atrophy Green tea decoction (10% and 20%) has shown no protecting action at different intestinal segments. But at intestinal crypt hyperplasia, green tea decoction has shown 65.74%, as compared to mucositis group. An increase of apoptotic bodies were acchieved at MTX group, CS reduced this occurrence. Conclusion: Taken together, our data indicate that green tea (20%) has a potential anti-inflammatory compared vitamin E antioxidant action and corroborates with the current trend of tea being promoted as “health drink”. However more pharmacological and biochemical assays is necessary to elucidate mechanisms.Food and Nutrition Sciences2015-02-27T12:45:30Z2015-02-27T12:45:30Z2014-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfALMEIDA, S. B. de et al. Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice. Food and Nutrition Sciences, v. 5, n. 5, p. 443-448, fev. 2014.2157-944X Print2157-9458 Onlinehttp://www.repositorio.ufc.br/handle/riufc/10809Almeida, Samuel Brito deMonteiro, Manuel Carlos Serra AzulLima, Ana Valêska Pinto deMenezes, Dalgimar Beserra deMonteiro, Sandra Maria Nunesengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-14T13:59:31Zoai:repositorio.ufc.br:riufc/10809Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:53:19.141849Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice |
title |
Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice |
spellingShingle |
Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice Almeida, Samuel Brito de Mucosite Vitamina E Camellia sinensis |
title_short |
Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice |
title_full |
Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice |
title_fullStr |
Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice |
title_full_unstemmed |
Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice |
title_sort |
Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice |
author |
Almeida, Samuel Brito de |
author_facet |
Almeida, Samuel Brito de Monteiro, Manuel Carlos Serra Azul Lima, Ana Valêska Pinto de Menezes, Dalgimar Beserra de Monteiro, Sandra Maria Nunes |
author_role |
author |
author2 |
Monteiro, Manuel Carlos Serra Azul Lima, Ana Valêska Pinto de Menezes, Dalgimar Beserra de Monteiro, Sandra Maria Nunes |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Almeida, Samuel Brito de Monteiro, Manuel Carlos Serra Azul Lima, Ana Valêska Pinto de Menezes, Dalgimar Beserra de Monteiro, Sandra Maria Nunes |
dc.subject.por.fl_str_mv |
Mucosite Vitamina E Camellia sinensis |
topic |
Mucosite Vitamina E Camellia sinensis |
description |
Background: Green tea has been used as a daily beverage for several years. Anti-inflammatory effect of tea has also been depicted in different papers. Therefore we had set forward this study to examine the potential antiinflammatory activity of green tea in small intestine mucositis experimental models. Aims: Evaluation of antiinflammatory effects of green tea on mice. Materials and Methods: Green tea decoction (20%) was prepared by soaking 20 g of green tea in 100 ml boiled water separately, soaked for 2 minutes and thereafter filtered. Inflammatory activity was induced using methotrexate (2.75 g/kg/24 h sc), and a protecting effect of mucositis condition was investigated by vitamin E and Camellia sinensis decoction. Study Design: An experimental study was approved by an Animal Ethical Commitee. Results: Green tea decoction (20%) has shown significant anti-inflammatory effects (65% and 70%) on methotrexate-induced acute mucositis model. In villous atrophy Green tea decoction (10% and 20%) has shown no protecting action at different intestinal segments. But at intestinal crypt hyperplasia, green tea decoction has shown 65.74%, as compared to mucositis group. An increase of apoptotic bodies were acchieved at MTX group, CS reduced this occurrence. Conclusion: Taken together, our data indicate that green tea (20%) has a potential anti-inflammatory compared vitamin E antioxidant action and corroborates with the current trend of tea being promoted as “health drink”. However more pharmacological and biochemical assays is necessary to elucidate mechanisms. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-02 2015-02-27T12:45:30Z 2015-02-27T12:45:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ALMEIDA, S. B. de et al. Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice. Food and Nutrition Sciences, v. 5, n. 5, p. 443-448, fev. 2014. 2157-944X Print 2157-9458 Online http://www.repositorio.ufc.br/handle/riufc/10809 |
identifier_str_mv |
ALMEIDA, S. B. de et al. Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice. Food and Nutrition Sciences, v. 5, n. 5, p. 443-448, fev. 2014. 2157-944X Print 2157-9458 Online |
url |
http://www.repositorio.ufc.br/handle/riufc/10809 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Food and Nutrition Sciences |
publisher.none.fl_str_mv |
Food and Nutrition Sciences |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813028984997281792 |