Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice

Detalhes bibliográficos
Autor(a) principal: Almeida, Samuel Brito de
Data de Publicação: 2014
Outros Autores: Monteiro, Manuel Carlos Serra Azul, Lima, Ana Valêska Pinto de, Menezes, Dalgimar Beserra de, Monteiro, Sandra Maria Nunes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/10809
Resumo: Background: Green tea has been used as a daily beverage for several years. Anti-inflammatory effect of tea has also been depicted in different papers. Therefore we had set forward this study to examine the potential antiinflammatory activity of green tea in small intestine mucositis experimental models. Aims: Evaluation of antiinflammatory effects of green tea on mice. Materials and Methods: Green tea decoction (20%) was prepared by soaking 20 g of green tea in 100 ml boiled water separately, soaked for 2 minutes and thereafter filtered. Inflammatory activity was induced using methotrexate (2.75 g/kg/24 h sc), and a protecting effect of mucositis condition was investigated by vitamin E and Camellia sinensis decoction. Study Design: An experimental study was approved by an Animal Ethical Commitee. Results: Green tea decoction (20%) has shown significant anti-inflammatory effects (65% and 70%) on methotrexate-induced acute mucositis model. In villous atrophy Green tea decoction (10% and 20%) has shown no protecting action at different intestinal segments. But at intestinal crypt hyperplasia, green tea decoction has shown 65.74%, as compared to mucositis group. An increase of apoptotic bodies were acchieved at MTX group, CS reduced this occurrence. Conclusion: Taken together, our data indicate that green tea (20%) has a potential anti-inflammatory compared vitamin E antioxidant action and corroborates with the current trend of tea being promoted as “health drink”. However more pharmacological and biochemical assays is necessary to elucidate mechanisms.
id UFC-7_afa306d3aa5637cf4f433083d968d725
oai_identifier_str oai:repositorio.ufc.br:riufc/10809
network_acronym_str UFC-7
network_name_str Repositório Institucional da Universidade Federal do Ceará (UFC)
repository_id_str
spelling Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in miceMucositeVitamina ECamellia sinensisBackground: Green tea has been used as a daily beverage for several years. Anti-inflammatory effect of tea has also been depicted in different papers. Therefore we had set forward this study to examine the potential antiinflammatory activity of green tea in small intestine mucositis experimental models. Aims: Evaluation of antiinflammatory effects of green tea on mice. Materials and Methods: Green tea decoction (20%) was prepared by soaking 20 g of green tea in 100 ml boiled water separately, soaked for 2 minutes and thereafter filtered. Inflammatory activity was induced using methotrexate (2.75 g/kg/24 h sc), and a protecting effect of mucositis condition was investigated by vitamin E and Camellia sinensis decoction. Study Design: An experimental study was approved by an Animal Ethical Commitee. Results: Green tea decoction (20%) has shown significant anti-inflammatory effects (65% and 70%) on methotrexate-induced acute mucositis model. In villous atrophy Green tea decoction (10% and 20%) has shown no protecting action at different intestinal segments. But at intestinal crypt hyperplasia, green tea decoction has shown 65.74%, as compared to mucositis group. An increase of apoptotic bodies were acchieved at MTX group, CS reduced this occurrence. Conclusion: Taken together, our data indicate that green tea (20%) has a potential anti-inflammatory compared vitamin E antioxidant action and corroborates with the current trend of tea being promoted as “health drink”. However more pharmacological and biochemical assays is necessary to elucidate mechanisms.Food and Nutrition Sciences2015-02-27T12:45:30Z2015-02-27T12:45:30Z2014-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfALMEIDA, S. B. de et al. Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice. Food and Nutrition Sciences, v. 5, n. 5, p. 443-448, fev. 2014.2157-944X Print2157-9458 Onlinehttp://www.repositorio.ufc.br/handle/riufc/10809Almeida, Samuel Brito deMonteiro, Manuel Carlos Serra AzulLima, Ana Valêska Pinto deMenezes, Dalgimar Beserra deMonteiro, Sandra Maria Nunesengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-14T13:59:31Zoai:repositorio.ufc.br:riufc/10809Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:53:19.141849Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice
title Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice
spellingShingle Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice
Almeida, Samuel Brito de
Mucosite
Vitamina E
Camellia sinensis
title_short Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice
title_full Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice
title_fullStr Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice
title_full_unstemmed Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice
title_sort Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice
author Almeida, Samuel Brito de
author_facet Almeida, Samuel Brito de
Monteiro, Manuel Carlos Serra Azul
Lima, Ana Valêska Pinto de
Menezes, Dalgimar Beserra de
Monteiro, Sandra Maria Nunes
author_role author
author2 Monteiro, Manuel Carlos Serra Azul
Lima, Ana Valêska Pinto de
Menezes, Dalgimar Beserra de
Monteiro, Sandra Maria Nunes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Samuel Brito de
Monteiro, Manuel Carlos Serra Azul
Lima, Ana Valêska Pinto de
Menezes, Dalgimar Beserra de
Monteiro, Sandra Maria Nunes
dc.subject.por.fl_str_mv Mucosite
Vitamina E
Camellia sinensis
topic Mucosite
Vitamina E
Camellia sinensis
description Background: Green tea has been used as a daily beverage for several years. Anti-inflammatory effect of tea has also been depicted in different papers. Therefore we had set forward this study to examine the potential antiinflammatory activity of green tea in small intestine mucositis experimental models. Aims: Evaluation of antiinflammatory effects of green tea on mice. Materials and Methods: Green tea decoction (20%) was prepared by soaking 20 g of green tea in 100 ml boiled water separately, soaked for 2 minutes and thereafter filtered. Inflammatory activity was induced using methotrexate (2.75 g/kg/24 h sc), and a protecting effect of mucositis condition was investigated by vitamin E and Camellia sinensis decoction. Study Design: An experimental study was approved by an Animal Ethical Commitee. Results: Green tea decoction (20%) has shown significant anti-inflammatory effects (65% and 70%) on methotrexate-induced acute mucositis model. In villous atrophy Green tea decoction (10% and 20%) has shown no protecting action at different intestinal segments. But at intestinal crypt hyperplasia, green tea decoction has shown 65.74%, as compared to mucositis group. An increase of apoptotic bodies were acchieved at MTX group, CS reduced this occurrence. Conclusion: Taken together, our data indicate that green tea (20%) has a potential anti-inflammatory compared vitamin E antioxidant action and corroborates with the current trend of tea being promoted as “health drink”. However more pharmacological and biochemical assays is necessary to elucidate mechanisms.
publishDate 2014
dc.date.none.fl_str_mv 2014-02
2015-02-27T12:45:30Z
2015-02-27T12:45:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv ALMEIDA, S. B. de et al. Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice. Food and Nutrition Sciences, v. 5, n. 5, p. 443-448, fev. 2014.
2157-944X Print
2157-9458 Online
http://www.repositorio.ufc.br/handle/riufc/10809
identifier_str_mv ALMEIDA, S. B. de et al. Protective effect of Camellia sinensis on methotrexate-induced small intestinal mucositis in mice. Food and Nutrition Sciences, v. 5, n. 5, p. 443-448, fev. 2014.
2157-944X Print
2157-9458 Online
url http://www.repositorio.ufc.br/handle/riufc/10809
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Food and Nutrition Sciences
publisher.none.fl_str_mv Food and Nutrition Sciences
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1813028984997281792