Integrins, cancer and snake toxins (mini-review)

Detalhes bibliográficos
Autor(a) principal: Rádis-Baptista, Gandhi
Data de Publicação: 2005
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/65051
Resumo: Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM). Integrins work as bi-directional mechanotransducers, conveying mechanical signal from outside to inside the cell through a cascade of phosphorylation signals. On the other hand, the signal from inside to outside controls the strength and affinity of integrin adhesion. As proteins of focal contact, integrins are involved in diverse cell functions, such as cell activation, migration, growth, and survival. In the development of neoplastic disease and metastatic tumor, integrins can influence cancer invasiveness and progression, as well as mediate the formation of new blood vessels (angiogenesis). Diverse snake venom toxins have the ability to interact with multiple integrins, what results in inhibition of cell attachment, inhibition of angiogenesis, and induction of apoptotic death of tumor and vascular endothelial cells. The aim of this review is to present data about snake venom toxins that bind to integrins and evoke antiangiogenesis and antitumoral effects.
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spelling Integrins, cancer and snake toxins (mini-review)AngiogenesisCancer - ApoptosisSnake toxinAngiogêneseCâncer - ApoptoseToxinas - CobrasIntegrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM). Integrins work as bi-directional mechanotransducers, conveying mechanical signal from outside to inside the cell through a cascade of phosphorylation signals. On the other hand, the signal from inside to outside controls the strength and affinity of integrin adhesion. As proteins of focal contact, integrins are involved in diverse cell functions, such as cell activation, migration, growth, and survival. In the development of neoplastic disease and metastatic tumor, integrins can influence cancer invasiveness and progression, as well as mediate the formation of new blood vessels (angiogenesis). Diverse snake venom toxins have the ability to interact with multiple integrins, what results in inhibition of cell attachment, inhibition of angiogenesis, and induction of apoptotic death of tumor and vascular endothelial cells. The aim of this review is to present data about snake venom toxins that bind to integrins and evoke antiangiogenesis and antitumoral effects.Journal of Venomous Animals and Toxins Including Tropical Diseases2022-04-12T15:52:42Z2022-04-12T15:52:42Z2005info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfRÁDIS-BAPTISTA, Gandhi. Integrins, cancer and snake toxins (mini-review). Journal Of Venomous Animals and Toxins Including Tropical Diseases, São Paulo, v. 11, n.3, p.217-241, 2005.1678-9199http://www.repositorio.ufc.br/handle/riufc/65051Rádis-Baptista, Gandhiengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-06-06T17:29:38Zoai:repositorio.ufc.br:riufc/65051Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:16:32.456837Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Integrins, cancer and snake toxins (mini-review)
title Integrins, cancer and snake toxins (mini-review)
spellingShingle Integrins, cancer and snake toxins (mini-review)
Rádis-Baptista, Gandhi
Angiogenesis
Cancer - Apoptosis
Snake toxin
Angiogênese
Câncer - Apoptose
Toxinas - Cobras
title_short Integrins, cancer and snake toxins (mini-review)
title_full Integrins, cancer and snake toxins (mini-review)
title_fullStr Integrins, cancer and snake toxins (mini-review)
title_full_unstemmed Integrins, cancer and snake toxins (mini-review)
title_sort Integrins, cancer and snake toxins (mini-review)
author Rádis-Baptista, Gandhi
author_facet Rádis-Baptista, Gandhi
author_role author
dc.contributor.author.fl_str_mv Rádis-Baptista, Gandhi
dc.subject.por.fl_str_mv Angiogenesis
Cancer - Apoptosis
Snake toxin
Angiogênese
Câncer - Apoptose
Toxinas - Cobras
topic Angiogenesis
Cancer - Apoptosis
Snake toxin
Angiogênese
Câncer - Apoptose
Toxinas - Cobras
description Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM). Integrins work as bi-directional mechanotransducers, conveying mechanical signal from outside to inside the cell through a cascade of phosphorylation signals. On the other hand, the signal from inside to outside controls the strength and affinity of integrin adhesion. As proteins of focal contact, integrins are involved in diverse cell functions, such as cell activation, migration, growth, and survival. In the development of neoplastic disease and metastatic tumor, integrins can influence cancer invasiveness and progression, as well as mediate the formation of new blood vessels (angiogenesis). Diverse snake venom toxins have the ability to interact with multiple integrins, what results in inhibition of cell attachment, inhibition of angiogenesis, and induction of apoptotic death of tumor and vascular endothelial cells. The aim of this review is to present data about snake venom toxins that bind to integrins and evoke antiangiogenesis and antitumoral effects.
publishDate 2005
dc.date.none.fl_str_mv 2005
2022-04-12T15:52:42Z
2022-04-12T15:52:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv RÁDIS-BAPTISTA, Gandhi. Integrins, cancer and snake toxins (mini-review). Journal Of Venomous Animals and Toxins Including Tropical Diseases, São Paulo, v. 11, n.3, p.217-241, 2005.
1678-9199
http://www.repositorio.ufc.br/handle/riufc/65051
identifier_str_mv RÁDIS-BAPTISTA, Gandhi. Integrins, cancer and snake toxins (mini-review). Journal Of Venomous Animals and Toxins Including Tropical Diseases, São Paulo, v. 11, n.3, p.217-241, 2005.
1678-9199
url http://www.repositorio.ufc.br/handle/riufc/65051
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases
publisher.none.fl_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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