Integrins, cancer and snake toxins (mini-review)
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/65051 |
Resumo: | Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM). Integrins work as bi-directional mechanotransducers, conveying mechanical signal from outside to inside the cell through a cascade of phosphorylation signals. On the other hand, the signal from inside to outside controls the strength and affinity of integrin adhesion. As proteins of focal contact, integrins are involved in diverse cell functions, such as cell activation, migration, growth, and survival. In the development of neoplastic disease and metastatic tumor, integrins can influence cancer invasiveness and progression, as well as mediate the formation of new blood vessels (angiogenesis). Diverse snake venom toxins have the ability to interact with multiple integrins, what results in inhibition of cell attachment, inhibition of angiogenesis, and induction of apoptotic death of tumor and vascular endothelial cells. The aim of this review is to present data about snake venom toxins that bind to integrins and evoke antiangiogenesis and antitumoral effects. |
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Repositório Institucional da Universidade Federal do Ceará (UFC) |
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Integrins, cancer and snake toxins (mini-review)AngiogenesisCancer - ApoptosisSnake toxinAngiogêneseCâncer - ApoptoseToxinas - CobrasIntegrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM). Integrins work as bi-directional mechanotransducers, conveying mechanical signal from outside to inside the cell through a cascade of phosphorylation signals. On the other hand, the signal from inside to outside controls the strength and affinity of integrin adhesion. As proteins of focal contact, integrins are involved in diverse cell functions, such as cell activation, migration, growth, and survival. In the development of neoplastic disease and metastatic tumor, integrins can influence cancer invasiveness and progression, as well as mediate the formation of new blood vessels (angiogenesis). Diverse snake venom toxins have the ability to interact with multiple integrins, what results in inhibition of cell attachment, inhibition of angiogenesis, and induction of apoptotic death of tumor and vascular endothelial cells. The aim of this review is to present data about snake venom toxins that bind to integrins and evoke antiangiogenesis and antitumoral effects.Journal of Venomous Animals and Toxins Including Tropical Diseases2022-04-12T15:52:42Z2022-04-12T15:52:42Z2005info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfRÁDIS-BAPTISTA, Gandhi. Integrins, cancer and snake toxins (mini-review). Journal Of Venomous Animals and Toxins Including Tropical Diseases, São Paulo, v. 11, n.3, p.217-241, 2005.1678-9199http://www.repositorio.ufc.br/handle/riufc/65051Rádis-Baptista, Gandhiengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-06-06T17:29:38Zoai:repositorio.ufc.br:riufc/65051Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:16:32.456837Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Integrins, cancer and snake toxins (mini-review) |
title |
Integrins, cancer and snake toxins (mini-review) |
spellingShingle |
Integrins, cancer and snake toxins (mini-review) Rádis-Baptista, Gandhi Angiogenesis Cancer - Apoptosis Snake toxin Angiogênese Câncer - Apoptose Toxinas - Cobras |
title_short |
Integrins, cancer and snake toxins (mini-review) |
title_full |
Integrins, cancer and snake toxins (mini-review) |
title_fullStr |
Integrins, cancer and snake toxins (mini-review) |
title_full_unstemmed |
Integrins, cancer and snake toxins (mini-review) |
title_sort |
Integrins, cancer and snake toxins (mini-review) |
author |
Rádis-Baptista, Gandhi |
author_facet |
Rádis-Baptista, Gandhi |
author_role |
author |
dc.contributor.author.fl_str_mv |
Rádis-Baptista, Gandhi |
dc.subject.por.fl_str_mv |
Angiogenesis Cancer - Apoptosis Snake toxin Angiogênese Câncer - Apoptose Toxinas - Cobras |
topic |
Angiogenesis Cancer - Apoptosis Snake toxin Angiogênese Câncer - Apoptose Toxinas - Cobras |
description |
Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM). Integrins work as bi-directional mechanotransducers, conveying mechanical signal from outside to inside the cell through a cascade of phosphorylation signals. On the other hand, the signal from inside to outside controls the strength and affinity of integrin adhesion. As proteins of focal contact, integrins are involved in diverse cell functions, such as cell activation, migration, growth, and survival. In the development of neoplastic disease and metastatic tumor, integrins can influence cancer invasiveness and progression, as well as mediate the formation of new blood vessels (angiogenesis). Diverse snake venom toxins have the ability to interact with multiple integrins, what results in inhibition of cell attachment, inhibition of angiogenesis, and induction of apoptotic death of tumor and vascular endothelial cells. The aim of this review is to present data about snake venom toxins that bind to integrins and evoke antiangiogenesis and antitumoral effects. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005 2022-04-12T15:52:42Z 2022-04-12T15:52:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
RÁDIS-BAPTISTA, Gandhi. Integrins, cancer and snake toxins (mini-review). Journal Of Venomous Animals and Toxins Including Tropical Diseases, São Paulo, v. 11, n.3, p.217-241, 2005. 1678-9199 http://www.repositorio.ufc.br/handle/riufc/65051 |
identifier_str_mv |
RÁDIS-BAPTISTA, Gandhi. Integrins, cancer and snake toxins (mini-review). Journal Of Venomous Animals and Toxins Including Tropical Diseases, São Paulo, v. 11, n.3, p.217-241, 2005. 1678-9199 |
url |
http://www.repositorio.ufc.br/handle/riufc/65051 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases |
publisher.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813028733390422016 |