The renal effects of alginates isolated from brown seaweed Sargassum vulgare
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/5607 |
Resumo: | Alginates isolated from Sargassum vulgare , present a strong antitumor activity, associated with kidney reversible damage, as analysed by histopathology of treated animals. In the present study, the renal alteration mechanisms of S. vulgare alginates were investigated using the isolated perfused rat kidney and the isolated perfused rat mesenteric blood vessel methods. The results showed that the effects of Sargassum vulgare low viscosity (SVLV) alginate were more potent than those of Sargassum vulgare high viscosity (SVHV) alginate in the isolated rat kidney. The SVLV alginate caused considerable changes in renal physiology, as shown by an increase in parameters such as perfusion pressure, renal vascular resistance, glomerular filtration rate, urinary flow and sodium, potassium and chloride excretion and by reduction of chloride tubular transport. The effects of SVHV were weaker than those of SVLV. The effects of SVLV on kidney could be related to direct vascular action as demonstrated with SVLV alginate on mesenteric blood vessels. In conclusion, the Sargassum vulgare alginate altered the renal function parameters evaluated. S. vulgare low viscosity alginate renal effects were more potent than S. vulgare high viscosity alginate. It is suggested that physicochemical differences be- tween SVHV and SVLV could explain the differences found in the results. Copyright © 2007 John Wiley & Sons, Ltd. |
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The renal effects of alginates isolated from brown seaweed Sargassum vulgareAlginatosRimAlginates isolated from Sargassum vulgare , present a strong antitumor activity, associated with kidney reversible damage, as analysed by histopathology of treated animals. In the present study, the renal alteration mechanisms of S. vulgare alginates were investigated using the isolated perfused rat kidney and the isolated perfused rat mesenteric blood vessel methods. The results showed that the effects of Sargassum vulgare low viscosity (SVLV) alginate were more potent than those of Sargassum vulgare high viscosity (SVHV) alginate in the isolated rat kidney. The SVLV alginate caused considerable changes in renal physiology, as shown by an increase in parameters such as perfusion pressure, renal vascular resistance, glomerular filtration rate, urinary flow and sodium, potassium and chloride excretion and by reduction of chloride tubular transport. The effects of SVHV were weaker than those of SVLV. The effects of SVLV on kidney could be related to direct vascular action as demonstrated with SVLV alginate on mesenteric blood vessels. In conclusion, the Sargassum vulgare alginate altered the renal function parameters evaluated. S. vulgare low viscosity alginate renal effects were more potent than S. vulgare high viscosity alginate. It is suggested that physicochemical differences be- tween SVHV and SVLV could explain the differences found in the results. Copyright © 2007 John Wiley & Sons, Ltd.Journal of Applied Toxicology2013-08-13T12:42:26Z2013-08-13T12:42:26Z2008-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSOUSA, A. de P. A. et al. The renal effects of alginates isolated from brown seaweed Sargassum vulgare. Journal of applied toxicology, Chichester, Inglaterra, v. 28, n. 3, p. 364-369, abr. 2008.0260-437Xhttp://www.repositorio.ufc.br/handle/riufc/5607Sousa, Alessandra de Paula Alves ,Barbosa, Paulo Sergio FerreiraTorres, Márcia RochaMartins, Alice Maria CostaMartins, René DuarteAlves, Renata de SousaSousa, Daniel Freire deAlves, Claudênio DiógenesCosta-Lotufo, Letícia VerasMonteiro, Helena Serra Azulengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-15T17:47:03Zoai:repositorio.ufc.br:riufc/5607Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:36:03.250531Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
The renal effects of alginates isolated from brown seaweed Sargassum vulgare |
title |
The renal effects of alginates isolated from brown seaweed Sargassum vulgare |
spellingShingle |
The renal effects of alginates isolated from brown seaweed Sargassum vulgare Sousa, Alessandra de Paula Alves , Alginatos Rim |
title_short |
The renal effects of alginates isolated from brown seaweed Sargassum vulgare |
title_full |
The renal effects of alginates isolated from brown seaweed Sargassum vulgare |
title_fullStr |
The renal effects of alginates isolated from brown seaweed Sargassum vulgare |
title_full_unstemmed |
The renal effects of alginates isolated from brown seaweed Sargassum vulgare |
title_sort |
The renal effects of alginates isolated from brown seaweed Sargassum vulgare |
author |
Sousa, Alessandra de Paula Alves , |
author_facet |
Sousa, Alessandra de Paula Alves , Barbosa, Paulo Sergio Ferreira Torres, Márcia Rocha Martins, Alice Maria Costa Martins, René Duarte Alves, Renata de Sousa Sousa, Daniel Freire de Alves, Claudênio Diógenes Costa-Lotufo, Letícia Veras Monteiro, Helena Serra Azul |
author_role |
author |
author2 |
Barbosa, Paulo Sergio Ferreira Torres, Márcia Rocha Martins, Alice Maria Costa Martins, René Duarte Alves, Renata de Sousa Sousa, Daniel Freire de Alves, Claudênio Diógenes Costa-Lotufo, Letícia Veras Monteiro, Helena Serra Azul |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Sousa, Alessandra de Paula Alves , Barbosa, Paulo Sergio Ferreira Torres, Márcia Rocha Martins, Alice Maria Costa Martins, René Duarte Alves, Renata de Sousa Sousa, Daniel Freire de Alves, Claudênio Diógenes Costa-Lotufo, Letícia Veras Monteiro, Helena Serra Azul |
dc.subject.por.fl_str_mv |
Alginatos Rim |
topic |
Alginatos Rim |
description |
Alginates isolated from Sargassum vulgare , present a strong antitumor activity, associated with kidney reversible damage, as analysed by histopathology of treated animals. In the present study, the renal alteration mechanisms of S. vulgare alginates were investigated using the isolated perfused rat kidney and the isolated perfused rat mesenteric blood vessel methods. The results showed that the effects of Sargassum vulgare low viscosity (SVLV) alginate were more potent than those of Sargassum vulgare high viscosity (SVHV) alginate in the isolated rat kidney. The SVLV alginate caused considerable changes in renal physiology, as shown by an increase in parameters such as perfusion pressure, renal vascular resistance, glomerular filtration rate, urinary flow and sodium, potassium and chloride excretion and by reduction of chloride tubular transport. The effects of SVHV were weaker than those of SVLV. The effects of SVLV on kidney could be related to direct vascular action as demonstrated with SVLV alginate on mesenteric blood vessels. In conclusion, the Sargassum vulgare alginate altered the renal function parameters evaluated. S. vulgare low viscosity alginate renal effects were more potent than S. vulgare high viscosity alginate. It is suggested that physicochemical differences be- tween SVHV and SVLV could explain the differences found in the results. Copyright © 2007 John Wiley & Sons, Ltd. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-04 2013-08-13T12:42:26Z 2013-08-13T12:42:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
SOUSA, A. de P. A. et al. The renal effects of alginates isolated from brown seaweed Sargassum vulgare. Journal of applied toxicology, Chichester, Inglaterra, v. 28, n. 3, p. 364-369, abr. 2008. 0260-437X http://www.repositorio.ufc.br/handle/riufc/5607 |
identifier_str_mv |
SOUSA, A. de P. A. et al. The renal effects of alginates isolated from brown seaweed Sargassum vulgare. Journal of applied toxicology, Chichester, Inglaterra, v. 28, n. 3, p. 364-369, abr. 2008. 0260-437X |
url |
http://www.repositorio.ufc.br/handle/riufc/5607 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Journal of Applied Toxicology |
publisher.none.fl_str_mv |
Journal of Applied Toxicology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813028871572815872 |