The renal effects of alginates isolated from brown seaweed Sargassum vulgare

Detalhes bibliográficos
Autor(a) principal: Sousa, Alessandra de Paula Alves
Data de Publicação: 2008
Outros Autores: Barbosa, Paulo Sergio Ferreira, Torres, Márcia Rocha, Martins, Alice Maria Costa, Martins, René Duarte, Alves, Renata de Sousa, Sousa, Daniel Freire de, Alves, Claudênio Diógenes, Costa-Lotufo, Letícia Veras, Monteiro, Helena Serra Azul
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/5607
Resumo: Alginates isolated from Sargassum vulgare , present a strong antitumor activity, associated with kidney reversible damage, as analysed by histopathology of treated animals. In the present study, the renal alteration mechanisms of S. vulgare alginates were investigated using the isolated perfused rat kidney and the isolated perfused rat mesenteric blood vessel methods. The results showed that the effects of Sargassum vulgare low viscosity (SVLV) alginate were more potent than those of Sargassum vulgare high viscosity (SVHV) alginate in the isolated rat kidney. The SVLV alginate caused considerable changes in renal physiology, as shown by an increase in parameters such as perfusion pressure, renal vascular resistance, glomerular filtration rate, urinary flow and sodium, potassium and chloride excretion and by reduction of chloride tubular transport. The effects of SVHV were weaker than those of SVLV. The effects of SVLV on kidney could be related to direct vascular action as demonstrated with SVLV alginate on mesenteric blood vessels. In conclusion, the Sargassum vulgare alginate altered the renal function parameters evaluated. S. vulgare low viscosity alginate renal effects were more potent than S. vulgare high viscosity alginate. It is suggested that physicochemical differences be- tween SVHV and SVLV could explain the differences found in the results. Copyright © 2007 John Wiley & Sons, Ltd.
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spelling The renal effects of alginates isolated from brown seaweed Sargassum vulgareAlginatosRimAlginates isolated from Sargassum vulgare , present a strong antitumor activity, associated with kidney reversible damage, as analysed by histopathology of treated animals. In the present study, the renal alteration mechanisms of S. vulgare alginates were investigated using the isolated perfused rat kidney and the isolated perfused rat mesenteric blood vessel methods. The results showed that the effects of Sargassum vulgare low viscosity (SVLV) alginate were more potent than those of Sargassum vulgare high viscosity (SVHV) alginate in the isolated rat kidney. The SVLV alginate caused considerable changes in renal physiology, as shown by an increase in parameters such as perfusion pressure, renal vascular resistance, glomerular filtration rate, urinary flow and sodium, potassium and chloride excretion and by reduction of chloride tubular transport. The effects of SVHV were weaker than those of SVLV. The effects of SVLV on kidney could be related to direct vascular action as demonstrated with SVLV alginate on mesenteric blood vessels. In conclusion, the Sargassum vulgare alginate altered the renal function parameters evaluated. S. vulgare low viscosity alginate renal effects were more potent than S. vulgare high viscosity alginate. It is suggested that physicochemical differences be- tween SVHV and SVLV could explain the differences found in the results. Copyright © 2007 John Wiley & Sons, Ltd.Journal of Applied Toxicology2013-08-13T12:42:26Z2013-08-13T12:42:26Z2008-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSOUSA, A. de P. A. et al. The renal effects of alginates isolated from brown seaweed Sargassum vulgare. Journal of applied toxicology, Chichester, Inglaterra, v. 28, n. 3, p. 364-369, abr. 2008.0260-437Xhttp://www.repositorio.ufc.br/handle/riufc/5607Sousa, Alessandra de Paula Alves ,Barbosa, Paulo Sergio FerreiraTorres, Márcia RochaMartins, Alice Maria CostaMartins, René DuarteAlves, Renata de SousaSousa, Daniel Freire deAlves, Claudênio DiógenesCosta-Lotufo, Letícia VerasMonteiro, Helena Serra Azulengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-15T17:47:03Zoai:repositorio.ufc.br:riufc/5607Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:36:03.250531Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv The renal effects of alginates isolated from brown seaweed Sargassum vulgare
title The renal effects of alginates isolated from brown seaweed Sargassum vulgare
spellingShingle The renal effects of alginates isolated from brown seaweed Sargassum vulgare
Sousa, Alessandra de Paula Alves ,
Alginatos
Rim
title_short The renal effects of alginates isolated from brown seaweed Sargassum vulgare
title_full The renal effects of alginates isolated from brown seaweed Sargassum vulgare
title_fullStr The renal effects of alginates isolated from brown seaweed Sargassum vulgare
title_full_unstemmed The renal effects of alginates isolated from brown seaweed Sargassum vulgare
title_sort The renal effects of alginates isolated from brown seaweed Sargassum vulgare
author Sousa, Alessandra de Paula Alves ,
author_facet Sousa, Alessandra de Paula Alves ,
Barbosa, Paulo Sergio Ferreira
Torres, Márcia Rocha
Martins, Alice Maria Costa
Martins, René Duarte
Alves, Renata de Sousa
Sousa, Daniel Freire de
Alves, Claudênio Diógenes
Costa-Lotufo, Letícia Veras
Monteiro, Helena Serra Azul
author_role author
author2 Barbosa, Paulo Sergio Ferreira
Torres, Márcia Rocha
Martins, Alice Maria Costa
Martins, René Duarte
Alves, Renata de Sousa
Sousa, Daniel Freire de
Alves, Claudênio Diógenes
Costa-Lotufo, Letícia Veras
Monteiro, Helena Serra Azul
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sousa, Alessandra de Paula Alves ,
Barbosa, Paulo Sergio Ferreira
Torres, Márcia Rocha
Martins, Alice Maria Costa
Martins, René Duarte
Alves, Renata de Sousa
Sousa, Daniel Freire de
Alves, Claudênio Diógenes
Costa-Lotufo, Letícia Veras
Monteiro, Helena Serra Azul
dc.subject.por.fl_str_mv Alginatos
Rim
topic Alginatos
Rim
description Alginates isolated from Sargassum vulgare , present a strong antitumor activity, associated with kidney reversible damage, as analysed by histopathology of treated animals. In the present study, the renal alteration mechanisms of S. vulgare alginates were investigated using the isolated perfused rat kidney and the isolated perfused rat mesenteric blood vessel methods. The results showed that the effects of Sargassum vulgare low viscosity (SVLV) alginate were more potent than those of Sargassum vulgare high viscosity (SVHV) alginate in the isolated rat kidney. The SVLV alginate caused considerable changes in renal physiology, as shown by an increase in parameters such as perfusion pressure, renal vascular resistance, glomerular filtration rate, urinary flow and sodium, potassium and chloride excretion and by reduction of chloride tubular transport. The effects of SVHV were weaker than those of SVLV. The effects of SVLV on kidney could be related to direct vascular action as demonstrated with SVLV alginate on mesenteric blood vessels. In conclusion, the Sargassum vulgare alginate altered the renal function parameters evaluated. S. vulgare low viscosity alginate renal effects were more potent than S. vulgare high viscosity alginate. It is suggested that physicochemical differences be- tween SVHV and SVLV could explain the differences found in the results. Copyright © 2007 John Wiley & Sons, Ltd.
publishDate 2008
dc.date.none.fl_str_mv 2008-04
2013-08-13T12:42:26Z
2013-08-13T12:42:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SOUSA, A. de P. A. et al. The renal effects of alginates isolated from brown seaweed Sargassum vulgare. Journal of applied toxicology, Chichester, Inglaterra, v. 28, n. 3, p. 364-369, abr. 2008.
0260-437X
http://www.repositorio.ufc.br/handle/riufc/5607
identifier_str_mv SOUSA, A. de P. A. et al. The renal effects of alginates isolated from brown seaweed Sargassum vulgare. Journal of applied toxicology, Chichester, Inglaterra, v. 28, n. 3, p. 364-369, abr. 2008.
0260-437X
url http://www.repositorio.ufc.br/handle/riufc/5607
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of Applied Toxicology
publisher.none.fl_str_mv Journal of Applied Toxicology
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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