Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/59064 |
Resumo: | Spondias mombin L. (Anacardiaceae) is a tree known in Northeast Brazil as “cajazeira”. Besides producing fruit that is widely consumed (yellow mombin or hog plum in English, caja in Portuguese, among others), its leaves are extensively used in traditional medicine for its anti-inflammatory, antimicrobial and antiviral properties. This study aimed to develop a standardized hydroalcoholic extract of S. mombin leaves and to investigate the anti-inflammatory activity of the extract and geraniin from S. mombin in human neutrophils. The authors used an integrative approach, including histological and histochemical examination, HPLC analysis and microbiological control. The anti-inflammatory bioactivity of the standardized extract of S. mombin and geraniin was evaluated in a degranulation assay in human neutrophils. The leaves of S. mombin exhibited distinguishable histological features compared with other Spondias species. Idioblasts with phenolic compounds were histochemically identified. Purity parameters were determined in the drug as well as the total polyphenol content in the plant extract. HPLC analysis allowed detection and quantification of two bioactive phenols, geraniin and chlorogenic acid. The hydroalcoholic extract of S. mombin leaves and geraniin exhibited significant anti-inflammatory activity in human neutrophils. This study establishes an interdisciplinary method along with unprecedented specifications for the quality control of S. mombin and demonstrates that both standardized plant extract and geraniin showed anti-inflammatory activity. |
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Spondias mombin: Quality control and anti-inflammatory activity in human neutrophilsSpondias mombinQuality controlGeraniinChlorogenic acidAnti-inflammatory activitySpondias mombin L. (Anacardiaceae) is a tree known in Northeast Brazil as “cajazeira”. Besides producing fruit that is widely consumed (yellow mombin or hog plum in English, caja in Portuguese, among others), its leaves are extensively used in traditional medicine for its anti-inflammatory, antimicrobial and antiviral properties. This study aimed to develop a standardized hydroalcoholic extract of S. mombin leaves and to investigate the anti-inflammatory activity of the extract and geraniin from S. mombin in human neutrophils. The authors used an integrative approach, including histological and histochemical examination, HPLC analysis and microbiological control. The anti-inflammatory bioactivity of the standardized extract of S. mombin and geraniin was evaluated in a degranulation assay in human neutrophils. The leaves of S. mombin exhibited distinguishable histological features compared with other Spondias species. Idioblasts with phenolic compounds were histochemically identified. Purity parameters were determined in the drug as well as the total polyphenol content in the plant extract. HPLC analysis allowed detection and quantification of two bioactive phenols, geraniin and chlorogenic acid. The hydroalcoholic extract of S. mombin leaves and geraniin exhibited significant anti-inflammatory activity in human neutrophils. This study establishes an interdisciplinary method along with unprecedented specifications for the quality control of S. mombin and demonstrates that both standardized plant extract and geraniin showed anti-inflammatory activity.Journal of Herbal Medicine2021-06-17T16:35:28Z2021-06-17T16:35:28Z2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSILVA, Thiala S. J. da et al. Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils. Journal of Herbal Medicine, [s.l.], v. 24, p. 1-7, 2020.2210-8033http://www.repositorio.ufc.br/handle/riufc/59064Silva, Thiala S. J. daSoares, Arlete A.Rocha, Talita M.Pimenta, Antônia T. Á.Miron, DiogoSilva, Rolf J. F.Viana, Glauce S. B.Leal, Luzia Kalyne Almeida Moreirainfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFC2023-10-10T19:40:45Zoai:repositorio.ufc.br:riufc/59064Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:53:48.989211Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils |
title |
Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils |
spellingShingle |
Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils Silva, Thiala S. J. da Spondias mombin Quality control Geraniin Chlorogenic acid Anti-inflammatory activity |
title_short |
Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils |
title_full |
Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils |
title_fullStr |
Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils |
title_full_unstemmed |
Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils |
title_sort |
Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils |
author |
Silva, Thiala S. J. da |
author_facet |
Silva, Thiala S. J. da Soares, Arlete A. Rocha, Talita M. Pimenta, Antônia T. Á. Miron, Diogo Silva, Rolf J. F. Viana, Glauce S. B. Leal, Luzia Kalyne Almeida Moreira |
author_role |
author |
author2 |
Soares, Arlete A. Rocha, Talita M. Pimenta, Antônia T. Á. Miron, Diogo Silva, Rolf J. F. Viana, Glauce S. B. Leal, Luzia Kalyne Almeida Moreira |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Thiala S. J. da Soares, Arlete A. Rocha, Talita M. Pimenta, Antônia T. Á. Miron, Diogo Silva, Rolf J. F. Viana, Glauce S. B. Leal, Luzia Kalyne Almeida Moreira |
dc.subject.por.fl_str_mv |
Spondias mombin Quality control Geraniin Chlorogenic acid Anti-inflammatory activity |
topic |
Spondias mombin Quality control Geraniin Chlorogenic acid Anti-inflammatory activity |
description |
Spondias mombin L. (Anacardiaceae) is a tree known in Northeast Brazil as “cajazeira”. Besides producing fruit that is widely consumed (yellow mombin or hog plum in English, caja in Portuguese, among others), its leaves are extensively used in traditional medicine for its anti-inflammatory, antimicrobial and antiviral properties. This study aimed to develop a standardized hydroalcoholic extract of S. mombin leaves and to investigate the anti-inflammatory activity of the extract and geraniin from S. mombin in human neutrophils. The authors used an integrative approach, including histological and histochemical examination, HPLC analysis and microbiological control. The anti-inflammatory bioactivity of the standardized extract of S. mombin and geraniin was evaluated in a degranulation assay in human neutrophils. The leaves of S. mombin exhibited distinguishable histological features compared with other Spondias species. Idioblasts with phenolic compounds were histochemically identified. Purity parameters were determined in the drug as well as the total polyphenol content in the plant extract. HPLC analysis allowed detection and quantification of two bioactive phenols, geraniin and chlorogenic acid. The hydroalcoholic extract of S. mombin leaves and geraniin exhibited significant anti-inflammatory activity in human neutrophils. This study establishes an interdisciplinary method along with unprecedented specifications for the quality control of S. mombin and demonstrates that both standardized plant extract and geraniin showed anti-inflammatory activity. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2021-06-17T16:35:28Z 2021-06-17T16:35:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
SILVA, Thiala S. J. da et al. Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils. Journal of Herbal Medicine, [s.l.], v. 24, p. 1-7, 2020. 2210-8033 http://www.repositorio.ufc.br/handle/riufc/59064 |
identifier_str_mv |
SILVA, Thiala S. J. da et al. Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils. Journal of Herbal Medicine, [s.l.], v. 24, p. 1-7, 2020. 2210-8033 |
url |
http://www.repositorio.ufc.br/handle/riufc/59064 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Journal of Herbal Medicine |
publisher.none.fl_str_mv |
Journal of Herbal Medicine |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813028988123086848 |