Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils

Detalhes bibliográficos
Autor(a) principal: Silva, Thiala S. J. da
Data de Publicação: 2020
Outros Autores: Soares, Arlete A., Rocha, Talita M., Pimenta, Antônia T. Á., Miron, Diogo, Silva, Rolf J. F., Viana, Glauce S. B., Leal, Luzia Kalyne Almeida Moreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/59064
Resumo: Spondias mombin L. (Anacardiaceae) is a tree known in Northeast Brazil as “cajazeira”. Besides producing fruit that is widely consumed (yellow mombin or hog plum in English, caja in Portuguese, among others), its leaves are extensively used in traditional medicine for its anti-inflammatory, antimicrobial and antiviral properties. This study aimed to develop a standardized hydroalcoholic extract of S. mombin leaves and to investigate the anti-inflammatory activity of the extract and geraniin from S. mombin in human neutrophils. The authors used an integrative approach, including histological and histochemical examination, HPLC analysis and microbiological control. The anti-inflammatory bioactivity of the standardized extract of S. mombin and geraniin was evaluated in a degranulation assay in human neutrophils. The leaves of S. mombin exhibited distinguishable histological features compared with other Spondias species. Idioblasts with phenolic compounds were histochemically identified. Purity parameters were determined in the drug as well as the total polyphenol content in the plant extract. HPLC analysis allowed detection and quantification of two bioactive phenols, geraniin and chlorogenic acid. The hydroalcoholic extract of S. mombin leaves and geraniin exhibited significant anti-inflammatory activity in human neutrophils. This study establishes an interdisciplinary method along with unprecedented specifications for the quality control of S. mombin and demonstrates that both standardized plant extract and geraniin showed anti-inflammatory activity.
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spelling Spondias mombin: Quality control and anti-inflammatory activity in human neutrophilsSpondias mombinQuality controlGeraniinChlorogenic acidAnti-inflammatory activitySpondias mombin L. (Anacardiaceae) is a tree known in Northeast Brazil as “cajazeira”. Besides producing fruit that is widely consumed (yellow mombin or hog plum in English, caja in Portuguese, among others), its leaves are extensively used in traditional medicine for its anti-inflammatory, antimicrobial and antiviral properties. This study aimed to develop a standardized hydroalcoholic extract of S. mombin leaves and to investigate the anti-inflammatory activity of the extract and geraniin from S. mombin in human neutrophils. The authors used an integrative approach, including histological and histochemical examination, HPLC analysis and microbiological control. The anti-inflammatory bioactivity of the standardized extract of S. mombin and geraniin was evaluated in a degranulation assay in human neutrophils. The leaves of S. mombin exhibited distinguishable histological features compared with other Spondias species. Idioblasts with phenolic compounds were histochemically identified. Purity parameters were determined in the drug as well as the total polyphenol content in the plant extract. HPLC analysis allowed detection and quantification of two bioactive phenols, geraniin and chlorogenic acid. The hydroalcoholic extract of S. mombin leaves and geraniin exhibited significant anti-inflammatory activity in human neutrophils. This study establishes an interdisciplinary method along with unprecedented specifications for the quality control of S. mombin and demonstrates that both standardized plant extract and geraniin showed anti-inflammatory activity.Journal of Herbal Medicine2021-06-17T16:35:28Z2021-06-17T16:35:28Z2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSILVA, Thiala S. J. da et al. Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils. Journal of Herbal Medicine, [s.l.], v. 24, p. 1-7, 2020.2210-8033http://www.repositorio.ufc.br/handle/riufc/59064Silva, Thiala S. J. daSoares, Arlete A.Rocha, Talita M.Pimenta, Antônia T. Á.Miron, DiogoSilva, Rolf J. F.Viana, Glauce S. B.Leal, Luzia Kalyne Almeida Moreirainfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFC2023-10-10T19:40:45Zoai:repositorio.ufc.br:riufc/59064Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:53:48.989211Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils
title Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils
spellingShingle Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils
Silva, Thiala S. J. da
Spondias mombin
Quality control
Geraniin
Chlorogenic acid
Anti-inflammatory activity
title_short Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils
title_full Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils
title_fullStr Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils
title_full_unstemmed Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils
title_sort Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils
author Silva, Thiala S. J. da
author_facet Silva, Thiala S. J. da
Soares, Arlete A.
Rocha, Talita M.
Pimenta, Antônia T. Á.
Miron, Diogo
Silva, Rolf J. F.
Viana, Glauce S. B.
Leal, Luzia Kalyne Almeida Moreira
author_role author
author2 Soares, Arlete A.
Rocha, Talita M.
Pimenta, Antônia T. Á.
Miron, Diogo
Silva, Rolf J. F.
Viana, Glauce S. B.
Leal, Luzia Kalyne Almeida Moreira
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Thiala S. J. da
Soares, Arlete A.
Rocha, Talita M.
Pimenta, Antônia T. Á.
Miron, Diogo
Silva, Rolf J. F.
Viana, Glauce S. B.
Leal, Luzia Kalyne Almeida Moreira
dc.subject.por.fl_str_mv Spondias mombin
Quality control
Geraniin
Chlorogenic acid
Anti-inflammatory activity
topic Spondias mombin
Quality control
Geraniin
Chlorogenic acid
Anti-inflammatory activity
description Spondias mombin L. (Anacardiaceae) is a tree known in Northeast Brazil as “cajazeira”. Besides producing fruit that is widely consumed (yellow mombin or hog plum in English, caja in Portuguese, among others), its leaves are extensively used in traditional medicine for its anti-inflammatory, antimicrobial and antiviral properties. This study aimed to develop a standardized hydroalcoholic extract of S. mombin leaves and to investigate the anti-inflammatory activity of the extract and geraniin from S. mombin in human neutrophils. The authors used an integrative approach, including histological and histochemical examination, HPLC analysis and microbiological control. The anti-inflammatory bioactivity of the standardized extract of S. mombin and geraniin was evaluated in a degranulation assay in human neutrophils. The leaves of S. mombin exhibited distinguishable histological features compared with other Spondias species. Idioblasts with phenolic compounds were histochemically identified. Purity parameters were determined in the drug as well as the total polyphenol content in the plant extract. HPLC analysis allowed detection and quantification of two bioactive phenols, geraniin and chlorogenic acid. The hydroalcoholic extract of S. mombin leaves and geraniin exhibited significant anti-inflammatory activity in human neutrophils. This study establishes an interdisciplinary method along with unprecedented specifications for the quality control of S. mombin and demonstrates that both standardized plant extract and geraniin showed anti-inflammatory activity.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021-06-17T16:35:28Z
2021-06-17T16:35:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SILVA, Thiala S. J. da et al. Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils. Journal of Herbal Medicine, [s.l.], v. 24, p. 1-7, 2020.
2210-8033
http://www.repositorio.ufc.br/handle/riufc/59064
identifier_str_mv SILVA, Thiala S. J. da et al. Spondias mombin: Quality control and anti-inflammatory activity in human neutrophils. Journal of Herbal Medicine, [s.l.], v. 24, p. 1-7, 2020.
2210-8033
url http://www.repositorio.ufc.br/handle/riufc/59064
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of Herbal Medicine
publisher.none.fl_str_mv Journal of Herbal Medicine
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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