Synthesis and antimicrobial activities of 5-arylidene-thiazolidine-2,4-dione derivatives

• Autor(a) principal: Silva, Ivanildo Mangueira da
• Data de Publicação: 2014
• Outros Autores: Silva Filho, João da, Santiago, Priscila Brandão Gomes da Silva, Egito, Micalyne Soares do, Souza, Carlos André de, Gouveia, Frederico Leite, Ximenes, Rafael Matos, Sena, Kêsia Xisto da Fonseca Ribeiro de, Faria, Antonio Rodolfo de, Brondani, Dalci José, Albuquerque, Julianna Ferreira Cavalcanti de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
• Texto Completo: http://www.repositorio.ufc.br/handle/riufc/10828
• topic: Resistência a Medicamentos; Tiazolidinas

Antibiotic resistance is considered one of the world’s major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. Using a disc diffusion method, antimicrobial activity was verified against Gram-positive, Gramnegative, and alcohol acid resistant bacteria and yeast.The minimum inhibition concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined. All derivatives showed antimicrobial activity mainly against Gram-positive bacteria, with MIC values ranging from 2 to 16 μg/mL.