Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados

Detalhes bibliográficos
Autor(a) principal: Neves, José Ricardo Cunha
Data de Publicação: 2013
Tipo de documento: Tese
Idioma: por
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/10628
Resumo: Transient relaxations (rTEEI) of the lower esophageal sphincter,are characterized like the Pressure drop of the EEI of the levels of the intragastric pressure,not preceded for the swallow. rTEEI are the main mechanism of the Gastroesophageal reflux disease (DRGE). we aim to evaluate the effects of the rectal distention about the rates of the Rteei,like the neuro-hormonal mechanisms related to this phenomenum in hounds. We used (44) wandering hounds, SRD( no distinct breed ) males (10-20 kg),obtained from the control center of the zoonoses from the City Hall of Sobral. Followed by anesthesia (Ketamina 12,5mg/kg + xilasina 20mg/kg-IM).An catheter of esophageal manometry was introduced per os and positioned in the esophageal and in the stomach. We measure the intragastric pressure,of the EEI and of the esophageal corps. The central lumen was used to distend the stomach with air (50ml/kg).The distention already occurred through the latex baloon (5ml/kg). The animals were submitted a 3 experimental sequential protocols (n = 26). gastric distention (GD) isolated,2)rectal distention(RD) isolated and 3) gastric distention and rectal. we performed RD in three others groups of hounds after pre treatments.three others groups of hounds after the pre treatments pharmacological i.v.: atropine (0,15 mg/kg n=4). hexamethonium (10mg/kg n=4) ou baclofen(7,o ug/kg, n=3) or cirurgic:bilateral section of the pudendal nerves(SNP,n=4) or spinal cord transection(L3-L4) (TM,N=4). We evaluate the rate ,the latency and duration of the rTEEI,as well as the pressure of the EEI and gastricin relation to the baseline period(2.8+or-0.8 events/h) a GD,RD or GD+RD increased the rate of the rTEEI(6.,0±1,0 or-;5,2±1,8 or 9,5±2,5 events/h),respectively,p<0.05). The pre treatments with atrpine and baclofen, the TIM or SNP prevent the increase of the rate of the secondary rTEEI a DR. Already with the pre treatment with hexamethonium were capable of prevent the phenomenum. The results indicated the presence of one new gastrointestinal relfexs described as rectal esophageal reflex. This would be mediated via spinal nerves pudendal,with integration in the nervous central sistem,dependent of the transmission GABAégica and peripherally muscarinic receptor
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spelling Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiadosThe rectal distension increases the rates of the transient relaxations from the sphincter lower esophageal in anesthesia houndsTranstornos da Motilidade EsofágicaEsfíncter Esofágico InferiorTransient relaxations (rTEEI) of the lower esophageal sphincter,are characterized like the Pressure drop of the EEI of the levels of the intragastric pressure,not preceded for the swallow. rTEEI are the main mechanism of the Gastroesophageal reflux disease (DRGE). we aim to evaluate the effects of the rectal distention about the rates of the Rteei,like the neuro-hormonal mechanisms related to this phenomenum in hounds. We used (44) wandering hounds, SRD( no distinct breed ) males (10-20 kg),obtained from the control center of the zoonoses from the City Hall of Sobral. Followed by anesthesia (Ketamina 12,5mg/kg + xilasina 20mg/kg-IM).An catheter of esophageal manometry was introduced per os and positioned in the esophageal and in the stomach. We measure the intragastric pressure,of the EEI and of the esophageal corps. The central lumen was used to distend the stomach with air (50ml/kg).The distention already occurred through the latex baloon (5ml/kg). The animals were submitted a 3 experimental sequential protocols (n = 26). gastric distention (GD) isolated,2)rectal distention(RD) isolated and 3) gastric distention and rectal. we performed RD in three others groups of hounds after pre treatments.three others groups of hounds after the pre treatments pharmacological i.v.: atropine (0,15 mg/kg n=4). hexamethonium (10mg/kg n=4) ou baclofen(7,o ug/kg, n=3) or cirurgic:bilateral section of the pudendal nerves(SNP,n=4) or spinal cord transection(L3-L4) (TM,N=4). We evaluate the rate ,the latency and duration of the rTEEI,as well as the pressure of the EEI and gastricin relation to the baseline period(2.8+or-0.8 events/h) a GD,RD or GD+RD increased the rate of the rTEEI(6.,0±1,0 or-;5,2±1,8 or 9,5±2,5 events/h),respectively,p<0.05). The pre treatments with atrpine and baclofen, the TIM or SNP prevent the increase of the rate of the secondary rTEEI a DR. Already with the pre treatment with hexamethonium were capable of prevent the phenomenum. The results indicated the presence of one new gastrointestinal relfexs described as rectal esophageal reflex. This would be mediated via spinal nerves pudendal,with integration in the nervous central sistem,dependent of the transmission GABAégica and peripherally muscarinic receptorRelaxamentos transitórios (rTEEI) do esfíncter esofágico inferior (EEI), são caracterizados como quedas da pressão do EEI aos níveis da pressão intragástrica, não precedidos por deglutição. rTEEI são o principal mecanismo da doença do refluxo gastresofágico (DRGE). Objetivamos avaliar o efeito da distensão retal sobre a taxa de rTEEI, assim como os mecanismos neurohumorais relacionados a esse fenômeno em cães. Utilizamos (44) cães errantes, SRD(sem raça definida) machos (10-20Kg), obtidos do Centro de Controle de Zoonoses da Prefeitura Municipal de Sobral. Seguida anestesia (Ketamina12,5mg/kg + Xilasina 20mg/Kg - IM), um cateter de manometria esofágica foi introduzido per os e posicionado no estomago e esôfago. Medimos as pressões intragástrica, do EEI e do corpo esofágico. O lúmen central foi usado para distender o estomago com ar (50ml//kg,). Já distensão retal deu-se por meio de balão de látex (5ml//kg,). Os animais foram submetidos a 3 protocolos experimentais sequenciais (n = 26): I) distensão gástrica (DG) isolada,II) distensão retal (DR) isolada e III) distensão gástrica + retal. Realizamos DR em outros três grupos de animais após pré-tratamentos famacológicos i.v.: atropina (0,15 mg/kg/ n=4), hexametonio (10mg/kg/ n=4) ou baclofeno (7,0μg/Kg, n=3); ou cirúrgicos: secção bilateral dos nervos pudendos (SNP/ n=4) ou transecção medular (L3-L4) (TM, n=4). Avaliamos a taxa, a latencia e a duração dos rTEEI, bem como a pressão do EEI e gástrica. Em relação ao período basal (2,8±0,8 eventos/h) a DG, DR ou DG+DR aumentaram a taxa de rTEEI (6,0±1,0; 5,2±1,8 ou 9,5±2,5 eventos/h, respectivamente, p<0,05). Os pré-tratamentos com atropina ou baclofeno, a TM ou SNP preveniram o aumento da taxa de rTEEI secundário a DR. Já o pré-tratamento com hexametônio foi incapaz de prevenir o fenômeno . Os resultados indicam a presença de um novo reflexo gastrintestinal, ora descrito como reflexo reto-esofágico. Este seria mediado pelos nervos pudendos via medula espinhal, com integração no sistema nervoso central, dependente de transmissão GABAérgica e perifericamente dos receptores muscarínicos.Souza, Miguel Ângelo Nobre eNeves, José Ricardo Cunha2015-02-13T12:55:21Z2015-02-13T12:55:21Z2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfNEVES, José Ricardo Cunha. Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados. 69 f. Tese (Doutorado em Cirurgia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2013.http://www.repositorio.ufc.br/handle/riufc/10628porreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2018-12-14T16:15:42Zoai:repositorio.ufc.br:riufc/10628Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:55:44.073540Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados
The rectal distension increases the rates of the transient relaxations from the sphincter lower esophageal in anesthesia hounds
title Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados
spellingShingle Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados
Neves, José Ricardo Cunha
Transtornos da Motilidade Esofágica
Esfíncter Esofágico Inferior
title_short Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados
title_full Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados
title_fullStr Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados
title_full_unstemmed Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados
title_sort Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados
author Neves, José Ricardo Cunha
author_facet Neves, José Ricardo Cunha
author_role author
dc.contributor.none.fl_str_mv Souza, Miguel Ângelo Nobre e
dc.contributor.author.fl_str_mv Neves, José Ricardo Cunha
dc.subject.por.fl_str_mv Transtornos da Motilidade Esofágica
Esfíncter Esofágico Inferior
topic Transtornos da Motilidade Esofágica
Esfíncter Esofágico Inferior
description Transient relaxations (rTEEI) of the lower esophageal sphincter,are characterized like the Pressure drop of the EEI of the levels of the intragastric pressure,not preceded for the swallow. rTEEI are the main mechanism of the Gastroesophageal reflux disease (DRGE). we aim to evaluate the effects of the rectal distention about the rates of the Rteei,like the neuro-hormonal mechanisms related to this phenomenum in hounds. We used (44) wandering hounds, SRD( no distinct breed ) males (10-20 kg),obtained from the control center of the zoonoses from the City Hall of Sobral. Followed by anesthesia (Ketamina 12,5mg/kg + xilasina 20mg/kg-IM).An catheter of esophageal manometry was introduced per os and positioned in the esophageal and in the stomach. We measure the intragastric pressure,of the EEI and of the esophageal corps. The central lumen was used to distend the stomach with air (50ml/kg).The distention already occurred through the latex baloon (5ml/kg). The animals were submitted a 3 experimental sequential protocols (n = 26). gastric distention (GD) isolated,2)rectal distention(RD) isolated and 3) gastric distention and rectal. we performed RD in three others groups of hounds after pre treatments.three others groups of hounds after the pre treatments pharmacological i.v.: atropine (0,15 mg/kg n=4). hexamethonium (10mg/kg n=4) ou baclofen(7,o ug/kg, n=3) or cirurgic:bilateral section of the pudendal nerves(SNP,n=4) or spinal cord transection(L3-L4) (TM,N=4). We evaluate the rate ,the latency and duration of the rTEEI,as well as the pressure of the EEI and gastricin relation to the baseline period(2.8+or-0.8 events/h) a GD,RD or GD+RD increased the rate of the rTEEI(6.,0±1,0 or-;5,2±1,8 or 9,5±2,5 events/h),respectively,p<0.05). The pre treatments with atrpine and baclofen, the TIM or SNP prevent the increase of the rate of the secondary rTEEI a DR. Already with the pre treatment with hexamethonium were capable of prevent the phenomenum. The results indicated the presence of one new gastrointestinal relfexs described as rectal esophageal reflex. This would be mediated via spinal nerves pudendal,with integration in the nervous central sistem,dependent of the transmission GABAégica and peripherally muscarinic receptor
publishDate 2013
dc.date.none.fl_str_mv 2013
2015-02-13T12:55:21Z
2015-02-13T12:55:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
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status_str publishedVersion
dc.identifier.uri.fl_str_mv NEVES, José Ricardo Cunha. Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados. 69 f. Tese (Doutorado em Cirurgia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2013.
http://www.repositorio.ufc.br/handle/riufc/10628
identifier_str_mv NEVES, José Ricardo Cunha. Distensão retal aumenta a taxa de relaxamentos transitórios do esfíncter esofágico inferior em cães anestesiados. 69 f. Tese (Doutorado em Cirurgia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2013.
url http://www.repositorio.ufc.br/handle/riufc/10628
dc.language.iso.fl_str_mv por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
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reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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