Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws : a meta-analytic study

• Autor(a) principal: Osterne, Rafael Lima Verde
• Data de Publicação: 2013
• Outros Autores: Araújo, Phelype Maia, Carvalho, Abrahao Cavalcante Gomes de Souza, Cavalcante, Roberta Barroso, Sant’Ana, Eduardo, Nogueira, Renato Luiz Maia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
• Texto Completo: http://www.repositorio.ufc.br/handle/riufc/7785
• topic: Corticosteroides; Triancinolona Acetonida

Objective: The aim of this study was to evaluate the response of treatment of central giant cell lesion to intralesional corticosteroid injections. Study Design: Review of articles indexed in PubMed on the topic between the years 1988 and 2011, and development of a descriptive meta-analysis of the results. Results: Sample of 41 patients primarily treated with intralesional corticosteroid injections was obtained, with a male female ratio of 1:0.95, being 23 aggressive and 18 non-aggressive central giant cell lesions. Triamcinolone acetonide and triamcinolone hexacetonide were the drugs used, and 78.0% cases were considered as good result, 14.6% were considered as moderate response and 7.3% were considered as negative result to treatment. Considering the aggressiveness, 88.9% of non-aggressive lesions presented a good response to treatment, in aggressive central giant cell lesions, 69.6% presented a good response to intralesional corticosteroid injections. Conclusion: In view of the results analyzed, intralesional corticosteroid injections could be considered as first treatment option for central giant cell lesion.