Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/40332 |
Resumo: | Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during followup. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956). Conclusion: The results demonstrated that patients who did not use UDCA showed a 24.4- fold greater probability of developing cholelithiasis. |
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Repositório Institucional da Universidade Federal do Ceará (UFC) |
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Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypassObesidadeObesityCirurgia BariátricaBariatric SurgeryCálculos BiliaresGallstonesPurpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during followup. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956). Conclusion: The results demonstrated that patients who did not use UDCA showed a 24.4- fold greater probability of developing cholelithiasis.Acta Cirurgica Brasileira2019-03-18T17:26:24Z2019-03-18T17:26:24Z2019-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMachado, Francisco Heine Ferreira et al. Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass. Acta Cir. Bras., São Paulo, v. 34, n.1, feb. 2019.Print 0102-8650On-line 1678-2674http://www.repositorio.ufc.br/handle/riufc/40332Machado, Francisco Heine FerreiraCastro Filho, Heladio Feitosa deBabadopulos, Rodrigo Feitosa de Albuquerque LimaRocha, Hermano Alexandre LimaRocha, José Lima de CarvalhoMoraes Filho, Manoel Odorico deengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-10-16T14:49:15Zoai:repositorio.ufc.br:riufc/40332Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T19:01:46.817576Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass |
title |
Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass |
spellingShingle |
Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass Machado, Francisco Heine Ferreira Obesidade Obesity Cirurgia Bariátrica Bariatric Surgery Cálculos Biliares Gallstones |
title_short |
Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass |
title_full |
Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass |
title_fullStr |
Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass |
title_full_unstemmed |
Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass |
title_sort |
Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass |
author |
Machado, Francisco Heine Ferreira |
author_facet |
Machado, Francisco Heine Ferreira Castro Filho, Heladio Feitosa de Babadopulos, Rodrigo Feitosa de Albuquerque Lima Rocha, Hermano Alexandre Lima Rocha, José Lima de Carvalho Moraes Filho, Manoel Odorico de |
author_role |
author |
author2 |
Castro Filho, Heladio Feitosa de Babadopulos, Rodrigo Feitosa de Albuquerque Lima Rocha, Hermano Alexandre Lima Rocha, José Lima de Carvalho Moraes Filho, Manoel Odorico de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Machado, Francisco Heine Ferreira Castro Filho, Heladio Feitosa de Babadopulos, Rodrigo Feitosa de Albuquerque Lima Rocha, Hermano Alexandre Lima Rocha, José Lima de Carvalho Moraes Filho, Manoel Odorico de |
dc.subject.por.fl_str_mv |
Obesidade Obesity Cirurgia Bariátrica Bariatric Surgery Cálculos Biliares Gallstones |
topic |
Obesidade Obesity Cirurgia Bariátrica Bariatric Surgery Cálculos Biliares Gallstones |
description |
Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during followup. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956). Conclusion: The results demonstrated that patients who did not use UDCA showed a 24.4- fold greater probability of developing cholelithiasis. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-03-18T17:26:24Z 2019-03-18T17:26:24Z 2019-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Machado, Francisco Heine Ferreira et al. Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass. Acta Cir. Bras., São Paulo, v. 34, n.1, feb. 2019. Print 0102-8650 On-line 1678-2674 http://www.repositorio.ufc.br/handle/riufc/40332 |
identifier_str_mv |
Machado, Francisco Heine Ferreira et al. Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass. Acta Cir. Bras., São Paulo, v. 34, n.1, feb. 2019. Print 0102-8650 On-line 1678-2674 |
url |
http://www.repositorio.ufc.br/handle/riufc/40332 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Acta Cirurgica Brasileira |
publisher.none.fl_str_mv |
Acta Cirurgica Brasileira |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813029039181398016 |