Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass

Detalhes bibliográficos
Autor(a) principal: Machado, Francisco Heine Ferreira
Data de Publicação: 2019
Outros Autores: Castro Filho, Heladio Feitosa de, Babadopulos, Rodrigo Feitosa de Albuquerque Lima, Rocha, Hermano Alexandre Lima, Rocha, José Lima de Carvalho, Moraes Filho, Manoel Odorico de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/40332
Resumo: Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during followup. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956). Conclusion: The results demonstrated that patients who did not use UDCA showed a 24.4- fold greater probability of developing cholelithiasis.
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spelling Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypassObesidadeObesityCirurgia BariátricaBariatric SurgeryCálculos BiliaresGallstonesPurpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during followup. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956). Conclusion: The results demonstrated that patients who did not use UDCA showed a 24.4- fold greater probability of developing cholelithiasis.Acta Cirurgica Brasileira2019-03-18T17:26:24Z2019-03-18T17:26:24Z2019-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMachado, Francisco Heine Ferreira et al. Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass. Acta Cir. Bras., São Paulo, v. 34, n.1, feb. 2019.Print 0102-8650On-line 1678-2674http://www.repositorio.ufc.br/handle/riufc/40332Machado, Francisco Heine FerreiraCastro Filho, Heladio Feitosa deBabadopulos, Rodrigo Feitosa de Albuquerque LimaRocha, Hermano Alexandre LimaRocha, José Lima de CarvalhoMoraes Filho, Manoel Odorico deengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-10-16T14:49:15Zoai:repositorio.ufc.br:riufc/40332Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T19:01:46.817576Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
title Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
spellingShingle Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
Machado, Francisco Heine Ferreira
Obesidade
Obesity
Cirurgia Bariátrica
Bariatric Surgery
Cálculos Biliares
Gallstones
title_short Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
title_full Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
title_fullStr Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
title_full_unstemmed Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
title_sort Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass
author Machado, Francisco Heine Ferreira
author_facet Machado, Francisco Heine Ferreira
Castro Filho, Heladio Feitosa de
Babadopulos, Rodrigo Feitosa de Albuquerque Lima
Rocha, Hermano Alexandre Lima
Rocha, José Lima de Carvalho
Moraes Filho, Manoel Odorico de
author_role author
author2 Castro Filho, Heladio Feitosa de
Babadopulos, Rodrigo Feitosa de Albuquerque Lima
Rocha, Hermano Alexandre Lima
Rocha, José Lima de Carvalho
Moraes Filho, Manoel Odorico de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Machado, Francisco Heine Ferreira
Castro Filho, Heladio Feitosa de
Babadopulos, Rodrigo Feitosa de Albuquerque Lima
Rocha, Hermano Alexandre Lima
Rocha, José Lima de Carvalho
Moraes Filho, Manoel Odorico de
dc.subject.por.fl_str_mv Obesidade
Obesity
Cirurgia Bariátrica
Bariatric Surgery
Cálculos Biliares
Gallstones
topic Obesidade
Obesity
Cirurgia Bariátrica
Bariatric Surgery
Cálculos Biliares
Gallstones
description Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation. Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). The patients were followed-up, and ultrasonography was performed to determine the presence of gallstones at various times during followup. Demographic, anthropometric and comorbid indicators were obtained. The data were subjected to normality tests and evaluated using appropriate tests. Results: Patients did not differ in their baseline characteristics. Of the 69 patients who used UDCA, only one patient developed cholelithiasis (1%), whereas 18 controls (26%) formed gallstones (OR = 24.4, p <0.001). Also, other factors were found not to influence the formation of calculi, such as pre-operative or postoperative hepatic steatosis or diabetes (p = 0.759, 0.468, 0.956). Conclusion: The results demonstrated that patients who did not use UDCA showed a 24.4- fold greater probability of developing cholelithiasis.
publishDate 2019
dc.date.none.fl_str_mv 2019-03-18T17:26:24Z
2019-03-18T17:26:24Z
2019-02
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Machado, Francisco Heine Ferreira et al. Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass. Acta Cir. Bras., São Paulo, v. 34, n.1, feb. 2019.
Print 0102-8650
On-line 1678-2674
http://www.repositorio.ufc.br/handle/riufc/40332
identifier_str_mv Machado, Francisco Heine Ferreira et al. Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass. Acta Cir. Bras., São Paulo, v. 34, n.1, feb. 2019.
Print 0102-8650
On-line 1678-2674
url http://www.repositorio.ufc.br/handle/riufc/40332
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Acta Cirurgica Brasileira
publisher.none.fl_str_mv Acta Cirurgica Brasileira
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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