Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines

Detalhes bibliográficos
Autor(a) principal: Silva, Mauro G.
Data de Publicação: 2013
Outros Autores: Camara, Celso A., Silva, Tania M. S., Feitosa, Anderson C. S., Meira, Assuero S., Pessoa, Cláudia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
dARK ID: ark:/83112/001300000g98c
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/7208
Resumo: A series of 2,3-diyne-1,4-naphthoquinone derivatives was synthesized from 2,3-dibromo- 1,4-naphthoquinone and various functionalized terminal alkynes using palladium-catalyzed Sonogashira cross-coupling reaction. The diynes were evaluated as potential cytotoxic agents against three tumor cell lines: human ovarian adenocarcinoma (OVCAR-8), human metastatic prostate cancer (PC-3M) and human bronchoalveolar lung carcinoma (NCI-H358M), presenting, in general, satisfactory results for inhibition of cell growth.
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spelling Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell linesPaládioNeoplasiasA series of 2,3-diyne-1,4-naphthoquinone derivatives was synthesized from 2,3-dibromo- 1,4-naphthoquinone and various functionalized terminal alkynes using palladium-catalyzed Sonogashira cross-coupling reaction. The diynes were evaluated as potential cytotoxic agents against three tumor cell lines: human ovarian adenocarcinoma (OVCAR-8), human metastatic prostate cancer (PC-3M) and human bronchoalveolar lung carcinoma (NCI-H358M), presenting, in general, satisfactory results for inhibition of cell growth.Uma série de derivados 2,3-diino-1,4-naftoquinona foi sintetizada a partir do 2,3-dibromo- 1,4-naftoquinona e diversos alquinos terminais funcionalizados usando a reação de acoplamento de Sonogashira catalisada por paládio. Os compostos foram submetidos à avaliação do potencial citotóxico em três linhagens de células tumorais, OVCAR-8 (ovário), PC-3M (próstata) e NCI‑H358M (pulmão), apresentando, no geral, resultados satisfatórios para inibição do crescimento celular.Journal of the Brazilian Chemical Society2014-02-06T13:11:23Z2014-02-06T13:11:23Z2013-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSILVA, M. G. et al. Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines. Journal of the Brazilian Chemical Society, São Paulo, SP, v. 24, n. 9, p. 1420-1426, ago. 2013.0103-5053 Impresso1678-4790 On-linehttp://www.repositorio.ufc.br/handle/riufc/7208ark:/83112/001300000g98cSilva, Mauro G.Camara, Celso A.Silva, Tania M. S.Feitosa, Anderson C. S.Meira, Assuero S.Pessoa, Cláudiaengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-15T16:30:56Zoai:repositorio.ufc.br:riufc/7208Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:38:41.390509Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines
title Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines
spellingShingle Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines
Silva, Mauro G.
Paládio
Neoplasias
title_short Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines
title_full Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines
title_fullStr Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines
title_full_unstemmed Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines
title_sort Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines
author Silva, Mauro G.
author_facet Silva, Mauro G.
Camara, Celso A.
Silva, Tania M. S.
Feitosa, Anderson C. S.
Meira, Assuero S.
Pessoa, Cláudia
author_role author
author2 Camara, Celso A.
Silva, Tania M. S.
Feitosa, Anderson C. S.
Meira, Assuero S.
Pessoa, Cláudia
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Mauro G.
Camara, Celso A.
Silva, Tania M. S.
Feitosa, Anderson C. S.
Meira, Assuero S.
Pessoa, Cláudia
dc.subject.por.fl_str_mv Paládio
Neoplasias
topic Paládio
Neoplasias
description A series of 2,3-diyne-1,4-naphthoquinone derivatives was synthesized from 2,3-dibromo- 1,4-naphthoquinone and various functionalized terminal alkynes using palladium-catalyzed Sonogashira cross-coupling reaction. The diynes were evaluated as potential cytotoxic agents against three tumor cell lines: human ovarian adenocarcinoma (OVCAR-8), human metastatic prostate cancer (PC-3M) and human bronchoalveolar lung carcinoma (NCI-H358M), presenting, in general, satisfactory results for inhibition of cell growth.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
2014-02-06T13:11:23Z
2014-02-06T13:11:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SILVA, M. G. et al. Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines. Journal of the Brazilian Chemical Society, São Paulo, SP, v. 24, n. 9, p. 1420-1426, ago. 2013.
0103-5053 Impresso
1678-4790 On-line
http://www.repositorio.ufc.br/handle/riufc/7208
dc.identifier.dark.fl_str_mv ark:/83112/001300000g98c
identifier_str_mv SILVA, M. G. et al. Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines. Journal of the Brazilian Chemical Society, São Paulo, SP, v. 24, n. 9, p. 1420-1426, ago. 2013.
0103-5053 Impresso
1678-4790 On-line
ark:/83112/001300000g98c
url http://www.repositorio.ufc.br/handle/riufc/7208
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal of the Brazilian Chemical Society
publisher.none.fl_str_mv Journal of the Brazilian Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
_version_ 1818373769117302784

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