Physiological aspects of angiotensin II-dependent hypertension: an overview

Detalhes bibliográficos
Autor(a) principal: Calzerra, Natália Tabosa Machado
Data de Publicação: 2018
Outros Autores: Gomes, Camila Figueiredo, de Queiroz, Thyago Moreira
Tipo de documento: Artigo
Idioma: por
Título da fonte: Acta Brasiliensis (Online)
Texto Completo: http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/76
Resumo: Hypertension is one of the main causes of death in developed and developing countries, inducing great impact in human health. Oxidative stress has been implicated as a key mechanism in Angiotensin II-dependent hypertension, since it modulates the baroreflex function in many pathophysiological processes. This study aimed to conduct a literature review addressing the recent mechanisms that promote changes in Angiotensin II-dependent hypertension. Here we highlighted two Angiotensin II-dependent hypertension models: two kidney-one-clip (2K1C) and deoxycorticosterone (DOCA-salt) hypertension. Bases on latest studies presented in important data base, it is possible to suggest that Angiotensin II is one of the main agents in hypertension development and the increase of this peptide is derived by multiple causes, which, in particular, acts as an inductor in oxidative stress production, in turn, it induces changes in a metalloprotease 17 (ADAM-17) and disruption of ACE2 compensatory activity. Thus, new tools that induce a reduction of oxidative stress promote beneficial effects, providing novel therapeutic targets to prevent and treat the Angiotensin II-dependent hypertension.
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spelling Physiological aspects of angiotensin II-dependent hypertension: an overview Aspectos fisiopatológicos da hipertensão arterial dependente de angiotensina II: revisão integrada da literaturaHypertension is one of the main causes of death in developed and developing countries, inducing great impact in human health. Oxidative stress has been implicated as a key mechanism in Angiotensin II-dependent hypertension, since it modulates the baroreflex function in many pathophysiological processes. This study aimed to conduct a literature review addressing the recent mechanisms that promote changes in Angiotensin II-dependent hypertension. Here we highlighted two Angiotensin II-dependent hypertension models: two kidney-one-clip (2K1C) and deoxycorticosterone (DOCA-salt) hypertension. Bases on latest studies presented in important data base, it is possible to suggest that Angiotensin II is one of the main agents in hypertension development and the increase of this peptide is derived by multiple causes, which, in particular, acts as an inductor in oxidative stress production, in turn, it induces changes in a metalloprotease 17 (ADAM-17) and disruption of ACE2 compensatory activity. Thus, new tools that induce a reduction of oxidative stress promote beneficial effects, providing novel therapeutic targets to prevent and treat the Angiotensin II-dependent hypertension.A hipertensão arterial é uma das principais causas de morte em países desenvolvidos e em desenvolvimento, causando um grande impacto na saúde humana. O estresse oxidativo tem sido apontado como um mecanismo fundamental na hipertensão arterial dependente de angiotensina II, uma vez que modula a função barorreflexa em vários processos de fisiopatológicos. O presente trabalho teve como objetivo a realização de uma revisão de literatura abordando os recentes mecanismos que promovem alterações da hipertensão arterial dependente de angiotensina II. Foram enfatizados dois modelos dependentes de angiotensina II: dois-rins-um-clipe (2R1C) e desoxicorticosterona (DOCA-sal). A pesquisa corresponde a uma revisão bibliográfica de caráter descritivo, baseada na literatura científica atual, pesquisada em várias bases de dados. Estudos corroboram a hipótese que a angiotensina II é um dos principais agentes envolvidos no desenvolvimento da hipertensão arterial e que o aumento desse peptídeo é multifatorial, podendo induzir, em especial, o aumento do estresse oxidativo que, por sua vez, promove alterações em uma metaloprotease 17 (ADAM17) e disfunções na enzima conversora da angiotensina 2 (ECA2). Assim, novas ferramentas que induzam a diminuição do estresse oxidativo promovem efeitos benéficos, constituindo novos alvos terapêuticos na prevenção e tratamento de hipertensão arterial.Universidade Federal de Campina Grande - UFCG2018-05-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/7610.22571/2526-433876Acta Brasiliensis; Vol 2 No 2 (2018): Acta Brasiliensis; 69-73Acta Brasiliensis; Vol 2 No 2 (2018): Acta Brasiliensis; 69-73Acta Brasiliensis; Vol 2 No 2 (2018): Acta Brasiliensis; 69-732526-43382526-432Xreponame:Acta Brasiliensis (Online)instname:Universidade Federal de Campina Grande (UFCG)instacron:UFCGporhttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/76/42Copyright (c) 2018 Acta Brasiliensisinfo:eu-repo/semantics/openAccessCalzerra, Natália Tabosa MachadoGomes, Camila Figueiredode Queiroz, Thyago Moreira2021-07-12T20:04:09Zoai:ActaBra.revistas.ufcg.edu.br:article/76Revistahttp://revistas.ufcg.edu.br/ActaBraPUBhttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/oaiactabrasiliensis@gmail.com || actabrasiliensis@gmail.com2526-432X2526-4338opendoar:2021-07-12T20:04:09Acta Brasiliensis (Online) - Universidade Federal de Campina Grande (UFCG)false
dc.title.none.fl_str_mv Physiological aspects of angiotensin II-dependent hypertension: an overview

Aspectos fisiopatológicos da hipertensão arterial dependente de angiotensina II: revisão integrada da literatura
title Physiological aspects of angiotensin II-dependent hypertension: an overview
spellingShingle Physiological aspects of angiotensin II-dependent hypertension: an overview
Calzerra, Natália Tabosa Machado
title_short Physiological aspects of angiotensin II-dependent hypertension: an overview
title_full Physiological aspects of angiotensin II-dependent hypertension: an overview
title_fullStr Physiological aspects of angiotensin II-dependent hypertension: an overview
title_full_unstemmed Physiological aspects of angiotensin II-dependent hypertension: an overview
title_sort Physiological aspects of angiotensin II-dependent hypertension: an overview
author Calzerra, Natália Tabosa Machado
author_facet Calzerra, Natália Tabosa Machado
Gomes, Camila Figueiredo
de Queiroz, Thyago Moreira
author_role author
author2 Gomes, Camila Figueiredo
de Queiroz, Thyago Moreira
author2_role author
author
dc.contributor.author.fl_str_mv Calzerra, Natália Tabosa Machado
Gomes, Camila Figueiredo
de Queiroz, Thyago Moreira
description Hypertension is one of the main causes of death in developed and developing countries, inducing great impact in human health. Oxidative stress has been implicated as a key mechanism in Angiotensin II-dependent hypertension, since it modulates the baroreflex function in many pathophysiological processes. This study aimed to conduct a literature review addressing the recent mechanisms that promote changes in Angiotensin II-dependent hypertension. Here we highlighted two Angiotensin II-dependent hypertension models: two kidney-one-clip (2K1C) and deoxycorticosterone (DOCA-salt) hypertension. Bases on latest studies presented in important data base, it is possible to suggest that Angiotensin II is one of the main agents in hypertension development and the increase of this peptide is derived by multiple causes, which, in particular, acts as an inductor in oxidative stress production, in turn, it induces changes in a metalloprotease 17 (ADAM-17) and disruption of ACE2 compensatory activity. Thus, new tools that induce a reduction of oxidative stress promote beneficial effects, providing novel therapeutic targets to prevent and treat the Angiotensin II-dependent hypertension.
publishDate 2018
dc.date.none.fl_str_mv 2018-05-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/76
10.22571/2526-433876
url http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/76
identifier_str_mv 10.22571/2526-433876
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/76/42
dc.rights.driver.fl_str_mv Copyright (c) 2018 Acta Brasiliensis
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Acta Brasiliensis
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Campina Grande - UFCG
publisher.none.fl_str_mv Universidade Federal de Campina Grande - UFCG
dc.source.none.fl_str_mv Acta Brasiliensis; Vol 2 No 2 (2018): Acta Brasiliensis; 69-73
Acta Brasiliensis; Vol 2 No 2 (2018): Acta Brasiliensis; 69-73
Acta Brasiliensis; Vol 2 No 2 (2018): Acta Brasiliensis; 69-73
2526-4338
2526-432X
reponame:Acta Brasiliensis (Online)
instname:Universidade Federal de Campina Grande (UFCG)
instacron:UFCG
instname_str Universidade Federal de Campina Grande (UFCG)
instacron_str UFCG
institution UFCG
reponame_str Acta Brasiliensis (Online)
collection Acta Brasiliensis (Online)
repository.name.fl_str_mv Acta Brasiliensis (Online) - Universidade Federal de Campina Grande (UFCG)
repository.mail.fl_str_mv actabrasiliensis@gmail.com || actabrasiliensis@gmail.com
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