In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Alvarenga, Tavane Aparecida
Data de Publicação: 2021
Outros Autores: Alves, Osvaine Júnior Alvarenga, Pagotti, Mariana Cintra, Cunha, Wilson Roberto, Silva, Márcio Luís Andrade e, Sales, Juliana de Fátima, Silva, Fabiano Guimarães, Januario, Ana Helena, Magalhães, Lizandra Guidi, Pauletti, Patrícia Mendonça
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Brasiliensis (Online)
Texto Completo: http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/429
Resumo: This study analyzes the antileishmanial activity of the crude ethanol extract, fractions, and isolated compounds of A. othonianum nuts. Antileishmanial activity was evaluated against Leishmania amazonensis promastigotes in vitro. The phytochemical study was performed by high-performance liquid chromatography-high-resolution mass spectrometry-diode array detector (HPLC-HRMS-DAD) and by preparative HPLC. HPLC-HRMS-DAD analysis of the bioactive extract confirmed the presence of ten alkyl phenol derivatives that had previously been isolated from A. occidentale. Bioassay-guided isolation afforded cardanol triene, cardanol diene, cardanol monoene, cardol triene, anacardic acid triene, anacardic acid diene, and anacardic acid monoene. Cardol triene gave an IC50 of 80.66 µM. The obtained data suggest that the evaluated extract, fractions, and cardol triene had moderate activity against L. amazonensis promastigotes. This is the first description of alkyl phenols in A. othonianum.
id UFCG-6_beef1181d4a32de24fb09c91e4bb8fd4
oai_identifier_str oai:ActaBra.revistas.ufcg.edu.br:article/429
network_acronym_str UFCG-6
network_name_str Acta Brasiliensis (Online)
repository_id_str
spelling In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis Síntese, atividade antimicrobiana e estudo in silico de 1,2,4-oxadiazóis derivados do levulinato de etilaThis study analyzes the antileishmanial activity of the crude ethanol extract, fractions, and isolated compounds of A. othonianum nuts. Antileishmanial activity was evaluated against Leishmania amazonensis promastigotes in vitro. The phytochemical study was performed by high-performance liquid chromatography-high-resolution mass spectrometry-diode array detector (HPLC-HRMS-DAD) and by preparative HPLC. HPLC-HRMS-DAD analysis of the bioactive extract confirmed the presence of ten alkyl phenol derivatives that had previously been isolated from A. occidentale. Bioassay-guided isolation afforded cardanol triene, cardanol diene, cardanol monoene, cardol triene, anacardic acid triene, anacardic acid diene, and anacardic acid monoene. Cardol triene gave an IC50 of 80.66 µM. The obtained data suggest that the evaluated extract, fractions, and cardol triene had moderate activity against L. amazonensis promastigotes. This is the first description of alkyl phenols in A. othonianum.Este estudo visou avaliar a atividade antileishmanial do extrato bruto etanólico, frações e substâncias isoladas obtidos das castanhas de A. othonianum. A atividade antileishmania foi avaliada por ensaio in vitro nas formas promastigotas de Leishmania amazonensis. O estudo fitoquímico foi realizado por cromatografia líquida de alta eficiência - espectrometria de massa de alta resolução - detector de arranjo de diodos (CLAE-EMAR-DAD) e por CLAE-preparativa. A análise por CLAE-EMAR-DAD do extrato bioativo confirmou a presença de dez derivados de alquil-fenóis previamente isolados de A. occidentale.  A investigação bioguiada resultou no isolamento do cardanol trieno, cardanol dieno, cardanol monoeno, cardol trieno, ácido anacárdico trieno, ácido anacárico dieno e ácido anacárico monoeno. O cardol trieno apresentou uma CI50 de 80,66 µM. Os dados obtidos sugeriram que o extrato, frações e o cardol trieno possuem atividade moderada no ensaio nas formas promastigotas de L. amazonensis. Este é o primeiro relato de alquil-fenóis em A. othonianum.Universidade Federal de Campina Grande - UFCG2021-01-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/42910.22571/2526-4338429Acta Brasiliensis; Vol 5 No 1 (2021): Acta Brasiliensis; 44-47Acta Brasiliensis; Vol 5 No 1 (2021): Acta Brasiliensis; 44-47Acta Brasiliensis; Vol 5 No 1 (2021): Acta Brasiliensis; 44-472526-43382526-432Xreponame:Acta Brasiliensis (Online)instname:Universidade Federal de Campina Grande (UFCG)instacron:UFCGenghttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/429/120Copyright (c) 2020 Acta Brasiliensisinfo:eu-repo/semantics/openAccessAlvarenga, Tavane AparecidaAlves, Osvaine Júnior AlvarengaPagotti, Mariana CintraCunha, Wilson RobertoSilva, Márcio Luís Andrade eSales, Juliana de FátimaSilva, Fabiano GuimarãesJanuario, Ana HelenaMagalhães, Lizandra GuidiPauletti, Patrícia Mendonça2021-07-12T20:03:30Zoai:ActaBra.revistas.ufcg.edu.br:article/429Revistahttp://revistas.ufcg.edu.br/ActaBraPUBhttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/oaiactabrasiliensis@gmail.com || actabrasiliensis@gmail.com2526-432X2526-4338opendoar:2021-07-12T20:03:30Acta Brasiliensis (Online) - Universidade Federal de Campina Grande (UFCG)false
dc.title.none.fl_str_mv In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis

Síntese, atividade antimicrobiana e estudo in silico de 1,2,4-oxadiazóis derivados do levulinato de etila
title In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis
spellingShingle In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis
Alvarenga, Tavane Aparecida
title_short In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis
title_full In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis
title_fullStr In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis
title_full_unstemmed In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis
title_sort In vitro antileishmanial activity of Anacardium othonianum and isolated compounds against Leishmania amazonensis
author Alvarenga, Tavane Aparecida
author_facet Alvarenga, Tavane Aparecida
Alves, Osvaine Júnior Alvarenga
Pagotti, Mariana Cintra
Cunha, Wilson Roberto
Silva, Márcio Luís Andrade e
Sales, Juliana de Fátima
Silva, Fabiano Guimarães
Januario, Ana Helena
Magalhães, Lizandra Guidi
Pauletti, Patrícia Mendonça
author_role author
author2 Alves, Osvaine Júnior Alvarenga
Pagotti, Mariana Cintra
Cunha, Wilson Roberto
Silva, Márcio Luís Andrade e
Sales, Juliana de Fátima
Silva, Fabiano Guimarães
Januario, Ana Helena
Magalhães, Lizandra Guidi
Pauletti, Patrícia Mendonça
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alvarenga, Tavane Aparecida
Alves, Osvaine Júnior Alvarenga
Pagotti, Mariana Cintra
Cunha, Wilson Roberto
Silva, Márcio Luís Andrade e
Sales, Juliana de Fátima
Silva, Fabiano Guimarães
Januario, Ana Helena
Magalhães, Lizandra Guidi
Pauletti, Patrícia Mendonça
description This study analyzes the antileishmanial activity of the crude ethanol extract, fractions, and isolated compounds of A. othonianum nuts. Antileishmanial activity was evaluated against Leishmania amazonensis promastigotes in vitro. The phytochemical study was performed by high-performance liquid chromatography-high-resolution mass spectrometry-diode array detector (HPLC-HRMS-DAD) and by preparative HPLC. HPLC-HRMS-DAD analysis of the bioactive extract confirmed the presence of ten alkyl phenol derivatives that had previously been isolated from A. occidentale. Bioassay-guided isolation afforded cardanol triene, cardanol diene, cardanol monoene, cardol triene, anacardic acid triene, anacardic acid diene, and anacardic acid monoene. Cardol triene gave an IC50 of 80.66 µM. The obtained data suggest that the evaluated extract, fractions, and cardol triene had moderate activity against L. amazonensis promastigotes. This is the first description of alkyl phenols in A. othonianum.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/429
10.22571/2526-4338429
url http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/429
identifier_str_mv 10.22571/2526-4338429
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/429/120
dc.rights.driver.fl_str_mv Copyright (c) 2020 Acta Brasiliensis
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Acta Brasiliensis
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Campina Grande - UFCG
publisher.none.fl_str_mv Universidade Federal de Campina Grande - UFCG
dc.source.none.fl_str_mv Acta Brasiliensis; Vol 5 No 1 (2021): Acta Brasiliensis; 44-47
Acta Brasiliensis; Vol 5 No 1 (2021): Acta Brasiliensis; 44-47
Acta Brasiliensis; Vol 5 No 1 (2021): Acta Brasiliensis; 44-47
2526-4338
2526-432X
reponame:Acta Brasiliensis (Online)
instname:Universidade Federal de Campina Grande (UFCG)
instacron:UFCG
instname_str Universidade Federal de Campina Grande (UFCG)
instacron_str UFCG
institution UFCG
reponame_str Acta Brasiliensis (Online)
collection Acta Brasiliensis (Online)
repository.name.fl_str_mv Acta Brasiliensis (Online) - Universidade Federal de Campina Grande (UFCG)
repository.mail.fl_str_mv actabrasiliensis@gmail.com || actabrasiliensis@gmail.com
_version_ 1792204524156354560

Registros relacionados