Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFCG |
Texto Completo: | http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246 |
Resumo: | Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants. We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats. 4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μL. For in vitro experiments, 4TRP concentrations were 0.1 mM and 1.0 mM. 4TRP (i.p.) inhibited pentylenetetrazol- (PTZ-) induced seizures, indicating anticonvulsant effects. Electroencephalographic recordings showed that 4TRP (i.c.v.) protected against PTZ-induced seizures, corroborating the behavioural results. To determine whether 4TRP exerts anticonvulsant effects via regulation of GABAergic neurotransmission, we measured convulsions induced by 3-mercapto-propionic acid (3-MP). The obtained results showed involvement of the GABAergic system in the anticonvulsant action exerted by 4TRP, but flumazenil, a selective antagonist of the benzodiazepine site of the GABAA receptor, did not reverse the anticonvulsant effect, demonstrating that 4TRP does not bind to the benzodiazepine-binding site. Furthermore, 4TRP decreased the sodium current through voltage-dependent sodium channels, and thus its anticonvulsant effect may be related to changes in neuronal excitability because of modulation of these channels. |
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Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.O monoterpenoide terpinen-4-ol exibe atividade anticonvulsivante em estudos comportamentais e eletrofisiológicos.Monoterpenoid Terpinen-4-olPsychopharmacological - 4TRPElectrophysiological activities - 4TRPCentral nervous systemAnticonvulsant activityPsicofarmacológico - 4TRPAtividades eletrofisiológicas - 4TRPSistema nervoso centralAtividade anticonvulsivanteFarmácia.Química.Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants. We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats. 4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μL. For in vitro experiments, 4TRP concentrations were 0.1 mM and 1.0 mM. 4TRP (i.p.) inhibited pentylenetetrazol- (PTZ-) induced seizures, indicating anticonvulsant effects. Electroencephalographic recordings showed that 4TRP (i.c.v.) protected against PTZ-induced seizures, corroborating the behavioural results. To determine whether 4TRP exerts anticonvulsant effects via regulation of GABAergic neurotransmission, we measured convulsions induced by 3-mercapto-propionic acid (3-MP). The obtained results showed involvement of the GABAergic system in the anticonvulsant action exerted by 4TRP, but flumazenil, a selective antagonist of the benzodiazepine site of the GABAA receptor, did not reverse the anticonvulsant effect, demonstrating that 4TRP does not bind to the benzodiazepine-binding site. Furthermore, 4TRP decreased the sodium current through voltage-dependent sodium channels, and thus its anticonvulsant effect may be related to changes in neuronal excitability because of modulation of these channels.Universidade Federal de Campina GrandeBrasilUFCG20142024-08-09T18:27:00Z2024-08-092024-08-09T18:27:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246NÓBREGA, Franklin Ferreira de Farias; SALVADORI, Mirian Graciela da Silva Stiebbe; MASSON, Cintia Junia; MELLO, Carlos Fernando de; SANTOS-NASCIMENTO, T.; LEAL-CARDOSO, Jose Henrique; SOUSA, Damião Pergentino de; ALMEIDA, Reinaldo Nobrega de. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies Oxidative Medicine and Cellular Longevity (Print) , v. 2014, p. 703848, 2014. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246engNÓBREGA, Franklin Ferreira de Farias.SALVADORI, Mirian Graciela da Silva Stiebbe.MASSON, Cintia Junia.MELLO, Carlos Fernando de.SANTOS-NASCIMENTO, T.LEAL-CARDOSO, Jose HenriqueSOUSA, Damião Pergentino de.ALMEIDA, Reinaldo Nobrega de.info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFCGinstname:Universidade Federal de Campina Grande (UFCG)instacron:UFCG2024-08-09T18:27:51Zoai:localhost:riufcg/37246Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.ufcg.edu.br/PUBhttp://dspace.sti.ufcg.edu.br:8080/oai/requestbdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.bropendoar:48512024-08-09T18:27:51Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG)false |
dc.title.none.fl_str_mv |
Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies. O monoterpenoide terpinen-4-ol exibe atividade anticonvulsivante em estudos comportamentais e eletrofisiológicos. |
title |
Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies. |
spellingShingle |
Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies. NÓBREGA, Franklin Ferreira de Farias. Monoterpenoid Terpinen-4-ol Psychopharmacological - 4TRP Electrophysiological activities - 4TRP Central nervous system Anticonvulsant activity Psicofarmacológico - 4TRP Atividades eletrofisiológicas - 4TRP Sistema nervoso central Atividade anticonvulsivante Farmácia. Química. |
title_short |
Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies. |
title_full |
Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies. |
title_fullStr |
Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies. |
title_full_unstemmed |
Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies. |
title_sort |
Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies. |
author |
NÓBREGA, Franklin Ferreira de Farias. |
author_facet |
NÓBREGA, Franklin Ferreira de Farias. SALVADORI, Mirian Graciela da Silva Stiebbe. MASSON, Cintia Junia. MELLO, Carlos Fernando de. SANTOS-NASCIMENTO, T. LEAL-CARDOSO, Jose Henrique SOUSA, Damião Pergentino de. ALMEIDA, Reinaldo Nobrega de. |
author_role |
author |
author2 |
SALVADORI, Mirian Graciela da Silva Stiebbe. MASSON, Cintia Junia. MELLO, Carlos Fernando de. SANTOS-NASCIMENTO, T. LEAL-CARDOSO, Jose Henrique SOUSA, Damião Pergentino de. ALMEIDA, Reinaldo Nobrega de. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
NÓBREGA, Franklin Ferreira de Farias. SALVADORI, Mirian Graciela da Silva Stiebbe. MASSON, Cintia Junia. MELLO, Carlos Fernando de. SANTOS-NASCIMENTO, T. LEAL-CARDOSO, Jose Henrique SOUSA, Damião Pergentino de. ALMEIDA, Reinaldo Nobrega de. |
dc.subject.por.fl_str_mv |
Monoterpenoid Terpinen-4-ol Psychopharmacological - 4TRP Electrophysiological activities - 4TRP Central nervous system Anticonvulsant activity Psicofarmacológico - 4TRP Atividades eletrofisiológicas - 4TRP Sistema nervoso central Atividade anticonvulsivante Farmácia. Química. |
topic |
Monoterpenoid Terpinen-4-ol Psychopharmacological - 4TRP Electrophysiological activities - 4TRP Central nervous system Anticonvulsant activity Psicofarmacológico - 4TRP Atividades eletrofisiológicas - 4TRP Sistema nervoso central Atividade anticonvulsivante Farmácia. Química. |
description |
Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants. We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats. 4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μL. For in vitro experiments, 4TRP concentrations were 0.1 mM and 1.0 mM. 4TRP (i.p.) inhibited pentylenetetrazol- (PTZ-) induced seizures, indicating anticonvulsant effects. Electroencephalographic recordings showed that 4TRP (i.c.v.) protected against PTZ-induced seizures, corroborating the behavioural results. To determine whether 4TRP exerts anticonvulsant effects via regulation of GABAergic neurotransmission, we measured convulsions induced by 3-mercapto-propionic acid (3-MP). The obtained results showed involvement of the GABAergic system in the anticonvulsant action exerted by 4TRP, but flumazenil, a selective antagonist of the benzodiazepine site of the GABAA receptor, did not reverse the anticonvulsant effect, demonstrating that 4TRP does not bind to the benzodiazepine-binding site. Furthermore, 4TRP decreased the sodium current through voltage-dependent sodium channels, and thus its anticonvulsant effect may be related to changes in neuronal excitability because of modulation of these channels. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2024-08-09T18:27:00Z 2024-08-09 2024-08-09T18:27:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246 NÓBREGA, Franklin Ferreira de Farias; SALVADORI, Mirian Graciela da Silva Stiebbe; MASSON, Cintia Junia; MELLO, Carlos Fernando de; SANTOS-NASCIMENTO, T.; LEAL-CARDOSO, Jose Henrique; SOUSA, Damião Pergentino de; ALMEIDA, Reinaldo Nobrega de. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies Oxidative Medicine and Cellular Longevity (Print) , v. 2014, p. 703848, 2014. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246 |
url |
http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246 |
identifier_str_mv |
NÓBREGA, Franklin Ferreira de Farias; SALVADORI, Mirian Graciela da Silva Stiebbe; MASSON, Cintia Junia; MELLO, Carlos Fernando de; SANTOS-NASCIMENTO, T.; LEAL-CARDOSO, Jose Henrique; SOUSA, Damião Pergentino de; ALMEIDA, Reinaldo Nobrega de. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies Oxidative Medicine and Cellular Longevity (Print) , v. 2014, p. 703848, 2014. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Campina Grande Brasil UFCG |
publisher.none.fl_str_mv |
Universidade Federal de Campina Grande Brasil UFCG |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFCG instname:Universidade Federal de Campina Grande (UFCG) instacron:UFCG |
instname_str |
Universidade Federal de Campina Grande (UFCG) |
instacron_str |
UFCG |
institution |
UFCG |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UFCG |
collection |
Biblioteca Digital de Teses e Dissertações da UFCG |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG) |
repository.mail.fl_str_mv |
bdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.br |
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1809744632843599872 |