Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.

Detalhes bibliográficos
Autor(a) principal: NÓBREGA, Franklin Ferreira de Farias.
Data de Publicação: 2014
Outros Autores: SALVADORI, Mirian Graciela da Silva Stiebbe., MASSON, Cintia Junia., MELLO, Carlos Fernando de., SANTOS-NASCIMENTO, T., LEAL-CARDOSO, Jose Henrique, SOUSA, Damião Pergentino de., ALMEIDA, Reinaldo Nobrega de.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFCG
Texto Completo: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246
Resumo: Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants. We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats. 4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μL. For in vitro experiments, 4TRP concentrations were 0.1 mM and 1.0 mM. 4TRP (i.p.) inhibited pentylenetetrazol- (PTZ-) induced seizures, indicating anticonvulsant effects. Electroencephalographic recordings showed that 4TRP (i.c.v.) protected against PTZ-induced seizures, corroborating the behavioural results. To determine whether 4TRP exerts anticonvulsant effects via regulation of GABAergic neurotransmission, we measured convulsions induced by 3-mercapto-propionic acid (3-MP). The obtained results showed involvement of the GABAergic system in the anticonvulsant action exerted by 4TRP, but flumazenil, a selective antagonist of the benzodiazepine site of the GABAA receptor, did not reverse the anticonvulsant effect, demonstrating that 4TRP does not bind to the benzodiazepine-binding site. Furthermore, 4TRP decreased the sodium current through voltage-dependent sodium channels, and thus its anticonvulsant effect may be related to changes in neuronal excitability because of modulation of these channels.
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spelling Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.O monoterpenoide terpinen-4-ol exibe atividade anticonvulsivante em estudos comportamentais e eletrofisiológicos.Monoterpenoid Terpinen-4-olPsychopharmacological - 4TRPElectrophysiological activities - 4TRPCentral nervous systemAnticonvulsant activityPsicofarmacológico - 4TRPAtividades eletrofisiológicas - 4TRPSistema nervoso centralAtividade anticonvulsivanteFarmácia.Química.Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants. We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats. 4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μL. For in vitro experiments, 4TRP concentrations were 0.1 mM and 1.0 mM. 4TRP (i.p.) inhibited pentylenetetrazol- (PTZ-) induced seizures, indicating anticonvulsant effects. Electroencephalographic recordings showed that 4TRP (i.c.v.) protected against PTZ-induced seizures, corroborating the behavioural results. To determine whether 4TRP exerts anticonvulsant effects via regulation of GABAergic neurotransmission, we measured convulsions induced by 3-mercapto-propionic acid (3-MP). The obtained results showed involvement of the GABAergic system in the anticonvulsant action exerted by 4TRP, but flumazenil, a selective antagonist of the benzodiazepine site of the GABAA receptor, did not reverse the anticonvulsant effect, demonstrating that 4TRP does not bind to the benzodiazepine-binding site. Furthermore, 4TRP decreased the sodium current through voltage-dependent sodium channels, and thus its anticonvulsant effect may be related to changes in neuronal excitability because of modulation of these channels.Universidade Federal de Campina GrandeBrasilUFCG20142024-08-09T18:27:00Z2024-08-092024-08-09T18:27:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246NÓBREGA, Franklin Ferreira de Farias; SALVADORI, Mirian Graciela da Silva Stiebbe; MASSON, Cintia Junia; MELLO, Carlos Fernando de; SANTOS-NASCIMENTO, T.; LEAL-CARDOSO, Jose Henrique; SOUSA, Damião Pergentino de; ALMEIDA, Reinaldo Nobrega de. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies Oxidative Medicine and Cellular Longevity (Print) , v. 2014, p. 703848, 2014. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246engNÓBREGA, Franklin Ferreira de Farias.SALVADORI, Mirian Graciela da Silva Stiebbe.MASSON, Cintia Junia.MELLO, Carlos Fernando de.SANTOS-NASCIMENTO, T.LEAL-CARDOSO, Jose HenriqueSOUSA, Damião Pergentino de.ALMEIDA, Reinaldo Nobrega de.info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFCGinstname:Universidade Federal de Campina Grande (UFCG)instacron:UFCG2024-08-09T18:27:51Zoai:localhost:riufcg/37246Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.ufcg.edu.br/PUBhttp://dspace.sti.ufcg.edu.br:8080/oai/requestbdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.bropendoar:48512024-08-09T18:27:51Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG)false
dc.title.none.fl_str_mv Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
O monoterpenoide terpinen-4-ol exibe atividade anticonvulsivante em estudos comportamentais e eletrofisiológicos.
title Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
spellingShingle Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
NÓBREGA, Franklin Ferreira de Farias.
Monoterpenoid Terpinen-4-ol
Psychopharmacological - 4TRP
Electrophysiological activities - 4TRP
Central nervous system
Anticonvulsant activity
Psicofarmacológico - 4TRP
Atividades eletrofisiológicas - 4TRP
Sistema nervoso central
Atividade anticonvulsivante
Farmácia.
Química.
title_short Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
title_full Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
title_fullStr Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
title_full_unstemmed Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
title_sort Monoterpenoid Terpinen-4-ol exhibits anticonvulsant activity in behavioural and electrophysiological studies.
author NÓBREGA, Franklin Ferreira de Farias.
author_facet NÓBREGA, Franklin Ferreira de Farias.
SALVADORI, Mirian Graciela da Silva Stiebbe.
MASSON, Cintia Junia.
MELLO, Carlos Fernando de.
SANTOS-NASCIMENTO, T.
LEAL-CARDOSO, Jose Henrique
SOUSA, Damião Pergentino de.
ALMEIDA, Reinaldo Nobrega de.
author_role author
author2 SALVADORI, Mirian Graciela da Silva Stiebbe.
MASSON, Cintia Junia.
MELLO, Carlos Fernando de.
SANTOS-NASCIMENTO, T.
LEAL-CARDOSO, Jose Henrique
SOUSA, Damião Pergentino de.
ALMEIDA, Reinaldo Nobrega de.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv NÓBREGA, Franklin Ferreira de Farias.
SALVADORI, Mirian Graciela da Silva Stiebbe.
MASSON, Cintia Junia.
MELLO, Carlos Fernando de.
SANTOS-NASCIMENTO, T.
LEAL-CARDOSO, Jose Henrique
SOUSA, Damião Pergentino de.
ALMEIDA, Reinaldo Nobrega de.
dc.subject.por.fl_str_mv Monoterpenoid Terpinen-4-ol
Psychopharmacological - 4TRP
Electrophysiological activities - 4TRP
Central nervous system
Anticonvulsant activity
Psicofarmacológico - 4TRP
Atividades eletrofisiológicas - 4TRP
Sistema nervoso central
Atividade anticonvulsivante
Farmácia.
Química.
topic Monoterpenoid Terpinen-4-ol
Psychopharmacological - 4TRP
Electrophysiological activities - 4TRP
Central nervous system
Anticonvulsant activity
Psicofarmacológico - 4TRP
Atividades eletrofisiológicas - 4TRP
Sistema nervoso central
Atividade anticonvulsivante
Farmácia.
Química.
description Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants. We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats. 4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μL. For in vitro experiments, 4TRP concentrations were 0.1 mM and 1.0 mM. 4TRP (i.p.) inhibited pentylenetetrazol- (PTZ-) induced seizures, indicating anticonvulsant effects. Electroencephalographic recordings showed that 4TRP (i.c.v.) protected against PTZ-induced seizures, corroborating the behavioural results. To determine whether 4TRP exerts anticonvulsant effects via regulation of GABAergic neurotransmission, we measured convulsions induced by 3-mercapto-propionic acid (3-MP). The obtained results showed involvement of the GABAergic system in the anticonvulsant action exerted by 4TRP, but flumazenil, a selective antagonist of the benzodiazepine site of the GABAA receptor, did not reverse the anticonvulsant effect, demonstrating that 4TRP does not bind to the benzodiazepine-binding site. Furthermore, 4TRP decreased the sodium current through voltage-dependent sodium channels, and thus its anticonvulsant effect may be related to changes in neuronal excitability because of modulation of these channels.
publishDate 2014
dc.date.none.fl_str_mv 2014
2024-08-09T18:27:00Z
2024-08-09
2024-08-09T18:27:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246
NÓBREGA, Franklin Ferreira de Farias; SALVADORI, Mirian Graciela da Silva Stiebbe; MASSON, Cintia Junia; MELLO, Carlos Fernando de; SANTOS-NASCIMENTO, T.; LEAL-CARDOSO, Jose Henrique; SOUSA, Damião Pergentino de; ALMEIDA, Reinaldo Nobrega de. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies Oxidative Medicine and Cellular Longevity (Print) , v. 2014, p. 703848, 2014. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246
url http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246
identifier_str_mv NÓBREGA, Franklin Ferreira de Farias; SALVADORI, Mirian Graciela da Silva Stiebbe; MASSON, Cintia Junia; MELLO, Carlos Fernando de; SANTOS-NASCIMENTO, T.; LEAL-CARDOSO, Jose Henrique; SOUSA, Damião Pergentino de; ALMEIDA, Reinaldo Nobrega de. Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies Oxidative Medicine and Cellular Longevity (Print) , v. 2014, p. 703848, 2014. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37246
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Campina Grande
Brasil
UFCG
publisher.none.fl_str_mv Universidade Federal de Campina Grande
Brasil
UFCG
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFCG
instname:Universidade Federal de Campina Grande (UFCG)
instacron:UFCG
instname_str Universidade Federal de Campina Grande (UFCG)
instacron_str UFCG
institution UFCG
reponame_str Biblioteca Digital de Teses e Dissertações da UFCG
collection Biblioteca Digital de Teses e Dissertações da UFCG
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG)
repository.mail.fl_str_mv bdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.br
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