Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.

Detalhes bibliográficos
Autor(a) principal: SOUSA, Damião Pergentino de.
Data de Publicação: 2011
Outros Autores: NÓBREGA, Franklin Ferreira de Farias., LIMA, Maria Raquel Vitorino de., ALMEIDA, Reinaldo Nóbrega de.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFCG
Texto Completo: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259
Resumo: (R)-(+)-Pulegone is a monoterpene found in essential oils from plants of the Labiatae family. This compound is a major constituent of Agastache formosanum oil. In this study, the effect of (R)-(+)-pulegone on the central nervous system was evaluated. (R)-(+)-Pulegone caused a signifi cant decrease in ambulation and an increase in pentobarbital-induced sleeping time in mice, indicating a central depressant effect. (+)-Pulegone also significantly increased the latency of convulsions as assessed by the pentylenetetrazole (PTZ) method. The antinociceptive properties of this monoterpene were studied in chemical and thermal models of nociception. Chemical nociception induced in the first and second phase of the subplantar formalin test was significantly inhibited by (R)-(+)-pulegone and was not blocked by naloxone. Thermal nociception was also signifi cantly inhibited while (R)-(+)-pulegone increased the reaction latency of the mice in the hot plate test. These results suggest that (R)-(+)-pulegone is a psychoactive compound and has the profile of an analgesic drug.
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spelling Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.Atividade farmacológica de (R)-(+)-Pulegona, um constituinte químico de óleos essenciais.Essential oilsAntinociceptiveAnalgesicCentral nervous system(R)-(+)-PulegoneÓleos essenciaisAntinociceptivoAnalgésicoSistema nervoso central(R)-(+)-PulegonaFarmácia.Química.(R)-(+)-Pulegone is a monoterpene found in essential oils from plants of the Labiatae family. This compound is a major constituent of Agastache formosanum oil. In this study, the effect of (R)-(+)-pulegone on the central nervous system was evaluated. (R)-(+)-Pulegone caused a signifi cant decrease in ambulation and an increase in pentobarbital-induced sleeping time in mice, indicating a central depressant effect. (+)-Pulegone also significantly increased the latency of convulsions as assessed by the pentylenetetrazole (PTZ) method. The antinociceptive properties of this monoterpene were studied in chemical and thermal models of nociception. Chemical nociception induced in the first and second phase of the subplantar formalin test was significantly inhibited by (R)-(+)-pulegone and was not blocked by naloxone. Thermal nociception was also signifi cantly inhibited while (R)-(+)-pulegone increased the reaction latency of the mice in the hot plate test. These results suggest that (R)-(+)-pulegone is a psychoactive compound and has the profile of an analgesic drug.Universidade Federal de Campina GrandeBrasilUFCG20112024-08-12T18:14:42Z2024-08-122024-08-12T18:14:42Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259SOUSA, Damião Pergentino de; NÓBREGA, Franklin Ferreira de Farias; LIMA, Maria Raquel Vitorino de; ALMEIDA, Reinaldo Nóbrega de. Psychopharmacological activity of (R)-(+)-pulegone, a chemical constituent of essential oils. Natural Product Communications, v. 66, p. 353-359, 2011. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259engSOUSA, Damião Pergentino de.NÓBREGA, Franklin Ferreira de Farias.LIMA, Maria Raquel Vitorino de.ALMEIDA, Reinaldo Nóbrega de.info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFCGinstname:Universidade Federal de Campina Grande (UFCG)instacron:UFCG2024-08-12T18:15:14Zoai:localhost:riufcg/37259Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.ufcg.edu.br/PUBhttp://dspace.sti.ufcg.edu.br:8080/oai/requestbdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.bropendoar:48512024-08-12T18:15:14Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG)false
dc.title.none.fl_str_mv Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.
Atividade farmacológica de (R)-(+)-Pulegona, um constituinte químico de óleos essenciais.
title Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.
spellingShingle Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.
SOUSA, Damião Pergentino de.
Essential oils
Antinociceptive
Analgesic
Central nervous system
(R)-(+)-Pulegone
Óleos essenciais
Antinociceptivo
Analgésico
Sistema nervoso central
(R)-(+)-Pulegona
Farmácia.
Química.
title_short Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.
title_full Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.
title_fullStr Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.
title_full_unstemmed Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.
title_sort Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.
author SOUSA, Damião Pergentino de.
author_facet SOUSA, Damião Pergentino de.
NÓBREGA, Franklin Ferreira de Farias.
LIMA, Maria Raquel Vitorino de.
ALMEIDA, Reinaldo Nóbrega de.
author_role author
author2 NÓBREGA, Franklin Ferreira de Farias.
LIMA, Maria Raquel Vitorino de.
ALMEIDA, Reinaldo Nóbrega de.
author2_role author
author
author
dc.contributor.author.fl_str_mv SOUSA, Damião Pergentino de.
NÓBREGA, Franklin Ferreira de Farias.
LIMA, Maria Raquel Vitorino de.
ALMEIDA, Reinaldo Nóbrega de.
dc.subject.por.fl_str_mv Essential oils
Antinociceptive
Analgesic
Central nervous system
(R)-(+)-Pulegone
Óleos essenciais
Antinociceptivo
Analgésico
Sistema nervoso central
(R)-(+)-Pulegona
Farmácia.
Química.
topic Essential oils
Antinociceptive
Analgesic
Central nervous system
(R)-(+)-Pulegone
Óleos essenciais
Antinociceptivo
Analgésico
Sistema nervoso central
(R)-(+)-Pulegona
Farmácia.
Química.
description (R)-(+)-Pulegone is a monoterpene found in essential oils from plants of the Labiatae family. This compound is a major constituent of Agastache formosanum oil. In this study, the effect of (R)-(+)-pulegone on the central nervous system was evaluated. (R)-(+)-Pulegone caused a signifi cant decrease in ambulation and an increase in pentobarbital-induced sleeping time in mice, indicating a central depressant effect. (+)-Pulegone also significantly increased the latency of convulsions as assessed by the pentylenetetrazole (PTZ) method. The antinociceptive properties of this monoterpene were studied in chemical and thermal models of nociception. Chemical nociception induced in the first and second phase of the subplantar formalin test was significantly inhibited by (R)-(+)-pulegone and was not blocked by naloxone. Thermal nociception was also signifi cantly inhibited while (R)-(+)-pulegone increased the reaction latency of the mice in the hot plate test. These results suggest that (R)-(+)-pulegone is a psychoactive compound and has the profile of an analgesic drug.
publishDate 2011
dc.date.none.fl_str_mv 2011
2024-08-12T18:14:42Z
2024-08-12
2024-08-12T18:14:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259
SOUSA, Damião Pergentino de; NÓBREGA, Franklin Ferreira de Farias; LIMA, Maria Raquel Vitorino de; ALMEIDA, Reinaldo Nóbrega de. Psychopharmacological activity of (R)-(+)-pulegone, a chemical constituent of essential oils. Natural Product Communications, v. 66, p. 353-359, 2011. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259
url http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259
identifier_str_mv SOUSA, Damião Pergentino de; NÓBREGA, Franklin Ferreira de Farias; LIMA, Maria Raquel Vitorino de; ALMEIDA, Reinaldo Nóbrega de. Psychopharmacological activity of (R)-(+)-pulegone, a chemical constituent of essential oils. Natural Product Communications, v. 66, p. 353-359, 2011. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Campina Grande
Brasil
UFCG
publisher.none.fl_str_mv Universidade Federal de Campina Grande
Brasil
UFCG
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFCG
instname:Universidade Federal de Campina Grande (UFCG)
instacron:UFCG
instname_str Universidade Federal de Campina Grande (UFCG)
instacron_str UFCG
institution UFCG
reponame_str Biblioteca Digital de Teses e Dissertações da UFCG
collection Biblioteca Digital de Teses e Dissertações da UFCG
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG)
repository.mail.fl_str_mv bdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.br
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