Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFCG |
Texto Completo: | http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259 |
Resumo: | (R)-(+)-Pulegone is a monoterpene found in essential oils from plants of the Labiatae family. This compound is a major constituent of Agastache formosanum oil. In this study, the effect of (R)-(+)-pulegone on the central nervous system was evaluated. (R)-(+)-Pulegone caused a signifi cant decrease in ambulation and an increase in pentobarbital-induced sleeping time in mice, indicating a central depressant effect. (+)-Pulegone also significantly increased the latency of convulsions as assessed by the pentylenetetrazole (PTZ) method. The antinociceptive properties of this monoterpene were studied in chemical and thermal models of nociception. Chemical nociception induced in the first and second phase of the subplantar formalin test was significantly inhibited by (R)-(+)-pulegone and was not blocked by naloxone. Thermal nociception was also signifi cantly inhibited while (R)-(+)-pulegone increased the reaction latency of the mice in the hot plate test. These results suggest that (R)-(+)-pulegone is a psychoactive compound and has the profile of an analgesic drug. |
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Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils.Atividade farmacológica de (R)-(+)-Pulegona, um constituinte químico de óleos essenciais.Essential oilsAntinociceptiveAnalgesicCentral nervous system(R)-(+)-PulegoneÓleos essenciaisAntinociceptivoAnalgésicoSistema nervoso central(R)-(+)-PulegonaFarmácia.Química.(R)-(+)-Pulegone is a monoterpene found in essential oils from plants of the Labiatae family. This compound is a major constituent of Agastache formosanum oil. In this study, the effect of (R)-(+)-pulegone on the central nervous system was evaluated. (R)-(+)-Pulegone caused a signifi cant decrease in ambulation and an increase in pentobarbital-induced sleeping time in mice, indicating a central depressant effect. (+)-Pulegone also significantly increased the latency of convulsions as assessed by the pentylenetetrazole (PTZ) method. The antinociceptive properties of this monoterpene were studied in chemical and thermal models of nociception. Chemical nociception induced in the first and second phase of the subplantar formalin test was significantly inhibited by (R)-(+)-pulegone and was not blocked by naloxone. Thermal nociception was also signifi cantly inhibited while (R)-(+)-pulegone increased the reaction latency of the mice in the hot plate test. These results suggest that (R)-(+)-pulegone is a psychoactive compound and has the profile of an analgesic drug.Universidade Federal de Campina GrandeBrasilUFCG20112024-08-12T18:14:42Z2024-08-122024-08-12T18:14:42Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259SOUSA, Damião Pergentino de; NÓBREGA, Franklin Ferreira de Farias; LIMA, Maria Raquel Vitorino de; ALMEIDA, Reinaldo Nóbrega de. Psychopharmacological activity of (R)-(+)-pulegone, a chemical constituent of essential oils. Natural Product Communications, v. 66, p. 353-359, 2011. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259engSOUSA, Damião Pergentino de.NÓBREGA, Franklin Ferreira de Farias.LIMA, Maria Raquel Vitorino de.ALMEIDA, Reinaldo Nóbrega de.info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFCGinstname:Universidade Federal de Campina Grande (UFCG)instacron:UFCG2024-08-12T18:15:14Zoai:localhost:riufcg/37259Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.ufcg.edu.br/PUBhttp://dspace.sti.ufcg.edu.br:8080/oai/requestbdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.bropendoar:48512024-08-12T18:15:14Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG)false |
dc.title.none.fl_str_mv |
Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils. Atividade farmacológica de (R)-(+)-Pulegona, um constituinte químico de óleos essenciais. |
title |
Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils. |
spellingShingle |
Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils. SOUSA, Damião Pergentino de. Essential oils Antinociceptive Analgesic Central nervous system (R)-(+)-Pulegone Óleos essenciais Antinociceptivo Analgésico Sistema nervoso central (R)-(+)-Pulegona Farmácia. Química. |
title_short |
Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils. |
title_full |
Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils. |
title_fullStr |
Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils. |
title_full_unstemmed |
Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils. |
title_sort |
Pharmacological activity of (R)-(+)-Pulegone, a chemical constituent of essential Oils. |
author |
SOUSA, Damião Pergentino de. |
author_facet |
SOUSA, Damião Pergentino de. NÓBREGA, Franklin Ferreira de Farias. LIMA, Maria Raquel Vitorino de. ALMEIDA, Reinaldo Nóbrega de. |
author_role |
author |
author2 |
NÓBREGA, Franklin Ferreira de Farias. LIMA, Maria Raquel Vitorino de. ALMEIDA, Reinaldo Nóbrega de. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
SOUSA, Damião Pergentino de. NÓBREGA, Franklin Ferreira de Farias. LIMA, Maria Raquel Vitorino de. ALMEIDA, Reinaldo Nóbrega de. |
dc.subject.por.fl_str_mv |
Essential oils Antinociceptive Analgesic Central nervous system (R)-(+)-Pulegone Óleos essenciais Antinociceptivo Analgésico Sistema nervoso central (R)-(+)-Pulegona Farmácia. Química. |
topic |
Essential oils Antinociceptive Analgesic Central nervous system (R)-(+)-Pulegone Óleos essenciais Antinociceptivo Analgésico Sistema nervoso central (R)-(+)-Pulegona Farmácia. Química. |
description |
(R)-(+)-Pulegone is a monoterpene found in essential oils from plants of the Labiatae family. This compound is a major constituent of Agastache formosanum oil. In this study, the effect of (R)-(+)-pulegone on the central nervous system was evaluated. (R)-(+)-Pulegone caused a signifi cant decrease in ambulation and an increase in pentobarbital-induced sleeping time in mice, indicating a central depressant effect. (+)-Pulegone also significantly increased the latency of convulsions as assessed by the pentylenetetrazole (PTZ) method. The antinociceptive properties of this monoterpene were studied in chemical and thermal models of nociception. Chemical nociception induced in the first and second phase of the subplantar formalin test was significantly inhibited by (R)-(+)-pulegone and was not blocked by naloxone. Thermal nociception was also signifi cantly inhibited while (R)-(+)-pulegone increased the reaction latency of the mice in the hot plate test. These results suggest that (R)-(+)-pulegone is a psychoactive compound and has the profile of an analgesic drug. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 2024-08-12T18:14:42Z 2024-08-12 2024-08-12T18:14:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259 SOUSA, Damião Pergentino de; NÓBREGA, Franklin Ferreira de Farias; LIMA, Maria Raquel Vitorino de; ALMEIDA, Reinaldo Nóbrega de. Psychopharmacological activity of (R)-(+)-pulegone, a chemical constituent of essential oils. Natural Product Communications, v. 66, p. 353-359, 2011. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259 |
url |
http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259 |
identifier_str_mv |
SOUSA, Damião Pergentino de; NÓBREGA, Franklin Ferreira de Farias; LIMA, Maria Raquel Vitorino de; ALMEIDA, Reinaldo Nóbrega de. Psychopharmacological activity of (R)-(+)-pulegone, a chemical constituent of essential oils. Natural Product Communications, v. 66, p. 353-359, 2011. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37259 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Campina Grande Brasil UFCG |
publisher.none.fl_str_mv |
Universidade Federal de Campina Grande Brasil UFCG |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFCG instname:Universidade Federal de Campina Grande (UFCG) instacron:UFCG |
instname_str |
Universidade Federal de Campina Grande (UFCG) |
instacron_str |
UFCG |
institution |
UFCG |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UFCG |
collection |
Biblioteca Digital de Teses e Dissertações da UFCG |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UFCG - Universidade Federal de Campina Grande (UFCG) |
repository.mail.fl_str_mv |
bdtd@setor.ufcg.edu.br || bdtd@setor.ufcg.edu.br |
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1809744632875057152 |