Estudo quÃmico de Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)

Detalhes bibliográficos
Autor(a) principal: Antonio HonÃrio de Sousa
Data de Publicação: 2014
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFC
Texto Completo: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14361
Resumo: The present work reports the chemical study related to the stem and the roots of Croton limae, collected in AndaraÃ/BA. The phytochemical investigation of ethanol extract from the stem lead to the isolation of two kaurane-type diterpenes, ent-kaur-16-en-18-oic acid and ent-kaur-16-en-15-oxo-18-oic acid, two clerodane-type diterpenes, 3,12-dioxo-15,16-epoxy-4α-hydroxycleroda-13(16),14-diene and 3-oxo-4α-hydroxy-13,14,15,16-tetranorclerodan-12-oic acid, and the flavonoid quercetin 3-O-β-D-glucopyranoside. The investigation of the hexane extract from the roots lead to the isolation of one triterpene, acetyl aleuritolic acid, the new dimer ent-17(α-pinen-10â-yl)-15-oxokauran-18-oic acid, two news clerodane diterpenes, 3-oxo-15,16-epoxy-4α,12-dihydroxycleroda-13(16),14-diene and 15,16-epoxy-3α,4α,12-trihydroxycleroda-13(16),14-diene, one halimane-type diterpene, 15,16-epoxy-3α,12-dihydroxyhalima-5(10),13(16),14-triene and the mixture of steroids β-sitosterol and stigmasterol. From the ethanol extract of the roots, it was possible to isolate the flavonoids kaempferol 3-O-β-glucopyranoside and ombuine 3-O-β-rutinoside and the three new clerodane diterpenes 3α,4α,15,16-tetrahydroxyclerod-13-ene, 6-(β-D-glucopyranosyl)-3,12-dioxo-15,16-epoxi-4α-hydroxycleroda-13(16),14-dieno and 3-oxo-4α,12-dihydroxy-14,15,16-trinorclerodan-13-oic acid. Four aromatic derivatives amides from ent-kaur-16-en-18-oic acid were prepared through nucleophilic substitutive reactions. The corresponding methyl esters from the ent-kaur-16-en-18-oic acid and ent-kaur-16-en-15-oxo-18-oic acid were also obtained. Two new derivatives from 3,12-dioxo-15,16-epoxi-4α-hidroxicleroda-13(16),14-dieno were prepared through reduction reaction and another one by the biotransformation of diterpene, made by the fungus Rhizopus stolonifer. Some isolated compounds and derivatives were submited to cytotoxic activity using ovarian (OVCAR-8), glioblastoma (SF-295) and colon (HCT-116) cell lines, and the compounds ent-kaur-16-en-15-oxo-18-oic acid and ent-17(α-pinen-10â-yl)-15-oxokauran-18-oic acid registered activity during preliminaries assays. The secondary metabolites were isolated through usual chromatography techniques, using thin layer chromatography, column chromatography, size exclusion chromatography and high performance liquid chromatography. The determination of the structure of the isolated compounds was performed through physical (melting point and optical rotation) and spectrometric techniques, such infrared (IR), high resolution mass spectrometry and nuclear magnetic resonance (NMR), including bidimensional experiments, and comparison with literature data.
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spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisEstudo quÃmico de Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)Chemical study of Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)2014-08-22Mary Anne Sousa Lima32421508304http://lattes.cnpq.br/0781721524175361 Francisco Josà Queiroz Monte02045737349http://lattes.cnpq.br/5189263761682019Maria Rose Jane Ribeiro Albuquerque26642280300http://lattes.cnpq.br/5606331204668066Francisco Geraldo Barbosa56168250344Selene Maia de Morais05167965349http://lattes.cnpq.br/998026392636313400023755326http://lattes.cnpq.br/7572639531262727Antonio HonÃrio de SousaUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em QuÃmica UFCBRDiterpenos cauranos Diterpenos clerodanos Atividade citotÃxicaKaurane diterpenes Clerodane diterpenes Cytotoxic activityQUIMICA ORGANICAThe present work reports the chemical study related to the stem and the roots of Croton limae, collected in AndaraÃ/BA. The phytochemical investigation of ethanol extract from the stem lead to the isolation of two kaurane-type diterpenes, ent-kaur-16-en-18-oic acid and ent-kaur-16-en-15-oxo-18-oic acid, two clerodane-type diterpenes, 3,12-dioxo-15,16-epoxy-4α-hydroxycleroda-13(16),14-diene and 3-oxo-4α-hydroxy-13,14,15,16-tetranorclerodan-12-oic acid, and the flavonoid quercetin 3-O-β-D-glucopyranoside. The investigation of the hexane extract from the roots lead to the isolation of one triterpene, acetyl aleuritolic acid, the new dimer ent-17(α-pinen-10â-yl)-15-oxokauran-18-oic acid, two news clerodane diterpenes, 3-oxo-15,16-epoxy-4α,12-dihydroxycleroda-13(16),14-diene and 15,16-epoxy-3α,4α,12-trihydroxycleroda-13(16),14-diene, one halimane-type diterpene, 15,16-epoxy-3α,12-dihydroxyhalima-5(10),13(16),14-triene and the mixture of steroids β-sitosterol and stigmasterol. From the ethanol extract of the roots, it was possible to isolate the flavonoids kaempferol 3-O-β-glucopyranoside and ombuine 3-O-β-rutinoside and the three new clerodane diterpenes 3α,4α,15,16-tetrahydroxyclerod-13-ene, 6-(β-D-glucopyranosyl)-3,12-dioxo-15,16-epoxi-4α-hydroxycleroda-13(16),14-dieno and 3-oxo-4α,12-dihydroxy-14,15,16-trinorclerodan-13-oic acid. Four aromatic derivatives amides from ent-kaur-16-en-18-oic acid were prepared through nucleophilic substitutive reactions. The corresponding methyl esters from the ent-kaur-16-en-18-oic acid and ent-kaur-16-en-15-oxo-18-oic acid were also obtained. Two new derivatives from 3,12-dioxo-15,16-epoxi-4α-hidroxicleroda-13(16),14-dieno were prepared through reduction reaction and another one by the biotransformation of diterpene, made by the fungus Rhizopus stolonifer. Some isolated compounds and derivatives were submited to cytotoxic activity using ovarian (OVCAR-8), glioblastoma (SF-295) and colon (HCT-116) cell lines, and the compounds ent-kaur-16-en-15-oxo-18-oic acid and ent-17(α-pinen-10â-yl)-15-oxokauran-18-oic acid registered activity during preliminaries assays. The secondary metabolites were isolated through usual chromatography techniques, using thin layer chromatography, column chromatography, size exclusion chromatography and high performance liquid chromatography. The determination of the structure of the isolated compounds was performed through physical (melting point and optical rotation) and spectrometric techniques, such infrared (IR), high resolution mass spectrometry and nuclear magnetic resonance (NMR), including bidimensional experiments, and comparison with literature data.O presente trabalho relata o estudo quÃmico do caule e das raÃzes de Croton limae, coletado no municÃpio de AndaraÃ-BA. A investigaÃÃo fitoquÃmica do extrato etanÃlico do caule levou ao isolamento de dois diterpenos do tipo caurano, Ãcido ent-caur-16-en-18-oico e Ãcido ent-caur-16-en-15-oxo-18-oico, dois diterpenos do tipo clerodano, 3,12-dioxo-15,16-epoxi-4α-hidroxicleroda-13(16),14-dieno e Ãcido 3-oxo-4α-hidroxi-13,14,15,16-tetranorclerodan-12-oico, e do flavonoide 3-O-β-D-glicopiranosilquercetina. A investigaÃÃo do extrato hexÃnico das raÃzes levou ao isolamento de um triterpeno, Ãcido acetilaleuritÃlico, do dÃmero inÃdito Ãcido ent-17(α-pinen-10â-il)-15-oxocauran-18-oico, de dois novos diterpenos clerodanos, 3-oxo-15,16-epoxi-4α,12-dihidroxicleroda-13(16),14-dieno e 15,16-epoxi-3α,4α,12-trihidroxicleroda-13(16),14-dieno, um diterpeno do tipo halimano, 15,16-epoxi-3α,12-dihidroxihalima-5(10),13(16),14-trieno, e da mistura dos esteroides β-sitosterol e estigmasterol. Do extrato etanÃlico das raÃzes foram isolados dois flavonoides, 3-O-β-D-glicopiranosilcanferol e ombuina-3-O-β-rutinosÃdeo, e trÃs diterpenos clerodanos inÃditos, 3α,4α,15,16-tetrahidroxicleroda-13-eno, 6-(β-D-glicopiranosil)-3,12-dioxo-15,16-epoxi-4α-hidroxicleroda-13(16),14-dieno e Ãcido 3-oxo-4α,12-dihidroxi-14,15,16-trinorclerodan-13-oico. Foram preparadas quatro amidas aromÃticas derivadas do Ãcido ent-caur-16-en-18-oico e os respectivos Ãsteres metÃlicos dos Ãcidos ent-caur-16-en-18-oico e ent-caur-16-en-15-oxo-18-oico. Foram preparados dois derivados reacionais obtidos atravÃs de reaÃÃes de reduÃÃo do diterpeno clerodano 3,12-dioxo-15,16-epoxi-4α-hidroxicleroda-13(16),14-dieno e outro atravÃs da biotransformaÃÃo deste diterpeno pelo fungo Rhizopus stolonifer. Alguns compostos isolados e derivados foram submetidos a testes de atividade citotÃxica, utilizando linhagens de cÃlulas tumorais de ovÃrio (OVCAR-8), glioblastoma (SF-295) e colÃn (HCT-116), onde testes preliminares indicaram que os compostos ent-caur-16-en-15-oxo-18-oico e Ãcido ent-17(α-pinen-10â-il)-15-oxocauran-18-oico apresentaram atividade. Os metabÃlitos secundÃrios foram isolados atravÃs de tÃcnicas cromatogrÃficas usuais, utilizando cromatografia em camada delgada, cromatografia em coluna, cromatografia por exclusÃo molecular e cromatografia lÃquida de alta eficiÃncia. A determinaÃÃo estrutural foi realizada atravÃs de mÃtodos fÃsicos (ponto de fusÃo e rotaÃÃo Ãptica) e do uso de tÃcnicas espectroscÃpicas e espectromÃtricas como infravermelho (IV), espectrometria de massas de alta resoluÃÃo e ressonÃncia magnÃtica nuclear de hidrogÃnio (RMN 1H) e carbono-13 (RMN 13C), incluindo experimentos bidimensionais, alÃm de comparaÃÃo com dados da literatura.CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superiorhttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14361application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:27:34Zmail@mail.com -
dc.title.pt.fl_str_mv Estudo quÃmico de Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)
dc.title.alternative.en.fl_str_mv Chemical study of Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)
title Estudo quÃmico de Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)
spellingShingle Estudo quÃmico de Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)
Antonio HonÃrio de Sousa
Diterpenos cauranos
Diterpenos clerodanos
Atividade citotÃxica
Kaurane diterpenes
Clerodane diterpenes
Cytotoxic activity
QUIMICA ORGANICA
title_short Estudo quÃmico de Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)
title_full Estudo quÃmico de Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)
title_fullStr Estudo quÃmico de Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)
title_full_unstemmed Estudo quÃmico de Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)
title_sort Estudo quÃmico de Croton Limae A. P. S. Gomes, M. F. Sales & P. E. Berry (Euphorbiaceae)
author Antonio HonÃrio de Sousa
author_facet Antonio HonÃrio de Sousa
author_role author
dc.contributor.advisor1.fl_str_mv Mary Anne Sousa Lima
dc.contributor.advisor1ID.fl_str_mv 32421508304
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/0781721524175361
dc.contributor.referee1.fl_str_mv Francisco Josà Queiroz Monte
dc.contributor.referee1ID.fl_str_mv 02045737349
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/5189263761682019
dc.contributor.referee2.fl_str_mv Maria Rose Jane Ribeiro Albuquerque
dc.contributor.referee2ID.fl_str_mv 26642280300
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/5606331204668066
dc.contributor.referee3.fl_str_mv Francisco Geraldo Barbosa
dc.contributor.referee3ID.fl_str_mv 56168250344
dc.contributor.referee4.fl_str_mv Selene Maia de Morais
dc.contributor.referee4ID.fl_str_mv 05167965349
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/9980263926363134
dc.contributor.authorID.fl_str_mv 00023755326
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/7572639531262727
dc.contributor.author.fl_str_mv Antonio HonÃrio de Sousa
contributor_str_mv Mary Anne Sousa Lima
Francisco Josà Queiroz Monte
Maria Rose Jane Ribeiro Albuquerque
Francisco Geraldo Barbosa
Selene Maia de Morais
dc.subject.por.fl_str_mv Diterpenos cauranos
Diterpenos clerodanos
Atividade citotÃxica
topic Diterpenos cauranos
Diterpenos clerodanos
Atividade citotÃxica
Kaurane diterpenes
Clerodane diterpenes
Cytotoxic activity
QUIMICA ORGANICA
dc.subject.eng.fl_str_mv Kaurane diterpenes
Clerodane diterpenes
Cytotoxic activity
dc.subject.cnpq.fl_str_mv QUIMICA ORGANICA
dc.description.sponsorship.fl_txt_mv CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior
dc.description.abstract.por.fl_txt_mv The present work reports the chemical study related to the stem and the roots of Croton limae, collected in AndaraÃ/BA. The phytochemical investigation of ethanol extract from the stem lead to the isolation of two kaurane-type diterpenes, ent-kaur-16-en-18-oic acid and ent-kaur-16-en-15-oxo-18-oic acid, two clerodane-type diterpenes, 3,12-dioxo-15,16-epoxy-4α-hydroxycleroda-13(16),14-diene and 3-oxo-4α-hydroxy-13,14,15,16-tetranorclerodan-12-oic acid, and the flavonoid quercetin 3-O-β-D-glucopyranoside. The investigation of the hexane extract from the roots lead to the isolation of one triterpene, acetyl aleuritolic acid, the new dimer ent-17(α-pinen-10â-yl)-15-oxokauran-18-oic acid, two news clerodane diterpenes, 3-oxo-15,16-epoxy-4α,12-dihydroxycleroda-13(16),14-diene and 15,16-epoxy-3α,4α,12-trihydroxycleroda-13(16),14-diene, one halimane-type diterpene, 15,16-epoxy-3α,12-dihydroxyhalima-5(10),13(16),14-triene and the mixture of steroids β-sitosterol and stigmasterol. From the ethanol extract of the roots, it was possible to isolate the flavonoids kaempferol 3-O-β-glucopyranoside and ombuine 3-O-β-rutinoside and the three new clerodane diterpenes 3α,4α,15,16-tetrahydroxyclerod-13-ene, 6-(β-D-glucopyranosyl)-3,12-dioxo-15,16-epoxi-4α-hydroxycleroda-13(16),14-dieno and 3-oxo-4α,12-dihydroxy-14,15,16-trinorclerodan-13-oic acid. Four aromatic derivatives amides from ent-kaur-16-en-18-oic acid were prepared through nucleophilic substitutive reactions. The corresponding methyl esters from the ent-kaur-16-en-18-oic acid and ent-kaur-16-en-15-oxo-18-oic acid were also obtained. Two new derivatives from 3,12-dioxo-15,16-epoxi-4α-hidroxicleroda-13(16),14-dieno were prepared through reduction reaction and another one by the biotransformation of diterpene, made by the fungus Rhizopus stolonifer. Some isolated compounds and derivatives were submited to cytotoxic activity using ovarian (OVCAR-8), glioblastoma (SF-295) and colon (HCT-116) cell lines, and the compounds ent-kaur-16-en-15-oxo-18-oic acid and ent-17(α-pinen-10â-yl)-15-oxokauran-18-oic acid registered activity during preliminaries assays. The secondary metabolites were isolated through usual chromatography techniques, using thin layer chromatography, column chromatography, size exclusion chromatography and high performance liquid chromatography. The determination of the structure of the isolated compounds was performed through physical (melting point and optical rotation) and spectrometric techniques, such infrared (IR), high resolution mass spectrometry and nuclear magnetic resonance (NMR), including bidimensional experiments, and comparison with literature data.
O presente trabalho relata o estudo quÃmico do caule e das raÃzes de Croton limae, coletado no municÃpio de AndaraÃ-BA. A investigaÃÃo fitoquÃmica do extrato etanÃlico do caule levou ao isolamento de dois diterpenos do tipo caurano, Ãcido ent-caur-16-en-18-oico e Ãcido ent-caur-16-en-15-oxo-18-oico, dois diterpenos do tipo clerodano, 3,12-dioxo-15,16-epoxi-4α-hidroxicleroda-13(16),14-dieno e Ãcido 3-oxo-4α-hidroxi-13,14,15,16-tetranorclerodan-12-oico, e do flavonoide 3-O-β-D-glicopiranosilquercetina. A investigaÃÃo do extrato hexÃnico das raÃzes levou ao isolamento de um triterpeno, Ãcido acetilaleuritÃlico, do dÃmero inÃdito Ãcido ent-17(α-pinen-10â-il)-15-oxocauran-18-oico, de dois novos diterpenos clerodanos, 3-oxo-15,16-epoxi-4α,12-dihidroxicleroda-13(16),14-dieno e 15,16-epoxi-3α,4α,12-trihidroxicleroda-13(16),14-dieno, um diterpeno do tipo halimano, 15,16-epoxi-3α,12-dihidroxihalima-5(10),13(16),14-trieno, e da mistura dos esteroides β-sitosterol e estigmasterol. Do extrato etanÃlico das raÃzes foram isolados dois flavonoides, 3-O-β-D-glicopiranosilcanferol e ombuina-3-O-β-rutinosÃdeo, e trÃs diterpenos clerodanos inÃditos, 3α,4α,15,16-tetrahidroxicleroda-13-eno, 6-(β-D-glicopiranosil)-3,12-dioxo-15,16-epoxi-4α-hidroxicleroda-13(16),14-dieno e Ãcido 3-oxo-4α,12-dihidroxi-14,15,16-trinorclerodan-13-oico. Foram preparadas quatro amidas aromÃticas derivadas do Ãcido ent-caur-16-en-18-oico e os respectivos Ãsteres metÃlicos dos Ãcidos ent-caur-16-en-18-oico e ent-caur-16-en-15-oxo-18-oico. Foram preparados dois derivados reacionais obtidos atravÃs de reaÃÃes de reduÃÃo do diterpeno clerodano 3,12-dioxo-15,16-epoxi-4α-hidroxicleroda-13(16),14-dieno e outro atravÃs da biotransformaÃÃo deste diterpeno pelo fungo Rhizopus stolonifer. Alguns compostos isolados e derivados foram submetidos a testes de atividade citotÃxica, utilizando linhagens de cÃlulas tumorais de ovÃrio (OVCAR-8), glioblastoma (SF-295) e colÃn (HCT-116), onde testes preliminares indicaram que os compostos ent-caur-16-en-15-oxo-18-oico e Ãcido ent-17(α-pinen-10â-il)-15-oxocauran-18-oico apresentaram atividade. Os metabÃlitos secundÃrios foram isolados atravÃs de tÃcnicas cromatogrÃficas usuais, utilizando cromatografia em camada delgada, cromatografia em coluna, cromatografia por exclusÃo molecular e cromatografia lÃquida de alta eficiÃncia. A determinaÃÃo estrutural foi realizada atravÃs de mÃtodos fÃsicos (ponto de fusÃo e rotaÃÃo Ãptica) e do uso de tÃcnicas espectroscÃpicas e espectromÃtricas como infravermelho (IV), espectrometria de massas de alta resoluÃÃo e ressonÃncia magnÃtica nuclear de hidrogÃnio (RMN 1H) e carbono-13 (RMN 13C), incluindo experimentos bidimensionais, alÃm de comparaÃÃo com dados da literatura.
description The present work reports the chemical study related to the stem and the roots of Croton limae, collected in AndaraÃ/BA. The phytochemical investigation of ethanol extract from the stem lead to the isolation of two kaurane-type diterpenes, ent-kaur-16-en-18-oic acid and ent-kaur-16-en-15-oxo-18-oic acid, two clerodane-type diterpenes, 3,12-dioxo-15,16-epoxy-4α-hydroxycleroda-13(16),14-diene and 3-oxo-4α-hydroxy-13,14,15,16-tetranorclerodan-12-oic acid, and the flavonoid quercetin 3-O-β-D-glucopyranoside. The investigation of the hexane extract from the roots lead to the isolation of one triterpene, acetyl aleuritolic acid, the new dimer ent-17(α-pinen-10â-yl)-15-oxokauran-18-oic acid, two news clerodane diterpenes, 3-oxo-15,16-epoxy-4α,12-dihydroxycleroda-13(16),14-diene and 15,16-epoxy-3α,4α,12-trihydroxycleroda-13(16),14-diene, one halimane-type diterpene, 15,16-epoxy-3α,12-dihydroxyhalima-5(10),13(16),14-triene and the mixture of steroids β-sitosterol and stigmasterol. From the ethanol extract of the roots, it was possible to isolate the flavonoids kaempferol 3-O-β-glucopyranoside and ombuine 3-O-β-rutinoside and the three new clerodane diterpenes 3α,4α,15,16-tetrahydroxyclerod-13-ene, 6-(β-D-glucopyranosyl)-3,12-dioxo-15,16-epoxi-4α-hydroxycleroda-13(16),14-dieno and 3-oxo-4α,12-dihydroxy-14,15,16-trinorclerodan-13-oic acid. Four aromatic derivatives amides from ent-kaur-16-en-18-oic acid were prepared through nucleophilic substitutive reactions. The corresponding methyl esters from the ent-kaur-16-en-18-oic acid and ent-kaur-16-en-15-oxo-18-oic acid were also obtained. Two new derivatives from 3,12-dioxo-15,16-epoxi-4α-hidroxicleroda-13(16),14-dieno were prepared through reduction reaction and another one by the biotransformation of diterpene, made by the fungus Rhizopus stolonifer. Some isolated compounds and derivatives were submited to cytotoxic activity using ovarian (OVCAR-8), glioblastoma (SF-295) and colon (HCT-116) cell lines, and the compounds ent-kaur-16-en-15-oxo-18-oic acid and ent-17(α-pinen-10â-yl)-15-oxokauran-18-oic acid registered activity during preliminaries assays. The secondary metabolites were isolated through usual chromatography techniques, using thin layer chromatography, column chromatography, size exclusion chromatography and high performance liquid chromatography. The determination of the structure of the isolated compounds was performed through physical (melting point and optical rotation) and spectrometric techniques, such infrared (IR), high resolution mass spectrometry and nuclear magnetic resonance (NMR), including bidimensional experiments, and comparison with literature data.
publishDate 2014
dc.date.issued.fl_str_mv 2014-08-22
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
status_str publishedVersion
format doctoralThesis
dc.identifier.uri.fl_str_mv http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14361
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dc.publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.publisher.program.fl_str_mv Programa de PÃs-GraduaÃÃo em QuÃmica
dc.publisher.initials.fl_str_mv UFC
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFC
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instname_str Universidade Federal do Ceará
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