Study about renal effects of <i>Crotalus durissus collilineatus</i> snake venom
Autor(a) principal: | |
---|---|
Data de Publicação: | 2005 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFC |
Texto Completo: | http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13 |
Resumo: | Crotalus durissus collilineatus is a snake usually found in semideciduous forest, the Cerrado region and its bites constitutes an important health problem. The most serious systemic change and primary cause of death is acute renal failure although the mecanisms of the damaging effects are not totally understood. We investigated the biological effects promoted by Crotalus durissus collilineatus crude venom and its fractions crotoxin and phopholipase A2. The toxic effects of C d collilineatus crude venom were evaluated by the histopathological analysis of organs such as heart, kidney, brain, lung and liver. Wistar rats were inoculated intraperitoneally with C d collilineatus crude venom. The liver showed steatosis and microvacuolation.The other organs showed normal morphological aspects. Renal effects were evaluated by the isolated perfused rat kidney method.The crude venom used at the lowest dose (10Âg) increased perfusion pressure (PP), urinary flow (UF), and glomerular filtration rate (GFR), with maximal effect at 120min (PP: control(120) 110.3+/-3.69; venom(120) 126.8+/-10.2; UF: control(120) 0.19+/-0.03; venom(120) 0.23+/-0.06; GFR: control(120) 0.79+/-0.07; venom(120) 1.17+/-0.4). There was no effect on the percent of sodium tubular transport (%TNa+), the percent of potassium tubular transport (%TK+) and the percent of chloride tubular transport (%TCl-) The highest dose of the crude venom (30Âg) caused a significantly decrease in PP (control(120) 110.3Â3.69; venom(120) 96.7Â8.1), RVR (control(120) 6.42Â0.78; venom(120)4.8Â0.56), UF (control(120) 0.19Â0.03; venom(120) 0.12Â0.01) and GFR (control(120) 0.79Â0.07; venom(120)0.53Â0.09). There was not effect on the percent of electrolytes tubular transport (%TNa+, %TK+ and %TCl-). Crotoxin (10mcg) produced a decrease in GFR (control(120) 0.79Â0.07; crotoxin(120) 0.31Â0.10), while PP, RVR and UF remained stable. Crotoxin also reduced %TK+ (control(120) 69.94Â6.49; crotoxin(120) 33.28Â4.78) and %TCl- (control(120) 79.53Â2.67; crotoxin (120) 64.62Â6.93) with maximal effect at 120min. Kidney perfused with phospholipase A2 (PLA2) showed a decrease in GFR (control(120) 0.79Â0.07; PLA2 (120) 0.52Â0.07) at 120min, whereas PP, RVR, UF and %TNa+ remained stable. PLA2 also reduced %TK+ (control(120) 69.94Â6.49; PLA2 (120) 56.26Â6.81) and %TCl- (control(60) 82.25Â2.72; PLA2 (60) 75.04Â4.26) at 60min. These results altogether indicate that Crotalus durissus collilineatus venom caused significative alterations in the renal parameters as well as hepatic damage. |
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info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisStudy about renal effects of <i>Crotalus durissus collilineatus</i> snake venomEstudo dos efeitos renais do veneno da serpente <i>Crotalus durissus collilineatus</i>2005-01-12Helena Serra Azul Monteiro03277470300http://lattes.cnpq.br/3830155707659519Francisca ClÃa FlorenÃo de Sousa31636020372http://lattes.cnpq.br/1180465052181572Gisela Costa CamarÃo06001734372http://lattes.cnpq.br/881251533662289380790739372http://buscatextual.cnpq.br/buscatextual/visualizacv.jsp?id=K4739922P3Daniela Nascimento AmoraUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em FarmacologiaUFCBRCrotalus Rim PerfusÃoCrotalus Snake venom Crotoxin Kidney PerfusionFARMACOLOGIA CARDIORENALCrotalus durissus collilineatus is a snake usually found in semideciduous forest, the Cerrado region and its bites constitutes an important health problem. The most serious systemic change and primary cause of death is acute renal failure although the mecanisms of the damaging effects are not totally understood. We investigated the biological effects promoted by Crotalus durissus collilineatus crude venom and its fractions crotoxin and phopholipase A2. The toxic effects of C d collilineatus crude venom were evaluated by the histopathological analysis of organs such as heart, kidney, brain, lung and liver. Wistar rats were inoculated intraperitoneally with C d collilineatus crude venom. The liver showed steatosis and microvacuolation.The other organs showed normal morphological aspects. Renal effects were evaluated by the isolated perfused rat kidney method.The crude venom used at the lowest dose (10Âg) increased perfusion pressure (PP), urinary flow (UF), and glomerular filtration rate (GFR), with maximal effect at 120min (PP: control(120) 110.3+/-3.69; venom(120) 126.8+/-10.2; UF: control(120) 0.19+/-0.03; venom(120) 0.23+/-0.06; GFR: control(120) 0.79+/-0.07; venom(120) 1.17+/-0.4). There was no effect on the percent of sodium tubular transport (%TNa+), the percent of potassium tubular transport (%TK+) and the percent of chloride tubular transport (%TCl-) The highest dose of the crude venom (30Âg) caused a significantly decrease in PP (control(120) 110.3Â3.69; venom(120) 96.7Â8.1), RVR (control(120) 6.42Â0.78; venom(120)4.8Â0.56), UF (control(120) 0.19Â0.03; venom(120) 0.12Â0.01) and GFR (control(120) 0.79Â0.07; venom(120)0.53Â0.09). There was not effect on the percent of electrolytes tubular transport (%TNa+, %TK+ and %TCl-). Crotoxin (10mcg) produced a decrease in GFR (control(120) 0.79Â0.07; crotoxin(120) 0.31Â0.10), while PP, RVR and UF remained stable. Crotoxin also reduced %TK+ (control(120) 69.94Â6.49; crotoxin(120) 33.28Â4.78) and %TCl- (control(120) 79.53Â2.67; crotoxin (120) 64.62Â6.93) with maximal effect at 120min. Kidney perfused with phospholipase A2 (PLA2) showed a decrease in GFR (control(120) 0.79Â0.07; PLA2 (120) 0.52Â0.07) at 120min, whereas PP, RVR, UF and %TNa+ remained stable. PLA2 also reduced %TK+ (control(120) 69.94Â6.49; PLA2 (120) 56.26Â6.81) and %TCl- (control(60) 82.25Â2.72; PLA2 (60) 75.04Â4.26) at 60min. These results altogether indicate that Crotalus durissus collilineatus venom caused significative alterations in the renal parameters as well as hepatic damage.A serpente Crotalus durissus collilineatus à encontrada na regiÃo do Cerrado e o acidente causado por esta espÃcie constitui um problema de saÃde pÃblica. A insuficiÃncia renal aguda à a alteraÃÃo sistÃmica mais sÃria, apesar dos seus mecanismos nÃo serem completamente esclarecidos. O objetivo deste trabalho foi estudar os efeitos biolÃgicos produzidos pelo veneno bruto de Crotalus durissus collilineatus e pelas fraÃÃes crotoxina e fosfolipase A2. Foi realizado o estudo da toxicidade aguda do veneno bruto de C d collilineatus, atravÃs da anÃlise histolÃgica de coraÃÃo, cÃrebro, rins, pulmÃes e fÃgado de ratos tratados com doses crescente do veneno. Nesse estudo foi observada a presenÃa de alteraÃÃes hepÃticas como microvacualizaÃÃo e esteatose, enquanto os demais ÃrgÃos apresentaram aspectos normais. Os efeitos renais foram avaliados atravÃs do mÃtodo de perfusÃo de rim isolado de rato. O veneno bruto, usado na dose de 10Âg, causou um aumento na pressÃo de perfusÃo (PP), no fluxo urinÃrio (FU) e no ritmo de filtraÃÃo glomerular (RFG), com efeito mÃximo aos 120min (PP: controle(120) 110,3+/-3,69; veneno(120) 126,8+/-10,2;FU: controle(120) 0,19+/-0,03; veneno(120) 0,23+/-0,06; RFG: controle(120) 0,79+/-0,07; veneno(120) 1,17+/-0,4). Essa dose nÃo produziu alteraÃÃes no transporte tubular de sÃdio (%TNa+), potÃssio (%TK+) e de cloreto (%TCl-). A dose mais elevada de veneno bruto (30Âg) causou um decrÃscimo significativo, com efeito mÃximo, aos 120min, na PP(controle(120) 110,3+/-3,69; veneno(120) 96,7+/-8,1), na RVR (controle(120) 6,42+/-0,78; veneno(120) 4,8+/-0,56), no FU (controle(120) 0,19+/-0,03; veneno(120) 0,12+/-0,01) e no RFG (controle(120) 0,79+/-0,07; veneno(120) 0,53+/-0,09). NÃo ocorreram alteraÃÃes no transporte tubular de eletrÃlitos. A fraÃÃo crotoxina nÃo produziu alteraÃÃes no RFG (controle(120) 0,79+/-0,07; crotoxina(120) 0,31+/-0,10). Esta fraÃÃo tambÃm reduziu os %TK+ (controle(120) 69,94+/-6,49; crotoxina(120) 33,28+/-4,78) e %TCl- (controle(120) 79,53+/-2,67, crotoxina(120) 64,62+/-6,93). O grupo perfundido com FLA2 apresentou um decrÃscimo no RFG (controle(120) 0,79+/-0,07; FLA2 (120) 0,52+/-0,07), enquanto a PP, a RVR, o FU e o %TNa+ permaneceram estÃveis. Foram observadas reduÃÃes no %TK+ aos 120min (controle(120) 69,94+/-6,49; FLA2(120) 56,26+/-6,81) e aos 60min, no %TCl- (controle(60) 82,25+/-2,72; FLA2(60) 75,04+/-4,26). Foi observada degeneraÃÃo hidrÃpico vacuolar e a presenÃa de material proteinÃceo nos tÃbulos renais, na anÃlise histolÃgica dos rins perfundidos tanto com veneno bruto quanto com as fraÃÃes. Estes resultados indicam que o veneno de Crotalus durissus collilineatus causou alteraÃÃes significativas nos parÃmetros renais e nos aspectos morfolÃgicos hepÃticos.FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgicoCoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superiorhttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:13:06Zmail@mail.com - |
dc.title.en.fl_str_mv |
Study about renal effects of <i>Crotalus durissus collilineatus</i> snake venom |
dc.title.alternative.pt.fl_str_mv |
Estudo dos efeitos renais do veneno da serpente <i>Crotalus durissus collilineatus</i> |
title |
Study about renal effects of <i>Crotalus durissus collilineatus</i> snake venom |
spellingShingle |
Study about renal effects of <i>Crotalus durissus collilineatus</i> snake venom Daniela Nascimento Amora Crotalus Rim PerfusÃo Crotalus Snake venom Crotoxin Kidney Perfusion FARMACOLOGIA CARDIORENAL |
title_short |
Study about renal effects of <i>Crotalus durissus collilineatus</i> snake venom |
title_full |
Study about renal effects of <i>Crotalus durissus collilineatus</i> snake venom |
title_fullStr |
Study about renal effects of <i>Crotalus durissus collilineatus</i> snake venom |
title_full_unstemmed |
Study about renal effects of <i>Crotalus durissus collilineatus</i> snake venom |
title_sort |
Study about renal effects of <i>Crotalus durissus collilineatus</i> snake venom |
author |
Daniela Nascimento Amora |
author_facet |
Daniela Nascimento Amora |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Helena Serra Azul Monteiro |
dc.contributor.advisor1ID.fl_str_mv |
03277470300 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3830155707659519 |
dc.contributor.referee1.fl_str_mv |
Francisca ClÃa FlorenÃo de Sousa |
dc.contributor.referee1ID.fl_str_mv |
31636020372 |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/1180465052181572 |
dc.contributor.referee2.fl_str_mv |
Gisela Costa CamarÃo |
dc.contributor.referee2ID.fl_str_mv |
06001734372 |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/8812515336622893 |
dc.contributor.authorID.fl_str_mv |
80790739372 |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.jsp?id=K4739922P3 |
dc.contributor.author.fl_str_mv |
Daniela Nascimento Amora |
contributor_str_mv |
Helena Serra Azul Monteiro Francisca ClÃa FlorenÃo de Sousa Gisela Costa CamarÃo |
dc.subject.por.fl_str_mv |
Crotalus Rim PerfusÃo |
topic |
Crotalus Rim PerfusÃo Crotalus Snake venom Crotoxin Kidney Perfusion FARMACOLOGIA CARDIORENAL |
dc.subject.eng.fl_str_mv |
Crotalus Snake venom Crotoxin Kidney Perfusion |
dc.subject.cnpq.fl_str_mv |
FARMACOLOGIA CARDIORENAL |
dc.description.sponsorship.fl_txt_mv |
FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior |
dc.description.abstract.por.fl_txt_mv |
Crotalus durissus collilineatus is a snake usually found in semideciduous forest, the Cerrado region and its bites constitutes an important health problem. The most serious systemic change and primary cause of death is acute renal failure although the mecanisms of the damaging effects are not totally understood. We investigated the biological effects promoted by Crotalus durissus collilineatus crude venom and its fractions crotoxin and phopholipase A2. The toxic effects of C d collilineatus crude venom were evaluated by the histopathological analysis of organs such as heart, kidney, brain, lung and liver. Wistar rats were inoculated intraperitoneally with C d collilineatus crude venom. The liver showed steatosis and microvacuolation.The other organs showed normal morphological aspects. Renal effects were evaluated by the isolated perfused rat kidney method.The crude venom used at the lowest dose (10Âg) increased perfusion pressure (PP), urinary flow (UF), and glomerular filtration rate (GFR), with maximal effect at 120min (PP: control(120) 110.3+/-3.69; venom(120) 126.8+/-10.2; UF: control(120) 0.19+/-0.03; venom(120) 0.23+/-0.06; GFR: control(120) 0.79+/-0.07; venom(120) 1.17+/-0.4). There was no effect on the percent of sodium tubular transport (%TNa+), the percent of potassium tubular transport (%TK+) and the percent of chloride tubular transport (%TCl-) The highest dose of the crude venom (30Âg) caused a significantly decrease in PP (control(120) 110.3Â3.69; venom(120) 96.7Â8.1), RVR (control(120) 6.42Â0.78; venom(120)4.8Â0.56), UF (control(120) 0.19Â0.03; venom(120) 0.12Â0.01) and GFR (control(120) 0.79Â0.07; venom(120)0.53Â0.09). There was not effect on the percent of electrolytes tubular transport (%TNa+, %TK+ and %TCl-). Crotoxin (10mcg) produced a decrease in GFR (control(120) 0.79Â0.07; crotoxin(120) 0.31Â0.10), while PP, RVR and UF remained stable. Crotoxin also reduced %TK+ (control(120) 69.94Â6.49; crotoxin(120) 33.28Â4.78) and %TCl- (control(120) 79.53Â2.67; crotoxin (120) 64.62Â6.93) with maximal effect at 120min. Kidney perfused with phospholipase A2 (PLA2) showed a decrease in GFR (control(120) 0.79Â0.07; PLA2 (120) 0.52Â0.07) at 120min, whereas PP, RVR, UF and %TNa+ remained stable. PLA2 also reduced %TK+ (control(120) 69.94Â6.49; PLA2 (120) 56.26Â6.81) and %TCl- (control(60) 82.25Â2.72; PLA2 (60) 75.04Â4.26) at 60min. These results altogether indicate that Crotalus durissus collilineatus venom caused significative alterations in the renal parameters as well as hepatic damage. A serpente Crotalus durissus collilineatus à encontrada na regiÃo do Cerrado e o acidente causado por esta espÃcie constitui um problema de saÃde pÃblica. A insuficiÃncia renal aguda à a alteraÃÃo sistÃmica mais sÃria, apesar dos seus mecanismos nÃo serem completamente esclarecidos. O objetivo deste trabalho foi estudar os efeitos biolÃgicos produzidos pelo veneno bruto de Crotalus durissus collilineatus e pelas fraÃÃes crotoxina e fosfolipase A2. Foi realizado o estudo da toxicidade aguda do veneno bruto de C d collilineatus, atravÃs da anÃlise histolÃgica de coraÃÃo, cÃrebro, rins, pulmÃes e fÃgado de ratos tratados com doses crescente do veneno. Nesse estudo foi observada a presenÃa de alteraÃÃes hepÃticas como microvacualizaÃÃo e esteatose, enquanto os demais ÃrgÃos apresentaram aspectos normais. Os efeitos renais foram avaliados atravÃs do mÃtodo de perfusÃo de rim isolado de rato. O veneno bruto, usado na dose de 10Âg, causou um aumento na pressÃo de perfusÃo (PP), no fluxo urinÃrio (FU) e no ritmo de filtraÃÃo glomerular (RFG), com efeito mÃximo aos 120min (PP: controle(120) 110,3+/-3,69; veneno(120) 126,8+/-10,2;FU: controle(120) 0,19+/-0,03; veneno(120) 0,23+/-0,06; RFG: controle(120) 0,79+/-0,07; veneno(120) 1,17+/-0,4). Essa dose nÃo produziu alteraÃÃes no transporte tubular de sÃdio (%TNa+), potÃssio (%TK+) e de cloreto (%TCl-). A dose mais elevada de veneno bruto (30Âg) causou um decrÃscimo significativo, com efeito mÃximo, aos 120min, na PP(controle(120) 110,3+/-3,69; veneno(120) 96,7+/-8,1), na RVR (controle(120) 6,42+/-0,78; veneno(120) 4,8+/-0,56), no FU (controle(120) 0,19+/-0,03; veneno(120) 0,12+/-0,01) e no RFG (controle(120) 0,79+/-0,07; veneno(120) 0,53+/-0,09). NÃo ocorreram alteraÃÃes no transporte tubular de eletrÃlitos. A fraÃÃo crotoxina nÃo produziu alteraÃÃes no RFG (controle(120) 0,79+/-0,07; crotoxina(120) 0,31+/-0,10). Esta fraÃÃo tambÃm reduziu os %TK+ (controle(120) 69,94+/-6,49; crotoxina(120) 33,28+/-4,78) e %TCl- (controle(120) 79,53+/-2,67, crotoxina(120) 64,62+/-6,93). O grupo perfundido com FLA2 apresentou um decrÃscimo no RFG (controle(120) 0,79+/-0,07; FLA2 (120) 0,52+/-0,07), enquanto a PP, a RVR, o FU e o %TNa+ permaneceram estÃveis. Foram observadas reduÃÃes no %TK+ aos 120min (controle(120) 69,94+/-6,49; FLA2(120) 56,26+/-6,81) e aos 60min, no %TCl- (controle(60) 82,25+/-2,72; FLA2(60) 75,04+/-4,26). Foi observada degeneraÃÃo hidrÃpico vacuolar e a presenÃa de material proteinÃceo nos tÃbulos renais, na anÃlise histolÃgica dos rins perfundidos tanto com veneno bruto quanto com as fraÃÃes. Estes resultados indicam que o veneno de Crotalus durissus collilineatus causou alteraÃÃes significativas nos parÃmetros renais e nos aspectos morfolÃgicos hepÃticos. |
description |
Crotalus durissus collilineatus is a snake usually found in semideciduous forest, the Cerrado region and its bites constitutes an important health problem. The most serious systemic change and primary cause of death is acute renal failure although the mecanisms of the damaging effects are not totally understood. We investigated the biological effects promoted by Crotalus durissus collilineatus crude venom and its fractions crotoxin and phopholipase A2. The toxic effects of C d collilineatus crude venom were evaluated by the histopathological analysis of organs such as heart, kidney, brain, lung and liver. Wistar rats were inoculated intraperitoneally with C d collilineatus crude venom. The liver showed steatosis and microvacuolation.The other organs showed normal morphological aspects. Renal effects were evaluated by the isolated perfused rat kidney method.The crude venom used at the lowest dose (10Âg) increased perfusion pressure (PP), urinary flow (UF), and glomerular filtration rate (GFR), with maximal effect at 120min (PP: control(120) 110.3+/-3.69; venom(120) 126.8+/-10.2; UF: control(120) 0.19+/-0.03; venom(120) 0.23+/-0.06; GFR: control(120) 0.79+/-0.07; venom(120) 1.17+/-0.4). There was no effect on the percent of sodium tubular transport (%TNa+), the percent of potassium tubular transport (%TK+) and the percent of chloride tubular transport (%TCl-) The highest dose of the crude venom (30Âg) caused a significantly decrease in PP (control(120) 110.3Â3.69; venom(120) 96.7Â8.1), RVR (control(120) 6.42Â0.78; venom(120)4.8Â0.56), UF (control(120) 0.19Â0.03; venom(120) 0.12Â0.01) and GFR (control(120) 0.79Â0.07; venom(120)0.53Â0.09). There was not effect on the percent of electrolytes tubular transport (%TNa+, %TK+ and %TCl-). Crotoxin (10mcg) produced a decrease in GFR (control(120) 0.79Â0.07; crotoxin(120) 0.31Â0.10), while PP, RVR and UF remained stable. Crotoxin also reduced %TK+ (control(120) 69.94Â6.49; crotoxin(120) 33.28Â4.78) and %TCl- (control(120) 79.53Â2.67; crotoxin (120) 64.62Â6.93) with maximal effect at 120min. Kidney perfused with phospholipase A2 (PLA2) showed a decrease in GFR (control(120) 0.79Â0.07; PLA2 (120) 0.52Â0.07) at 120min, whereas PP, RVR, UF and %TNa+ remained stable. PLA2 also reduced %TK+ (control(120) 69.94Â6.49; PLA2 (120) 56.26Â6.81) and %TCl- (control(60) 82.25Â2.72; PLA2 (60) 75.04Â4.26) at 60min. These results altogether indicate that Crotalus durissus collilineatus venom caused significative alterations in the renal parameters as well as hepatic damage. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005-01-12 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
status_str |
publishedVersion |
format |
masterThesis |
dc.identifier.uri.fl_str_mv |
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13 |
url |
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal do Cearà |
dc.publisher.program.fl_str_mv |
Programa de PÃs-GraduaÃÃo em Farmacologia |
dc.publisher.initials.fl_str_mv |
UFC |
dc.publisher.country.fl_str_mv |
BR |
publisher.none.fl_str_mv |
Universidade Federal do Cearà |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFC instname:Universidade Federal do Ceará instacron:UFC |
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Biblioteca Digital de Teses e Dissertações da UFC |
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Biblioteca Digital de Teses e Dissertações da UFC |
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Universidade Federal do Ceará |
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UFC |
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UFC |
repository.name.fl_str_mv |
-
|
repository.mail.fl_str_mv |
mail@mail.com |
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1643295113029353472 |