Biomonitoramento CitogenÃtico, HematolÃgico e BioquÃmico em Agentes de Endemias Expostos à AgrotÃxicos no municÃpio de ValenÃa - PiauÃ
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFC |
Texto Completo: | http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15380 |
Resumo: | Insecticides based on organophosphates are widely used in eradication campaigns and high application of these products, without the use of biosecurity measures, contributes to the increased incidence of occupational poisoning in endemic agents. The study aimed to conduct a biomonitoring through biochemical, hematological and cytogenetic analyzes of agents of endemic occupationally exposed to organophosphate insecticides in the city of Valencia PiauÃ. The survey was conducted with 20 agents endemic and 20 non exposed workers. Applied a questionnaire recommended by the International Commission for Protection Against Environmental Mutagens and Carcinogens-ICPEMC, and biological material was collected for hematological, biochemical and cytogenetic analyzes. The population studied had a mean age of 44.15 years, working time of 14.75 years, weekly workload of 40 hours and 55% of agents said they use PPE. As for lifestyle 25% were smokers, 85% consumed alcohol and 30% report some underlying disease. Evaluating the hematological parameters no statistical significance when comparing the two groups. As biochemical variables for urea, creatinine, ALT, AST and BChE showed significant changes. In dosages of alkaline phosphatase and gamma glutamyl transferase, significant (p <0.01) compared to the unexposed group. Regarding the genotoxic analysis (cells with micronuclei), there was a statistically significant difference between the exposed groups (2.78) and unexposed (0.56). The nuclear changes were evidenced cariorrex (184.1 versus 717.0), karyolysis (138.5 versus 47.48), and binucleated cells (0.1413 versus 0.06087) of the exposed compared to the control group respectively. Although the numbers of karyorrhexis were more evident in the control group, and karyolysis binucleation parameters were genotoxicity along with micronuclei. |
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info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisBiomonitoramento CitogenÃtico, HematolÃgico e BioquÃmico em Agentes de Endemias Expostos à AgrotÃxicos no municÃpio de ValenÃa - PiauÃCytogenetic biomonitoring and laboratory in agents endemics exposed to pesticides organophosphorus the municipality of Valencia â PI2014-03-14Maria Elisabete Amaral de Moraes09041389334http://lattes.cnpq.br/3565768281344086Nylane Maria Nunes de Alencar32184573353http://lattes.cnpq.br/9219662256316695FabrÃcio Pires de Moura do Amaral90012291315http://lattes.cnpq.br/509494971314270370688621368http://lattes.cnpq.br/2936594950081795Tacyana Pires de Carvalho CostaUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em FarmacologiaUFCBRFARMACOLOGIA CLINICAInsecticides based on organophosphates are widely used in eradication campaigns and high application of these products, without the use of biosecurity measures, contributes to the increased incidence of occupational poisoning in endemic agents. The study aimed to conduct a biomonitoring through biochemical, hematological and cytogenetic analyzes of agents of endemic occupationally exposed to organophosphate insecticides in the city of Valencia PiauÃ. The survey was conducted with 20 agents endemic and 20 non exposed workers. Applied a questionnaire recommended by the International Commission for Protection Against Environmental Mutagens and Carcinogens-ICPEMC, and biological material was collected for hematological, biochemical and cytogenetic analyzes. The population studied had a mean age of 44.15 years, working time of 14.75 years, weekly workload of 40 hours and 55% of agents said they use PPE. As for lifestyle 25% were smokers, 85% consumed alcohol and 30% report some underlying disease. Evaluating the hematological parameters no statistical significance when comparing the two groups. As biochemical variables for urea, creatinine, ALT, AST and BChE showed significant changes. In dosages of alkaline phosphatase and gamma glutamyl transferase, significant (p <0.01) compared to the unexposed group. Regarding the genotoxic analysis (cells with micronuclei), there was a statistically significant difference between the exposed groups (2.78) and unexposed (0.56). The nuclear changes were evidenced cariorrex (184.1 versus 717.0), karyolysis (138.5 versus 47.48), and binucleated cells (0.1413 versus 0.06087) of the exposed compared to the control group respectively. Although the numbers of karyorrhexis were more evident in the control group, and karyolysis binucleation parameters were genotoxicity along with micronuclei.Os inseticidas à base de organofosforados sÃo amplamente utilizados em campanhas antivetoriais e a elevada aplicaÃÃo desses produtos, sem o emprego de medidas de biosseguranÃa, contribui para o aumento da incidÃncia de intoxicaÃÃo ocupacional em agentes de endemias. O estudo objetivou realizar um biomonitoramento atravÃs de anÃlises bioquÃmica, hematolÃgica e citogenÃtica de agentes de endemias expostos ocupacionalmente a inseticidas organofosforados no municÃpio de ValenÃa do PiauÃ. A pesquisa foi realizada com 20 agentes de endemias e 20 trabalhadores nÃo expostos ocupacionalmente. Aplicou-se um questionÃrio recomendado pela International Commission for Protection Against Environmental Mutagens and Carcinogens-ICPEMC, e coletou-se material biolÃgico para as anÃlises hematolÃgicas, bioquÃmicas e citogenÃtica. A populaÃÃo exposta apresentou mÃdia de idade de 44,15 anos, tempo de trabalho de 14,75 anos, carga horÃria semanal de 40 horas e 55% dos agentes afirmaram utilizar EPIs. Quanto aos hÃbitos de vida 25% sÃo tabagistas, 85% etilistas e 30% referem alguma doenÃa de base. Avaliando os parÃmetros hematolÃgicos nÃo houve significÃncia estatÃstica quando comparados os dois grupos. Quanto as variÃveis bioquÃmicas para ureia, creatinina, ALT, AST e BChE nÃo apresentaram alteraÃÃes significantes. Nas dosagens de fosfatase alcalina e gama glutamiltransferase, houve significÃncia (p<0,01) em relaÃÃo ao grupo nÃo exposto. Em relaÃÃo à anÃlise genotÃxica (cÃlulas com micronÃcleos), houve diferenÃa estatÃstica significativa entre os grupos exposto (2,78) e nÃo exposto (0,56). As alteraÃÃes nucleares evidenciadas foram cariorrex (184,1 contra 717,0), cariÃlise (138,5 contra 47,48), cÃlulas binucleadas (0,1413 contra 0,06087) do grupo exposto em relaÃÃo ao controle respectivamente. Embora os nÃmeros de cariorrex tenham sido mais evidenciados no grupo controle, as cariÃlises e as binucleaÃÃes foram parÃmetros de genotoxicidade juntamente com os micronÃcleos.nÃo hÃhttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15380application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:28:34Zmail@mail.com - |
dc.title.pt.fl_str_mv |
Biomonitoramento CitogenÃtico, HematolÃgico e BioquÃmico em Agentes de Endemias Expostos à AgrotÃxicos no municÃpio de ValenÃa - Piauà |
dc.title.alternative..fl_str_mv |
Cytogenetic biomonitoring and laboratory in agents endemics exposed to pesticides organophosphorus the municipality of Valencia â PI |
title |
Biomonitoramento CitogenÃtico, HematolÃgico e BioquÃmico em Agentes de Endemias Expostos à AgrotÃxicos no municÃpio de ValenÃa - Piauà |
spellingShingle |
Biomonitoramento CitogenÃtico, HematolÃgico e BioquÃmico em Agentes de Endemias Expostos à AgrotÃxicos no municÃpio de ValenÃa - Piauà Tacyana Pires de Carvalho Costa FARMACOLOGIA CLINICA |
title_short |
Biomonitoramento CitogenÃtico, HematolÃgico e BioquÃmico em Agentes de Endemias Expostos à AgrotÃxicos no municÃpio de ValenÃa - Piauà |
title_full |
Biomonitoramento CitogenÃtico, HematolÃgico e BioquÃmico em Agentes de Endemias Expostos à AgrotÃxicos no municÃpio de ValenÃa - Piauà |
title_fullStr |
Biomonitoramento CitogenÃtico, HematolÃgico e BioquÃmico em Agentes de Endemias Expostos à AgrotÃxicos no municÃpio de ValenÃa - Piauà |
title_full_unstemmed |
Biomonitoramento CitogenÃtico, HematolÃgico e BioquÃmico em Agentes de Endemias Expostos à AgrotÃxicos no municÃpio de ValenÃa - Piauà |
title_sort |
Biomonitoramento CitogenÃtico, HematolÃgico e BioquÃmico em Agentes de Endemias Expostos à AgrotÃxicos no municÃpio de ValenÃa - Piauà |
author |
Tacyana Pires de Carvalho Costa |
author_facet |
Tacyana Pires de Carvalho Costa |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Maria Elisabete Amaral de Moraes |
dc.contributor.advisor1ID.fl_str_mv |
09041389334 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3565768281344086 |
dc.contributor.referee1.fl_str_mv |
Nylane Maria Nunes de Alencar |
dc.contributor.referee1ID.fl_str_mv |
32184573353 |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/9219662256316695 |
dc.contributor.referee2.fl_str_mv |
FabrÃcio Pires de Moura do Amaral |
dc.contributor.referee2ID.fl_str_mv |
90012291315 |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/5094949713142703 |
dc.contributor.authorID.fl_str_mv |
70688621368 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/2936594950081795 |
dc.contributor.author.fl_str_mv |
Tacyana Pires de Carvalho Costa |
contributor_str_mv |
Maria Elisabete Amaral de Moraes Nylane Maria Nunes de Alencar FabrÃcio Pires de Moura do Amaral |
dc.subject.cnpq.fl_str_mv |
FARMACOLOGIA CLINICA |
topic |
FARMACOLOGIA CLINICA |
dc.description.sponsorship.fl_txt_mv |
nÃo hà |
dc.description.abstract..fl_txt_mv |
Insecticides based on organophosphates are widely used in eradication campaigns and high application of these products, without the use of biosecurity measures, contributes to the increased incidence of occupational poisoning in endemic agents. The study aimed to conduct a biomonitoring through biochemical, hematological and cytogenetic analyzes of agents of endemic occupationally exposed to organophosphate insecticides in the city of Valencia PiauÃ. The survey was conducted with 20 agents endemic and 20 non exposed workers. Applied a questionnaire recommended by the International Commission for Protection Against Environmental Mutagens and Carcinogens-ICPEMC, and biological material was collected for hematological, biochemical and cytogenetic analyzes. The population studied had a mean age of 44.15 years, working time of 14.75 years, weekly workload of 40 hours and 55% of agents said they use PPE. As for lifestyle 25% were smokers, 85% consumed alcohol and 30% report some underlying disease. Evaluating the hematological parameters no statistical significance when comparing the two groups. As biochemical variables for urea, creatinine, ALT, AST and BChE showed significant changes. In dosages of alkaline phosphatase and gamma glutamyl transferase, significant (p <0.01) compared to the unexposed group. Regarding the genotoxic analysis (cells with micronuclei), there was a statistically significant difference between the exposed groups (2.78) and unexposed (0.56). The nuclear changes were evidenced cariorrex (184.1 versus 717.0), karyolysis (138.5 versus 47.48), and binucleated cells (0.1413 versus 0.06087) of the exposed compared to the control group respectively. Although the numbers of karyorrhexis were more evident in the control group, and karyolysis binucleation parameters were genotoxicity along with micronuclei. |
dc.description.abstract.por.fl_txt_mv |
Os inseticidas à base de organofosforados sÃo amplamente utilizados em campanhas antivetoriais e a elevada aplicaÃÃo desses produtos, sem o emprego de medidas de biosseguranÃa, contribui para o aumento da incidÃncia de intoxicaÃÃo ocupacional em agentes de endemias. O estudo objetivou realizar um biomonitoramento atravÃs de anÃlises bioquÃmica, hematolÃgica e citogenÃtica de agentes de endemias expostos ocupacionalmente a inseticidas organofosforados no municÃpio de ValenÃa do PiauÃ. A pesquisa foi realizada com 20 agentes de endemias e 20 trabalhadores nÃo expostos ocupacionalmente. Aplicou-se um questionÃrio recomendado pela International Commission for Protection Against Environmental Mutagens and Carcinogens-ICPEMC, e coletou-se material biolÃgico para as anÃlises hematolÃgicas, bioquÃmicas e citogenÃtica. A populaÃÃo exposta apresentou mÃdia de idade de 44,15 anos, tempo de trabalho de 14,75 anos, carga horÃria semanal de 40 horas e 55% dos agentes afirmaram utilizar EPIs. Quanto aos hÃbitos de vida 25% sÃo tabagistas, 85% etilistas e 30% referem alguma doenÃa de base. Avaliando os parÃmetros hematolÃgicos nÃo houve significÃncia estatÃstica quando comparados os dois grupos. Quanto as variÃveis bioquÃmicas para ureia, creatinina, ALT, AST e BChE nÃo apresentaram alteraÃÃes significantes. Nas dosagens de fosfatase alcalina e gama glutamiltransferase, houve significÃncia (p<0,01) em relaÃÃo ao grupo nÃo exposto. Em relaÃÃo à anÃlise genotÃxica (cÃlulas com micronÃcleos), houve diferenÃa estatÃstica significativa entre os grupos exposto (2,78) e nÃo exposto (0,56). As alteraÃÃes nucleares evidenciadas foram cariorrex (184,1 contra 717,0), cariÃlise (138,5 contra 47,48), cÃlulas binucleadas (0,1413 contra 0,06087) do grupo exposto em relaÃÃo ao controle respectivamente. Embora os nÃmeros de cariorrex tenham sido mais evidenciados no grupo controle, as cariÃlises e as binucleaÃÃes foram parÃmetros de genotoxicidade juntamente com os micronÃcleos. |
description |
Insecticides based on organophosphates are widely used in eradication campaigns and high application of these products, without the use of biosecurity measures, contributes to the increased incidence of occupational poisoning in endemic agents. The study aimed to conduct a biomonitoring through biochemical, hematological and cytogenetic analyzes of agents of endemic occupationally exposed to organophosphate insecticides in the city of Valencia PiauÃ. The survey was conducted with 20 agents endemic and 20 non exposed workers. Applied a questionnaire recommended by the International Commission for Protection Against Environmental Mutagens and Carcinogens-ICPEMC, and biological material was collected for hematological, biochemical and cytogenetic analyzes. The population studied had a mean age of 44.15 years, working time of 14.75 years, weekly workload of 40 hours and 55% of agents said they use PPE. As for lifestyle 25% were smokers, 85% consumed alcohol and 30% report some underlying disease. Evaluating the hematological parameters no statistical significance when comparing the two groups. As biochemical variables for urea, creatinine, ALT, AST and BChE showed significant changes. In dosages of alkaline phosphatase and gamma glutamyl transferase, significant (p <0.01) compared to the unexposed group. Regarding the genotoxic analysis (cells with micronuclei), there was a statistically significant difference between the exposed groups (2.78) and unexposed (0.56). The nuclear changes were evidenced cariorrex (184.1 versus 717.0), karyolysis (138.5 versus 47.48), and binucleated cells (0.1413 versus 0.06087) of the exposed compared to the control group respectively. Although the numbers of karyorrhexis were more evident in the control group, and karyolysis binucleation parameters were genotoxicity along with micronuclei. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-03-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
status_str |
publishedVersion |
format |
masterThesis |
dc.identifier.uri.fl_str_mv |
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15380 |
url |
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15380 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal do Cearà |
dc.publisher.program.fl_str_mv |
Programa de PÃs-GraduaÃÃo em Farmacologia |
dc.publisher.initials.fl_str_mv |
UFC |
dc.publisher.country.fl_str_mv |
BR |
publisher.none.fl_str_mv |
Universidade Federal do Cearà |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFC instname:Universidade Federal do Ceará instacron:UFC |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UFC |
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Biblioteca Digital de Teses e Dissertações da UFC |
instname_str |
Universidade Federal do Ceará |
instacron_str |
UFC |
institution |
UFC |
repository.name.fl_str_mv |
-
|
repository.mail.fl_str_mv |
mail@mail.com |
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1643295210405363712 |