Chemical and pharmacological study of Senna georgica H.S Irwin & Barneby.

Detalhes bibliográficos
Autor(a) principal: Irvila Ricarte de Oliveira
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFC
Texto Completo: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11016
Resumo: The known metabolites of the genus Senna have a variety of applications, while the oldest is like purging and preparation is present in the British Pharmacopoeia, European, American and Brazilian indicated for cases of constipation. Are used in folk medicine preparations of various species of the genus as, stomachic, febrifuge, antianemics, antiblenorrÃgica, antinefrÃtica,antidot a, antimycotic, diuretic, fungicidal, laxative and against skin diseases. In this stdy is described the investigation of chemical of Senna georgica H. S. Irwin Barneby (Leguminoseae), popularly known as "Lava pratoâ and "mata pasto". The literature review revealed the complete absence of studies chemical, biological and pharmacological performed with this species, which is why the plant was selected for the study. The chemical study started with chromatographic treatment of hexane andethanol extracts of Senna which allowed the isolation and identification of two anthraquinones crisofanol and fisciona,the triterpene lupeol, two phytosteroid shaped and acid free and glycosylated triacontanÃico. Another stage of the work was devoted to the pharmacological study of S.georgica, which analyzed by testing the antioxidant potential, cytotoxicity and anticolinasterÃsico of extracts hexane and ethanol of flowers, pods, leaves, stem and root of the plant. The structural determinations were made using techniques of infrared spectroscopy, nuclear magnetic resonance of a 1-H-and C-13 uni-dimensional, mass spectrometry and comparison with data reported in the literature.
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spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisChemical and pharmacological study of Senna georgica H.S Irwin & Barneby.Estudo quÃmico e farmacolÃgico de Senna georgica H. S Irwin & Barneby2012-01-27Maria Goretti de Vasconcelos Silva12249610304Maria Teresa Salles Trevisan05006874805http://lattes.cnpq.br/9109195307461296Edy Sousa de Brito56506155434http://lattes.cnpq.br/516880677681600996314702372http://lattes.cnpq.br/8872908140082915 Irvila Ricarte de OliveiraUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em QuÃmica UFCBRSenna Antraquinonas TriterpenosSenna Antraquinones Triterpene QUIMICA ORGANICAThe known metabolites of the genus Senna have a variety of applications, while the oldest is like purging and preparation is present in the British Pharmacopoeia, European, American and Brazilian indicated for cases of constipation. Are used in folk medicine preparations of various species of the genus as, stomachic, febrifuge, antianemics, antiblenorrÃgica, antinefrÃtica,antidot a, antimycotic, diuretic, fungicidal, laxative and against skin diseases. In this stdy is described the investigation of chemical of Senna georgica H. S. Irwin Barneby (Leguminoseae), popularly known as "Lava pratoâ and "mata pasto". The literature review revealed the complete absence of studies chemical, biological and pharmacological performed with this species, which is why the plant was selected for the study. The chemical study started with chromatographic treatment of hexane andethanol extracts of Senna which allowed the isolation and identification of two anthraquinones crisofanol and fisciona,the triterpene lupeol, two phytosteroid shaped and acid free and glycosylated triacontanÃico. Another stage of the work was devoted to the pharmacological study of S.georgica, which analyzed by testing the antioxidant potential, cytotoxicity and anticolinasterÃsico of extracts hexane and ethanol of flowers, pods, leaves, stem and root of the plant. The structural determinations were made using techniques of infrared spectroscopy, nuclear magnetic resonance of a 1-H-and C-13 uni-dimensional, mass spectrometry and comparison with data reported in the literature. Os metabÃlitos conhecidos do gÃnero Senna apresentam uma variedade de aplicaÃÃes, embora a mais antiga seja como purgativa e sua preparaÃÃo està presente na FarmacopÃia britÃnica, europÃia, americana e brasileira com indicaÃÃo para casos de constipaÃÃo. Na medicina popular sÃo utilizadas preparaÃÃes de vÃrias espÃcies do gÃnero como tÃnica, estomÃquica, febrÃfuga, anti-herpÃtica, antianÃmica, antiblenorrÃgica, antinefrÃtica, antÃdota, antimicÃtica, diurÃtica, parasiticida, laxante, e contra doenÃas de pele. Este trabalho descreve a investigaÃÃo quÃmica de Senna georgica H. S. Irwin & Barneby (Leguminoseae), popularmente conhecida como âmata pastoâ e âlava pratoâ. O levantamento bibliogrÃfico revelou a completa ausÃncia de estudos quÃmicos, biolÃgicos e farmacolÃgicos realizados com esta espÃcie, motivo pela qual selecionou-se a planta para o estudo. O estudo quÃmico iniciou-se com o tratamento cromatogrÃfico dos extratos hexÃnico e etanÃlico do caule de S. georgica o que possibilitou o isolamento e identificaÃÃo das antraquinonas crisofanol e fisciona, o triterpeno de esqueleto lupano, o lupeol, dois fitoesteroides em forma livre e glicosilados e o Ãcido triacontanÃico. Outra etapa do trabalho foi dedicada ao estudo farmacolÃgico de S. georgica, que atravÃs de ensaios analisou o potencial antioxidante, citotoxidade e anticolinasterÃsico dos extratos etanÃlico e hexÃnico das flores, vagens, folhas, caule e raiz da planta. As determinaÃÃes estruturais foram realizadas atravÃs das tÃcnicas espectromÃtricas de infravermelho, ressonÃncia magnÃtica nuclear de hidrogÃnio-1 e carbono-13 uni e bidimensionais, espectrometria de massas e comparaÃÃes com dados relatados na literatura. Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgicoUniversidade Federal do CearÃCoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superiorhttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11016application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:24:13Zmail@mail.com -
dc.title.en.fl_str_mv Chemical and pharmacological study of Senna georgica H.S Irwin & Barneby.
dc.title.alternative.pt.fl_str_mv Estudo quÃmico e farmacolÃgico de Senna georgica H. S Irwin & Barneby
title Chemical and pharmacological study of Senna georgica H.S Irwin & Barneby.
spellingShingle Chemical and pharmacological study of Senna georgica H.S Irwin & Barneby.
Irvila Ricarte de Oliveira
Senna
Antraquinonas
Triterpenos
Senna
Antraquinones
Triterpene
QUIMICA ORGANICA
title_short Chemical and pharmacological study of Senna georgica H.S Irwin & Barneby.
title_full Chemical and pharmacological study of Senna georgica H.S Irwin & Barneby.
title_fullStr Chemical and pharmacological study of Senna georgica H.S Irwin & Barneby.
title_full_unstemmed Chemical and pharmacological study of Senna georgica H.S Irwin & Barneby.
title_sort Chemical and pharmacological study of Senna georgica H.S Irwin & Barneby.
author Irvila Ricarte de Oliveira
author_facet Irvila Ricarte de Oliveira
author_role author
dc.contributor.advisor1.fl_str_mv Maria Goretti de Vasconcelos Silva
dc.contributor.advisor1ID.fl_str_mv 12249610304
dc.contributor.referee1.fl_str_mv Maria Teresa Salles Trevisan
dc.contributor.referee1ID.fl_str_mv 05006874805
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/9109195307461296
dc.contributor.referee2.fl_str_mv Edy Sousa de Brito
dc.contributor.referee2ID.fl_str_mv 56506155434
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/5168806776816009
dc.contributor.authorID.fl_str_mv 96314702372
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/8872908140082915
dc.contributor.author.fl_str_mv Irvila Ricarte de Oliveira
contributor_str_mv Maria Goretti de Vasconcelos Silva
Maria Teresa Salles Trevisan
Edy Sousa de Brito
dc.subject.por.fl_str_mv Senna
Antraquinonas
Triterpenos
topic Senna
Antraquinonas
Triterpenos
Senna
Antraquinones
Triterpene
QUIMICA ORGANICA
dc.subject.eng.fl_str_mv Senna
Antraquinones
Triterpene
dc.subject.cnpq.fl_str_mv QUIMICA ORGANICA
dc.description.sponsorship.fl_txt_mv Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico
Universidade Federal do CearÃ
CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior
dc.description.abstract.por.fl_txt_mv The known metabolites of the genus Senna have a variety of applications, while the oldest is like purging and preparation is present in the British Pharmacopoeia, European, American and Brazilian indicated for cases of constipation. Are used in folk medicine preparations of various species of the genus as, stomachic, febrifuge, antianemics, antiblenorrÃgica, antinefrÃtica,antidot a, antimycotic, diuretic, fungicidal, laxative and against skin diseases. In this stdy is described the investigation of chemical of Senna georgica H. S. Irwin Barneby (Leguminoseae), popularly known as "Lava pratoâ and "mata pasto". The literature review revealed the complete absence of studies chemical, biological and pharmacological performed with this species, which is why the plant was selected for the study. The chemical study started with chromatographic treatment of hexane andethanol extracts of Senna which allowed the isolation and identification of two anthraquinones crisofanol and fisciona,the triterpene lupeol, two phytosteroid shaped and acid free and glycosylated triacontanÃico. Another stage of the work was devoted to the pharmacological study of S.georgica, which analyzed by testing the antioxidant potential, cytotoxicity and anticolinasterÃsico of extracts hexane and ethanol of flowers, pods, leaves, stem and root of the plant. The structural determinations were made using techniques of infrared spectroscopy, nuclear magnetic resonance of a 1-H-and C-13 uni-dimensional, mass spectrometry and comparison with data reported in the literature.
Os metabÃlitos conhecidos do gÃnero Senna apresentam uma variedade de aplicaÃÃes, embora a mais antiga seja como purgativa e sua preparaÃÃo està presente na FarmacopÃia britÃnica, europÃia, americana e brasileira com indicaÃÃo para casos de constipaÃÃo. Na medicina popular sÃo utilizadas preparaÃÃes de vÃrias espÃcies do gÃnero como tÃnica, estomÃquica, febrÃfuga, anti-herpÃtica, antianÃmica, antiblenorrÃgica, antinefrÃtica, antÃdota, antimicÃtica, diurÃtica, parasiticida, laxante, e contra doenÃas de pele. Este trabalho descreve a investigaÃÃo quÃmica de Senna georgica H. S. Irwin & Barneby (Leguminoseae), popularmente conhecida como âmata pastoâ e âlava pratoâ. O levantamento bibliogrÃfico revelou a completa ausÃncia de estudos quÃmicos, biolÃgicos e farmacolÃgicos realizados com esta espÃcie, motivo pela qual selecionou-se a planta para o estudo. O estudo quÃmico iniciou-se com o tratamento cromatogrÃfico dos extratos hexÃnico e etanÃlico do caule de S. georgica o que possibilitou o isolamento e identificaÃÃo das antraquinonas crisofanol e fisciona, o triterpeno de esqueleto lupano, o lupeol, dois fitoesteroides em forma livre e glicosilados e o Ãcido triacontanÃico. Outra etapa do trabalho foi dedicada ao estudo farmacolÃgico de S. georgica, que atravÃs de ensaios analisou o potencial antioxidante, citotoxidade e anticolinasterÃsico dos extratos etanÃlico e hexÃnico das flores, vagens, folhas, caule e raiz da planta. As determinaÃÃes estruturais foram realizadas atravÃs das tÃcnicas espectromÃtricas de infravermelho, ressonÃncia magnÃtica nuclear de hidrogÃnio-1 e carbono-13 uni e bidimensionais, espectrometria de massas e comparaÃÃes com dados relatados na literatura.
description The known metabolites of the genus Senna have a variety of applications, while the oldest is like purging and preparation is present in the British Pharmacopoeia, European, American and Brazilian indicated for cases of constipation. Are used in folk medicine preparations of various species of the genus as, stomachic, febrifuge, antianemics, antiblenorrÃgica, antinefrÃtica,antidot a, antimycotic, diuretic, fungicidal, laxative and against skin diseases. In this stdy is described the investigation of chemical of Senna georgica H. S. Irwin Barneby (Leguminoseae), popularly known as "Lava pratoâ and "mata pasto". The literature review revealed the complete absence of studies chemical, biological and pharmacological performed with this species, which is why the plant was selected for the study. The chemical study started with chromatographic treatment of hexane andethanol extracts of Senna which allowed the isolation and identification of two anthraquinones crisofanol and fisciona,the triterpene lupeol, two phytosteroid shaped and acid free and glycosylated triacontanÃico. Another stage of the work was devoted to the pharmacological study of S.georgica, which analyzed by testing the antioxidant potential, cytotoxicity and anticolinasterÃsico of extracts hexane and ethanol of flowers, pods, leaves, stem and root of the plant. The structural determinations were made using techniques of infrared spectroscopy, nuclear magnetic resonance of a 1-H-and C-13 uni-dimensional, mass spectrometry and comparison with data reported in the literature.
publishDate 2012
dc.date.issued.fl_str_mv 2012-01-27
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
status_str publishedVersion
format masterThesis
dc.identifier.uri.fl_str_mv http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11016
url http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11016
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.publisher.program.fl_str_mv Programa de PÃs-GraduaÃÃo em QuÃmica
dc.publisher.initials.fl_str_mv UFC
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFC
instname:Universidade Federal do Ceará
instacron:UFC
reponame_str Biblioteca Digital de Teses e Dissertações da UFC
collection Biblioteca Digital de Teses e Dissertações da UFC
instname_str Universidade Federal do Ceará
instacron_str UFC
institution UFC
repository.name.fl_str_mv -
repository.mail.fl_str_mv mail@mail.com
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