Comparative study about the effect of nimesulide and ketoprfen on inflammatory events in third molars surgeries: a split-mouth, prospective, randomized, double-bind study

Detalhes bibliográficos
Autor(a) principal: Ernest Cavalcante Pouchain
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFC
Texto Completo: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14239
Resumo: This study aimed to compare the effect of nimesulide and ketoprofen on inflammatory parameters related to the surgical removal of third molars. A split-mouth, prospective, randomized, double-blind study was conducted in patients undergoing removal of four third molars. Eighteen eligible patients were allocated to one of two groups to receive treatment two times a day with either ketoprofen 100 mg or nimesulide 100 mg for a period of 3 days. The rescue medication intake (number) and pain intensity were evaluated at 6, 12, 24, and 48 h, and at 7 days postoperative. Swelling and maximum mouth opening were evaluated at 24 h, 72 h, and 7 days postoperatively. The peak pain score occurred at 6 h (nimesulide group) and 12 h (ketoprofen group) after surgery. There was no statistically significant difference between the groups, although pain relief was observed after 48 h in the nimesulide group and after 7 days in the ketoprofen group. In each group, there was a statically significant difference in pain scores among the studied periods (P < 0.0001). None of the patients required rescue medication. There was a statistically significant difference in maximum mouth opening between the preoperative and postoperative periods (P < 0.0001). Ketoprofen and nimesulide were effective at controlling pain, swelling, and trismus after the surgical removal of third molars.
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spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisComparative study about the effect of nimesulide and ketoprfen on inflammatory events in third molars surgeries: a split-mouth, prospective, randomized, double-bind study Estudo comparativo da aÃÃo da nimesulida e do cetoprofeno sobre os eventos inflamatÃrios de cirurgias de terceiros molares: estudo boca-dividida, prospectivo, randomizado, duplo-cego.2012-09-27Eduardo Costa Studart Soares38949806304http://buscatextual.cnpq.br/buscatextual/visualizacv.jsp?id=K4700080E2TÃcio Pinheiro Bezerra82257191315http://lattes.cnpq.br/7823107300672141Rodrygo Nunes Tavares74509365349http://lattes.cnpq.br/460715976384502388133460344 http://lattes.cnpq.br/1228125860155583Ernest Cavalcante PouchainUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em OdontologiaUFCBRCIRURGIA BUCO-MAXILO-FACIALThis study aimed to compare the effect of nimesulide and ketoprofen on inflammatory parameters related to the surgical removal of third molars. A split-mouth, prospective, randomized, double-blind study was conducted in patients undergoing removal of four third molars. Eighteen eligible patients were allocated to one of two groups to receive treatment two times a day with either ketoprofen 100 mg or nimesulide 100 mg for a period of 3 days. The rescue medication intake (number) and pain intensity were evaluated at 6, 12, 24, and 48 h, and at 7 days postoperative. Swelling and maximum mouth opening were evaluated at 24 h, 72 h, and 7 days postoperatively. The peak pain score occurred at 6 h (nimesulide group) and 12 h (ketoprofen group) after surgery. There was no statistically significant difference between the groups, although pain relief was observed after 48 h in the nimesulide group and after 7 days in the ketoprofen group. In each group, there was a statically significant difference in pain scores among the studied periods (P < 0.0001). None of the patients required rescue medication. There was a statistically significant difference in maximum mouth opening between the preoperative and postoperative periods (P < 0.0001). Ketoprofen and nimesulide were effective at controlling pain, swelling, and trismus after the surgical removal of third molars. A remoÃÃo cirÃrgica dos terceiros molares à considerado um procedimento relativamente comum em odontologia, no qual uma reaÃÃo inflamatÃria aguda à particularmente observada durante os trÃs primeiros dias pÃs-operatÃrios. Diversos ensaios clÃnicos tÃm utilizado o modelo farmacolÃgico com a cirurgia de terceiros molares, para avaliar o efeito de medicamentos nos eventos pÃs-operatÃrios. No entanto nenhum estudo comparando o cetoprofeno e a nimesulida administrados por via oral foi publicado. O objetivo do presente trabalho foi comparar o efeito do cetoprofeno e da nimesulida sobre parÃmetros inflamatÃrios relacionados à remoÃÃo de terceiros molares. Foi realizado um estudo piloto duplo-cego, randomizado, prospectivo, do tipo âboca-divididaâ em pacientes submetidos à remoÃÃo de quatro terceiros molares sob anestesia local. A amostra foi composta por 18 pacientes que seguiram os critÃrios de inclusÃo e exclusÃo do presente estudo. Cada paciente recebeu dois procedimentos cirÃrgicos, sendo um lado experimental e outro controle. A escolha dos tratamentos foi de forma aleatÃria a qual indicava o uso de nimesulida 100 mg (controle) ou cetoprofeno 100 mg (experimental) duas vezes por dia durante 3 dias apÃs o primeiro procedimento. ApÃs a segunda cirurgia o outro medicamento era utilizado seguindo-se a mesma posologia. O nÃmero de medicamentos de resgate, intensidade de dor, edema e abertura bucal mÃxima foram avaliados. Os perÃodos da intensidade de dor foram avaliados com 6, 12, 24, 72 horas e 7 dias enquanto que edema e abertura bucal foram avaliados com 24, 72 horas e 7 dias. Em relaÃÃo à dor, o pico mÃximo ocorreu 6 horas apÃs o procedimento cirÃrgico e nÃo houve diferenÃa estatisticamente significante entre os grupos. O sexo feminino foi o mais prevalente (88,8%). O tempo mÃdio das cirurgias foi de 29 minutos ( 7,2 min). Nenhum paciente necessitou de medicaÃÃo de resgate. NÃo houve diferenÃa estatisticamente significante entre os grupos com relaÃÃo ao edema e o trismo, porÃm, quando os grupos de medicamentos foram avaliados individualmente, este mostraram reduÃÃo significante no limite de abertura apÃs 72 horas e 7 dias (P < 0.0001) para ambos os grupos. De acordo com os resultados do presente estudo piloto, tanto o cetoprofeno quanto a nimesulida mostraram-se eficazes no controle da dor, edema e trismo apÃs cirurgia para remoÃÃo de terceiros molares. CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14239application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:27:25Zmail@mail.com -
dc.title.en.fl_str_mv Comparative study about the effect of nimesulide and ketoprfen on inflammatory events in third molars surgeries: a split-mouth, prospective, randomized, double-bind study
dc.title.alternative.pt.fl_str_mv Estudo comparativo da aÃÃo da nimesulida e do cetoprofeno sobre os eventos inflamatÃrios de cirurgias de terceiros molares: estudo boca-dividida, prospectivo, randomizado, duplo-cego.
title Comparative study about the effect of nimesulide and ketoprfen on inflammatory events in third molars surgeries: a split-mouth, prospective, randomized, double-bind study
spellingShingle Comparative study about the effect of nimesulide and ketoprfen on inflammatory events in third molars surgeries: a split-mouth, prospective, randomized, double-bind study
Ernest Cavalcante Pouchain
CIRURGIA BUCO-MAXILO-FACIAL
title_short Comparative study about the effect of nimesulide and ketoprfen on inflammatory events in third molars surgeries: a split-mouth, prospective, randomized, double-bind study
title_full Comparative study about the effect of nimesulide and ketoprfen on inflammatory events in third molars surgeries: a split-mouth, prospective, randomized, double-bind study
title_fullStr Comparative study about the effect of nimesulide and ketoprfen on inflammatory events in third molars surgeries: a split-mouth, prospective, randomized, double-bind study
title_full_unstemmed Comparative study about the effect of nimesulide and ketoprfen on inflammatory events in third molars surgeries: a split-mouth, prospective, randomized, double-bind study
title_sort Comparative study about the effect of nimesulide and ketoprfen on inflammatory events in third molars surgeries: a split-mouth, prospective, randomized, double-bind study
author Ernest Cavalcante Pouchain
author_facet Ernest Cavalcante Pouchain
author_role author
dc.contributor.advisor1.fl_str_mv Eduardo Costa Studart Soares
dc.contributor.advisor1ID.fl_str_mv 38949806304
dc.contributor.advisor1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.jsp?id=K4700080E2
dc.contributor.referee1.fl_str_mv TÃcio Pinheiro Bezerra
dc.contributor.referee1ID.fl_str_mv 82257191315
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/7823107300672141
dc.contributor.referee2.fl_str_mv Rodrygo Nunes Tavares
dc.contributor.referee2ID.fl_str_mv 74509365349
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/4607159763845023
dc.contributor.authorID.fl_str_mv 88133460344
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1228125860155583
dc.contributor.author.fl_str_mv Ernest Cavalcante Pouchain
contributor_str_mv Eduardo Costa Studart Soares
TÃcio Pinheiro Bezerra
Rodrygo Nunes Tavares
dc.subject.cnpq.fl_str_mv CIRURGIA BUCO-MAXILO-FACIAL
topic CIRURGIA BUCO-MAXILO-FACIAL
dc.description.sponsorship.fl_txt_mv CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior
dc.description.abstract.por.fl_txt_mv This study aimed to compare the effect of nimesulide and ketoprofen on inflammatory parameters related to the surgical removal of third molars. A split-mouth, prospective, randomized, double-blind study was conducted in patients undergoing removal of four third molars. Eighteen eligible patients were allocated to one of two groups to receive treatment two times a day with either ketoprofen 100 mg or nimesulide 100 mg for a period of 3 days. The rescue medication intake (number) and pain intensity were evaluated at 6, 12, 24, and 48 h, and at 7 days postoperative. Swelling and maximum mouth opening were evaluated at 24 h, 72 h, and 7 days postoperatively. The peak pain score occurred at 6 h (nimesulide group) and 12 h (ketoprofen group) after surgery. There was no statistically significant difference between the groups, although pain relief was observed after 48 h in the nimesulide group and after 7 days in the ketoprofen group. In each group, there was a statically significant difference in pain scores among the studied periods (P < 0.0001). None of the patients required rescue medication. There was a statistically significant difference in maximum mouth opening between the preoperative and postoperative periods (P < 0.0001). Ketoprofen and nimesulide were effective at controlling pain, swelling, and trismus after the surgical removal of third molars.
A remoÃÃo cirÃrgica dos terceiros molares à considerado um procedimento relativamente comum em odontologia, no qual uma reaÃÃo inflamatÃria aguda à particularmente observada durante os trÃs primeiros dias pÃs-operatÃrios. Diversos ensaios clÃnicos tÃm utilizado o modelo farmacolÃgico com a cirurgia de terceiros molares, para avaliar o efeito de medicamentos nos eventos pÃs-operatÃrios. No entanto nenhum estudo comparando o cetoprofeno e a nimesulida administrados por via oral foi publicado. O objetivo do presente trabalho foi comparar o efeito do cetoprofeno e da nimesulida sobre parÃmetros inflamatÃrios relacionados à remoÃÃo de terceiros molares. Foi realizado um estudo piloto duplo-cego, randomizado, prospectivo, do tipo âboca-divididaâ em pacientes submetidos à remoÃÃo de quatro terceiros molares sob anestesia local. A amostra foi composta por 18 pacientes que seguiram os critÃrios de inclusÃo e exclusÃo do presente estudo. Cada paciente recebeu dois procedimentos cirÃrgicos, sendo um lado experimental e outro controle. A escolha dos tratamentos foi de forma aleatÃria a qual indicava o uso de nimesulida 100 mg (controle) ou cetoprofeno 100 mg (experimental) duas vezes por dia durante 3 dias apÃs o primeiro procedimento. ApÃs a segunda cirurgia o outro medicamento era utilizado seguindo-se a mesma posologia. O nÃmero de medicamentos de resgate, intensidade de dor, edema e abertura bucal mÃxima foram avaliados. Os perÃodos da intensidade de dor foram avaliados com 6, 12, 24, 72 horas e 7 dias enquanto que edema e abertura bucal foram avaliados com 24, 72 horas e 7 dias. Em relaÃÃo à dor, o pico mÃximo ocorreu 6 horas apÃs o procedimento cirÃrgico e nÃo houve diferenÃa estatisticamente significante entre os grupos. O sexo feminino foi o mais prevalente (88,8%). O tempo mÃdio das cirurgias foi de 29 minutos ( 7,2 min). Nenhum paciente necessitou de medicaÃÃo de resgate. NÃo houve diferenÃa estatisticamente significante entre os grupos com relaÃÃo ao edema e o trismo, porÃm, quando os grupos de medicamentos foram avaliados individualmente, este mostraram reduÃÃo significante no limite de abertura apÃs 72 horas e 7 dias (P < 0.0001) para ambos os grupos. De acordo com os resultados do presente estudo piloto, tanto o cetoprofeno quanto a nimesulida mostraram-se eficazes no controle da dor, edema e trismo apÃs cirurgia para remoÃÃo de terceiros molares.
description This study aimed to compare the effect of nimesulide and ketoprofen on inflammatory parameters related to the surgical removal of third molars. A split-mouth, prospective, randomized, double-blind study was conducted in patients undergoing removal of four third molars. Eighteen eligible patients were allocated to one of two groups to receive treatment two times a day with either ketoprofen 100 mg or nimesulide 100 mg for a period of 3 days. The rescue medication intake (number) and pain intensity were evaluated at 6, 12, 24, and 48 h, and at 7 days postoperative. Swelling and maximum mouth opening were evaluated at 24 h, 72 h, and 7 days postoperatively. The peak pain score occurred at 6 h (nimesulide group) and 12 h (ketoprofen group) after surgery. There was no statistically significant difference between the groups, although pain relief was observed after 48 h in the nimesulide group and after 7 days in the ketoprofen group. In each group, there was a statically significant difference in pain scores among the studied periods (P < 0.0001). None of the patients required rescue medication. There was a statistically significant difference in maximum mouth opening between the preoperative and postoperative periods (P < 0.0001). Ketoprofen and nimesulide were effective at controlling pain, swelling, and trismus after the surgical removal of third molars.
publishDate 2012
dc.date.issued.fl_str_mv 2012-09-27
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
status_str publishedVersion
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dc.identifier.uri.fl_str_mv http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14239
url http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14239
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.publisher.program.fl_str_mv Programa de PÃs-GraduaÃÃo em Odontologia
dc.publisher.initials.fl_str_mv UFC
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFC
instname:Universidade Federal do Ceará
instacron:UFC
reponame_str Biblioteca Digital de Teses e Dissertações da UFC
collection Biblioteca Digital de Teses e Dissertações da UFC
instname_str Universidade Federal do Ceará
instacron_str UFC
institution UFC
repository.name.fl_str_mv -
repository.mail.fl_str_mv mail@mail.com
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