Phytochemical and Biological Investigation of Humirianthera ampla Miers (Icacinaceae)

Detalhes bibliográficos
Autor(a) principal: Ricardo de AraÃjo Marques
Data de Publicação: 2007
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFC
Texto Completo: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7212
Resumo: The phytochemical investigation of the roots of Humiranthera ampla (Icacinaceae) resulted in the isolation and identification of a mixture of beta-sitosterol and stigmasterol, annonalide, lupeol and the 3-beta-O-beta-D-glucopyranosyl sitosterol. The structures of these compounds were established by spectrometric analysis (IR, MS, NMR 1H and 13C) including bidimensional NRM techniques (COSY, HMQC, HMBC and NOESY) and for comparison with data described in the literature. All extracts were tested using the Ellman assay. Only ethyl acetate extract and their fractions showed acetylcholinesterase inhibition. The antioxidant capacity of the extracts were measured as method described by Owen et al, 2001. The ethanolic extract was the most active. The ethyl acetate extract showed xanthine oxidase inhibition.
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spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisPhytochemical and Biological Investigation of Humirianthera ampla Miers (Icacinaceae)Estudo FitoquÃmico e BiolÃgico de Humirianthera ampla Miers (Icacinaceae)2007-02-23Maria Teresa Salles Trevisan05006874805http://lattes.cnpq.br/9109195307461296Maria da ConceiÃÃo Ferreira de Oliveira97771430791Janete Eliza Soares de Lima3691693433497395889304http://lattes.cnpq.br/1715805139205744 Ricardo de AraÃjo MarquesUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em QuÃmica UFCBRQUIMICA ORGANICAThe phytochemical investigation of the roots of Humiranthera ampla (Icacinaceae) resulted in the isolation and identification of a mixture of beta-sitosterol and stigmasterol, annonalide, lupeol and the 3-beta-O-beta-D-glucopyranosyl sitosterol. The structures of these compounds were established by spectrometric analysis (IR, MS, NMR 1H and 13C) including bidimensional NRM techniques (COSY, HMQC, HMBC and NOESY) and for comparison with data described in the literature. All extracts were tested using the Ellman assay. Only ethyl acetate extract and their fractions showed acetylcholinesterase inhibition. The antioxidant capacity of the extracts were measured as method described by Owen et al, 2001. The ethanolic extract was the most active. The ethyl acetate extract showed xanthine oxidase inhibition.A investigaÃÃo fitoquÃmica das raÃzes de Humirianthera ampla (Icacinaceae) resultou no isolamento e identificaÃÃo da mistura de beta-sitosterol e estigmasterol, annonalida, lupeol e 3-beta-O-beta-D-glicopiranosil sitosterol. As estruturas destes compostos foram estabelecidas por anÃlise espectromÃtricas (IV, EM, RMN 1H e 13C) incluindo tÃcnicas de RMN bidimensional (COSY, HMQC, HMBC E NOESY) e por comparaÃÃo com dados registrados na literatura. Todos os extratos foram testados usando o ensaio de Ellman. Somente o extrato acetato de etila e suas fraÃÃes mostraram inibiÃÃo da acetilcolinesterase. A capacidade antioxidante dos extratos foi avaliada pelo mÃtodo descrito por Owen et al, 2001. O extrato etanÃlico foi o mais ativo. O extrato acetato de etila mostrou inibiÃÃo da enzima xantina oxidase. CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superiorhttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7212application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:20:13Zmail@mail.com -
dc.title.en.fl_str_mv Phytochemical and Biological Investigation of Humirianthera ampla Miers (Icacinaceae)
dc.title.alternative.pt.fl_str_mv Estudo FitoquÃmico e BiolÃgico de Humirianthera ampla Miers (Icacinaceae)
title Phytochemical and Biological Investigation of Humirianthera ampla Miers (Icacinaceae)
spellingShingle Phytochemical and Biological Investigation of Humirianthera ampla Miers (Icacinaceae)
Ricardo de AraÃjo Marques
QUIMICA ORGANICA
title_short Phytochemical and Biological Investigation of Humirianthera ampla Miers (Icacinaceae)
title_full Phytochemical and Biological Investigation of Humirianthera ampla Miers (Icacinaceae)
title_fullStr Phytochemical and Biological Investigation of Humirianthera ampla Miers (Icacinaceae)
title_full_unstemmed Phytochemical and Biological Investigation of Humirianthera ampla Miers (Icacinaceae)
title_sort Phytochemical and Biological Investigation of Humirianthera ampla Miers (Icacinaceae)
author Ricardo de AraÃjo Marques
author_facet Ricardo de AraÃjo Marques
author_role author
dc.contributor.advisor1.fl_str_mv Maria Teresa Salles Trevisan
dc.contributor.advisor1ID.fl_str_mv 05006874805
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/9109195307461296
dc.contributor.referee1.fl_str_mv Maria da ConceiÃÃo Ferreira de Oliveira
dc.contributor.referee1ID.fl_str_mv 97771430791
dc.contributor.referee2.fl_str_mv Janete Eliza Soares de Lima
dc.contributor.referee2ID.fl_str_mv 36916934334
dc.contributor.authorID.fl_str_mv 97395889304
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1715805139205744
dc.contributor.author.fl_str_mv Ricardo de AraÃjo Marques
contributor_str_mv Maria Teresa Salles Trevisan
Maria da ConceiÃÃo Ferreira de Oliveira
Janete Eliza Soares de Lima
dc.subject.cnpq.fl_str_mv QUIMICA ORGANICA
topic QUIMICA ORGANICA
dc.description.sponsorship.fl_txt_mv CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior
dc.description.abstract.por.fl_txt_mv The phytochemical investigation of the roots of Humiranthera ampla (Icacinaceae) resulted in the isolation and identification of a mixture of beta-sitosterol and stigmasterol, annonalide, lupeol and the 3-beta-O-beta-D-glucopyranosyl sitosterol. The structures of these compounds were established by spectrometric analysis (IR, MS, NMR 1H and 13C) including bidimensional NRM techniques (COSY, HMQC, HMBC and NOESY) and for comparison with data described in the literature. All extracts were tested using the Ellman assay. Only ethyl acetate extract and their fractions showed acetylcholinesterase inhibition. The antioxidant capacity of the extracts were measured as method described by Owen et al, 2001. The ethanolic extract was the most active. The ethyl acetate extract showed xanthine oxidase inhibition.
A investigaÃÃo fitoquÃmica das raÃzes de Humirianthera ampla (Icacinaceae) resultou no isolamento e identificaÃÃo da mistura de beta-sitosterol e estigmasterol, annonalida, lupeol e 3-beta-O-beta-D-glicopiranosil sitosterol. As estruturas destes compostos foram estabelecidas por anÃlise espectromÃtricas (IV, EM, RMN 1H e 13C) incluindo tÃcnicas de RMN bidimensional (COSY, HMQC, HMBC E NOESY) e por comparaÃÃo com dados registrados na literatura. Todos os extratos foram testados usando o ensaio de Ellman. Somente o extrato acetato de etila e suas fraÃÃes mostraram inibiÃÃo da acetilcolinesterase. A capacidade antioxidante dos extratos foi avaliada pelo mÃtodo descrito por Owen et al, 2001. O extrato etanÃlico foi o mais ativo. O extrato acetato de etila mostrou inibiÃÃo da enzima xantina oxidase.
description The phytochemical investigation of the roots of Humiranthera ampla (Icacinaceae) resulted in the isolation and identification of a mixture of beta-sitosterol and stigmasterol, annonalide, lupeol and the 3-beta-O-beta-D-glucopyranosyl sitosterol. The structures of these compounds were established by spectrometric analysis (IR, MS, NMR 1H and 13C) including bidimensional NRM techniques (COSY, HMQC, HMBC and NOESY) and for comparison with data described in the literature. All extracts were tested using the Ellman assay. Only ethyl acetate extract and their fractions showed acetylcholinesterase inhibition. The antioxidant capacity of the extracts were measured as method described by Owen et al, 2001. The ethanolic extract was the most active. The ethyl acetate extract showed xanthine oxidase inhibition.
publishDate 2007
dc.date.issued.fl_str_mv 2007-02-23
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
status_str publishedVersion
format masterThesis
dc.identifier.uri.fl_str_mv http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7212
url http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7212
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.publisher.program.fl_str_mv Programa de PÃs-GraduaÃÃo em QuÃmica
dc.publisher.initials.fl_str_mv UFC
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFC
instname:Universidade Federal do Ceará
instacron:UFC
reponame_str Biblioteca Digital de Teses e Dissertações da UFC
collection Biblioteca Digital de Teses e Dissertações da UFC
instname_str Universidade Federal do Ceará
instacron_str UFC
institution UFC
repository.name.fl_str_mv -
repository.mail.fl_str_mv mail@mail.com
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