Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats

Detalhes bibliográficos
Autor(a) principal: Boudiaf, Fella
Data de Publicação: 2020
Outros Autores: Chouba, Ibtissem, Amri, Naziha, Tahraoui, Abdelkarim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of Animal Behaviour and Biometeorology
Texto Completo: https://malque.pub/ojs/index.php/jabb/article/view/841
Resumo: We aim was to evaluate the protective effects of the antioxidants cinnamon and quercetin on neurobehavioral alterations and complications, besides biochemical parameters of induced-diabetics Wistar rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin at a dose of (45 mg/kg). The administration of streptozotocin was considered acting on anxiety behaviors and biochemical parameters in adult Wistar rats. On the other hand, the protective role of antioxidants (cinnamon and quercetin) on streptozotocin-induced disorders was also evaluated. Behavioral tests in the open field (OF) revealed that diabetic animals exhibited an anxious behavior and an alteration in the locomotive and exploratory activities when compared to control. The administration of the cinnamon (2g/kg) and Quercetin (0.5g/kg) by gastric gavage reduces anxiety and decreases hyperglycemia-related harm. However, antioxidants cinnamon and quercetin administration significantly alleviated anxious and depressive behaviors.
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spelling Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics ratsantioxidantsanxietydiabetesWe aim was to evaluate the protective effects of the antioxidants cinnamon and quercetin on neurobehavioral alterations and complications, besides biochemical parameters of induced-diabetics Wistar rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin at a dose of (45 mg/kg). The administration of streptozotocin was considered acting on anxiety behaviors and biochemical parameters in adult Wistar rats. On the other hand, the protective role of antioxidants (cinnamon and quercetin) on streptozotocin-induced disorders was also evaluated. Behavioral tests in the open field (OF) revealed that diabetic animals exhibited an anxious behavior and an alteration in the locomotive and exploratory activities when compared to control. The administration of the cinnamon (2g/kg) and Quercetin (0.5g/kg) by gastric gavage reduces anxiety and decreases hyperglycemia-related harm. However, antioxidants cinnamon and quercetin administration significantly alleviated anxious and depressive behaviors.Malque Publishing2020-05-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionResearch Articlesapplication/pdfhttps://malque.pub/ojs/index.php/jabb/article/view/841Journal of Animal Behaviour and Biometeorology; Vol. 8 No. 3 (2020): July; 190-1952318-12652318-1265reponame:Journal of Animal Behaviour and Biometeorologyinstname:Universidade Federal Rural do Semi-Árido (UFERSA)instacron:UFERSAenghttps://malque.pub/ojs/index.php/jabb/article/view/841/457Copyright (c) 2020 Malque Publishinghttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessBoudiaf, FellaChouba, IbtissemAmri, NazihaTahraoui, Abdelkarim2023-05-22T20:31:15Zoai:ojs2.malque.pub:article/841Revistahttps://periodicos.ufersa.edu.br/index.php/jabbPUBhttp://periodicos.ufersa.edu.br/revistas/index.php/jabb/oai||souza.jr@ufersa.edu.br2318-12652318-1265opendoar:2023-05-22T20:31:15Journal of Animal Behaviour and Biometeorology - Universidade Federal Rural do Semi-Árido (UFERSA)false
dc.title.none.fl_str_mv Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats
title Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats
spellingShingle Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats
Boudiaf, Fella
antioxidants
anxiety
diabetes
title_short Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats
title_full Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats
title_fullStr Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats
title_full_unstemmed Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats
title_sort Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats
author Boudiaf, Fella
author_facet Boudiaf, Fella
Chouba, Ibtissem
Amri, Naziha
Tahraoui, Abdelkarim
author_role author
author2 Chouba, Ibtissem
Amri, Naziha
Tahraoui, Abdelkarim
author2_role author
author
author
dc.contributor.author.fl_str_mv Boudiaf, Fella
Chouba, Ibtissem
Amri, Naziha
Tahraoui, Abdelkarim
dc.subject.por.fl_str_mv antioxidants
anxiety
diabetes
topic antioxidants
anxiety
diabetes
description We aim was to evaluate the protective effects of the antioxidants cinnamon and quercetin on neurobehavioral alterations and complications, besides biochemical parameters of induced-diabetics Wistar rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin at a dose of (45 mg/kg). The administration of streptozotocin was considered acting on anxiety behaviors and biochemical parameters in adult Wistar rats. On the other hand, the protective role of antioxidants (cinnamon and quercetin) on streptozotocin-induced disorders was also evaluated. Behavioral tests in the open field (OF) revealed that diabetic animals exhibited an anxious behavior and an alteration in the locomotive and exploratory activities when compared to control. The administration of the cinnamon (2g/kg) and Quercetin (0.5g/kg) by gastric gavage reduces anxiety and decreases hyperglycemia-related harm. However, antioxidants cinnamon and quercetin administration significantly alleviated anxious and depressive behaviors.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Research Articles
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://malque.pub/ojs/index.php/jabb/article/view/841
url https://malque.pub/ojs/index.php/jabb/article/view/841
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://malque.pub/ojs/index.php/jabb/article/view/841/457
dc.rights.driver.fl_str_mv Copyright (c) 2020 Malque Publishing
https://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Malque Publishing
https://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Malque Publishing
publisher.none.fl_str_mv Malque Publishing
dc.source.none.fl_str_mv Journal of Animal Behaviour and Biometeorology; Vol. 8 No. 3 (2020): July; 190-195
2318-1265
2318-1265
reponame:Journal of Animal Behaviour and Biometeorology
instname:Universidade Federal Rural do Semi-Árido (UFERSA)
instacron:UFERSA
instname_str Universidade Federal Rural do Semi-Árido (UFERSA)
instacron_str UFERSA
institution UFERSA
reponame_str Journal of Animal Behaviour and Biometeorology
collection Journal of Animal Behaviour and Biometeorology
repository.name.fl_str_mv Journal of Animal Behaviour and Biometeorology - Universidade Federal Rural do Semi-Árido (UFERSA)
repository.mail.fl_str_mv ||souza.jr@ufersa.edu.br
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