Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice

Detalhes bibliográficos
Autor(a) principal: Oliveira, Maria Clara Barbosa de
Data de Publicação: 2023
Outros Autores: Melo, Paolo Oliveira, Silva, Marcos Henrique Gonçalves da, Silva, Flávio Santos da, Silva, Felipe Andrade Carvalho da, Araujo, Bruno Vinicios Silva de, Oliveira, Moacir Franco de, Correia, Aristides Tadeu, Sakamoto, Sidnei Miyoshi, Valença, Samuel Santos, Lanzetti, Manuella, Schmidt, Martina, Feitosa, Emanuel Kennedy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU)
DOI: 10.3390/antiox12061258
Texto Completo: https://repositorio.ufersa.edu.br/handle/prefix/9967
Resumo: This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.
id UFER_80f785fa20b0b66e7e101ae9aa465cef
oai_identifier_str oai:repositorio.ufersa.edu.br:prefix/9967
network_acronym_str UFER
network_name_str Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU)
spelling Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in miceCIENCIAS DA SAUDE::MEDICINACigaretteMacrophagesPulmonary inflammationOxidative stressEugenolThis study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.Artigo derivado do TCC publicado no Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU). Disponível em: https://repositorio.ufersa.edu.br/handle/prefix/9966.Centro de Ciências Biológicas e da Saúde - CCBSSwitzerlandMDPIMDPI2023-12-28T19:24:57Z2023-12-28T19:24:57Z2023-06-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfBarbosa-de-Oliveira, M. C. et al. Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice. Antioxidants, v. 12, i. 6, 2023. DOI: 10.3390/antiox12061258. Disponível em: https://doi.org/10.3390/antiox12061258.10.3390/antiox120612582076-3921https://repositorio.ufersa.edu.br/handle/prefix/9967info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/br/Oliveira, Maria Clara Barbosa deMelo, Paolo OliveiraSilva, Marcos Henrique Gonçalves daSilva, Flávio Santos daSilva, Felipe Andrade Carvalho daAraujo, Bruno Vinicios Silva deOliveira, Moacir Franco deCorreia, Aristides TadeuSakamoto, Sidnei MiyoshiValença, Samuel SantosLanzetti, ManuellaSchmidt, MartinaFeitosa, Emanuel Kennedyengreponame:Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU)instname:Universidade Federal Rural do Semi-Árido (UFERSA)instacron:UFERSA2023-12-30T03:00:39Zoai:repositorio.ufersa.edu.br:prefix/9967Repositório Institucionalhttps://repositorio.ufersa.edu.br/PUBhttps://repositorio.ufersa.edu.br/server/oai/requestrepositorio@ufersa.edu.br || admrepositorio@ufersa.edu.bropendoar:2023-12-30T03:00:39Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU) - Universidade Federal Rural do Semi-Árido (UFERSA)false
dc.title.none.fl_str_mv Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
title Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
spellingShingle Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
Oliveira, Maria Clara Barbosa de
CIENCIAS DA SAUDE::MEDICINA
Cigarette
Macrophages
Pulmonary inflammation
Oxidative stress
Eugenol
Oliveira, Maria Clara Barbosa de
CIENCIAS DA SAUDE::MEDICINA
Cigarette
Macrophages
Pulmonary inflammation
Oxidative stress
Eugenol
title_short Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
title_full Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
title_fullStr Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
title_full_unstemmed Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
title_sort Modulation of alveolar macrophage activity by eugenol attenuates cigarette-smoke-induced acute lung injury in mice
author Oliveira, Maria Clara Barbosa de
author_facet Oliveira, Maria Clara Barbosa de
Oliveira, Maria Clara Barbosa de
Melo, Paolo Oliveira
Silva, Marcos Henrique Gonçalves da
Silva, Flávio Santos da
Silva, Felipe Andrade Carvalho da
Araujo, Bruno Vinicios Silva de
Oliveira, Moacir Franco de
Correia, Aristides Tadeu
Sakamoto, Sidnei Miyoshi
Valença, Samuel Santos
Lanzetti, Manuella
Schmidt, Martina
Feitosa, Emanuel Kennedy
Melo, Paolo Oliveira
Silva, Marcos Henrique Gonçalves da
Silva, Flávio Santos da
Silva, Felipe Andrade Carvalho da
Araujo, Bruno Vinicios Silva de
Oliveira, Moacir Franco de
Correia, Aristides Tadeu
Sakamoto, Sidnei Miyoshi
Valença, Samuel Santos
Lanzetti, Manuella
Schmidt, Martina
Feitosa, Emanuel Kennedy
author_role author
author2 Melo, Paolo Oliveira
Silva, Marcos Henrique Gonçalves da
Silva, Flávio Santos da
Silva, Felipe Andrade Carvalho da
Araujo, Bruno Vinicios Silva de
Oliveira, Moacir Franco de
Correia, Aristides Tadeu
Sakamoto, Sidnei Miyoshi
Valença, Samuel Santos
Lanzetti, Manuella
Schmidt, Martina
Feitosa, Emanuel Kennedy
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Maria Clara Barbosa de
Melo, Paolo Oliveira
Silva, Marcos Henrique Gonçalves da
Silva, Flávio Santos da
Silva, Felipe Andrade Carvalho da
Araujo, Bruno Vinicios Silva de
Oliveira, Moacir Franco de
Correia, Aristides Tadeu
Sakamoto, Sidnei Miyoshi
Valença, Samuel Santos
Lanzetti, Manuella
Schmidt, Martina
Feitosa, Emanuel Kennedy
dc.subject.por.fl_str_mv CIENCIAS DA SAUDE::MEDICINA
Cigarette
Macrophages
Pulmonary inflammation
Oxidative stress
Eugenol
topic CIENCIAS DA SAUDE::MEDICINA
Cigarette
Macrophages
Pulmonary inflammation
Oxidative stress
Eugenol
description This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-28T19:24:57Z
2023-12-28T19:24:57Z
2023-06-23
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Barbosa-de-Oliveira, M. C. et al. Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice. Antioxidants, v. 12, i. 6, 2023. DOI: 10.3390/antiox12061258. Disponível em: https://doi.org/10.3390/antiox12061258.
10.3390/antiox12061258
2076-3921
https://repositorio.ufersa.edu.br/handle/prefix/9967
identifier_str_mv Barbosa-de-Oliveira, M. C. et al. Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice. Antioxidants, v. 12, i. 6, 2023. DOI: 10.3390/antiox12061258. Disponível em: https://doi.org/10.3390/antiox12061258.
10.3390/antiox12061258
2076-3921
url https://repositorio.ufersa.edu.br/handle/prefix/9967
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/br/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/br/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Centro de Ciências Biológicas e da Saúde - CCBS
Switzerland
MDPI
MDPI
publisher.none.fl_str_mv Centro de Ciências Biológicas e da Saúde - CCBS
Switzerland
MDPI
MDPI
dc.source.none.fl_str_mv reponame:Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU)
instname:Universidade Federal Rural do Semi-Árido (UFERSA)
instacron:UFERSA
instname_str Universidade Federal Rural do Semi-Árido (UFERSA)
instacron_str UFERSA
institution UFERSA
reponame_str Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU)
collection Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU)
repository.name.fl_str_mv Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU) - Universidade Federal Rural do Semi-Árido (UFERSA)
repository.mail.fl_str_mv repositorio@ufersa.edu.br || admrepositorio@ufersa.edu.br
_version_ 1822223299455746048
dc.identifier.doi.none.fl_str_mv 10.3390/antiox12061258

Registros relacionados