Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU) |
Texto Completo: | https://repositorio.ufersa.edu.br/handle/tede/708 |
Resumo: | This study aimed to evaluate the regenerative and analgesic effects of the aqueous and hydroalcoholic extract of Caesalpinia ferrea pods – daily dosage of 300 mg/kg – on experimental sciatic neuropathy and non-neuropathic peripheral pain. An amount of 82 male Wistar rats was used in the experiment. There were 40 neuropathic rats divided in four groups of ten animals. They were treated with aqueous extract, hydroalcoholic extract, saline solution, and one them was pseudo-operated. The other 42 rats were distributed in six groups of seven animals. Three groups were led to writhing test induced by acetic acid administration, and the other three groups to termal test induced by carrageenan. The groups had different treatments with aqueous and hydroalcoholic extract and saline solution. Spontaneous (motor and pain) and induced (hyperalgesia and flare) behavioural studies were conducted. There were not significant difference between the groups treated or not with the extracts. However, in the third week, the induced behaviors of interdigital and lateral pinch presented significant difference between the groups treated with extracts and the ones treated with saline solution, which suggests analgesic effect for this behaviour. The dosage of 300 mg/kg of aqueous and hydroalcoholic extracts of Caesalpinia ferrea pods in the experimental traumatic sciatic neuropathy may not be used as analgesic. This dosage suggests analgesic effects for the induced behaviour of pinch. It shows they may be tested in studies evaluating axonal regeneration. Histological results suggest a higher axonal integrity in animals treated with the extracts, similar to the sham group |
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Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratosRegenerative and analgesic effects of aqueous and hydroalcoholic extracts of Caesalpinia ferrea in experimental sciatic neuropathy in ratsComportamento induzidoJucáHiperalgesiaAlodiniaNervo ciáticoInduced behaviourCaesalpinia ferreaHyperalgesiaAllodyniasciatic nerveCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIAThis study aimed to evaluate the regenerative and analgesic effects of the aqueous and hydroalcoholic extract of Caesalpinia ferrea pods – daily dosage of 300 mg/kg – on experimental sciatic neuropathy and non-neuropathic peripheral pain. An amount of 82 male Wistar rats was used in the experiment. There were 40 neuropathic rats divided in four groups of ten animals. They were treated with aqueous extract, hydroalcoholic extract, saline solution, and one them was pseudo-operated. The other 42 rats were distributed in six groups of seven animals. Three groups were led to writhing test induced by acetic acid administration, and the other three groups to termal test induced by carrageenan. The groups had different treatments with aqueous and hydroalcoholic extract and saline solution. Spontaneous (motor and pain) and induced (hyperalgesia and flare) behavioural studies were conducted. There were not significant difference between the groups treated or not with the extracts. However, in the third week, the induced behaviors of interdigital and lateral pinch presented significant difference between the groups treated with extracts and the ones treated with saline solution, which suggests analgesic effect for this behaviour. The dosage of 300 mg/kg of aqueous and hydroalcoholic extracts of Caesalpinia ferrea pods in the experimental traumatic sciatic neuropathy may not be used as analgesic. This dosage suggests analgesic effects for the induced behaviour of pinch. It shows they may be tested in studies evaluating axonal regeneration. Histological results suggest a higher axonal integrity in animals treated with the extracts, similar to the sham group2017-05-23Este estudo avaliou os efeitos regenerativo e analgésico do extrato aquoso (EACF) e hidroalcoólico (EHCF) da vagem do jucá na neuropatia ciática experimental e na dor periférica não neuropática em ratos, em uma dose diária de 300 mg/kg. Foram utilizados 82 ratos machos da linhagem Wistar, distribuídos da seguinte forma: 40 animais neuropáticos divididos em quatro grupos de dez animais, tratados com o EAFC, EHCF, solução salina e um pseudo-operado. Quarenta e dois animais foram distribuídos em seis grupos de sete animais cada, sendo três para realização de testes de contorção abdominal induzida por ácido acético e três para realização de teste térmico induzido por carragenina. Os grupos receberam tratamentos com EAFC, EHCF e solução salina. Estudos comportamentais espontâneos (motricidade e dor) e induzidos (hiperalgesia e reflexos) foram avaliados, não havendo diferença significativa entre os grupos tratados e não tratados, entretanto nos comportamentos induzidos de pinçar interdigital e lateral da região plantar, houve uma diferença significativa entre os grupos tratados com os extratos e tratados com solução salina, , sugerindo um efeito analgésico. A dose de 300mg/kg de EACF e EHCF na neuropatia traumática experimental não pode ser utilizada como analgésico, porém sugerem a existência de efeitos analgésicos para os comportamentos induzidos de pinçar. Os resultados histológicos sugerem uma maior integridade axonal dos animais tratados com os extractos, semelhante ao grupo ShamBrasilUFERSAPrograma de Pós-Graduação em Ciência AnimalCâmara, Carlos Campos24157309391http://lattes.cnpq.br/2324710721164042Oliveira, Moacir Franco de32594950459http://lattes.cnpq.br/884311323326261903396778480http://lattes.cnpq.br/9023302857284287Câmara, Carlos Campos24157309391http://lattes.cnpq.br/2324710721164042Menezes, Danilo José Ayres de69816980304http://lattes.cnpq.br/4003577127443065Freitas, Maisa Oliveira de2017-05-23T13:58:52Z2013-08-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfFREITAS, Maisa Oliveira de. Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos. 2013. 65 f. Dissertação (Mestrado) - Curso de Pós-graduação em Ciência Animal, Universidade Federal Rural do Semi-Árido, Mossoró, 2013.https://repositorio.ufersa.edu.br/handle/tede/708porCC-BY-SAinfo:eu-repo/semantics/openAccessreponame:Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU)instname:Universidade Federal Rural do Semi-Árido (UFERSA)instacron:UFERSA2023-10-30T20:23:44Zoai:repositorio.ufersa.edu.br:tede/708Repositório Institucionalhttps://repositorio.ufersa.edu.br/PUBhttps://repositorio.ufersa.edu.br/server/oai/requestrepositorio@ufersa.edu.br || admrepositorio@ufersa.edu.bropendoar:2023-10-30T20:23:44Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU) - Universidade Federal Rural do Semi-Árido (UFERSA)false |
dc.title.none.fl_str_mv |
Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos Regenerative and analgesic effects of aqueous and hydroalcoholic extracts of Caesalpinia ferrea in experimental sciatic neuropathy in rats |
title |
Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos |
spellingShingle |
Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos Freitas, Maisa Oliveira de Comportamento induzido Jucá Hiperalgesia Alodinia Nervo ciático Induced behaviour Caesalpinia ferrea Hyperalgesia Allodynia sciatic nerve CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos |
title_full |
Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos |
title_fullStr |
Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos |
title_full_unstemmed |
Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos |
title_sort |
Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos |
author |
Freitas, Maisa Oliveira de |
author_facet |
Freitas, Maisa Oliveira de |
author_role |
author |
dc.contributor.none.fl_str_mv |
Câmara, Carlos Campos 24157309391 http://lattes.cnpq.br/2324710721164042 Oliveira, Moacir Franco de 32594950459 http://lattes.cnpq.br/8843113233262619 03396778480 http://lattes.cnpq.br/9023302857284287 Câmara, Carlos Campos 24157309391 http://lattes.cnpq.br/2324710721164042 Menezes, Danilo José Ayres de 69816980304 http://lattes.cnpq.br/4003577127443065 |
dc.contributor.author.fl_str_mv |
Freitas, Maisa Oliveira de |
dc.subject.por.fl_str_mv |
Comportamento induzido Jucá Hiperalgesia Alodinia Nervo ciático Induced behaviour Caesalpinia ferrea Hyperalgesia Allodynia sciatic nerve CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
topic |
Comportamento induzido Jucá Hiperalgesia Alodinia Nervo ciático Induced behaviour Caesalpinia ferrea Hyperalgesia Allodynia sciatic nerve CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
This study aimed to evaluate the regenerative and analgesic effects of the aqueous and hydroalcoholic extract of Caesalpinia ferrea pods – daily dosage of 300 mg/kg – on experimental sciatic neuropathy and non-neuropathic peripheral pain. An amount of 82 male Wistar rats was used in the experiment. There were 40 neuropathic rats divided in four groups of ten animals. They were treated with aqueous extract, hydroalcoholic extract, saline solution, and one them was pseudo-operated. The other 42 rats were distributed in six groups of seven animals. Three groups were led to writhing test induced by acetic acid administration, and the other three groups to termal test induced by carrageenan. The groups had different treatments with aqueous and hydroalcoholic extract and saline solution. Spontaneous (motor and pain) and induced (hyperalgesia and flare) behavioural studies were conducted. There were not significant difference between the groups treated or not with the extracts. However, in the third week, the induced behaviors of interdigital and lateral pinch presented significant difference between the groups treated with extracts and the ones treated with saline solution, which suggests analgesic effect for this behaviour. The dosage of 300 mg/kg of aqueous and hydroalcoholic extracts of Caesalpinia ferrea pods in the experimental traumatic sciatic neuropathy may not be used as analgesic. This dosage suggests analgesic effects for the induced behaviour of pinch. It shows they may be tested in studies evaluating axonal regeneration. Histological results suggest a higher axonal integrity in animals treated with the extracts, similar to the sham group |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-08-29 2017-05-23T13:58:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
FREITAS, Maisa Oliveira de. Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos. 2013. 65 f. Dissertação (Mestrado) - Curso de Pós-graduação em Ciência Animal, Universidade Federal Rural do Semi-Árido, Mossoró, 2013. https://repositorio.ufersa.edu.br/handle/tede/708 |
identifier_str_mv |
FREITAS, Maisa Oliveira de. Efeitos regenerativo e analgesico dos extratos aquoso e hidroalcoolico de Caesalpinea ferrea Martius na neuropatia ciática experimental em ratos. 2013. 65 f. Dissertação (Mestrado) - Curso de Pós-graduação em Ciência Animal, Universidade Federal Rural do Semi-Árido, Mossoró, 2013. |
url |
https://repositorio.ufersa.edu.br/handle/tede/708 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
CC-BY-SA info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
CC-BY-SA |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Brasil UFERSA Programa de Pós-Graduação em Ciência Animal |
publisher.none.fl_str_mv |
Brasil UFERSA Programa de Pós-Graduação em Ciência Animal |
dc.source.none.fl_str_mv |
reponame:Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU) instname:Universidade Federal Rural do Semi-Árido (UFERSA) instacron:UFERSA |
instname_str |
Universidade Federal Rural do Semi-Árido (UFERSA) |
instacron_str |
UFERSA |
institution |
UFERSA |
reponame_str |
Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU) |
collection |
Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU) |
repository.name.fl_str_mv |
Repositório Digital da Universidade Federal Rural do Semi-Árido (RDU) - Universidade Federal Rural do Semi-Árido (UFERSA) |
repository.mail.fl_str_mv |
repositorio@ufersa.edu.br || admrepositorio@ufersa.edu.br |
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1809747440661692416 |