Tuberculose na população privada de liberdade : características clínicas e epidemiológicas relacionadas à doença

Detalhes bibliográficos
Autor(a) principal: Macêdo, Laylla Ribeiro
Data de Publicação: 2014
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da Universidade Federal do Espírito Santo (riUfes)
Texto Completo: http://repositorio.ufes.br/handle/10/1121
Resumo: Introduction: There are about two decades, tuberculosis (TB) was considered by the World Health Organization (WHO) as a disease in a state of emergency throughout the world. Currently, despite all efforts to control the disease, yet it is an important public health problem, showing strong relationship with socioeconomic issues, which entail greater illness in specific groups, such as prisoners. Data for TB in vulnerable populations can achieve even higher levels and therefore worrying. Objectives: To analyze the clinical and epidemiological characteristics associated with the outcomes of tuberculosis treatment in the prison population of Brazil, registered in the Information System for Notifiable Diseases (SINAN), 2007-2011; understand the incidence and mortality TB in prisoners of the state of Espírito Santo from July 2009 to July 2010 , and to identify the clinical and epidemiological characteristics of all diagnosed cases of tuberculosis in prisoners of the Holy Spirit , from July 2009 to July 2010. Methods: The study population consisted of diagnosed inmates with identified tuberculosis through SINAN, between January 2007 and December 2011 and diagnoses cases of tuberculosis among inmates of the Espírito Santo in the period from 1st July 2009 to 30 June 2010. The chi - square test and polynomial regression model were used to analyze, in addition to descriptive statistics, through tables and graphs. Results: Compared with patients in TB prisoners in Brazil, it is noted that prisoners who abandoned treatment were younger (P < 0.001), less educated (P < 0.001) and greater likelihood of alcoholism (P < 0.001), were more likely to have recurrent TB or recurrence (P < 0.001) and they were not under directly observed treatment (P < 0.001) compared with those who completed the treatment of tuberculosis. Those who died of tuberculosis tend to be older (P < 0.001) and alcoholics (P < 0.001) were also more likely to unknown type of treatment (P < 0.001) and presenting pulmonary TB and extrapulmonary TB (EPTB). Prisoners who developed MDR TB were more likely to experience recurrence of TB, return after default and transfer of the treatment site. Furthermore, we observed 167 cases of tuberculosis (incidence rate of 1962.6 per 100,000 inmates) in Espírito Santo. Males showed a higher number of patients, as well as the age group of 25-36 years and the pulmonary form. It is noteworthy that 109 (65.3 %) patients were discharged as cured, two patients died during the period, with the rate of tuberculosis mortality of 11 11.7 per 100,000 inmates. The highest incidence of tuberculosis in patients was located in the prisons of the metropolitan area and a small number of cases occurred in other sites out of prisons. Conclusion: Our results highlight the need to improve policies for TB control in prisons, as well as the outcomes of the treatment of prisoners in order to prevent transmission to other inmates, their families and health professionals.
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spelling Maciel, Ethel Leonor NóiaMacêdo, Laylla RibeiroSanchez, Mauro NiskierMiranda, Angélica Espinosa Barbosa2014-11-18T19:03:08Z2014-11-18T19:03:08Z2014-02-272014-02-27Introduction: There are about two decades, tuberculosis (TB) was considered by the World Health Organization (WHO) as a disease in a state of emergency throughout the world. Currently, despite all efforts to control the disease, yet it is an important public health problem, showing strong relationship with socioeconomic issues, which entail greater illness in specific groups, such as prisoners. Data for TB in vulnerable populations can achieve even higher levels and therefore worrying. Objectives: To analyze the clinical and epidemiological characteristics associated with the outcomes of tuberculosis treatment in the prison population of Brazil, registered in the Information System for Notifiable Diseases (SINAN), 2007-2011; understand the incidence and mortality TB in prisoners of the state of Espírito Santo from July 2009 to July 2010 , and to identify the clinical and epidemiological characteristics of all diagnosed cases of tuberculosis in prisoners of the Holy Spirit , from July 2009 to July 2010. Methods: The study population consisted of diagnosed inmates with identified tuberculosis through SINAN, between January 2007 and December 2011 and diagnoses cases of tuberculosis among inmates of the Espírito Santo in the period from 1st July 2009 to 30 June 2010. The chi - square test and polynomial regression model were used to analyze, in addition to descriptive statistics, through tables and graphs. Results: Compared with patients in TB prisoners in Brazil, it is noted that prisoners who abandoned treatment were younger (P < 0.001), less educated (P < 0.001) and greater likelihood of alcoholism (P < 0.001), were more likely to have recurrent TB or recurrence (P < 0.001) and they were not under directly observed treatment (P < 0.001) compared with those who completed the treatment of tuberculosis. Those who died of tuberculosis tend to be older (P < 0.001) and alcoholics (P < 0.001) were also more likely to unknown type of treatment (P < 0.001) and presenting pulmonary TB and extrapulmonary TB (EPTB). Prisoners who developed MDR TB were more likely to experience recurrence of TB, return after default and transfer of the treatment site. Furthermore, we observed 167 cases of tuberculosis (incidence rate of 1962.6 per 100,000 inmates) in Espírito Santo. Males showed a higher number of patients, as well as the age group of 25-36 years and the pulmonary form. It is noteworthy that 109 (65.3 %) patients were discharged as cured, two patients died during the period, with the rate of tuberculosis mortality of 11 11.7 per 100,000 inmates. The highest incidence of tuberculosis in patients was located in the prisons of the metropolitan area and a small number of cases occurred in other sites out of prisons. Conclusion: Our results highlight the need to improve policies for TB control in prisons, as well as the outcomes of the treatment of prisoners in order to prevent transmission to other inmates, their families and health professionals.Introdução: Há cerca de duas décadas, a tuberculose (TB) foi considerada pela Organização Mundial de Saúde (OMS) como uma doença em estado de emergência em todo o mundo. Atualmente, apesar de todas as ações de controle da doença, ainda trata-se de um importante problema de saúde pública, apresentando forte relação com questões socioeconômicas, o que acarreta no maior adoecimento em grupos específicos, tais como a população privada de liberdade. Os dados de tuberculose em populações vulneráveis podem atingir índices ainda mais altos e por isso preocupante. Objetivos: Analisar as características clínicas e epidemiológicas associadas com os desfechos do tratamento da tuberculose na população privada de liberdade do Brasil, registrado no Sistema de Informação de Agravos de Notificação (SINAN), de 2007 a 2011; conhecer a taxa de incidência e de mortalidade por tuberculose na população privada de liberdade do Espírito Santo, de julho de 2009 a julho de 2010; e identificar as características clínicas e epidemiológicas dos casos diagnosticados de tuberculose na população privada de liberdade do Espírito Santo, de julho de 2009 a julho de 2010. Métodos: A população do estudo consistiu em presos diagnosticados com tuberculose identificados através do SINAN, entre janeiro de 2007 e dezembro de 2011 e dos casos diagnosticados de tuberculose na população prisional do Espírito Santo no período de 1º de julho de 2009 a 30 de junho de 2010. O teste de qui-quadrado de Pearson e o modelo de regressão polinomial foram utilizados na analise, além de estatística descritiva, por meio de tabelas e gráficos. Resultados: Em relação pacientes com TB na população privada de liberdade do Brasil, nota-se que os presos que abandonaram o tratamento eram mais jovens (P <0,001), com menor escolaridade (P <0,001) e maior probabilidade de alcoolismo (P < 0,001), eram mais propensos a ter TB recorrente ou recidiva (P < 0,001) e eles não estavam sob tratamento diretamente observado (TDO) (P < 0,001), comparados com aqueles que completaram o tratamento da tuberculose. Aqueles que morreram de tuberculose tendem a ter idade ⩾ 43 anos (P < 0,001) e alcoolistas (P < 0,001), também eram mais propensos a tipo de tratamento desconhecido (P <0,001) e apresentar tuberculose pulmonar e tuberculose extrapulmonar (TBEP). Presos que desenvolveram tuberculose multidroga resistente (TB-MDR) foram mais propensos a 9 experiência de recorrência de TB, retorno após abandono e transferência de local de tratamento. Além disso, observou-se 167 casos de tuberculose (taxa de incidência de 1962,6 por 100 mil presos) no Espírito Santo. O sexo masculino apresentou maior número de pacientes, assim como a faixa etária de 25 a 36 anos e a forma clínica pulmonar. Destaca-se que 109 (65,3%) pacientes tiveram alta por cura, ocorrendo dois óbitos durante o período, sendo a taxa de mortalidade por tuberculose de 11,7 por 100 mil presos. A maior incidência da tuberculose foi em pacientes localizados nas unidades prisionais da Região Metropolitana e um pequeno número de casos ocorreu em outros locais externos às unidades prisionais. Conclusão: Nossos resultados destacam a necessidade de melhorar as políticas de controle da TB nas penitenciárias, bem como os desfechos do tratamento de presos a fim de impedir a transmissão para outros presos, seus familiares e profissionais de saúde.Texthttp://repositorio.ufes.br/handle/10/1121porUniversidade Federal do Espírito SantoMestrado em Doenças InfecciosasPrograma de Pós-Graduação em Doenças InfecciosasUFESBRCentro de Ciências da SaúdeTurbeculosisPrisonsBrazilTuberculosePrisõesBrasilDoenças Infecciosas e Parasitárias61Tuberculose na população privada de liberdade : características clínicas e epidemiológicas relacionadas à doençainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da Universidade Federal do Espírito Santo (riUfes)instname:Universidade Federal do Espírito Santo (UFES)instacron:UFESORIGINALDissertacao.Texto.Laylla.pdfDissertacao.Texto.Laylla.pdfapplication/pdf857089http://repositorio.ufes.br/bitstreams/a8252422-66ca-417a-9f2b-b2be982d7814/download5705cdfc992eb9bdf61e36c584240cadMD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://repositorio.ufes.br/bitstreams/cd628ec3-0c16-43d4-bdf0-dd999e8d400e/download4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-822302http://repositorio.ufes.br/bitstreams/2e9582d9-f110-415f-8276-ae4b306c7073/download1e0094e9d8adcf16b18effef4ce7ed83MD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-823148http://repositorio.ufes.br/bitstreams/922a04af-0073-4107-b1b8-73a772214599/download9da0b6dfac957114c6a7714714b86306MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ufes.br/bitstreams/188b8de9-e3cc-497a-a81b-8fb97d73465d/download8a4605be74aa9ea9d79846c1fba20a33MD5510/11212024-07-16 17:05:05.921oai:repositorio.ufes.br:10/1121http://repositorio.ufes.brRepositório InstitucionalPUBhttp://repositorio.ufes.br/oai/requestopendoar:21082024-10-15T18:01:28.786504Repositório Institucional da Universidade Federal do Espírito Santo (riUfes) - Universidade Federal do Espírito Santo (UFES)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
dc.title.none.fl_str_mv Tuberculose na população privada de liberdade : características clínicas e epidemiológicas relacionadas à doença
title Tuberculose na população privada de liberdade : características clínicas e epidemiológicas relacionadas à doença
spellingShingle Tuberculose na população privada de liberdade : características clínicas e epidemiológicas relacionadas à doença
Macêdo, Laylla Ribeiro
Turbeculosis
Prisons
Brazil
Doenças Infecciosas e Parasitárias
Tuberculose
Prisões
Brasil
61
title_short Tuberculose na população privada de liberdade : características clínicas e epidemiológicas relacionadas à doença
title_full Tuberculose na população privada de liberdade : características clínicas e epidemiológicas relacionadas à doença
title_fullStr Tuberculose na população privada de liberdade : características clínicas e epidemiológicas relacionadas à doença
title_full_unstemmed Tuberculose na população privada de liberdade : características clínicas e epidemiológicas relacionadas à doença
title_sort Tuberculose na população privada de liberdade : características clínicas e epidemiológicas relacionadas à doença
author Macêdo, Laylla Ribeiro
author_facet Macêdo, Laylla Ribeiro
author_role author
dc.contributor.advisor1.fl_str_mv Maciel, Ethel Leonor Nóia
dc.contributor.author.fl_str_mv Macêdo, Laylla Ribeiro
dc.contributor.referee1.fl_str_mv Sanchez, Mauro Niskier
dc.contributor.referee2.fl_str_mv Miranda, Angélica Espinosa Barbosa
contributor_str_mv Maciel, Ethel Leonor Nóia
Sanchez, Mauro Niskier
Miranda, Angélica Espinosa Barbosa
dc.subject.eng.fl_str_mv Turbeculosis
Prisons
Brazil
topic Turbeculosis
Prisons
Brazil
Doenças Infecciosas e Parasitárias
Tuberculose
Prisões
Brasil
61
dc.subject.cnpq.fl_str_mv Doenças Infecciosas e Parasitárias
dc.subject.br-rjbn.none.fl_str_mv Tuberculose
Prisões
Brasil
dc.subject.udc.none.fl_str_mv 61
description Introduction: There are about two decades, tuberculosis (TB) was considered by the World Health Organization (WHO) as a disease in a state of emergency throughout the world. Currently, despite all efforts to control the disease, yet it is an important public health problem, showing strong relationship with socioeconomic issues, which entail greater illness in specific groups, such as prisoners. Data for TB in vulnerable populations can achieve even higher levels and therefore worrying. Objectives: To analyze the clinical and epidemiological characteristics associated with the outcomes of tuberculosis treatment in the prison population of Brazil, registered in the Information System for Notifiable Diseases (SINAN), 2007-2011; understand the incidence and mortality TB in prisoners of the state of Espírito Santo from July 2009 to July 2010 , and to identify the clinical and epidemiological characteristics of all diagnosed cases of tuberculosis in prisoners of the Holy Spirit , from July 2009 to July 2010. Methods: The study population consisted of diagnosed inmates with identified tuberculosis through SINAN, between January 2007 and December 2011 and diagnoses cases of tuberculosis among inmates of the Espírito Santo in the period from 1st July 2009 to 30 June 2010. The chi - square test and polynomial regression model were used to analyze, in addition to descriptive statistics, through tables and graphs. Results: Compared with patients in TB prisoners in Brazil, it is noted that prisoners who abandoned treatment were younger (P < 0.001), less educated (P < 0.001) and greater likelihood of alcoholism (P < 0.001), were more likely to have recurrent TB or recurrence (P < 0.001) and they were not under directly observed treatment (P < 0.001) compared with those who completed the treatment of tuberculosis. Those who died of tuberculosis tend to be older (P < 0.001) and alcoholics (P < 0.001) were also more likely to unknown type of treatment (P < 0.001) and presenting pulmonary TB and extrapulmonary TB (EPTB). Prisoners who developed MDR TB were more likely to experience recurrence of TB, return after default and transfer of the treatment site. Furthermore, we observed 167 cases of tuberculosis (incidence rate of 1962.6 per 100,000 inmates) in Espírito Santo. Males showed a higher number of patients, as well as the age group of 25-36 years and the pulmonary form. It is noteworthy that 109 (65.3 %) patients were discharged as cured, two patients died during the period, with the rate of tuberculosis mortality of 11 11.7 per 100,000 inmates. The highest incidence of tuberculosis in patients was located in the prisons of the metropolitan area and a small number of cases occurred in other sites out of prisons. Conclusion: Our results highlight the need to improve policies for TB control in prisons, as well as the outcomes of the treatment of prisoners in order to prevent transmission to other inmates, their families and health professionals.
publishDate 2014
dc.date.submitted.none.fl_str_mv 2014-02-27
dc.date.accessioned.fl_str_mv 2014-11-18T19:03:08Z
dc.date.available.fl_str_mv 2014-11-18T19:03:08Z
dc.date.issued.fl_str_mv 2014-02-27
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dc.publisher.none.fl_str_mv Universidade Federal do Espírito Santo
Mestrado em Doenças Infecciosas
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dc.publisher.initials.fl_str_mv UFES
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dc.publisher.department.fl_str_mv Centro de Ciências da Saúde
publisher.none.fl_str_mv Universidade Federal do Espírito Santo
Mestrado em Doenças Infecciosas
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