Acurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da Universidade Federal do Espírito Santo (riUfes) |
Texto Completo: | http://repositorio.ufes.br/handle/10/12626 |
Resumo: | Studies involving new tests and diagnostic methods used to screen for lesions that precede oral cancer are carried out, however, it becomes necessary to investigate the diagnostic accuracy index for its application. The objective of this Systematic Review (RS) was to collect the accuracy of autofluorescence in the early diagnosis of oral disorders with malignant potential (ODMPs). The search was carried out in nine electronic databases, three of which were gray literature, with no language or time restrictions. The studies included patients with ODMPs with microscopic examination – standard reference – obligatorily as a comparison to the autofluorescence method (test index). In selecting the two-phase studies, 17 of 3429 studies were included. The QUADAS-2 tool was used for risk of bias analysis with support from the Review Manager 5.0 tool for risk of bias analysis. The sensitivity and specificity of the studies varied considerably, with a minimum of 30% and a maximum of 100% for sensitivity, and a minimum of 15% and a maximum of 100% for specificity, which demonstrates exceptional accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and unclear in most studies in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The sensitivity and specificity of the studies varied considerably, with a minimum of 30 and a maximum of 100 for sensitivity and a minimum of 15 and a maximum of 100 for specificity, which demonstrates intellectual accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and it was not clear in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The autofluorescence of the selected studies showed moderate to uncertain accuracy due to the heterogeneity of the results and raises an alert for the development of more primary studies consistent in design and conduct.The applicability of autofluorescence in aiding the diagnosis of ODMPs should prosper ecause it is a non-invasive method, easy to handle, accessible in the dentist's routine, despite the variable cost, ubject to the standardization of protocols and the physician's experience., more studies are necessary due to the analysis of the risk of bias and the asymmetry of the sensitivity and specificity of the results. |
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Barros, Liliana Aparecida Pimenta dehttp://lattes.cnpq.br/8635277660080840Freitas, Lara Weinert dehttps://orcid.org/0000-0001-5999-0713http://lattes.cnpq.br/9739624818971642Lima, Thiago Farias Rochahttp://lattes.cnpq.br/3369191934450137Lourenco, Simone de Queiroz Chaves2024-05-29T20:55:33Z2024-05-29T20:55:33Z2023-07-14Studies involving new tests and diagnostic methods used to screen for lesions that precede oral cancer are carried out, however, it becomes necessary to investigate the diagnostic accuracy index for its application. The objective of this Systematic Review (RS) was to collect the accuracy of autofluorescence in the early diagnosis of oral disorders with malignant potential (ODMPs). The search was carried out in nine electronic databases, three of which were gray literature, with no language or time restrictions. The studies included patients with ODMPs with microscopic examination – standard reference – obligatorily as a comparison to the autofluorescence method (test index). In selecting the two-phase studies, 17 of 3429 studies were included. The QUADAS-2 tool was used for risk of bias analysis with support from the Review Manager 5.0 tool for risk of bias analysis. The sensitivity and specificity of the studies varied considerably, with a minimum of 30% and a maximum of 100% for sensitivity, and a minimum of 15% and a maximum of 100% for specificity, which demonstrates exceptional accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and unclear in most studies in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The sensitivity and specificity of the studies varied considerably, with a minimum of 30 and a maximum of 100 for sensitivity and a minimum of 15 and a maximum of 100 for specificity, which demonstrates intellectual accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and it was not clear in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The autofluorescence of the selected studies showed moderate to uncertain accuracy due to the heterogeneity of the results and raises an alert for the development of more primary studies consistent in design and conduct.The applicability of autofluorescence in aiding the diagnosis of ODMPs should prosper ecause it is a non-invasive method, easy to handle, accessible in the dentist's routine, despite the variable cost, ubject to the standardization of protocols and the physician's experience., more studies are necessary due to the analysis of the risk of bias and the asymmetry of the sensitivity and specificity of the results.Estudos envolvendo novos testes e métodos diagnósticos usados para rastrear lesões que precedem o câncer de boca são realizados, entretanto, tornar-se necessário investigar o índice de acurácia diagnóstica para sua aplicação. O objetivo desta Revisão Sistemática (RS) foi coletar a acurácia da autofluorescência no diagnóstico precoce de desordens orais com potencial de malignização (DOPMs). A busca foi realizada em nove bases de dados eletrônicos, sendo três da literatura cinzenta, sem restrições de idioma ou tempo. Os estudos incluídos envolveram pacientes com DOPMs com exame microscópico – padrão referência – obrigatoriamente como comparativo ao método de autofluorescência (teste índice). Na seleção dos estudos de duas fases, 17 de 3.429 estudos foram incluídos. A ferramenta QUADAS-2 foi utilizada para análise do risco de viés com suporte do Review Manager 5.0. A sensibilidade e especificidade dos estudos variaram consideravelmente, com mínimo de 30% e máximo de 100% para a sensibilidade, e mínimo de 15% e máximo de 100% na especificidade, o que demonstra uma acurácia instável dentro dos estudos. O risco de viés foi baixo na maioria dos estudos no domínio 1(seleção de paciente) e não ficou claro nos domínios 2(teste índice), 3(padrão referência) e 4(fluxo e tempo). A autofluorescência dos estudos selecionados mostrou acurácia de moderada a incerta devida à heterogeneidade dos resultados e levanta um alerta para o desenvolvimento de mais estudos primários consistentes no desenho e condução. A aplicabilidade da autofluorescência no auxílio do diagnóstico nas DOPMs deve prosperar por ser um método não invasivo, de fácil manejo, acessível na rotina do cirurgião-dentista, apesar do custo variável, ficando condicionada a padronização de protocolos e experiência do examinador.Fundação de Amparo à Pesquisa do Espírito Santo (FAPES)Texthttp://repositorio.ufes.br/handle/10/12626porUniversidade Federal do Espírito SantoMestrado em Ciências OdontológicasPrograma de Pós-Graduação em Ciências OdontológicasUFESBRCentro de Ciências da SaúdeCiências da SaúdeAutofluorescênciaCâncer oralBiópsiaAcurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemáticainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da Universidade Federal do Espírito Santo (riUfes)instname:Universidade Federal do Espírito Santo (UFES)instacron:UFESORIGINALEMBARGADO-RESTRITO.pdfapplication/pdf275372http://repositorio.ufes.br/bitstreams/26dbc6f9-14c0-4388-9940-62caf82078b9/downloadf19515a01cb1c30076d7f7ba8c48dd73MD5110/126262024-09-11 16:04:54.254oai:repositorio.ufes.br:10/12626http://repositorio.ufes.brRepositório InstitucionalPUBhttp://repositorio.ufes.br/oai/requestopendoar:21082024-10-15T17:51:26.838419Repositório Institucional da Universidade Federal do Espírito Santo (riUfes) - Universidade Federal do Espírito Santo (UFES)false |
dc.title.none.fl_str_mv |
Acurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática |
title |
Acurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática |
spellingShingle |
Acurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática Freitas, Lara Weinert de Ciências da Saúde Autofluorescência Câncer oral Biópsia |
title_short |
Acurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática |
title_full |
Acurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática |
title_fullStr |
Acurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática |
title_full_unstemmed |
Acurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática |
title_sort |
Acurácia da autofluorescência para diagnóstico precoce de desordens orais potencialmente malignas: revisão sistemática |
author |
Freitas, Lara Weinert de |
author_facet |
Freitas, Lara Weinert de |
author_role |
author |
dc.contributor.authorID.none.fl_str_mv |
https://orcid.org/0000-0001-5999-0713 |
dc.contributor.authorLattes.none.fl_str_mv |
http://lattes.cnpq.br/9739624818971642 |
dc.contributor.advisor1.fl_str_mv |
Barros, Liliana Aparecida Pimenta de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/8635277660080840 |
dc.contributor.author.fl_str_mv |
Freitas, Lara Weinert de |
dc.contributor.referee1.fl_str_mv |
Lima, Thiago Farias Rocha |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/3369191934450137 |
dc.contributor.referee2.fl_str_mv |
Lourenco, Simone de Queiroz Chaves |
contributor_str_mv |
Barros, Liliana Aparecida Pimenta de Lima, Thiago Farias Rocha Lourenco, Simone de Queiroz Chaves |
dc.subject.cnpq.fl_str_mv |
Ciências da Saúde |
topic |
Ciências da Saúde Autofluorescência Câncer oral Biópsia |
dc.subject.por.fl_str_mv |
Autofluorescência Câncer oral Biópsia |
description |
Studies involving new tests and diagnostic methods used to screen for lesions that precede oral cancer are carried out, however, it becomes necessary to investigate the diagnostic accuracy index for its application. The objective of this Systematic Review (RS) was to collect the accuracy of autofluorescence in the early diagnosis of oral disorders with malignant potential (ODMPs). The search was carried out in nine electronic databases, three of which were gray literature, with no language or time restrictions. The studies included patients with ODMPs with microscopic examination – standard reference – obligatorily as a comparison to the autofluorescence method (test index). In selecting the two-phase studies, 17 of 3429 studies were included. The QUADAS-2 tool was used for risk of bias analysis with support from the Review Manager 5.0 tool for risk of bias analysis. The sensitivity and specificity of the studies varied considerably, with a minimum of 30% and a maximum of 100% for sensitivity, and a minimum of 15% and a maximum of 100% for specificity, which demonstrates exceptional accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and unclear in most studies in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The sensitivity and specificity of the studies varied considerably, with a minimum of 30 and a maximum of 100 for sensitivity and a minimum of 15 and a maximum of 100 for specificity, which demonstrates intellectual accuracy within the studies. The risk of bias was low in most studies in domain 1 (patient selection) and it was not clear in domains 2 (index test), 3 (reference standard) and 4 (flow and time). The autofluorescence of the selected studies showed moderate to uncertain accuracy due to the heterogeneity of the results and raises an alert for the development of more primary studies consistent in design and conduct.The applicability of autofluorescence in aiding the diagnosis of ODMPs should prosper ecause it is a non-invasive method, easy to handle, accessible in the dentist's routine, despite the variable cost, ubject to the standardization of protocols and the physician's experience., more studies are necessary due to the analysis of the risk of bias and the asymmetry of the sensitivity and specificity of the results. |
publishDate |
2023 |
dc.date.issued.fl_str_mv |
2023-07-14 |
dc.date.accessioned.fl_str_mv |
2024-05-29T20:55:33Z |
dc.date.available.fl_str_mv |
2024-05-29T20:55:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufes.br/handle/10/12626 |
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http://repositorio.ufes.br/handle/10/12626 |
dc.language.iso.fl_str_mv |
por |
language |
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dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
Text |
dc.publisher.none.fl_str_mv |
Universidade Federal do Espírito Santo Mestrado em Ciências Odontológicas |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Odontológicas |
dc.publisher.initials.fl_str_mv |
UFES |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Centro de Ciências da Saúde |
publisher.none.fl_str_mv |
Universidade Federal do Espírito Santo Mestrado em Ciências Odontológicas |
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Repositório Institucional da Universidade Federal do Espírito Santo (riUfes) |
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