Leucoplasia oral e leucoplasia verrucosa proliferativa: análise clínico-patológica e imunohistoquímica

• Autor(a) principal: Pereira, Luanna Canal
• Data de Publicação: 2023
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da Universidade Federal do Espírito Santo (riUfes)
• Texto Completo: http://repositorio.ufes.br/handle/10/12673
• topic: Ciências da Saúde; Leucoplasia oral; Carcinoma de células escamosas; Citoqueratina

Introduction: Oral potentially malignant disorders (OPMDs) are a group of oral lesions associated with a variable risk of progression to oral carcinomas. Oral leukoplakia (OL) is the most common OPMD. Proliferative verrucous leukoplakia (PVL) is a subtype of OL with a high risk of progression to carcinoma. Cytokeratin 10 (CK10) acts to differentiate normal from dysplastic epithelium. Objectives: Compare sociodemographic, clinical, histopathological and immunohistochemical characteristics of CK10 in OL and PVL and apply two diagnostic criteria for PVL. Materials and methods: Cases diagnosed as OL, PVL, epithelial dysplasia and hyperkeratosis without and with dysplasia were selected from the Oral Pathological Anatomy Service of the Federal University of Espírito Santo, in ten years. Sociodemographic, clinicopathological and immunohistochemical data were collected. A p-value ≤.05 was considered was considered statistically significant. Results: 51 patients (n=32, 62.7% LVP and n=19, 37.3% LO) and 104 lesions (n=76, 73% LVP and n=28, 26.9% LO) were selected, with 53 lesions submitted to immunohistochemical staining for CK10 (n=40, 75.4% LVP and n=13, 24.5% LO), with a mean follow-up of 13 months for LO and 27 months for LVP (p=0.038). There was a predominance of females in both, an association between tobacco use and LO (p= 0.007) and the presence of recurrence in PVL lesions (p=0.028). There was malignant transformation in two cases of PVL and one of LO. Almost all lesions were positive for CK10 (n=51, 96.3%). No lesion showed CK10 expression in the basal layer. When applying the criteria for PVL, all met the criteria of Cerero-Lapiedra et al., 2010 and 19 patients met the criteria of Villa et al., 2018. Conclusions: Tobacco use is associated with LO, but not with LVP. The two criteria applied were useful, CereroLapiedra et al., 2010 selects more patients, a favorable fact for better monitoring of the disease. There was no difference in CK10 expression between the lesions studied.