Aplicação de ICP-MS e ICP OES no estudo do perfil inorgânico de amostras de cocaína de rua

• Autor(a) principal: Amorim, Zanata Brandão
• Data de Publicação: 2015
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da Universidade Federal do Espírito Santo (riUfes)
• Texto Completo: http://repositorio.ufes.br/handle/10/4731
• topic: Inorganic elements; Cocaine; Forensic chemistry; Chemometrics; Elementos inorgânicos; Química forense; Quimiometria; Cocaína; Química; Drogas - Abuso; Cocaína; 54

The abusive use of drugs has become a global problem that has serious consequences for both drug users and society. Determining the inorganic constituents of illicit drugs can be used to indicate the quality (the purity and concentration of other constituents of the drugs). Variations in drug purity can be used to formulate hypotheses about the structure of the illegal drug market in terms of differences in distribution and delivery. Fifty two street cocaine samples that were seized in different regions of the Espírito Santo State of Brazil were analysed. The sample pretreatment consisted of digesting 0.1 g of a sample with 6 mL 5% v/v HNO3 in a microwave closed-vessel system after diluting the sample to a 15mL volume. Inductively coupled plasma optical emission spectrometry (ICP OES) or inductively coupled plasma mass spectrometry (ICP-MS) were then used to determine the concentrations of Al, Ca, Cu, Fe, Mn, Mg, Zn, Mo, Co, Pb and P in these samples. The accuracy of the procedures was verified using recovery tests at two concentrations (50 and 100 µg L-1 ). The resulting data were then statistically analysed. Using Hierarchical Cluster Analysis (HCA) was possible differentiation of the seizure Regions. Pearson correlations allowed to correlate the elemental concentrations with the chemicals compounds that are used in the production and adulteration of cocaine. Boxplot analysis confirmed the distinction of the seizure regions.