Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil

Detalhes bibliográficos
Autor(a) principal: Nascimento, Kamila Paschoal Magno do
Data de Publicação: 2017
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da Universidade Federal do Espírito Santo (riUfes)
Texto Completo: http://repositorio.ufes.br/handle/10/8335
Resumo: Introduction: Basal cell carcinoma (BCC) is the commonest type of cancer among humans. About 85% are located on the face and trunk and 10-15% in usually photoprotected areas. Objective: To compare epidemiological, clinical and histopathological aspects of BCCs from non-photoexposed areas with those of photoexposed areas. Patients and methods: Observational, retrospective and casecontrol study of patients with clinical and histopathological diagnosis of BCC by the Dermatology Service of Vitória-ES, from 2008 to 2015. A total of 107 BCCs were assessed, from which 32 (29 , 9%) were located in non-photoexposed areas and 75 (71.1%) in photoexposed areas (nose). Results: The median age was 70 years; 62% of the patients were women as for the BCCs in the non-photoexposed regions; The commonest histological subtype in the two groups was the nodular one, followed by the superficial one in the non-photoexposed area, with 10 (31.3%) cases (OR = 2,051-5,267; p = 0,0001). Micronodular and baso-squamous subtypes were not observed in this group. Twelve (37.5%) cases in the non-photoexposed areas presented mild or absent elastosis (OR = 1,789-4,919; p = 0,0001). There was a predominance of a large number of mononuclears in the group of non-photoexposed areas: 12 (37.5%) cases, compared to eight (10.7%) cases in the photoexposed areas group (OR: 1,543-4,414; p = 0.002). Regarding the pattern of growth of BCCs, in the group of cases of the non-photoexposed areas, there was a predominance of the low risk pattern in 23 (71.9%) cases of nonphotoexposed areas versus 42 (56%) cases in the group of photoexposed areas (P = 0.137). Discussion: Despite the higher frequency of the nodular subtype in the two analyzed regions, the superficial subtype was more frequent in the non-photoexposed area, with a statistical difference, validating the literature. There was a higher frequency of moderate / severe elastosis in both regions, similar to the literature, but its absence was three times more likely to occur in the non-exposed area. The predominance of mononuclear cells in the non-photoexposed areas, possibly prevented the tumor from spreading. Regarding the pathological condition, the BCCs of the non-photoexposed areas were categorized as low risk in 65.5% of the cases. Conclusion: In the study, the BCCs in the non-photoexposed regions showed a better prognosis than the photoexposed areas, assessed through the histological factors.
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spelling Diniz, Lucia MartinsNascimento, Kamila Paschoal Magno doLuz, Flávio BarbosaSantos, Maria Carmen Lopes Ferreira SilvaMusso, Carlos2018-08-01T23:27:38Z2018-08-01T23:27:38Z2017-01-20Introduction: Basal cell carcinoma (BCC) is the commonest type of cancer among humans. About 85% are located on the face and trunk and 10-15% in usually photoprotected areas. Objective: To compare epidemiological, clinical and histopathological aspects of BCCs from non-photoexposed areas with those of photoexposed areas. Patients and methods: Observational, retrospective and casecontrol study of patients with clinical and histopathological diagnosis of BCC by the Dermatology Service of Vitória-ES, from 2008 to 2015. A total of 107 BCCs were assessed, from which 32 (29 , 9%) were located in non-photoexposed areas and 75 (71.1%) in photoexposed areas (nose). Results: The median age was 70 years; 62% of the patients were women as for the BCCs in the non-photoexposed regions; The commonest histological subtype in the two groups was the nodular one, followed by the superficial one in the non-photoexposed area, with 10 (31.3%) cases (OR = 2,051-5,267; p = 0,0001). Micronodular and baso-squamous subtypes were not observed in this group. Twelve (37.5%) cases in the non-photoexposed areas presented mild or absent elastosis (OR = 1,789-4,919; p = 0,0001). There was a predominance of a large number of mononuclears in the group of non-photoexposed areas: 12 (37.5%) cases, compared to eight (10.7%) cases in the photoexposed areas group (OR: 1,543-4,414; p = 0.002). Regarding the pattern of growth of BCCs, in the group of cases of the non-photoexposed areas, there was a predominance of the low risk pattern in 23 (71.9%) cases of nonphotoexposed areas versus 42 (56%) cases in the group of photoexposed areas (P = 0.137). Discussion: Despite the higher frequency of the nodular subtype in the two analyzed regions, the superficial subtype was more frequent in the non-photoexposed area, with a statistical difference, validating the literature. There was a higher frequency of moderate / severe elastosis in both regions, similar to the literature, but its absence was three times more likely to occur in the non-exposed area. The predominance of mononuclear cells in the non-photoexposed areas, possibly prevented the tumor from spreading. Regarding the pathological condition, the BCCs of the non-photoexposed areas were categorized as low risk in 65.5% of the cases. Conclusion: In the study, the BCCs in the non-photoexposed regions showed a better prognosis than the photoexposed areas, assessed through the histological factors.Introdução: O carcinoma basocelular (CBC) é o câncer mais comum entre os humanos. Cerca de 85% se localizam na face e no tronco e 10 a 15% em áreas usualmente fotoprotegidas. Objetivo: Comparar aspectos epidemiológicos, clínicos e histopatológicos dos CBCs de áreas não fotoexpostas com os de áreas fotoexpostas. Pacientes e métodos: Estudo observacional, retrospectivo e caso-controle de pacientes com diagnóstico clínico e histopatológico de CBCs advindos do programa de extensão de um Serviço de Dermatologia de Vitória ES, entre 2008 e 2015. Foram avaliados 107 CBCs, sendo 32 (29,9%) em áreas não fotoexpostas e 75 (71,1%) em áreas fotoexpostas (nariz). Resultados: A mediana de idade foi de 70 anos; 62% dos pacientes eram mulheres para os CBCs das regiões não fotoexpostas; o subtipo histológico mais observado nos dois grupos foi o nodular, seguido do superficial na área não fotoexposta, com 10 (31,3%) casos (OR=2,051-5,267;p=0,0001). Não foram observados os subtipos micronodular e basoescamoso neste grupo. Doze (37,5%) casos nas áreas não fotoexpostas apresentavam elastose de grau leve ou ausente (OR=1,789-4,919;p=0,0001). Houve predominância de grande número de mononucleares no grupo das áreas não fotoexpostas: 12 (37,5%) casos, comparados aos oito (10,7%) casos no grupo das áreas fotoexpostas (OR:1,543-4,414;p=0,002). Em relação ao padrão de crescimento dos CBCs, no grupo de casos nas áreas não fotoexpostas, houve predomínio do padrão de baixo risco em 23 (71,9%) casos das áreas não fotoexpostas contra 42 (56%) casos no grupo das áreas fotoexpostas (p=0,137). Discussão: Apesar da maior frequência do subtipo nodular nas duas regiões analisadas, o subtipo superficial foi mais frequente na área não fotoexposta, com diferença estatística, corroborando a literatura. Houve maior frequência da elastose moderada/grave nas duas regiões, semelhante à literatura, mas a sua ausência apresentou três vezes mais chance de ocorrer na área não fotoexposta. A predominância das células mononucleares nas áreas não fotoexpostas, possivelmente, sugere o bloqueio da disseminação do tumor. Quanto ao status patológico, os CBCs das áreas não fotoexpostas foram classificados como de baixo risco em 65,5% dos casos. Conclusão: No estudo, os CBCs nas regiões não fotoexpostas apresentaram prognóstico melhor em relação aos de áreas fotoexpostas, observado através dos fatores histológicos analisados.TextNASCIMENTO, Kamila Paschoal Magno do. Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil. 2017. 91 f. Dissertação (Mestrado em Medicina) - Programa de Pós-Graduação em Medicina, Universidade Federal do Espírito Santo, Vitória, 2017.http://repositorio.ufes.br/handle/10/8335porUniversidade Federal do Espírito SantoMestrado em MedicinaPrograma de Pós-Graduação em MedicinaUFESBRCentro de Ciências da SaúdeBasal cell carcinomaCutaneous neoplasmsBasal cell epitheliomaSkin cancerSkinNeoplasias cutâneasCarcinoma basocelularEpitelioma basocelularCâncer de pelePeleCâncerTumoresMedicina61Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da Universidade Federal do Espírito Santo (riUfes)instname:Universidade Federal do Espírito Santo (UFES)instacron:UFESORIGINALtese_10559_TESE KAMILA - CBC EM ÁREA NÃO EXPOSTA AO SOL.pdfapplication/pdf3128935http://repositorio.ufes.br/bitstreams/a8aaa180-f494-4bc8-b5fb-4e7e9e5805c0/download6d83a03e5f5debb63fb6966eff5b49eeMD5110/83352024-07-16 17:09:32.366oai:repositorio.ufes.br:10/8335http://repositorio.ufes.brRepositório InstitucionalPUBhttp://repositorio.ufes.br/oai/requestopendoar:21082024-10-15T18:00:35.491684Repositório Institucional da Universidade Federal do Espírito Santo (riUfes) - Universidade Federal do Espírito Santo (UFES)false
dc.title.none.fl_str_mv Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil
title Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil
spellingShingle Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil
Nascimento, Kamila Paschoal Magno do
Basal cell carcinoma
Cutaneous neoplasms
Basal cell epithelioma
Skin cancer
Skin
Neoplasias cutâneas
Carcinoma basocelular
Epitelioma basocelular
Câncer de pele
Medicina
Pele
Câncer
Tumores
61
title_short Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil
title_full Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil
title_fullStr Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil
title_full_unstemmed Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil
title_sort Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil
author Nascimento, Kamila Paschoal Magno do
author_facet Nascimento, Kamila Paschoal Magno do
author_role author
dc.contributor.advisor1.fl_str_mv Diniz, Lucia Martins
dc.contributor.author.fl_str_mv Nascimento, Kamila Paschoal Magno do
dc.contributor.referee1.fl_str_mv Luz, Flávio Barbosa
dc.contributor.referee2.fl_str_mv Santos, Maria Carmen Lopes Ferreira Silva
dc.contributor.referee3.fl_str_mv Musso, Carlos
contributor_str_mv Diniz, Lucia Martins
Luz, Flávio Barbosa
Santos, Maria Carmen Lopes Ferreira Silva
Musso, Carlos
dc.subject.eng.fl_str_mv Basal cell carcinoma
Cutaneous neoplasms
Basal cell epithelioma
Skin cancer
Skin
topic Basal cell carcinoma
Cutaneous neoplasms
Basal cell epithelioma
Skin cancer
Skin
Neoplasias cutâneas
Carcinoma basocelular
Epitelioma basocelular
Câncer de pele
Medicina
Pele
Câncer
Tumores
61
dc.subject.por.fl_str_mv Neoplasias cutâneas
Carcinoma basocelular
Epitelioma basocelular
Câncer de pele
dc.subject.cnpq.fl_str_mv Medicina
dc.subject.br-rjbn.none.fl_str_mv Pele
Câncer
Tumores
dc.subject.udc.none.fl_str_mv 61
description Introduction: Basal cell carcinoma (BCC) is the commonest type of cancer among humans. About 85% are located on the face and trunk and 10-15% in usually photoprotected areas. Objective: To compare epidemiological, clinical and histopathological aspects of BCCs from non-photoexposed areas with those of photoexposed areas. Patients and methods: Observational, retrospective and casecontrol study of patients with clinical and histopathological diagnosis of BCC by the Dermatology Service of Vitória-ES, from 2008 to 2015. A total of 107 BCCs were assessed, from which 32 (29 , 9%) were located in non-photoexposed areas and 75 (71.1%) in photoexposed areas (nose). Results: The median age was 70 years; 62% of the patients were women as for the BCCs in the non-photoexposed regions; The commonest histological subtype in the two groups was the nodular one, followed by the superficial one in the non-photoexposed area, with 10 (31.3%) cases (OR = 2,051-5,267; p = 0,0001). Micronodular and baso-squamous subtypes were not observed in this group. Twelve (37.5%) cases in the non-photoexposed areas presented mild or absent elastosis (OR = 1,789-4,919; p = 0,0001). There was a predominance of a large number of mononuclears in the group of non-photoexposed areas: 12 (37.5%) cases, compared to eight (10.7%) cases in the photoexposed areas group (OR: 1,543-4,414; p = 0.002). Regarding the pattern of growth of BCCs, in the group of cases of the non-photoexposed areas, there was a predominance of the low risk pattern in 23 (71.9%) cases of nonphotoexposed areas versus 42 (56%) cases in the group of photoexposed areas (P = 0.137). Discussion: Despite the higher frequency of the nodular subtype in the two analyzed regions, the superficial subtype was more frequent in the non-photoexposed area, with a statistical difference, validating the literature. There was a higher frequency of moderate / severe elastosis in both regions, similar to the literature, but its absence was three times more likely to occur in the non-exposed area. The predominance of mononuclear cells in the non-photoexposed areas, possibly prevented the tumor from spreading. Regarding the pathological condition, the BCCs of the non-photoexposed areas were categorized as low risk in 65.5% of the cases. Conclusion: In the study, the BCCs in the non-photoexposed regions showed a better prognosis than the photoexposed areas, assessed through the histological factors.
publishDate 2017
dc.date.issued.fl_str_mv 2017-01-20
dc.date.accessioned.fl_str_mv 2018-08-01T23:27:38Z
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dc.identifier.citation.fl_str_mv NASCIMENTO, Kamila Paschoal Magno do. Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil. 2017. 91 f. Dissertação (Mestrado em Medicina) - Programa de Pós-Graduação em Medicina, Universidade Federal do Espírito Santo, Vitória, 2017.
dc.identifier.uri.fl_str_mv http://repositorio.ufes.br/handle/10/8335
identifier_str_mv NASCIMENTO, Kamila Paschoal Magno do. Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil. 2017. 91 f. Dissertação (Mestrado em Medicina) - Programa de Pós-Graduação em Medicina, Universidade Federal do Espírito Santo, Vitória, 2017.
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Mestrado em Medicina
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publisher.none.fl_str_mv Universidade Federal do Espírito Santo
Mestrado em Medicina
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