Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da Universidade Federal do Espírito Santo (riUfes) |
Texto Completo: | http://repositorio.ufes.br/handle/10/8335 |
Resumo: | Introduction: Basal cell carcinoma (BCC) is the commonest type of cancer among humans. About 85% are located on the face and trunk and 10-15% in usually photoprotected areas. Objective: To compare epidemiological, clinical and histopathological aspects of BCCs from non-photoexposed areas with those of photoexposed areas. Patients and methods: Observational, retrospective and casecontrol study of patients with clinical and histopathological diagnosis of BCC by the Dermatology Service of Vitória-ES, from 2008 to 2015. A total of 107 BCCs were assessed, from which 32 (29 , 9%) were located in non-photoexposed areas and 75 (71.1%) in photoexposed areas (nose). Results: The median age was 70 years; 62% of the patients were women as for the BCCs in the non-photoexposed regions; The commonest histological subtype in the two groups was the nodular one, followed by the superficial one in the non-photoexposed area, with 10 (31.3%) cases (OR = 2,051-5,267; p = 0,0001). Micronodular and baso-squamous subtypes were not observed in this group. Twelve (37.5%) cases in the non-photoexposed areas presented mild or absent elastosis (OR = 1,789-4,919; p = 0,0001). There was a predominance of a large number of mononuclears in the group of non-photoexposed areas: 12 (37.5%) cases, compared to eight (10.7%) cases in the photoexposed areas group (OR: 1,543-4,414; p = 0.002). Regarding the pattern of growth of BCCs, in the group of cases of the non-photoexposed areas, there was a predominance of the low risk pattern in 23 (71.9%) cases of nonphotoexposed areas versus 42 (56%) cases in the group of photoexposed areas (P = 0.137). Discussion: Despite the higher frequency of the nodular subtype in the two analyzed regions, the superficial subtype was more frequent in the non-photoexposed area, with a statistical difference, validating the literature. There was a higher frequency of moderate / severe elastosis in both regions, similar to the literature, but its absence was three times more likely to occur in the non-exposed area. The predominance of mononuclear cells in the non-photoexposed areas, possibly prevented the tumor from spreading. Regarding the pathological condition, the BCCs of the non-photoexposed areas were categorized as low risk in 65.5% of the cases. Conclusion: In the study, the BCCs in the non-photoexposed regions showed a better prognosis than the photoexposed areas, assessed through the histological factors. |
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Diniz, Lucia MartinsNascimento, Kamila Paschoal Magno doLuz, Flávio BarbosaSantos, Maria Carmen Lopes Ferreira SilvaMusso, Carlos2018-08-01T23:27:38Z2018-08-01T23:27:38Z2017-01-20Introduction: Basal cell carcinoma (BCC) is the commonest type of cancer among humans. About 85% are located on the face and trunk and 10-15% in usually photoprotected areas. Objective: To compare epidemiological, clinical and histopathological aspects of BCCs from non-photoexposed areas with those of photoexposed areas. Patients and methods: Observational, retrospective and casecontrol study of patients with clinical and histopathological diagnosis of BCC by the Dermatology Service of Vitória-ES, from 2008 to 2015. A total of 107 BCCs were assessed, from which 32 (29 , 9%) were located in non-photoexposed areas and 75 (71.1%) in photoexposed areas (nose). Results: The median age was 70 years; 62% of the patients were women as for the BCCs in the non-photoexposed regions; The commonest histological subtype in the two groups was the nodular one, followed by the superficial one in the non-photoexposed area, with 10 (31.3%) cases (OR = 2,051-5,267; p = 0,0001). Micronodular and baso-squamous subtypes were not observed in this group. Twelve (37.5%) cases in the non-photoexposed areas presented mild or absent elastosis (OR = 1,789-4,919; p = 0,0001). There was a predominance of a large number of mononuclears in the group of non-photoexposed areas: 12 (37.5%) cases, compared to eight (10.7%) cases in the photoexposed areas group (OR: 1,543-4,414; p = 0.002). Regarding the pattern of growth of BCCs, in the group of cases of the non-photoexposed areas, there was a predominance of the low risk pattern in 23 (71.9%) cases of nonphotoexposed areas versus 42 (56%) cases in the group of photoexposed areas (P = 0.137). Discussion: Despite the higher frequency of the nodular subtype in the two analyzed regions, the superficial subtype was more frequent in the non-photoexposed area, with a statistical difference, validating the literature. There was a higher frequency of moderate / severe elastosis in both regions, similar to the literature, but its absence was three times more likely to occur in the non-exposed area. The predominance of mononuclear cells in the non-photoexposed areas, possibly prevented the tumor from spreading. Regarding the pathological condition, the BCCs of the non-photoexposed areas were categorized as low risk in 65.5% of the cases. Conclusion: In the study, the BCCs in the non-photoexposed regions showed a better prognosis than the photoexposed areas, assessed through the histological factors.Introdução: O carcinoma basocelular (CBC) é o câncer mais comum entre os humanos. Cerca de 85% se localizam na face e no tronco e 10 a 15% em áreas usualmente fotoprotegidas. Objetivo: Comparar aspectos epidemiológicos, clínicos e histopatológicos dos CBCs de áreas não fotoexpostas com os de áreas fotoexpostas. Pacientes e métodos: Estudo observacional, retrospectivo e caso-controle de pacientes com diagnóstico clínico e histopatológico de CBCs advindos do programa de extensão de um Serviço de Dermatologia de Vitória ES, entre 2008 e 2015. Foram avaliados 107 CBCs, sendo 32 (29,9%) em áreas não fotoexpostas e 75 (71,1%) em áreas fotoexpostas (nariz). Resultados: A mediana de idade foi de 70 anos; 62% dos pacientes eram mulheres para os CBCs das regiões não fotoexpostas; o subtipo histológico mais observado nos dois grupos foi o nodular, seguido do superficial na área não fotoexposta, com 10 (31,3%) casos (OR=2,051-5,267;p=0,0001). Não foram observados os subtipos micronodular e basoescamoso neste grupo. Doze (37,5%) casos nas áreas não fotoexpostas apresentavam elastose de grau leve ou ausente (OR=1,789-4,919;p=0,0001). Houve predominância de grande número de mononucleares no grupo das áreas não fotoexpostas: 12 (37,5%) casos, comparados aos oito (10,7%) casos no grupo das áreas fotoexpostas (OR:1,543-4,414;p=0,002). Em relação ao padrão de crescimento dos CBCs, no grupo de casos nas áreas não fotoexpostas, houve predomínio do padrão de baixo risco em 23 (71,9%) casos das áreas não fotoexpostas contra 42 (56%) casos no grupo das áreas fotoexpostas (p=0,137). Discussão: Apesar da maior frequência do subtipo nodular nas duas regiões analisadas, o subtipo superficial foi mais frequente na área não fotoexposta, com diferença estatística, corroborando a literatura. Houve maior frequência da elastose moderada/grave nas duas regiões, semelhante à literatura, mas a sua ausência apresentou três vezes mais chance de ocorrer na área não fotoexposta. A predominância das células mononucleares nas áreas não fotoexpostas, possivelmente, sugere o bloqueio da disseminação do tumor. Quanto ao status patológico, os CBCs das áreas não fotoexpostas foram classificados como de baixo risco em 65,5% dos casos. Conclusão: No estudo, os CBCs nas regiões não fotoexpostas apresentaram prognóstico melhor em relação aos de áreas fotoexpostas, observado através dos fatores histológicos analisados.TextNASCIMENTO, Kamila Paschoal Magno do. Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil. 2017. 91 f. Dissertação (Mestrado em Medicina) - Programa de Pós-Graduação em Medicina, Universidade Federal do Espírito Santo, Vitória, 2017.http://repositorio.ufes.br/handle/10/8335porUniversidade Federal do Espírito SantoMestrado em MedicinaPrograma de Pós-Graduação em MedicinaUFESBRCentro de Ciências da SaúdeBasal cell carcinomaCutaneous neoplasmsBasal cell epitheliomaSkin cancerSkinNeoplasias cutâneasCarcinoma basocelularEpitelioma basocelularCâncer de pelePeleCâncerTumoresMedicina61Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da Universidade Federal do Espírito Santo (riUfes)instname:Universidade Federal do Espírito Santo (UFES)instacron:UFESORIGINALtese_10559_TESE KAMILA - CBC EM ÁREA NÃO EXPOSTA AO SOL.pdfapplication/pdf3128935http://repositorio.ufes.br/bitstreams/a8aaa180-f494-4bc8-b5fb-4e7e9e5805c0/download6d83a03e5f5debb63fb6966eff5b49eeMD5110/83352024-07-16 17:09:32.366oai:repositorio.ufes.br:10/8335http://repositorio.ufes.brRepositório InstitucionalPUBhttp://repositorio.ufes.br/oai/requestopendoar:21082024-10-15T18:00:35.491684Repositório Institucional da Universidade Federal do Espírito Santo (riUfes) - Universidade Federal do Espírito Santo (UFES)false |
dc.title.none.fl_str_mv |
Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil |
title |
Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil |
spellingShingle |
Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil Nascimento, Kamila Paschoal Magno do Basal cell carcinoma Cutaneous neoplasms Basal cell epithelioma Skin cancer Skin Neoplasias cutâneas Carcinoma basocelular Epitelioma basocelular Câncer de pele Medicina Pele Câncer Tumores 61 |
title_short |
Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil |
title_full |
Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil |
title_fullStr |
Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil |
title_full_unstemmed |
Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil |
title_sort |
Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil |
author |
Nascimento, Kamila Paschoal Magno do |
author_facet |
Nascimento, Kamila Paschoal Magno do |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Diniz, Lucia Martins |
dc.contributor.author.fl_str_mv |
Nascimento, Kamila Paschoal Magno do |
dc.contributor.referee1.fl_str_mv |
Luz, Flávio Barbosa |
dc.contributor.referee2.fl_str_mv |
Santos, Maria Carmen Lopes Ferreira Silva |
dc.contributor.referee3.fl_str_mv |
Musso, Carlos |
contributor_str_mv |
Diniz, Lucia Martins Luz, Flávio Barbosa Santos, Maria Carmen Lopes Ferreira Silva Musso, Carlos |
dc.subject.eng.fl_str_mv |
Basal cell carcinoma Cutaneous neoplasms Basal cell epithelioma Skin cancer Skin |
topic |
Basal cell carcinoma Cutaneous neoplasms Basal cell epithelioma Skin cancer Skin Neoplasias cutâneas Carcinoma basocelular Epitelioma basocelular Câncer de pele Medicina Pele Câncer Tumores 61 |
dc.subject.por.fl_str_mv |
Neoplasias cutâneas Carcinoma basocelular Epitelioma basocelular Câncer de pele |
dc.subject.cnpq.fl_str_mv |
Medicina |
dc.subject.br-rjbn.none.fl_str_mv |
Pele Câncer Tumores |
dc.subject.udc.none.fl_str_mv |
61 |
description |
Introduction: Basal cell carcinoma (BCC) is the commonest type of cancer among humans. About 85% are located on the face and trunk and 10-15% in usually photoprotected areas. Objective: To compare epidemiological, clinical and histopathological aspects of BCCs from non-photoexposed areas with those of photoexposed areas. Patients and methods: Observational, retrospective and casecontrol study of patients with clinical and histopathological diagnosis of BCC by the Dermatology Service of Vitória-ES, from 2008 to 2015. A total of 107 BCCs were assessed, from which 32 (29 , 9%) were located in non-photoexposed areas and 75 (71.1%) in photoexposed areas (nose). Results: The median age was 70 years; 62% of the patients were women as for the BCCs in the non-photoexposed regions; The commonest histological subtype in the two groups was the nodular one, followed by the superficial one in the non-photoexposed area, with 10 (31.3%) cases (OR = 2,051-5,267; p = 0,0001). Micronodular and baso-squamous subtypes were not observed in this group. Twelve (37.5%) cases in the non-photoexposed areas presented mild or absent elastosis (OR = 1,789-4,919; p = 0,0001). There was a predominance of a large number of mononuclears in the group of non-photoexposed areas: 12 (37.5%) cases, compared to eight (10.7%) cases in the photoexposed areas group (OR: 1,543-4,414; p = 0.002). Regarding the pattern of growth of BCCs, in the group of cases of the non-photoexposed areas, there was a predominance of the low risk pattern in 23 (71.9%) cases of nonphotoexposed areas versus 42 (56%) cases in the group of photoexposed areas (P = 0.137). Discussion: Despite the higher frequency of the nodular subtype in the two analyzed regions, the superficial subtype was more frequent in the non-photoexposed area, with a statistical difference, validating the literature. There was a higher frequency of moderate / severe elastosis in both regions, similar to the literature, but its absence was three times more likely to occur in the non-exposed area. The predominance of mononuclear cells in the non-photoexposed areas, possibly prevented the tumor from spreading. Regarding the pathological condition, the BCCs of the non-photoexposed areas were categorized as low risk in 65.5% of the cases. Conclusion: In the study, the BCCs in the non-photoexposed regions showed a better prognosis than the photoexposed areas, assessed through the histological factors. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-01-20 |
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2018-08-01T23:27:38Z |
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2018-08-01T23:27:38Z |
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NASCIMENTO, Kamila Paschoal Magno do. Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil. 2017. 91 f. Dissertação (Mestrado em Medicina) - Programa de Pós-Graduação em Medicina, Universidade Federal do Espírito Santo, Vitória, 2017. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufes.br/handle/10/8335 |
identifier_str_mv |
NASCIMENTO, Kamila Paschoal Magno do. Carcinoma basocelular em áreas incomuns : aspectos epidemiológicos, clínicos e terapêuticos em hospital universitário de Vitória-Espírito Santo-Brasil. 2017. 91 f. Dissertação (Mestrado em Medicina) - Programa de Pós-Graduação em Medicina, Universidade Federal do Espírito Santo, Vitória, 2017. |
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Universidade Federal do Espírito Santo Mestrado em Medicina |
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BR |
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Centro de Ciências da Saúde |
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Universidade Federal do Espírito Santo Mestrado em Medicina |
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