Efeitos dos hormônios sexuais femininos e da apolipoproteína E na expressão de biomarcadores característicos da Doença de Alzheimer em animais

• Autor(a) principal: Pedrosa, Diego França
• Data de Publicação: 2013
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Repositório Institucional da Universidade Federal do Espírito Santo (riUfes)
• Texto Completo: http://repositorio.ufes.br/handle/10/4516
• topic: Biotecnologia; Alzheimer, Doença de; Estrógenos; Ovariectomia; 61

Alzheimer's disease (AD) is a progressive neurodegenerative disease that compromises elements of the central nervous system, commonly associated to memory loss and dementia. There has been observed that AD’s patients brains exhibit extracellula plaques that consist in deposits of beta-amyloid (Aβ) peptide. Also, intracellular neurofibrillary tangles, which can be associated to intermediate filaments, appear mainly in the hippocampus and cerebral cortex of these patients. Anamnesis and molecular studies have suggested the presence of genetic elements involved in this pathophysiology, such as APOE gene, beta-amyloid precursor protein (APP) and TAU protein. However, some other comorbidity (high glycemic and lipid levels) may also contribute for the disease onset. Moreover, it is known that the disease incidence increases rapidly with advancing age and AD affects proportionately more women than men. It is believed that the decline in gonadal hormone levels in postmenopausal women may contribute to the observed difference between the sexes as long as it is also associated to many decline of body functions described above.