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spelling Brain and Covid-19: an integrative reviewBrainCOVID-19;Neurologic ManifestationsCOVID-192019 n-CoVSars-CoV-2CoronavírusNovo coronavírusBetacoronavirusCérebroManifestação neurológica© 2021 E-Cronicon Open Access, All rights reserved.Introduction: December 2019, an outbreak of Severe Acute Respiratory Distress Syndrome started in Wuhan, China. This injury spread rapidly until, in March 2020, the World Health Organization (WHO) declared a pandemic. Although respiratory symptoms are more reported, there is also evidence of impairment of the nervous system. Among the main neurological symptoms reported, the following stand out: headache, vertigo, altered consciousness, encephalopathies, cerebrovascular disease and seizures. Objectives: The objective of this study is to describe, based on the current literature, the main evidence of brain involvement by COVID-19 and its clinical manifestations. Methodology: This is an integrative literature review, carried out through the following databases: PubMed, LILACS, BIREME. The searches were limited to articles from the year 2020, in English and Portuguese. For this search, were used the descriptors indexed in MESH and DeCS “BRAIN” or “CEREBRAL” or “BRAIN INJURIES” or “CENTRAL NERVOUS SYSTEM” and “COVID-19” or “SARS-CoV-2”. Results: Through crossing of descriptors in the databases, and reverse search tools, 594 articles were found. Among these, 46 were selected to compose the sample. Discussion: Reports were found of patients with COVID-19 who had: benign intracranial hypertension, seizures, ischemic and hemorrhagic cerebrovascular diseases, acute necrotizing encephalopathy, Birkerstaff encephalitis, meningitis, and delirium. In addition, previous studies suggest that the involvement of the central nervous system by SARS-CoV-2 may induce an increase in neurodegenerative disorders in the future. Conclusion: It is a fact that the SARS-CoV-2 virus is capable of affecting the central nervous system. The clinical manifestations resulting from this are related to the greater severity of the condition, and a greater risk of unfavorable outcomes. Thus, it is imperative that the neurological examination of these patients is done extremely carefully, and that clinical findings are reported and notdisregarded.SimE-CRONICONN/A2021-07-19T16:48:24Z2021-07-19T16:48:24Z2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfNUNES, N. dos S. M.; NASCIMENTO, J. S. F.do; NASCIMENTO, J. K. F. do; CASTRO, R. R. T. de; AZIZI, M. A. A.; MARTINS JUNIOR, G. C.; CATHARINO, A. M. da S.; CAMARGO, V. S.; NEVES, M. A. O. Brain and Covid-19: an integrative review. E-CRONICON NEUROLOGY, v. 12, n.8, p. 101-107, 2020. Disponível em: https://www.ecronicon.com/ecne/pdf/ECNE-12-00741.pdf. Acesso em: 08 jan. 2020.https://app.uff.br/riuff/handle/1/22680N/AE-CRONICON NEUROLOGY. [s. l.] v. 12, n.8, 2020CC-BY-SAinfo:eu-repo/semantics/openAccessNunes, Nicolle dos Santos MoraesNascimento, Jacqueline Stephanie Fernandes doNascimento, Janie Kelly Fernandes doCastro, Renata Rodrigues Teixeira deAzizi, Marco Antônio AlvesMartins Junior, Gilberto CanedoCatharino, Antônio Marcos da SilvaCamargo, Valéria SilveiraNeves, Marco Antônio Orsiniengreponame:Repositório Institucional da Universidade Federal Fluminense (RIUFF)instname:Universidade Federal Fluminense (UFF)instacron:UFF2021-07-19T16:48:24Zoai:app.uff.br:1/22680Repositório InstitucionalPUBhttps://app.uff.br/oai/requestriuff@id.uff.bropendoar:21202021-07-19T16:48:24Repositório Institucional da Universidade Federal Fluminense (RIUFF) - Universidade Federal Fluminense (UFF)false
dc.title.none.fl_str_mv Brain and Covid-19: an integrative review
title Brain and Covid-19: an integrative review
spellingShingle Brain and Covid-19: an integrative review
Nunes, Nicolle dos Santos Moraes
Brain
COVID-19;
Neurologic Manifestations
COVID-19
2019 n-CoV
Sars-CoV-2
Coronavírus
Novo coronavírus
Betacoronavirus
Cérebro
Manifestação neurológica
title_short Brain and Covid-19: an integrative review
title_full Brain and Covid-19: an integrative review
title_fullStr Brain and Covid-19: an integrative review
title_full_unstemmed Brain and Covid-19: an integrative review
title_sort Brain and Covid-19: an integrative review
author Nunes, Nicolle dos Santos Moraes
author_facet Nunes, Nicolle dos Santos Moraes
Nascimento, Jacqueline Stephanie Fernandes do
Nascimento, Janie Kelly Fernandes do
Castro, Renata Rodrigues Teixeira de
Azizi, Marco Antônio Alves
Martins Junior, Gilberto Canedo
Catharino, Antônio Marcos da Silva
Camargo, Valéria Silveira
Neves, Marco Antônio Orsini
author_role author
author2 Nascimento, Jacqueline Stephanie Fernandes do
Nascimento, Janie Kelly Fernandes do
Castro, Renata Rodrigues Teixeira de
Azizi, Marco Antônio Alves
Martins Junior, Gilberto Canedo
Catharino, Antônio Marcos da Silva
Camargo, Valéria Silveira
Neves, Marco Antônio Orsini
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nunes, Nicolle dos Santos Moraes
Nascimento, Jacqueline Stephanie Fernandes do
Nascimento, Janie Kelly Fernandes do
Castro, Renata Rodrigues Teixeira de
Azizi, Marco Antônio Alves
Martins Junior, Gilberto Canedo
Catharino, Antônio Marcos da Silva
Camargo, Valéria Silveira
Neves, Marco Antônio Orsini
dc.subject.por.fl_str_mv Brain
COVID-19;
Neurologic Manifestations
COVID-19
2019 n-CoV
Sars-CoV-2
Coronavírus
Novo coronavírus
Betacoronavirus
Cérebro
Manifestação neurológica
topic Brain
COVID-19;
Neurologic Manifestations
COVID-19
2019 n-CoV
Sars-CoV-2
Coronavírus
Novo coronavírus
Betacoronavirus
Cérebro
Manifestação neurológica
description © 2021 E-Cronicon Open Access, All rights reserved.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021-07-19T16:48:24Z
2021-07-19T16:48:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv NUNES, N. dos S. M.; NASCIMENTO, J. S. F.do; NASCIMENTO, J. K. F. do; CASTRO, R. R. T. de; AZIZI, M. A. A.; MARTINS JUNIOR, G. C.; CATHARINO, A. M. da S.; CAMARGO, V. S.; NEVES, M. A. O. Brain and Covid-19: an integrative review. E-CRONICON NEUROLOGY, v. 12, n.8, p. 101-107, 2020. Disponível em: https://www.ecronicon.com/ecne/pdf/ECNE-12-00741.pdf. Acesso em: 08 jan. 2020.
https://app.uff.br/riuff/handle/1/22680
N/A
identifier_str_mv NUNES, N. dos S. M.; NASCIMENTO, J. S. F.do; NASCIMENTO, J. K. F. do; CASTRO, R. R. T. de; AZIZI, M. A. A.; MARTINS JUNIOR, G. C.; CATHARINO, A. M. da S.; CAMARGO, V. S.; NEVES, M. A. O. Brain and Covid-19: an integrative review. E-CRONICON NEUROLOGY, v. 12, n.8, p. 101-107, 2020. Disponível em: https://www.ecronicon.com/ecne/pdf/ECNE-12-00741.pdf. Acesso em: 08 jan. 2020.
N/A
url https://app.uff.br/riuff/handle/1/22680
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv E-CRONICON NEUROLOGY. [s. l.] v. 12, n.8, 2020
dc.rights.driver.fl_str_mv CC-BY-SA
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC-BY-SA
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv E-CRONICON
N/A
publisher.none.fl_str_mv E-CRONICON
N/A
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal Fluminense (RIUFF)
instname:Universidade Federal Fluminense (UFF)
instacron:UFF
instname_str Universidade Federal Fluminense (UFF)
instacron_str UFF
institution UFF
reponame_str Repositório Institucional da Universidade Federal Fluminense (RIUFF)
collection Repositório Institucional da Universidade Federal Fluminense (RIUFF)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal Fluminense (RIUFF) - Universidade Federal Fluminense (UFF)
repository.mail.fl_str_mv riuff@id.uff.br
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