Prevalência de HPV e seus Fatores de Risco em Adolescentes e Mulheres Jovens
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da Universidade Federal Fluminense (RIUFF) |
Texto Completo: | https://app.uff.br/riuff/handle/1/18444 |
Resumo: | Background: Human papillomavirus (HPV) infections are among the most important sexually transmitted diseases and are also considered a significant source of morbidity and mortality world wide, because of their etiological association with a variety of anogenital cancers. Estimates of HPV prevalence are extrapolated from epidemiological studies measuring current infection and vary by the population studied. The last decade has seen a significant increase in our knowwledge about HPV infections and its risk factors in adolescents. Several studies have reported that certain behavioral and biological risk factors are associated with this disease. HPV is so common and transmissible that having just one sexual partner often results in infection, therefore nearly all sexually active adolescents are at high risk for acquiring HPV. Studies of prevalence are important nowadays on the onset of vaccination programs for this population. Objectives: To determine the prevalence of HPV and analyse the demoghrafic, behavioral and biological risk factors associated to this infection, in an urban population of young students in Niterói, Rio de Janeiro. Methods: This study included 257 health adolescents and young women, sexually active, aged 14 to 26 years. The population sample was recruted from public schools in Niterói in 2004-2005. Subjects were excluded if they had a prior history of genital warts or an abnormal Papanicolaou smear. All subjects completed a self administered questionnaire regarding their demographic, comportamental, sexual and ginaecological history. A smear for cytologic examination was obtained and Human papillomavirus DNA was detected by the polymerase chain reaction (PCR) using consensus primers (MY09/11). Videodigital colposcopy with image capture, was also performed in all subjects. Results: The overall prevalence observed in our sample was 31,9%. An increased risk of HPV infection was significantly associated to withdrawal on the last intercourse (OR=3.00; CI 95% 1.13-7.92), alcohol consumption before sexual relations (OR=2,17; CI 95% 1,14-4,14), co-infection with trichomonas (OR=11.80; CI 95% 3.29- 42.38), and cervical ectopy (OR= 6.38; CI 95% 3.50-11.63). Logistic regression multivariated analysys demonstrated that the presence of ectopy, co-infection with trichomonas, and withdrawal on the last intercourse, remained as independent risk factors for HPV infection. Conclusions: Subjects with cervical ectopy and positive for trichomonas on citology were six and twelve times more likely to have an HPV infection respectively.These data are not very common on studies regarding this population, so further attention must be paid on these variables in oncoming studies to corroborate these findings. These data suggest that factors such as increased biologic vulnerability may play a role in HPV infections among adolescents and these findings may have important implications for primary prevention of HPV induced lesions. |
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Prevalência de HPV e seus Fatores de Risco em Adolescentes e Mulheres JovensHPVMEDICINACIÊNCIAS MÉDICASInfecção por pappilomavirusDoenças sexualmente transmissíveis-AdolescentesCNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICABackground: Human papillomavirus (HPV) infections are among the most important sexually transmitted diseases and are also considered a significant source of morbidity and mortality world wide, because of their etiological association with a variety of anogenital cancers. Estimates of HPV prevalence are extrapolated from epidemiological studies measuring current infection and vary by the population studied. The last decade has seen a significant increase in our knowwledge about HPV infections and its risk factors in adolescents. Several studies have reported that certain behavioral and biological risk factors are associated with this disease. HPV is so common and transmissible that having just one sexual partner often results in infection, therefore nearly all sexually active adolescents are at high risk for acquiring HPV. Studies of prevalence are important nowadays on the onset of vaccination programs for this population. Objectives: To determine the prevalence of HPV and analyse the demoghrafic, behavioral and biological risk factors associated to this infection, in an urban population of young students in Niterói, Rio de Janeiro. Methods: This study included 257 health adolescents and young women, sexually active, aged 14 to 26 years. The population sample was recruted from public schools in Niterói in 2004-2005. Subjects were excluded if they had a prior history of genital warts or an abnormal Papanicolaou smear. All subjects completed a self administered questionnaire regarding their demographic, comportamental, sexual and ginaecological history. A smear for cytologic examination was obtained and Human papillomavirus DNA was detected by the polymerase chain reaction (PCR) using consensus primers (MY09/11). Videodigital colposcopy with image capture, was also performed in all subjects. Results: The overall prevalence observed in our sample was 31,9%. An increased risk of HPV infection was significantly associated to withdrawal on the last intercourse (OR=3.00; CI 95% 1.13-7.92), alcohol consumption before sexual relations (OR=2,17; CI 95% 1,14-4,14), co-infection with trichomonas (OR=11.80; CI 95% 3.29- 42.38), and cervical ectopy (OR= 6.38; CI 95% 3.50-11.63). Logistic regression multivariated analysys demonstrated that the presence of ectopy, co-infection with trichomonas, and withdrawal on the last intercourse, remained as independent risk factors for HPV infection. Conclusions: Subjects with cervical ectopy and positive for trichomonas on citology were six and twelve times more likely to have an HPV infection respectively.These data are not very common on studies regarding this population, so further attention must be paid on these variables in oncoming studies to corroborate these findings. These data suggest that factors such as increased biologic vulnerability may play a role in HPV infections among adolescents and these findings may have important implications for primary prevention of HPV induced lesions.A infecção pelo HPV está entre as mais importantes DST`s da atualidade, sendo uma patologia que apresenta altos índices de morbidade e mortalidade devido à sua associação etiológica com uma grande variedade de câncer anogenital. Estudos epidemiológicos mostram que a prevalência de infecção pelo HPV varia de acordo com a população estudada, e com o método de screening. Na última década observamos um significante aumento em nosso conhecimento sobre os fatores de risco associados à infecção pelo HPV em adolescentes. Muitos estudos têm reportado que certos fatores de risco comportamentais e biológicos estão fortemente associados, o que torna as adolescentes mais vulneráveis a esta infecção. Estudos de prevalência são importantes na atualidade, devido à premência da implantação de programas de vacinação para esta população específica. Objetivos: Estimar a prevalência da infecção pelo HPV em adolescentes e em mulheres jovens sexualmente ativas, assim como avaliar os fatores de risco sócio-demográficos, comportamentais e biológicos associados à esta infecção. Métodos: Foram incluídas neste estudo 257 estudantes sexualmente ativas, assintomáticas e com idade variando entre 14 e 26 anos. A amostra foi selecionada em escolas públicas de Niterói no período compreendido entre 2004 e 2005. Foram excluídos os sujeitos de pesquisa que tivessem apresentado história prévia de verrugas genitais ou exame citológico alterado.Todas as alunas completaram um questionário de auto-preenchimento, com questões concernentes a dados demográficos e à história comportamental, sexual e ginecológica. As mesmas se submeteram ao exame citológico e à videocolposcopia digital com captura de imagem. O DNA do HPV foi detectado através da PCR (MY09/11). Resultados: A prevalência geral foi de 31,9%. A análise não ajustada mostrou uma associação estatisticamente significativa entre o resultado do PCR e as seguintes variáveis: prática de coito interrompido (OR=3,00; IC 95% 1,13-7,92), freqüência do uso de álcool antes das relações sexuais (OR=2,17; IC 95% 1,14-4,14), presença de tricomonas (OR=11,80; IC 95% 3,29-42,38),e presença de ectopia cervical (OR= 6,38; IC 95% 3,50-11,63). A análise multivariada da regressão logística demonstrou que a presença da ectopia, a co-infecção com tricomonas e o coito interrompido na última relação permaneceram na análise como fatores de risco independentes. Conclusões: Os sujeitos de pesquisa com ectopia cervical e positivos para tricomoníase, apresentaram uma associação positiva com a presença de DNA HPV seis e doze vezes maior, respectivamente, quando comparados com o resto da amostra. Estes resultados encontrados não são comuns em populações e em estudos semelhantes, portanto, uma maior atenção deve ser dada a estas variáveis nos próximos estudos para que estes dados possam ser corroborados e desdobrados. Estes resultados sugerem que um aumento da vulnerabilidade biológica entre as adolescentes possa propiciar um aumento na prevalência destas infecções, fato este que pode ter importantes implicações na prevenção primária das lesões HPV induzidas.Programa de Pós-graduação em Ciências MédicasCiências MédicasRosa, Maria Luiza GarciaCPF:00199818122http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785702Y6Oliveira, Ledy do Horto dos SantosCPF:05879256715http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4787020E1Oliveira, Solange Artimos deCPF:00988978622http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4780837E7Val, Isabel Cristina Chulvis doCPF:00148588222http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4704881E5Almeida Filho, Gutemberg Leão deCPF:05484456304Ferreira, Maria Diva Paz de Lima2021-03-10T20:44:36Z2009-06-172021-03-10T20:44:36Z2005-11-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://app.uff.br/riuff/handle/1/18444porCC-BY-SAinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da Universidade Federal Fluminense (RIUFF)instname:Universidade Federal Fluminense (UFF)instacron:UFF2021-03-10T20:44:36Zoai:app.uff.br:1/18444Repositório InstitucionalPUBhttps://app.uff.br/oai/requestriuff@id.uff.bropendoar:21202021-03-10T20:44:36Repositório Institucional da Universidade Federal Fluminense (RIUFF) - Universidade Federal Fluminense (UFF)false |
dc.title.none.fl_str_mv |
Prevalência de HPV e seus Fatores de Risco em Adolescentes e Mulheres Jovens |
title |
Prevalência de HPV e seus Fatores de Risco em Adolescentes e Mulheres Jovens |
spellingShingle |
Prevalência de HPV e seus Fatores de Risco em Adolescentes e Mulheres Jovens Ferreira, Maria Diva Paz de Lima HPV MEDICINA CIÊNCIAS MÉDICAS Infecção por pappilomavirus Doenças sexualmente transmissíveis-Adolescentes CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA |
title_short |
Prevalência de HPV e seus Fatores de Risco em Adolescentes e Mulheres Jovens |
title_full |
Prevalência de HPV e seus Fatores de Risco em Adolescentes e Mulheres Jovens |
title_fullStr |
Prevalência de HPV e seus Fatores de Risco em Adolescentes e Mulheres Jovens |
title_full_unstemmed |
Prevalência de HPV e seus Fatores de Risco em Adolescentes e Mulheres Jovens |
title_sort |
Prevalência de HPV e seus Fatores de Risco em Adolescentes e Mulheres Jovens |
author |
Ferreira, Maria Diva Paz de Lima |
author_facet |
Ferreira, Maria Diva Paz de Lima |
author_role |
author |
dc.contributor.none.fl_str_mv |
Rosa, Maria Luiza Garcia CPF:00199818122 http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785702Y6 Oliveira, Ledy do Horto dos Santos CPF:05879256715 http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4787020E1 Oliveira, Solange Artimos de CPF:00988978622 http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4780837E7 Val, Isabel Cristina Chulvis do CPF:00148588222 http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4704881E5 Almeida Filho, Gutemberg Leão de CPF:05484456304 |
dc.contributor.author.fl_str_mv |
Ferreira, Maria Diva Paz de Lima |
dc.subject.por.fl_str_mv |
HPV MEDICINA CIÊNCIAS MÉDICAS Infecção por pappilomavirus Doenças sexualmente transmissíveis-Adolescentes CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA |
topic |
HPV MEDICINA CIÊNCIAS MÉDICAS Infecção por pappilomavirus Doenças sexualmente transmissíveis-Adolescentes CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA |
description |
Background: Human papillomavirus (HPV) infections are among the most important sexually transmitted diseases and are also considered a significant source of morbidity and mortality world wide, because of their etiological association with a variety of anogenital cancers. Estimates of HPV prevalence are extrapolated from epidemiological studies measuring current infection and vary by the population studied. The last decade has seen a significant increase in our knowwledge about HPV infections and its risk factors in adolescents. Several studies have reported that certain behavioral and biological risk factors are associated with this disease. HPV is so common and transmissible that having just one sexual partner often results in infection, therefore nearly all sexually active adolescents are at high risk for acquiring HPV. Studies of prevalence are important nowadays on the onset of vaccination programs for this population. Objectives: To determine the prevalence of HPV and analyse the demoghrafic, behavioral and biological risk factors associated to this infection, in an urban population of young students in Niterói, Rio de Janeiro. Methods: This study included 257 health adolescents and young women, sexually active, aged 14 to 26 years. The population sample was recruted from public schools in Niterói in 2004-2005. Subjects were excluded if they had a prior history of genital warts or an abnormal Papanicolaou smear. All subjects completed a self administered questionnaire regarding their demographic, comportamental, sexual and ginaecological history. A smear for cytologic examination was obtained and Human papillomavirus DNA was detected by the polymerase chain reaction (PCR) using consensus primers (MY09/11). Videodigital colposcopy with image capture, was also performed in all subjects. Results: The overall prevalence observed in our sample was 31,9%. An increased risk of HPV infection was significantly associated to withdrawal on the last intercourse (OR=3.00; CI 95% 1.13-7.92), alcohol consumption before sexual relations (OR=2,17; CI 95% 1,14-4,14), co-infection with trichomonas (OR=11.80; CI 95% 3.29- 42.38), and cervical ectopy (OR= 6.38; CI 95% 3.50-11.63). Logistic regression multivariated analysys demonstrated that the presence of ectopy, co-infection with trichomonas, and withdrawal on the last intercourse, remained as independent risk factors for HPV infection. Conclusions: Subjects with cervical ectopy and positive for trichomonas on citology were six and twelve times more likely to have an HPV infection respectively.These data are not very common on studies regarding this population, so further attention must be paid on these variables in oncoming studies to corroborate these findings. These data suggest that factors such as increased biologic vulnerability may play a role in HPV infections among adolescents and these findings may have important implications for primary prevention of HPV induced lesions. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-11-28 2009-06-17 2021-03-10T20:44:36Z 2021-03-10T20:44:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
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publishedVersion |
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https://app.uff.br/riuff/handle/1/18444 |
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https://app.uff.br/riuff/handle/1/18444 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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CC-BY-SA info:eu-repo/semantics/openAccess |
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CC-BY-SA |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Programa de Pós-graduação em Ciências Médicas Ciências Médicas |
publisher.none.fl_str_mv |
Programa de Pós-graduação em Ciências Médicas Ciências Médicas |
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reponame:Repositório Institucional da Universidade Federal Fluminense (RIUFF) instname:Universidade Federal Fluminense (UFF) instacron:UFF |
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Universidade Federal Fluminense (UFF) |
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UFF |
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Repositório Institucional da Universidade Federal Fluminense (RIUFF) |
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Repositório Institucional da Universidade Federal Fluminense (RIUFF) |
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Repositório Institucional da Universidade Federal Fluminense (RIUFF) - Universidade Federal Fluminense (UFF) |
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riuff@id.uff.br |
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