Psycho-Neuriendocrine-Immune Interactions in COVID-19: Potential Impacts on Mental Health

• Autor(a) principal: Raony, Ícaro
• Data de Publicação: 2020
• Outros Autores: Figueiredo, Camila Saggioro, Pandolfo, Pablo, Araujo, Elizabeth Giestal de, Bomfim, Priscilla Oliveira Silva, Savino, Wilson
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da Universidade Federal Fluminense (RIUFF)
• Texto Completo: https://app.uff.br/riuff/handle/1/22736
• topic: Central Nervous System; COVID-19; Cytokine; HPA axis; Mental Health; Pandemic; SARS-Cov-2; Social Isolation; Sistema Nervoso Central; COVID-19; Citocina; Coronavírus; Saúde Mental; Saúde Mental

Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The impacts of the disease may be beyond the respiratory system, also affecting mental health. Several factors may be involved in the association between COVID-19 and psychiatric outcomes, such as fear inherent in the pandemic, adverse effects of treatments, as well as financial stress, and social isolation. We discuss the growing evidence suggesting that the relationship between SARS-CoV-2 and host can also trigger changes in the brain and behavior. Based on the similarity of SARS-CoV-2 with other coronaviruses, it is conceivable that changes in the endocrine and immune response in the periphery or in the central nervous system. The article highlights the hypothesis that neuroendocrine-immune interactions may be involved in negative impacts of SARS-CoV-2 infection and social isolation in psychiatric issues.