Síntese de novos fosforamidatos com avitidades ani-HSV-1

• Autor(a) principal: Macedo, William Pires de
• Data de Publicação: 2007
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Repositório Institucional da Universidade Federal Fluminense (RIUFF)
• Texto Completo: https://app.uff.br/riuff/handle/1/17982
• topic: Ácido fosforamídico; Fosforamidatos; Anti-HSV-1; Phosphoramidic acid; Phosphoramidates; Ani-HSV-1; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA

The number of the phosphoramidic acid derivatives associated with molecular systems of known biological activity is growing significantly. This is attributed, mainly, to the stability that the compound acquires in physiological environment, when it is incorporated into a phosphoramidic group, toward different enzymatic systems, like the nucleases. Based on a novel antiviral therapeutic concept, an efficient technique was developed, by which phosphoramidic groups are connected to heterocyclic systems with renowned biological activity, after modifications of known methodology for similar reactions. Herein, heterocyclic substrates such as 4-chloro-pirazolo[3,4-b]pyridine, 4-chloro-quinoline and 4-choloro-thieno[2,3-b]pyridine were phosphorylated by aminoalkyl phosphoramidic acid esters, generating three new phosphoramidate derivatives of series 60, 61 and 62,respectively.The products of the three series were obtained in good yield and tested against HSV-1 virus.