Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/9286 |
Resumo: | Piperazine derivatives correspond to an extensive chemical class of compounds with therapeutic potential to act as anxiolytic, antipsychotic and antidepressant drugs. This study was performed to assess the effects of the new piperazinic derivative [1-(4-((1-(4-chlorophenyl)-1H-pyrazol-4-yl) methyl) piperazine-1-yl) ethanone] (LQFM-030) on the expression of behaviors that have been associated with anxiety disorders in the mouse species. Male Swiss mice were orally treated with LQFM-030 prior to predictive behavioral tests as open field, elevated plus-maze and light-dark box tests. In addition, an experiment was performed to assess if the prior systemic administration of flumazenil, a benzodiazepine site competitive antagonist, or NAN-190, a 5-HT1A competitive antagonist, was able to counteract the anxiolytic-like effect induced by the injection of LQFM-030. The treatment with LQFM-030 did not interfere with locomotor activity but enhanced time spent at the center of the open field, suggesting an anxiolytic-like effect of this compound. This activity was confirmed by the results obtained in the plus-maze and light-dark box tests, and it was counteracted after pretreatment with flumazenil and NAN-190. Altogether, these data revealed that LQFM-030 is a new piperazine derivative that has an anxiolytic-like profile in different mouse anxiety tests, and this activity seems to involve the participation of benzodiazepine and 5-HT1A receptors. |
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Pobbe, Roger Luís Henschelhttp://lattes.cnpq.br/3003565465690718Pobbe, Roger Luís HenschelCosta, Renata Mazaro eSantos , Fernanda Cristina Alcantara doshttp://lattes.cnpq.br/9206574125945164Dias, Fernanda de Souza2019-02-14T11:13:52Z2019-01-16DIAS, F. S. Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos. 2019. 117 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Goiás, Goiânia, 2019.http://repositorio.bc.ufg.br/tede/handle/tede/9286ark:/38995/00130000011sfPiperazine derivatives correspond to an extensive chemical class of compounds with therapeutic potential to act as anxiolytic, antipsychotic and antidepressant drugs. This study was performed to assess the effects of the new piperazinic derivative [1-(4-((1-(4-chlorophenyl)-1H-pyrazol-4-yl) methyl) piperazine-1-yl) ethanone] (LQFM-030) on the expression of behaviors that have been associated with anxiety disorders in the mouse species. Male Swiss mice were orally treated with LQFM-030 prior to predictive behavioral tests as open field, elevated plus-maze and light-dark box tests. In addition, an experiment was performed to assess if the prior systemic administration of flumazenil, a benzodiazepine site competitive antagonist, or NAN-190, a 5-HT1A competitive antagonist, was able to counteract the anxiolytic-like effect induced by the injection of LQFM-030. The treatment with LQFM-030 did not interfere with locomotor activity but enhanced time spent at the center of the open field, suggesting an anxiolytic-like effect of this compound. This activity was confirmed by the results obtained in the plus-maze and light-dark box tests, and it was counteracted after pretreatment with flumazenil and NAN-190. Altogether, these data revealed that LQFM-030 is a new piperazine derivative that has an anxiolytic-like profile in different mouse anxiety tests, and this activity seems to involve the participation of benzodiazepine and 5-HT1A receptors.Os derivados piperazínicos correspondem a uma extensa classe química de compostos com potencial terapêutico para atuar como ansiolíticos, antipsicóticos e antidepressivos. Este estudo foi realizado para avaliar os efeitos do novo derivado piperazínico [1-(4-((1-(4-clorofenil)-1H–pirazol-4-il)metil)piperazina-1-il) etanona] (LQFM-030) sobre a expressão de comportamentos associados aos transtornos de ansiedade. Camundongos Swiss foram tratados oralmente com LQFM-030 antes de testes comportamentais, tais como campo aberto, labirinto em cruz elevado e caixa claro-escuro. Além disso, foi avaliado se a infusão prévia de flumazenil, um antagonista competitivo de receptores benzodiazepínicos, ou NAN-190, um antagonista competitivo de receptores do tipo 5-HT1A, era capaz de neutralizar o efeito ansiolítico induzido pela administração de LQFM-030. O tratamento com LQFM-030 não prejudicou a atividade locomotora dos animais, mas aumentou o tempo gasto no centro do campo aberto, sugerindo um efeito ansiolítico deste composto. Esta atividade foi confirmada pelos resultados obtidos nos testes do labirinto em cruz elevado e caixa-claro-escuro, e foi neutralizada após o pré-tratamento com flumazenil e NAN-190. Em conjunto, estes dados revelam que o LQFM-030 é um novo derivado de piperazina que tem um perfil ansiolítico em diferentes testes de ansiedade em camundongos, e esta atividade parece envolver a participação de receptores benzodiazepínicos e 5-HT1A.Submitted by Liliane Ferreira (ljuvencia30@gmail.com) on 2019-02-13T13:49:02Z No. of bitstreams: 2 Dissertação - Fernanda de Souza Dias - 2019.pdf: 3228162 bytes, checksum: f00da2f9e705121d8e4067d6468179e6 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2019-02-14T11:13:52Z (GMT) No. of bitstreams: 2 Dissertação - Fernanda de Souza Dias - 2019.pdf: 3228162 bytes, checksum: f00da2f9e705121d8e4067d6468179e6 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2019-02-14T11:13:52Z (GMT). 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dc.title.eng.fl_str_mv |
Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos |
dc.title.alternative.eng.fl_str_mv |
Anxiolytic-like effect of the new piperazine derivative LQFM-030 |
title |
Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos |
spellingShingle |
Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos Dias, Fernanda de Souza Derivado piperazínico Atividade ansiolítica Receptor 5-HT1A Receptor benzodiazepínico Piperazine derivative Anxiolytic-like activity 5-HT1A receptor Benzodiazepine receptor CIENCIAS BIOLOGICAS::FARMACOLOGIA |
title_short |
Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos |
title_full |
Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos |
title_fullStr |
Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos |
title_full_unstemmed |
Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos |
title_sort |
Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos |
author |
Dias, Fernanda de Souza |
author_facet |
Dias, Fernanda de Souza |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Pobbe, Roger Luís Henschel |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3003565465690718 |
dc.contributor.referee1.fl_str_mv |
Pobbe, Roger Luís Henschel |
dc.contributor.referee2.fl_str_mv |
Costa, Renata Mazaro e |
dc.contributor.referee3.fl_str_mv |
Santos , Fernanda Cristina Alcantara dos |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9206574125945164 |
dc.contributor.author.fl_str_mv |
Dias, Fernanda de Souza |
contributor_str_mv |
Pobbe, Roger Luís Henschel Pobbe, Roger Luís Henschel Costa, Renata Mazaro e Santos , Fernanda Cristina Alcantara dos |
dc.subject.por.fl_str_mv |
Derivado piperazínico Atividade ansiolítica Receptor 5-HT1A Receptor benzodiazepínico |
topic |
Derivado piperazínico Atividade ansiolítica Receptor 5-HT1A Receptor benzodiazepínico Piperazine derivative Anxiolytic-like activity 5-HT1A receptor Benzodiazepine receptor CIENCIAS BIOLOGICAS::FARMACOLOGIA |
dc.subject.eng.fl_str_mv |
Piperazine derivative Anxiolytic-like activity 5-HT1A receptor Benzodiazepine receptor |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::FARMACOLOGIA |
description |
Piperazine derivatives correspond to an extensive chemical class of compounds with therapeutic potential to act as anxiolytic, antipsychotic and antidepressant drugs. This study was performed to assess the effects of the new piperazinic derivative [1-(4-((1-(4-chlorophenyl)-1H-pyrazol-4-yl) methyl) piperazine-1-yl) ethanone] (LQFM-030) on the expression of behaviors that have been associated with anxiety disorders in the mouse species. Male Swiss mice were orally treated with LQFM-030 prior to predictive behavioral tests as open field, elevated plus-maze and light-dark box tests. In addition, an experiment was performed to assess if the prior systemic administration of flumazenil, a benzodiazepine site competitive antagonist, or NAN-190, a 5-HT1A competitive antagonist, was able to counteract the anxiolytic-like effect induced by the injection of LQFM-030. The treatment with LQFM-030 did not interfere with locomotor activity but enhanced time spent at the center of the open field, suggesting an anxiolytic-like effect of this compound. This activity was confirmed by the results obtained in the plus-maze and light-dark box tests, and it was counteracted after pretreatment with flumazenil and NAN-190. Altogether, these data revealed that LQFM-030 is a new piperazine derivative that has an anxiolytic-like profile in different mouse anxiety tests, and this activity seems to involve the participation of benzodiazepine and 5-HT1A receptors. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-02-14T11:13:52Z |
dc.date.issued.fl_str_mv |
2019-01-16 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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dc.identifier.citation.fl_str_mv |
DIAS, F. S. Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos. 2019. 117 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Goiás, Goiânia, 2019. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/9286 |
dc.identifier.dark.fl_str_mv |
ark:/38995/00130000011sf |
identifier_str_mv |
DIAS, F. S. Efeito ansiolítico do composto piperazínico LQFM-030 em camundongos. 2019. 117 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Goiás, Goiânia, 2019. ark:/38995/00130000011sf |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/9286 |
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por |
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por |
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600 600 600 600 |
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700814650651154363 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Ciências Biológicas (ICB) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Ciências Biológicas - ICB (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
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