Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais

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Autor(a) principal: Zampronha, Rossana de Araújo Catão
Data de Publicação: 2008
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/001300000ckgr
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/3217
Resumo: INTRODUCTION: The cervical cancer is the third most frequent malignant neoplasia among women in Brazil and it is responsible for the fourth cause of death for cancer. It is related among other causes to persistent infection by human papillomavirus. Doubts persist if HPV type could influence the tumor prognosis. OBJECTIVE: To study the prevalence of HPV 18 and HPV 16 in women presenting cervical cancer in clinic stage Ib, treated by radical hysterectomy with linfadenectomy, establishing prognostic correlation. METHODS: A retrospective cohort study, including 86 pacients with cervical cancer Ec I, submitted to radical hysterectomy, in a single center, in which were analysed the known prognostic factors and the positivity to HPV by PCR. Univariate analysis was performed, with Kaplan-Meir curves, for survival estimative. RESULTS: The prevalence of HPV 16 infection was 65.3% and HPV 18 prevalence was 33.3%. To both virus the prevalence was 26.9%. The overall survival for women presenting HPV 18 infection, in sixty months, was 91% and those women without HPV 18 infection, the overall survival was 96%. The overall survival for women with and without HPV16 infection was 94% and 96%, respectively. The disease free survival was not influenced by the presence of either virus. CONCLUSION: In the present study, in spite of the high prevalence of HPV 18 and HPV 16, the presence of these tipes of HPV have not influenced the prognosis of EcI cervixl cancer in women submitted to radical histerectomy.
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spelling Freitas Jr, Ruffohttp://lattes.cnpq.br/7343840830786566Murta, Eddie Fernando Cândidohttp://lattes.cnpq.br/4519373803760428Zampronha, Rossana de Araújo Catão2014-09-29T21:42:41Z2008-08-29ZAMPRONHA, Rossana de Araújo Catão. Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais. 2008. 92 f. Dissertação (Mestrado em Doenças Infecto-parasitárias) - Universidade Federal de Goiás, Goiânia, 2008.http://repositorio.bc.ufg.br/tede/handle/tede/3217ark:/38995/001300000ckgrINTRODUCTION: The cervical cancer is the third most frequent malignant neoplasia among women in Brazil and it is responsible for the fourth cause of death for cancer. It is related among other causes to persistent infection by human papillomavirus. Doubts persist if HPV type could influence the tumor prognosis. OBJECTIVE: To study the prevalence of HPV 18 and HPV 16 in women presenting cervical cancer in clinic stage Ib, treated by radical hysterectomy with linfadenectomy, establishing prognostic correlation. METHODS: A retrospective cohort study, including 86 pacients with cervical cancer Ec I, submitted to radical hysterectomy, in a single center, in which were analysed the known prognostic factors and the positivity to HPV by PCR. Univariate analysis was performed, with Kaplan-Meir curves, for survival estimative. RESULTS: The prevalence of HPV 16 infection was 65.3% and HPV 18 prevalence was 33.3%. To both virus the prevalence was 26.9%. The overall survival for women presenting HPV 18 infection, in sixty months, was 91% and those women without HPV 18 infection, the overall survival was 96%. The overall survival for women with and without HPV16 infection was 94% and 96%, respectively. The disease free survival was not influenced by the presence of either virus. CONCLUSION: In the present study, in spite of the high prevalence of HPV 18 and HPV 16, the presence of these tipes of HPV have not influenced the prognosis of EcI cervixl cancer in women submitted to radical histerectomy.INTRODUÇÃO: O câncer do colo uterino é a terceira neoplasia maligna mais frequente entre as mulheres no Brasil e entre elas é responsável pela quarta causa de morte por câncer. Está relacionado, entre outras causas, à infecção persistente pelo papilomavirus humano. Persistem dúvidas se o tipo de HPV exerce influência sobre o prognóstico da doença. OBJETIVO: Estudar a prevalência do HPV 18 e HPV 16 em mulheres com o câncer do colo uterino no estádio clínico Ib, tratadas por histerectomia radical com linfadenectomia pélvica, procurando estabelecer correlação prognóstica. MÉTODOS: Estudo de coorte retrospectivo, incluindo 86 pacientes com câncer do colo uterino Ec I, submetidas à histerectomia radical, em um único centro, no qual foram analisados os fatores prognósticos já conhecidos, além da presença do HPV 16 e 18, pesquisado por PCR. Utilizou-se análise univariada, com curvas de Kaplan-Meir, para estimativa de sobrevida. RESULTADOS: A prevalência do HPV 16 no grupo estudado foi de 65,3% e a prevalência do HPV 18 foi de 33,3%. A prevalência dos casos em que houve infecção por ambos os vírus foi de 26,9%. A sobrevida global para as mulheres portadoras do HPV 18, aos sessenta meses, foi de 91% e nas que não eram portadoras desse vírus foi de 96% (NS). Já para as mulheres portadoras do HPV 16 a sobrevida global foi de 94% e para as não portadoras desse vírus a sobrevida foi 96% (NS). A sobrevida livre de doença também não foi influenciada pela presença do HPV 18 e do HPV 16. CONCLUSÃO: No presente estudo, apesar da alta prevalência do HPV 18 e do HPV 16, a presença desses tipos de HPV não influenciaram o prognóstico das pacientes portadoras de câncer de colo uterino, Ec I, submetidas à histerectomia radical.Submitted by Erika Demachki (erikademachki@gmail.com) on 2014-09-29T21:15:45Z No. of bitstreams: 2 Dissertação Mestrado Rossana 28-11-12 3pdf.pdf: 712072 bytes, checksum: e167dad92cf8edd8b25298ca4f1f6951 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Jaqueline Silva (jtas29@gmail.com) on 2014-09-29T21:42:41Z (GMT) No. of bitstreams: 2 Dissertação Mestrado Rossana 28-11-12 3pdf.pdf: 712072 bytes, checksum: e167dad92cf8edd8b25298ca4f1f6951 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2014-09-29T21:42:41Z (GMT). No. of bitstreams: 2 Dissertação Mestrado Rossana 28-11-12 3pdf.pdf: 712072 bytes, checksum: e167dad92cf8edd8b25298ca4f1f6951 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2008-08-29application/pdfhttp://repositorio.bc.ufg.br/tede/retrieve/8940/Disserta%c3%a7%c3%a3o%20Mestrado%20Rossana%2028-11-12%203pdf.pdf.jpgporUniversidade Federal de GoiásPrograma de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP)UFGBrasilInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)Bachtiary B, Obermair A, Dreier B, Birner P, Breitenecker G, Knocke T-H, Selzer E, Potter R 2002. Impact of multiple HPV infection on response to treatment and survival in pacients receiving radical radiotherapy for cervical cancer. Int J Cancer. 102:237-243. Bellone S, Percorelli S, Cannom MJ, Santin AD 2007. Advances in dendritic-cell- based therapeutic vaccines for cervical cancer. Expert Rev Anticancer Ther. 7: 1473-86. 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dc.title.por.fl_str_mv Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais
dc.title.alternative.eng.fl_str_mv Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer
title Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais
spellingShingle Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais
Zampronha, Rossana de Araújo Catão
Papilomavirus humano
Câncer do colo uterino
Prognóstico
Human Papillomavirus
Cervix cancer
Prognosis
CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS
title_short Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais
title_full Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais
title_fullStr Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais
title_full_unstemmed Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais
title_sort Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais
author Zampronha, Rossana de Araújo Catão
author_facet Zampronha, Rossana de Araújo Catão
author_role author
dc.contributor.advisor1.fl_str_mv Freitas Jr, Ruffo
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/7343840830786566
dc.contributor.advisor-co1.fl_str_mv Murta, Eddie Fernando Cândido
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/4519373803760428
dc.contributor.author.fl_str_mv Zampronha, Rossana de Araújo Catão
contributor_str_mv Freitas Jr, Ruffo
Murta, Eddie Fernando Cândido
dc.subject.por.fl_str_mv Papilomavirus humano
Câncer do colo uterino
Prognóstico
topic Papilomavirus humano
Câncer do colo uterino
Prognóstico
Human Papillomavirus
Cervix cancer
Prognosis
CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS
dc.subject.eng.fl_str_mv Human Papillomavirus
Cervix cancer
Prognosis
dc.subject.cnpq.fl_str_mv CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS
description INTRODUCTION: The cervical cancer is the third most frequent malignant neoplasia among women in Brazil and it is responsible for the fourth cause of death for cancer. It is related among other causes to persistent infection by human papillomavirus. Doubts persist if HPV type could influence the tumor prognosis. OBJECTIVE: To study the prevalence of HPV 18 and HPV 16 in women presenting cervical cancer in clinic stage Ib, treated by radical hysterectomy with linfadenectomy, establishing prognostic correlation. METHODS: A retrospective cohort study, including 86 pacients with cervical cancer Ec I, submitted to radical hysterectomy, in a single center, in which were analysed the known prognostic factors and the positivity to HPV by PCR. Univariate analysis was performed, with Kaplan-Meir curves, for survival estimative. RESULTS: The prevalence of HPV 16 infection was 65.3% and HPV 18 prevalence was 33.3%. To both virus the prevalence was 26.9%. The overall survival for women presenting HPV 18 infection, in sixty months, was 91% and those women without HPV 18 infection, the overall survival was 96%. The overall survival for women with and without HPV16 infection was 94% and 96%, respectively. The disease free survival was not influenced by the presence of either virus. CONCLUSION: In the present study, in spite of the high prevalence of HPV 18 and HPV 16, the presence of these tipes of HPV have not influenced the prognosis of EcI cervixl cancer in women submitted to radical histerectomy.
publishDate 2008
dc.date.issued.fl_str_mv 2008-08-29
dc.date.accessioned.fl_str_mv 2014-09-29T21:42:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv ZAMPRONHA, Rossana de Araújo Catão. Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais. 2008. 92 f. Dissertação (Mestrado em Doenças Infecto-parasitárias) - Universidade Federal de Goiás, Goiânia, 2008.
dc.identifier.uri.fl_str_mv http://repositorio.bc.ufg.br/tede/handle/tede/3217
dc.identifier.dark.fl_str_mv ark:/38995/001300000ckgr
identifier_str_mv ZAMPRONHA, Rossana de Araújo Catão. Tipos de HPV e câncer do colo uterino: impacto no prognóstico das pacientes com tumores nos estádios iniciais. 2008. 92 f. Dissertação (Mestrado em Doenças Infecto-parasitárias) - Universidade Federal de Goiás, Goiânia, 2008.
ark:/38995/001300000ckgr
url http://repositorio.bc.ufg.br/tede/handle/tede/3217
dc.language.iso.fl_str_mv por
language por
dc.relation.program.fl_str_mv 6085308344741430434
dc.relation.confidence.fl_str_mv 600
600
600
dc.relation.department.fl_str_mv -7769011444564556288
dc.relation.cnpq.fl_str_mv 1767748423488408711
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