Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas

Detalhes bibliográficos
Autor(a) principal: Rodovalho, Luciana Ferreira Fonseca
Data de Publicação: 2009
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/0013000009sx7
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tde/2886
Resumo: Non-ionic surfactant vesicles (niosomes) and cyclodextrins (CDs) are able to modify physical-chemical properties of incorporated drugs. One of the major challenges for the topical administration of retinoids, such as isotretinoin (31cisRA), is the stability of these compounds in formulations capable of reducing their toxicity during the treatment. The purpose of this research was to develop vesicular carries capable to transport and deliver isotretinoin for topical application during acne treatment. The niosomes were obtained from Bryj®30:Cholesterol:DCP (50:25:10) by the film hydration method. The HP CDs:isotretinoin complex was obtained by agitation for 8 days in phosphate buffer pH 7.4. The vesicles were characterized and it was possible to encounter a large amount of morphological varieties, flexible structures and fluid membrane, after inclusion of free isotretinoin. The fluidness of the membrane that contains isotretinoin allowed leaking of the drug when in concentration above 5 mM. The HP CDs:Isotretinoin (20:1) increased the vesicle size considerably, also allowing drug leaking. The systems developed presented themselves as potential carries of isotretinoin for topical application and played the roll of drug delivery system,
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spelling Lima, Eliana Martinshttp://lattes.cnpq.br/7248774319455970http://lattes.cnpq.br/8587008150039543Rodovalho, Luciana Ferreira Fonseca2014-08-06T11:34:54Z2009-12-15RODOVALHO, Luciana Ferreira Fonseca. Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas. 2009. 81 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2009.http://repositorio.bc.ufg.br/tede/handle/tde/2886ark:/38995/0013000009sx7Non-ionic surfactant vesicles (niosomes) and cyclodextrins (CDs) are able to modify physical-chemical properties of incorporated drugs. One of the major challenges for the topical administration of retinoids, such as isotretinoin (31cisRA), is the stability of these compounds in formulations capable of reducing their toxicity during the treatment. The purpose of this research was to develop vesicular carries capable to transport and deliver isotretinoin for topical application during acne treatment. The niosomes were obtained from Bryj®30:Cholesterol:DCP (50:25:10) by the film hydration method. The HP CDs:isotretinoin complex was obtained by agitation for 8 days in phosphate buffer pH 7.4. The vesicles were characterized and it was possible to encounter a large amount of morphological varieties, flexible structures and fluid membrane, after inclusion of free isotretinoin. The fluidness of the membrane that contains isotretinoin allowed leaking of the drug when in concentration above 5 mM. The HP CDs:Isotretinoin (20:1) increased the vesicle size considerably, also allowing drug leaking. The systems developed presented themselves as potential carries of isotretinoin for topical application and played the roll of drug delivery system,Os niossomas, vesículas formadas por tensoativos não-iônicos, e as ciclodextrinas (HP CDs) são sistemas capazes de alterar as características físico-químicas originais de diversos fármacos. O maior desafio da administração tópica de retinóides, como isotretinoína (ácido 13-cis-retinóico), é a manutenção de sua estabilidade em formulações capazes de reduzir a sua toxicidade durante o tratamento. A proposta deste trabalho foi desenvolver sistema para o transporte e liberação da isotretinoína com potencial para aplicação na terapêutica tópica da acne. Os niossomas foram formados a partir de Brij®30:Colesterol:DCP (50:25:10) pelo método de hidratação do filme lipídico. O complexo HP Ciclodextrinasisotretinoína foi obtido por agitação durante 8 dias em tampão fosfato pH 7,4. Os niossomas foram caracterizados sendo possível verificar grande variedade morfológica, estruturas flexíveis e membrana fluída após a inclusão da isotretinoína livre. A fluidez da membrana que contém isotretinoína permitiu o vazamento de fármaco quando em concentrações maiores que 5 mM. O complexo HP CDs:isotretinoína (20:1) aumentou consideravelmente o tamanho das vesículas, também permitindo vazamentos. Os sistemas desenvolvidos possuem potencial para uso como carreadores da isotretinoína na aplicação tópica demonstrando comportamento de “sistema de liberação modificado”.Submitted by Cássia Santos (cassia.bcufg@gmail.com) on 2014-08-06T11:34:54Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Estudo_da_Encapsulacao_da_isotretinoina_nas_formas_livres_e_associada_a_ciclodextrinas_em_niossomas.pdf: 2030155 bytes, checksum: 19eecf0e1e4b0f42b01d0975d4634686 (MD5)Made available in DSpace on 2014-08-06T11:34:54Z (GMT). No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Estudo_da_Encapsulacao_da_isotretinoina_nas_formas_livres_e_associada_a_ciclodextrinas_em_niossomas.pdf: 2030155 bytes, checksum: 19eecf0e1e4b0f42b01d0975d4634686 (MD5) Previous issue date: 2009-12-15Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPqFundação de Apoio à Pesquisa - FUNAPEapplication/pdfhttp://repositorio.bc.ufg.br/tede/retrieve/6065/Estudo_da_Encapsulacao_da_isotretinoina_nas_formas_livres_e_associada_a_ciclodextrinas_em_niossomas.pdf.jpgporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências Farmacêuticas (FF)UFGBrasilFaculdade Farmácia - FF (RG)AHFS – DRUG INFORMATION. Skin and mucous membrane agentes: miscellaneous skin and mucous membrane agentes. Bthesda: AHFS, p. 2958- 2963, 1998. AGGARWAL D., PAL D., MITRA A. K., KAUR I. P. 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Characterization of the 13-cisretinoic acid / cyclodextrin inclusion complexes by phase solubility, photostability, physicochemical and computational analysis. 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dc.title.por.fl_str_mv Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas
dc.title.alternative.eng.fl_str_mv Research of isotretinoin encapsulation on its free form and associated to HP?Cyclodextrins in niosomes
title Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas
spellingShingle Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas
Rodovalho, Luciana Ferreira Fonseca
HP Ciclodextrinas
Niossomas
Isotretinoína
HP Cyclodextrins
Niosomes
Isotretinoin
CIENCIAS DA SAUDE::FARMACIA
title_short Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas
title_full Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas
title_fullStr Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas
title_full_unstemmed Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas
title_sort Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas
author Rodovalho, Luciana Ferreira Fonseca
author_facet Rodovalho, Luciana Ferreira Fonseca
author_role author
dc.contributor.advisor1.fl_str_mv Lima, Eliana Martins
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/7248774319455970
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/8587008150039543
dc.contributor.author.fl_str_mv Rodovalho, Luciana Ferreira Fonseca
contributor_str_mv Lima, Eliana Martins
dc.subject.por.fl_str_mv HP Ciclodextrinas
Niossomas
Isotretinoína
topic HP Ciclodextrinas
Niossomas
Isotretinoína
HP Cyclodextrins
Niosomes
Isotretinoin
CIENCIAS DA SAUDE::FARMACIA
dc.subject.eng.fl_str_mv HP Cyclodextrins
Niosomes
Isotretinoin
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE::FARMACIA
description Non-ionic surfactant vesicles (niosomes) and cyclodextrins (CDs) are able to modify physical-chemical properties of incorporated drugs. One of the major challenges for the topical administration of retinoids, such as isotretinoin (31cisRA), is the stability of these compounds in formulations capable of reducing their toxicity during the treatment. The purpose of this research was to develop vesicular carries capable to transport and deliver isotretinoin for topical application during acne treatment. The niosomes were obtained from Bryj®30:Cholesterol:DCP (50:25:10) by the film hydration method. The HP CDs:isotretinoin complex was obtained by agitation for 8 days in phosphate buffer pH 7.4. The vesicles were characterized and it was possible to encounter a large amount of morphological varieties, flexible structures and fluid membrane, after inclusion of free isotretinoin. The fluidness of the membrane that contains isotretinoin allowed leaking of the drug when in concentration above 5 mM. The HP CDs:Isotretinoin (20:1) increased the vesicle size considerably, also allowing drug leaking. The systems developed presented themselves as potential carries of isotretinoin for topical application and played the roll of drug delivery system,
publishDate 2009
dc.date.issued.fl_str_mv 2009-12-15
dc.date.accessioned.fl_str_mv 2014-08-06T11:34:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODOVALHO, Luciana Ferreira Fonseca. Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas. 2009. 81 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2009.
dc.identifier.uri.fl_str_mv http://repositorio.bc.ufg.br/tede/handle/tde/2886
dc.identifier.dark.fl_str_mv ark:/38995/0013000009sx7
identifier_str_mv RODOVALHO, Luciana Ferreira Fonseca. Estudo da encapsulação da isotretinoína nas formas livre e associada a ciclodextrinas em niossomas. 2009. 81 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2009.
ark:/38995/0013000009sx7
url http://repositorio.bc.ufg.br/tede/handle/tde/2886
dc.language.iso.fl_str_mv por
language por
dc.relation.program.fl_str_mv 824936988196152412
dc.relation.confidence.fl_str_mv 600
600
600
600
600
dc.relation.department.fl_str_mv 6010281161524209375
dc.relation.cnpq.fl_str_mv 6997636413449754996
dc.relation.sponsorship.fl_str_mv -2555911436985713659
-8644727573657825680
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