Avaliação da toxicidade oral aguda e atividade diurética de Celtis iguanaea (Jacq.) Sargent

• Autor(a) principal: GONÇALVES, Nádyla Zanon
• Data de Publicação: 2011
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tde/2108
• topic: Plantas medicinais; Celtis iguanaea; atividade diurética; Medicinal plants; Celtis iguanaea; diuretic activity; CNPQ::CIENCIAS DA SAUDE::FARMACIA::FARMACOTECNIA

Celtis iguanaea (Jacq.) Sargent is a species commonly known as cock-spur, in the Ulmaceae family and characterized as a shrub or small tree with branches long and very flexible. Is used for the treatment of urinary tract infections, kidney (kidney stones and pyelonephritis) and as a diuretic. Popular reports in the State of Goiás indicate the use of the spur cockscomb in the form of tea leaves. The aqueous extract of Celtis iguananea was tested in Wistar rats to assess single dose diuretic activity in observing the effect of same on urinary volume and products of metabolism (urea and creatinine) and assess the multiple-dose diuretic activity by observing the effect on the urinary volume and urinary excretion of electrolytes sodium (Na +) and potassium (K +), and also in Wistar rats and mice Swiss to test its acute oral toxicity following the Guide 423 (OECD), in which the animals were observed for 14 days after single administration of 2000mg/kg of extract, including this test the histopathological study of heart, lung, kidneys, liver, spleen, pancreas and intestines. The aqueous extract of cock-spur in their three doses (70, 200 and 600 mg/kg) did not submit multiple dose diuretic activity and only because it has not increased the excretion of water, electrolytes and metabolites of neither. The extract was framed in the class 5 (substance with Ld50 more than 2000 mg/kg and less than 5000 mg/kg), being considered of low toxicity, but histopathological findings cardiotoxicity and nephrotoxicity suggested does not extract any acute oral toxicity test (2000mg/kg), with an increase of absolut weight from the kidney and heart of male rats and mices treated with the extract and microscopic examination of kidney of male rats showing marked presence of cylinder hialinos no glomerulus.