Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/8563 |
Resumo: | This thesis presents the structure determination using single crystal x-ray crystallography of four drug candidates under ambient conditions of temperature and pressure, as well as submitted to high pressure. The crystallographic analysis of this type of compound allows to obtain the three-dimensional structure in an unambiguous way. This information is useful for the development process of new drugs in order to achieve the planned properties, such as the study of combinations of the drug with the excipients to be used to guarantee the rate of expected release of the drug in the human body and the optimization of interaction between the drug and the target. Furthermore during the process of drug manufacturing in the pharmaceutical industry polymorphic phases may arise due to the application of pressure, which occurs during grinding and in the preparation of tablets, which may alter the bioavailability, solubility and stability of the medicament. Thus, identifying the conditions under which such modifications may occur guarantees the reliability of the final product. In this sense, the crystallization and crystallographic analysis of drug candidates developed by the Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio) of the Universidade Federal do Rio de Janeiro (UFRJ) was carried out. The compounds analyzed were: LASSBio-1773 and LASSBio-1774, which have hypoglycemic activity, LASSBio-1606, with anti-inflammatory properties, and LASSBio-1735, which has been shown to be active against several types of cancer. For the compounds LASSBio-1774 and LASSBio-1606 X-ray diffraction at high pressures was also performed with Diamond Anvil Cell (DAC), determining their unit cells and analyzing the effects of pressure on the crystalline arrangement. In both compounds reversible phase transitions were observed. The analysis of the structural changes for LASSBio-1774 due to pressure was performed with the aid of strain tensors. |
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Sabino, José Ricardohttp://lattes.cnpq.br/9101677399031185Pinheiro, Carlos BasílioSantos Júnior, Sauli dosBufaiçal, Leandro Félix de SousaFonseca, Tertius Lima dahttp://lattes.cnpq.br/1117103500695625Castro, Rosane de Paula2018-06-11T15:49:37Z2018-05-07CASTRO, R. P. Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico. 2018. 99 f. Tese (Doutorado em Fisica) - Universidade Federal de Goiás, Goiânia, 2018.http://repositorio.bc.ufg.br/tede/handle/tede/8563This thesis presents the structure determination using single crystal x-ray crystallography of four drug candidates under ambient conditions of temperature and pressure, as well as submitted to high pressure. The crystallographic analysis of this type of compound allows to obtain the three-dimensional structure in an unambiguous way. This information is useful for the development process of new drugs in order to achieve the planned properties, such as the study of combinations of the drug with the excipients to be used to guarantee the rate of expected release of the drug in the human body and the optimization of interaction between the drug and the target. Furthermore during the process of drug manufacturing in the pharmaceutical industry polymorphic phases may arise due to the application of pressure, which occurs during grinding and in the preparation of tablets, which may alter the bioavailability, solubility and stability of the medicament. Thus, identifying the conditions under which such modifications may occur guarantees the reliability of the final product. In this sense, the crystallization and crystallographic analysis of drug candidates developed by the Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio) of the Universidade Federal do Rio de Janeiro (UFRJ) was carried out. The compounds analyzed were: LASSBio-1773 and LASSBio-1774, which have hypoglycemic activity, LASSBio-1606, with anti-inflammatory properties, and LASSBio-1735, which has been shown to be active against several types of cancer. For the compounds LASSBio-1774 and LASSBio-1606 X-ray diffraction at high pressures was also performed with Diamond Anvil Cell (DAC), determining their unit cells and analyzing the effects of pressure on the crystalline arrangement. In both compounds reversible phase transitions were observed. The analysis of the structural changes for LASSBio-1774 due to pressure was performed with the aid of strain tensors.Nesta tese serão apresentados os resultados de determinação estrutural por difração de raios X de monocristais de candidatos a fármacos em condições ambientes de temperatura e pressão, assim como submetidos à altas pressões. A análise cristalográfica desse tipo de composto permite obter a estrutura tridimensional de maneira inequívoca. Essa informação é útil para o processo de desenvolvimento de novos fármacos a fim de se alcançar as propriedades planejadas, tais como o estudo de combinações do fármaco com os excipientes a serem utilizados para garantir a taxa de liberação esperada do fármaco no corpo humano e a otimização da interação entre o fármaco e o alvo. Além disso, durante o processo de produção na indústria farmacêutica, podem surgir fases polimórficas devido à aplicação de pressão, que ocorre durante a moagem e na preparação de comprimidos, podendo alterar a biodisponibilidade, solubilidade e estabilidade do medicamento. Assim, identificar as condições nas quais tais modificações podem ocorrer, garante a confiabilidade do produto final. Nesse sentido, no presente trabalho foram realizadas a cristalização e análise cristalográfica de candidatos à fármacos desenvolvidos pelo Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio) da Universidade Federal do Rio de Janeiro (UFRJ). Os compostos analisados foram: LASSBio-1773 e LASSBio-1774, que possuem atividade hipoglicemiante, LASSBio-1606, com propriedade anti-inflamatória, e LASSBio-1735, que se mostrou ativo contra diversos tipos de câncer. Para os compostos LASSBio-1774 e LASSBio-1606 foi realizada também a difração de raios X em altas pressões, com a Diamond Anvil Cell (DAC), determinando suas células unitárias e analisando os efeitos da pressão sobre o arranjo cristalino. Em ambos os compostos foram observadas transições de fase reversíveis. Para o LASSBio-1774 a análise das mudanças estruturais devidas à pressão foi realizada com o auxílio dos tensores de strain.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2018-06-11T15:16:19Z No. of bitstreams: 2 Tese - Rosane de Paula Castro - 2018.pdf: 6915380 bytes, checksum: 2dd6980ad13f95405b57166fa1a2637c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-06-11T15:49:37Z (GMT) No. of bitstreams: 2 Tese - Rosane de Paula Castro - 2018.pdf: 6915380 bytes, checksum: 2dd6980ad13f95405b57166fa1a2637c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2018-06-11T15:49:37Z (GMT). No. of bitstreams: 2 Tese - Rosane de Paula Castro - 2018.pdf: 6915380 bytes, checksum: 2dd6980ad13f95405b57166fa1a2637c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2018-05-07Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Fisica (IF)UFGBrasilInstituto de Física - IF (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessCristalografia de raios XAltas pressõesDiamond anvil cellX-ray crystallographyHigh-pressureDiamond anvil cellFISICA DA MATERIA CONDENSADA::ESTRUTURA DE LIQUIDOS E SOLIDOS; CRISTALOGRAFIAAvaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêuticoEvaluation of pressure dependence of structural properties of organic compounds with pharmaceutical interestinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis3162138865744262028600600600600-402965885365204930659448136328237593682075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.eng.fl_str_mv |
Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico |
dc.title.alternative.eng.fl_str_mv |
Evaluation of pressure dependence of structural properties of organic compounds with pharmaceutical interest |
title |
Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico |
spellingShingle |
Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico Castro, Rosane de Paula Cristalografia de raios X Altas pressões Diamond anvil cell X-ray crystallography High-pressure Diamond anvil cell FISICA DA MATERIA CONDENSADA::ESTRUTURA DE LIQUIDOS E SOLIDOS; CRISTALOGRAFIA |
title_short |
Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico |
title_full |
Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico |
title_fullStr |
Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico |
title_full_unstemmed |
Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico |
title_sort |
Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico |
author |
Castro, Rosane de Paula |
author_facet |
Castro, Rosane de Paula |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Sabino, José Ricardo |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9101677399031185 |
dc.contributor.referee1.fl_str_mv |
Pinheiro, Carlos Basílio |
dc.contributor.referee2.fl_str_mv |
Santos Júnior, Sauli dos |
dc.contributor.referee3.fl_str_mv |
Bufaiçal, Leandro Félix de Sousa |
dc.contributor.referee4.fl_str_mv |
Fonseca, Tertius Lima da |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1117103500695625 |
dc.contributor.author.fl_str_mv |
Castro, Rosane de Paula |
contributor_str_mv |
Sabino, José Ricardo Pinheiro, Carlos Basílio Santos Júnior, Sauli dos Bufaiçal, Leandro Félix de Sousa Fonseca, Tertius Lima da |
dc.subject.por.fl_str_mv |
Cristalografia de raios X Altas pressões Diamond anvil cell |
topic |
Cristalografia de raios X Altas pressões Diamond anvil cell X-ray crystallography High-pressure Diamond anvil cell FISICA DA MATERIA CONDENSADA::ESTRUTURA DE LIQUIDOS E SOLIDOS; CRISTALOGRAFIA |
dc.subject.eng.fl_str_mv |
X-ray crystallography High-pressure Diamond anvil cell |
dc.subject.cnpq.fl_str_mv |
FISICA DA MATERIA CONDENSADA::ESTRUTURA DE LIQUIDOS E SOLIDOS; CRISTALOGRAFIA |
description |
This thesis presents the structure determination using single crystal x-ray crystallography of four drug candidates under ambient conditions of temperature and pressure, as well as submitted to high pressure. The crystallographic analysis of this type of compound allows to obtain the three-dimensional structure in an unambiguous way. This information is useful for the development process of new drugs in order to achieve the planned properties, such as the study of combinations of the drug with the excipients to be used to guarantee the rate of expected release of the drug in the human body and the optimization of interaction between the drug and the target. Furthermore during the process of drug manufacturing in the pharmaceutical industry polymorphic phases may arise due to the application of pressure, which occurs during grinding and in the preparation of tablets, which may alter the bioavailability, solubility and stability of the medicament. Thus, identifying the conditions under which such modifications may occur guarantees the reliability of the final product. In this sense, the crystallization and crystallographic analysis of drug candidates developed by the Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio) of the Universidade Federal do Rio de Janeiro (UFRJ) was carried out. The compounds analyzed were: LASSBio-1773 and LASSBio-1774, which have hypoglycemic activity, LASSBio-1606, with anti-inflammatory properties, and LASSBio-1735, which has been shown to be active against several types of cancer. For the compounds LASSBio-1774 and LASSBio-1606 X-ray diffraction at high pressures was also performed with Diamond Anvil Cell (DAC), determining their unit cells and analyzing the effects of pressure on the crystalline arrangement. In both compounds reversible phase transitions were observed. The analysis of the structural changes for LASSBio-1774 due to pressure was performed with the aid of strain tensors. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-06-11T15:49:37Z |
dc.date.issued.fl_str_mv |
2018-05-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CASTRO, R. P. Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico. 2018. 99 f. Tese (Doutorado em Fisica) - Universidade Federal de Goiás, Goiânia, 2018. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/8563 |
identifier_str_mv |
CASTRO, R. P. Avaliação da dependência com a pressão de propriedades estruturais de compostos orgânicos de interesse farmacêutico. 2018. 99 f. Tese (Doutorado em Fisica) - Universidade Federal de Goiás, Goiânia, 2018. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/8563 |
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por |
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por |
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3162138865744262028 |
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600 600 600 600 |
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dc.relation.cnpq.fl_str_mv |
5944813632823759368 |
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dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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Universidade Federal de Goiás |
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Programa de Pós-graduação em Fisica (IF) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Física - IF (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
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