Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/5489 |
Resumo: | Leishmaniasis are zoonoses present in several countries, being Leishmania (Viannia) braziliensis the main parasite that causes localized cutaneous (LCL) and / or mucous leishmaniasis (LM) in Brazil. It is not clear yet which factors favor the development of the mucosal form of the disease. The aim of this study was to evaluate the profile of experimental leishmaniasis in wild type mice and mice lacking the IFN, inos or gp91phox genes, after infection with L. (V.) braziliensis amastigotes isolated from patients with LCL or LM. Mice were inoculated with different amount of amastigote parasites in the foot paw and lesion development was measured weekly. Histopathological analyses were performed in hematoxilin eosin stained slides. The number of parasites present in the infected foot paw, lymph node and spleen during infection was estimated by the limiting dilution assay. It was observed that IFNγ or Phox KO mice infected with amastigotes isolated from LCL patients develop lesion earlier than mice infected with amastigotes from LM patients. iNOS KO mice infected with 1000 amastigotes isolated from LM patients developed greater lesion and more severe inflammation than mice infected with parasites from LCL at the 5th week. The IFNγ, iNOS and gp91phox mice had similar parasite number in the infected foot paw after infection with LM or LCL parasites .The parasite burden in lymph node and spleen was higher after infection with parasites from LM than LCL patients. The low ability of human macrophages to produce sufficient amount of NO can favor survive of LM parasites. Additionally, the increased ability of LM parasite to disseminate will facilitate migration to mucosal tissue to promote the mucosal disease. |
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Oliveira, Milton Adriano Pelli dehttp://lattes.cnpq.br/2152513705182408Oliveira, Milton Adriano Pelli deGonçalves, RicardoAndrade, Carolina HortaGomes, Rodrigo SaarFonseca, Simone Gonçalves dahttp://lattes.cnpq.br/8550177354539916Gomes, Clayson Moura2016-04-18T14:58:58Z2015-08-05GOMES, Clayson Moura. Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida. 2015. 105 f. Tese (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2015.http://repositorio.bc.ufg.br/tede/handle/tede/5489Leishmaniasis are zoonoses present in several countries, being Leishmania (Viannia) braziliensis the main parasite that causes localized cutaneous (LCL) and / or mucous leishmaniasis (LM) in Brazil. It is not clear yet which factors favor the development of the mucosal form of the disease. The aim of this study was to evaluate the profile of experimental leishmaniasis in wild type mice and mice lacking the IFN, inos or gp91phox genes, after infection with L. (V.) braziliensis amastigotes isolated from patients with LCL or LM. Mice were inoculated with different amount of amastigote parasites in the foot paw and lesion development was measured weekly. Histopathological analyses were performed in hematoxilin eosin stained slides. The number of parasites present in the infected foot paw, lymph node and spleen during infection was estimated by the limiting dilution assay. It was observed that IFNγ or Phox KO mice infected with amastigotes isolated from LCL patients develop lesion earlier than mice infected with amastigotes from LM patients. iNOS KO mice infected with 1000 amastigotes isolated from LM patients developed greater lesion and more severe inflammation than mice infected with parasites from LCL at the 5th week. The IFNγ, iNOS and gp91phox mice had similar parasite number in the infected foot paw after infection with LM or LCL parasites .The parasite burden in lymph node and spleen was higher after infection with parasites from LM than LCL patients. The low ability of human macrophages to produce sufficient amount of NO can favor survive of LM parasites. Additionally, the increased ability of LM parasite to disseminate will facilitate migration to mucosal tissue to promote the mucosal disease.As leishmanioses são zoonoses presentes em vários países do mundo, sendo Leishmania (Viania) braziliensis o parasito que causa a leishmaniose cutânea e/ou a leishmaniose mucosa no Brasil. Ainda não são claros os fatores que favorecem o desenvolvimento da forma mucosa da doença, porém é possível que fatores presentes nos parasitos sejam responsáveis pelo aparecimento de lesões mucosas. O objetivo deste estudo foi avaliar o perfil imunopatológico da leishmaniose experimental em camundongos do tipo selvagem e também em deficientes nos genes de IFN, inos ou gp91phox após a infecção com amastigotas de L. (V.) braziliensis isoladas de pacientes com leishmaniose cutânea localizada (LCL) ou leishmaniose mucosa (LM). Foram inoculadas diferentes quantidades de parasitos na pata dos camundongos e a progressão da lesão foi mensurada semanalmente. A análise histopatológica da lesão foi feita em lâminas coradas com hematoxilina e eosina. O número de parasitos presentes na pata infectada, linfonodo e baço dos animais infectados foi estimado pelo método de diluição limitante. Observou-se que os camundongos desprovidos de IFN ou phox infectados com amastigotas isoladas de pacientes com LCL desenvolveram a lesão mais precocemente do que camundongos infectados com amastigotas isoladas de pacientes com LM. A infecção de camundongos desprovidos de iNOS com 1000 amastigotas de pacientes com LM desencadeou uma lesão maior e com uma inflamação mais severa que aquela causada por parasitos de pacientes com LCL a partir da 5a semana. Animais deficientes de IFN, iNOS e gp91phox possuíam um número similar de parasitos na pata infectada, independente dos parasitos serem oriundos de pacientes com LCL ou LM. Nos linfonodos e baço foi observado mais parasitos quando os animais eram infectados com amastigotas de pacientes com LM. A pequena habilidade dos macrófagos humanos de produzir uma quantidade suficiente de NO pode favorecer a sobrevida de parasitos oriundos de LM. Além disso, o aumento da habilidade de parasitos de LM em se disseminar facilitaria a migração para os tecidos mucosos e promoveriam a doença na mucosa.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-04-18T14:57:11Z No. of bitstreams: 2 Tese - Clayson Moura Gomes - 2015.pdf: 2080474 bytes, checksum: e53c02c9eac98545d091fb13331c2b9a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-04-18T14:58:58Z (GMT) No. of bitstreams: 2 Tese - Clayson Moura Gomes - 2015.pdf: 2080474 bytes, checksum: e53c02c9eac98545d091fb13331c2b9a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2016-04-18T14:58:58Z (GMT). No. of bitstreams: 2 Tese - Clayson Moura Gomes - 2015.pdf: 2080474 bytes, checksum: e53c02c9eac98545d091fb13331c2b9a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2015-08-05Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEGCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP)UFGBrasilInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessLeishmania braziliensisMecanismos microbicidas e leishmaniose mucosaLeishmania braziliensisMicrobicidal mechanismsMucous leishmaniasisSAUDE COLETIVA::SAUDE PUBLICAInfecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzidaMurine infection by Leishmania (V.) braziliensis: model in mice deficient in gamma interferon, phagocyte oxidase or inducible nitric oxide synthaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis6085308344741430434600600600600600-77690114445645562883112649244584600979-9614098074407577782075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida |
dc.title.alternative.eng.fl_str_mv |
Murine infection by Leishmania (V.) braziliensis: model in mice deficient in gamma interferon, phagocyte oxidase or inducible nitric oxide synthase |
title |
Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida |
spellingShingle |
Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida Gomes, Clayson Moura Leishmania braziliensis Mecanismos microbicidas e leishmaniose mucosa Leishmania braziliensis Microbicidal mechanisms Mucous leishmaniasis SAUDE COLETIVA::SAUDE PUBLICA |
title_short |
Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida |
title_full |
Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida |
title_fullStr |
Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida |
title_full_unstemmed |
Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida |
title_sort |
Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida |
author |
Gomes, Clayson Moura |
author_facet |
Gomes, Clayson Moura |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Oliveira, Milton Adriano Pelli de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/2152513705182408 |
dc.contributor.referee1.fl_str_mv |
Oliveira, Milton Adriano Pelli de |
dc.contributor.referee2.fl_str_mv |
Gonçalves, Ricardo |
dc.contributor.referee3.fl_str_mv |
Andrade, Carolina Horta |
dc.contributor.referee4.fl_str_mv |
Gomes, Rodrigo Saar |
dc.contributor.referee5.fl_str_mv |
Fonseca, Simone Gonçalves da |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8550177354539916 |
dc.contributor.author.fl_str_mv |
Gomes, Clayson Moura |
contributor_str_mv |
Oliveira, Milton Adriano Pelli de Oliveira, Milton Adriano Pelli de Gonçalves, Ricardo Andrade, Carolina Horta Gomes, Rodrigo Saar Fonseca, Simone Gonçalves da |
dc.subject.por.fl_str_mv |
Leishmania braziliensis Mecanismos microbicidas e leishmaniose mucosa |
topic |
Leishmania braziliensis Mecanismos microbicidas e leishmaniose mucosa Leishmania braziliensis Microbicidal mechanisms Mucous leishmaniasis SAUDE COLETIVA::SAUDE PUBLICA |
dc.subject.eng.fl_str_mv |
Leishmania braziliensis Microbicidal mechanisms Mucous leishmaniasis |
dc.subject.cnpq.fl_str_mv |
SAUDE COLETIVA::SAUDE PUBLICA |
description |
Leishmaniasis are zoonoses present in several countries, being Leishmania (Viannia) braziliensis the main parasite that causes localized cutaneous (LCL) and / or mucous leishmaniasis (LM) in Brazil. It is not clear yet which factors favor the development of the mucosal form of the disease. The aim of this study was to evaluate the profile of experimental leishmaniasis in wild type mice and mice lacking the IFN, inos or gp91phox genes, after infection with L. (V.) braziliensis amastigotes isolated from patients with LCL or LM. Mice were inoculated with different amount of amastigote parasites in the foot paw and lesion development was measured weekly. Histopathological analyses were performed in hematoxilin eosin stained slides. The number of parasites present in the infected foot paw, lymph node and spleen during infection was estimated by the limiting dilution assay. It was observed that IFNγ or Phox KO mice infected with amastigotes isolated from LCL patients develop lesion earlier than mice infected with amastigotes from LM patients. iNOS KO mice infected with 1000 amastigotes isolated from LM patients developed greater lesion and more severe inflammation than mice infected with parasites from LCL at the 5th week. The IFNγ, iNOS and gp91phox mice had similar parasite number in the infected foot paw after infection with LM or LCL parasites .The parasite burden in lymph node and spleen was higher after infection with parasites from LM than LCL patients. The low ability of human macrophages to produce sufficient amount of NO can favor survive of LM parasites. Additionally, the increased ability of LM parasite to disseminate will facilitate migration to mucosal tissue to promote the mucosal disease. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-08-05 |
dc.date.accessioned.fl_str_mv |
2016-04-18T14:58:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GOMES, Clayson Moura. Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida. 2015. 105 f. Tese (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2015. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/5489 |
identifier_str_mv |
GOMES, Clayson Moura. Infecção murina por Leishmania (Viannia) braziliensis: modelo em camundongos deficientes em interferon gama, fagócito oxidase ou óxido nítrico sintase induzida. 2015. 105 f. Tese (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2015. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/5489 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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6085308344741430434 |
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600 600 600 600 600 |
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dc.relation.cnpq.fl_str_mv |
3112649244584600979 |
dc.relation.sponsorship.fl_str_mv |
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dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
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Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
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Universidade Federal de Goiás (UFG) |
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UFG |
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Repositório Institucional da UFG |
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bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f ef48816a10f2d45f2e2fee2f478e2faf 9da0b6dfac957114c6a7714714b86306 e53c02c9eac98545d091fb13331c2b9a |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798044316938010624 |